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P12733

- RL18E_HALMA

UniProt

P12733 - RL18E_HALMA

Protein

50S ribosomal protein L18e

Gene

rpl18e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Stabilizes the tertiary rRNA structure within the 23S rRNA domain (domain II) to which it binds.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-60-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L18e
    Alternative name(s):
    Hl29
    L19
    Gene namesi
    Name:rpl18e
    Ordered Locus Names:rrnAC0064
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 11611550S ribosomal protein L18ePRO_0000132787Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Interacts weakly with proteins L4 and L15. Has been cross-linked to L4.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC0064.

    Structurei

    Secondary structure

    1
    116
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 2116
    Helixi25 – 3410
    Helixi38 – 403
    Beta strandi41 – 455
    Helixi46 – 527
    Beta strandi57 – 6610
    Beta strandi76 – 827
    Helixi84 – 9310
    Beta strandi94 – 985
    Helixi99 – 1057
    Beta strandi111 – 1144

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40L2-116[»]
    1JJ2X-ray2.40N2-116[»]
    1K73X-ray3.01P2-116[»]
    1K8AX-ray3.00P2-116[»]
    1K9MX-ray3.00P2-116[»]
    1KC8X-ray3.01P2-116[»]
    1KD1X-ray3.00P2-116[»]
    1KQSX-ray3.10N2-116[»]
    1M1KX-ray3.20P2-116[»]
    1M90X-ray2.80P2-116[»]
    1N8RX-ray3.00P2-116[»]
    1NJIX-ray3.00P2-116[»]
    1Q7YX-ray3.20P2-116[»]
    1Q81X-ray2.95P2-116[»]
    1Q82X-ray2.98P2-116[»]
    1Q86X-ray3.00P2-116[»]
    1QVFX-ray3.10N2-116[»]
    1QVGX-ray2.90N2-116[»]
    1S72X-ray2.40O1-116[»]
    1VQ4X-ray2.70O1-116[»]
    1VQ5X-ray2.60O1-116[»]
    1VQ6X-ray2.70O1-116[»]
    1VQ7X-ray2.50O1-116[»]
    1VQ8X-ray2.20O1-116[»]
    1VQ9X-ray2.40O1-116[»]
    1VQKX-ray2.30O1-116[»]
    1VQLX-ray2.30O1-116[»]
    1VQMX-ray2.30O1-116[»]
    1VQNX-ray2.40O1-116[»]
    1VQOX-ray2.20O1-116[»]
    1VQPX-ray2.25O1-116[»]
    1W2BX-ray3.50N2-116[»]
    1YHQX-ray2.40O1-116[»]
    1YI2X-ray2.65O1-116[»]
    1YIJX-ray2.60O1-116[»]
    1YITX-ray2.80O1-116[»]
    1YJ9X-ray2.90O1-116[»]
    1YJNX-ray3.00O1-116[»]
    1YJWX-ray2.90O1-116[»]
    2OTJX-ray2.90O1-116[»]
    2OTLX-ray2.70O1-116[»]
    2QA4X-ray3.00O1-116[»]
    2QEXX-ray2.90O1-116[»]
    3CC2X-ray2.40O1-116[»]
    3CC4X-ray2.70O1-116[»]
    3CC7X-ray2.70O1-116[»]
    3CCEX-ray2.75O1-116[»]
    3CCJX-ray2.70O1-116[»]
    3CCLX-ray2.90O1-116[»]
    3CCMX-ray2.55O1-116[»]
    3CCQX-ray2.90O1-116[»]
    3CCRX-ray3.00O1-116[»]
    3CCSX-ray2.95O1-116[»]
    3CCUX-ray2.80O1-116[»]
    3CCVX-ray2.90O1-116[»]
    3CD6X-ray2.75O1-116[»]
    3CMAX-ray2.80O1-116[»]
    3CMEX-ray2.95O1-116[»]
    3CPWX-ray2.70N1-116[»]
    3CXCX-ray3.00N2-116[»]
    3G4SX-ray3.20O2-116[»]
    3G6EX-ray2.70O2-116[»]
    3G71X-ray2.85O2-116[»]
    3I55X-ray3.11O1-116[»]
    3I56X-ray2.90O1-116[»]
    3OW2X-ray2.70N2-116[»]
    4ADXelectron microscopy6.60O1-116[»]
    4HUBX-ray2.40O1-116[»]
    ProteinModelPortaliP12733.
    SMRiP12733. Positions 2-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12733.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L18e family.Curated

    Phylogenomic databases

    eggNOGiCOG1727.
    HOGENOMiHOG000225300.
    KOiK02883.
    OMAiASCHAHG.

    Family and domain databases

    HAMAPiMF_00329. Ribosomal_L18e.
    InterProiIPR001196. Ribosomal_L15_CS.
    IPR000039. Ribosomal_L18e.
    IPR021131. Ribosomal_L18e/L15P.
    IPR022947. Ribosomal_L18e_arc.
    IPR021132. Ribosomal_L18e_CS.
    [Graphical view]
    PANTHERiPTHR10934. PTHR10934. 1 hit.
    PfamiPF00828. Ribosomal_L18e. 1 hit.
    [Graphical view]
    SUPFAMiSSF52080. SSF52080. 1 hit.
    PROSITEiPS01106. RIBOSOMAL_L18E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12733-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKTNPRLSS LIADLKSAAR SSGGAVWGDV AERLEKPRRT HAEVNLGRIE    50
    RYAQEDETVV VPGKVLGSGV LQKDVTVAAV DFSGTAETKI DQVGEAVSLE 100
    QAIENNPEGS HVRVIR 116
    Length:116
    Mass (Da):12,422
    Last modified:January 23, 2007 - v2
    Checksum:iBFACD702AE94474D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76567 Genomic DNA. Translation: AAA73096.1.
    AY596297 Genomic DNA. Translation: AAV45144.1.
    M87833 Genomic DNA. Translation: AAA73213.1.
    PIRiA41715. R5HSH9.
    RefSeqiYP_134850.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45144; AAV45144; rrnAC0064.
    GeneIDi3130533.
    KEGGihma:rrnAC0064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76567 Genomic DNA. Translation: AAA73096.1 .
    AY596297 Genomic DNA. Translation: AAV45144.1 .
    M87833 Genomic DNA. Translation: AAA73213.1 .
    PIRi A41715. R5HSH9.
    RefSeqi YP_134850.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 L 2-116 [» ]
    1JJ2 X-ray 2.40 N 2-116 [» ]
    1K73 X-ray 3.01 P 2-116 [» ]
    1K8A X-ray 3.00 P 2-116 [» ]
    1K9M X-ray 3.00 P 2-116 [» ]
    1KC8 X-ray 3.01 P 2-116 [» ]
    1KD1 X-ray 3.00 P 2-116 [» ]
    1KQS X-ray 3.10 N 2-116 [» ]
    1M1K X-ray 3.20 P 2-116 [» ]
    1M90 X-ray 2.80 P 2-116 [» ]
    1N8R X-ray 3.00 P 2-116 [» ]
    1NJI X-ray 3.00 P 2-116 [» ]
    1Q7Y X-ray 3.20 P 2-116 [» ]
    1Q81 X-ray 2.95 P 2-116 [» ]
    1Q82 X-ray 2.98 P 2-116 [» ]
    1Q86 X-ray 3.00 P 2-116 [» ]
    1QVF X-ray 3.10 N 2-116 [» ]
    1QVG X-ray 2.90 N 2-116 [» ]
    1S72 X-ray 2.40 O 1-116 [» ]
    1VQ4 X-ray 2.70 O 1-116 [» ]
    1VQ5 X-ray 2.60 O 1-116 [» ]
    1VQ6 X-ray 2.70 O 1-116 [» ]
    1VQ7 X-ray 2.50 O 1-116 [» ]
    1VQ8 X-ray 2.20 O 1-116 [» ]
    1VQ9 X-ray 2.40 O 1-116 [» ]
    1VQK X-ray 2.30 O 1-116 [» ]
    1VQL X-ray 2.30 O 1-116 [» ]
    1VQM X-ray 2.30 O 1-116 [» ]
    1VQN X-ray 2.40 O 1-116 [» ]
    1VQO X-ray 2.20 O 1-116 [» ]
    1VQP X-ray 2.25 O 1-116 [» ]
    1W2B X-ray 3.50 N 2-116 [» ]
    1YHQ X-ray 2.40 O 1-116 [» ]
    1YI2 X-ray 2.65 O 1-116 [» ]
    1YIJ X-ray 2.60 O 1-116 [» ]
    1YIT X-ray 2.80 O 1-116 [» ]
    1YJ9 X-ray 2.90 O 1-116 [» ]
    1YJN X-ray 3.00 O 1-116 [» ]
    1YJW X-ray 2.90 O 1-116 [» ]
    2OTJ X-ray 2.90 O 1-116 [» ]
    2OTL X-ray 2.70 O 1-116 [» ]
    2QA4 X-ray 3.00 O 1-116 [» ]
    2QEX X-ray 2.90 O 1-116 [» ]
    3CC2 X-ray 2.40 O 1-116 [» ]
    3CC4 X-ray 2.70 O 1-116 [» ]
    3CC7 X-ray 2.70 O 1-116 [» ]
    3CCE X-ray 2.75 O 1-116 [» ]
    3CCJ X-ray 2.70 O 1-116 [» ]
    3CCL X-ray 2.90 O 1-116 [» ]
    3CCM X-ray 2.55 O 1-116 [» ]
    3CCQ X-ray 2.90 O 1-116 [» ]
    3CCR X-ray 3.00 O 1-116 [» ]
    3CCS X-ray 2.95 O 1-116 [» ]
    3CCU X-ray 2.80 O 1-116 [» ]
    3CCV X-ray 2.90 O 1-116 [» ]
    3CD6 X-ray 2.75 O 1-116 [» ]
    3CMA X-ray 2.80 O 1-116 [» ]
    3CME X-ray 2.95 O 1-116 [» ]
    3CPW X-ray 2.70 N 1-116 [» ]
    3CXC X-ray 3.00 N 2-116 [» ]
    3G4S X-ray 3.20 O 2-116 [» ]
    3G6E X-ray 2.70 O 2-116 [» ]
    3G71 X-ray 2.85 O 2-116 [» ]
    3I55 X-ray 3.11 O 1-116 [» ]
    3I56 X-ray 2.90 O 1-116 [» ]
    3OW2 X-ray 2.70 N 2-116 [» ]
    4ADX electron microscopy 6.60 O 1-116 [» ]
    4HUB X-ray 2.40 O 1-116 [» ]
    ProteinModelPortali P12733.
    SMRi P12733. Positions 2-116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45144 ; AAV45144 ; rrnAC0064 .
    GeneIDi 3130533.
    KEGGi hma:rrnAC0064.

    Phylogenomic databases

    eggNOGi COG1727.
    HOGENOMi HOG000225300.
    KOi K02883.
    OMAi ASCHAHG.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-60-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P12733.

    Family and domain databases

    HAMAPi MF_00329. Ribosomal_L18e.
    InterProi IPR001196. Ribosomal_L15_CS.
    IPR000039. Ribosomal_L18e.
    IPR021131. Ribosomal_L18e/L15P.
    IPR022947. Ribosomal_L18e_arc.
    IPR021132. Ribosomal_L18e_CS.
    [Graphical view ]
    PANTHERi PTHR10934. PTHR10934. 1 hit.
    Pfami PF00828. Ribosomal_L18e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52080. SSF52080. 1 hit.
    PROSITEi PS01106. RIBOSOMAL_L18E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Halobacterial S9 operon. Three ribosomal protein genes are cotranscribed with genes encoding a tRNA(Leu), the enolase, and a putative membrane protein in the archaebacterium Haloarcula (Halobacterium) marismortui."
      Kroemer W.J., Arndt E.
      J. Biol. Chem. 266:24573-24579(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    3. "Complete amino acid sequences of the ribosomal proteins L25, L29 and L31 from the archaebacterium Halobacterium marismortui."
      Hatakeyama T., Kimura M.
      Eur. J. Biochem. 172:703-711(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-116.
    4. "The alpha-operon equivalent genome region in the extreme halophilic archaebacterium Haloarcula (Halobacterium) marismortui."
      Scholzen T., Arndt E.
      J. Biol. Chem. 267:12123-12130(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72.
    5. "Extended N-terminal sequencing of proteins of archaebacterial ribosomes blotted from two-dimensional gels onto glass fiber and poly(vinylidene difluoride) membrane."
      Walsh M.J., McDougall J., Wittmann-Liebold B.
      Biochemistry 27:6867-6876(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-24.
    6. "Localization of proteins HL29 and HL31 from Haloarcula marismortui within the 50 S ribosomal subunit by chemical crosslinking."
      Bergmann U., Wittmann-Liebold B.
      J. Mol. Biol. 232:693-700(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 4-27; 37-39 AND 65-82, CROSS-LINKING TO L4.
    7. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    11. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    13. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    14. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    15. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL18E_HALMA
    AccessioniPrimary (citable) accession number: P12733
    Secondary accession number(s): Q5V5Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3