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P12732

- RL23_HALMA

UniProt

P12732 - RL23_HALMA

Protein

50S ribosomal protein L23P

Gene

rpl23p

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to a specific region on the 23S rRNA. Located at the polypeptide exit tunnel on the outside of the subunit.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. rRNA binding Source: UniProtKB-HAMAP
    3. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1465-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L23PUniRule annotation
    Alternative name(s):
    Hl25
    Hmal23
    L21
    Gene namesi
    Name:rpl23pUniRule annotation
    Ordered Locus Names:rrnAC1609
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 858450S ribosomal protein L23PPRO_0000129435Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Interacts with protein L29 and weakly with protein L39e.2 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC1609.

    Structurei

    Secondary structure

    1
    85
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 95
    Helixi13 – 219
    Beta strandi24 – 296
    Helixi35 – 4612
    Beta strandi50 – 578
    Beta strandi61 – 699
    Beta strandi71 – 733
    Helixi75 – 795

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40P2-85[»]
    1JJ2X-ray2.40R2-85[»]
    1K73X-ray3.01T2-85[»]
    1K8AX-ray3.00T2-85[»]
    1K9MX-ray3.00T2-85[»]
    1KC8X-ray3.01T2-85[»]
    1KD1X-ray3.00T2-85[»]
    1KQSX-ray3.10R2-85[»]
    1M1KX-ray3.20T2-85[»]
    1M90X-ray2.80T2-85[»]
    1N8RX-ray3.00T2-85[»]
    1NJIX-ray3.00T2-85[»]
    1Q7YX-ray3.20T2-85[»]
    1Q81X-ray2.95T2-85[»]
    1Q82X-ray2.98T2-85[»]
    1Q86X-ray3.00T2-85[»]
    1QVFX-ray3.10R2-85[»]
    1QVGX-ray2.90R2-85[»]
    1S72X-ray2.40S1-85[»]
    1VQ4X-ray2.70S1-85[»]
    1VQ5X-ray2.60S1-85[»]
    1VQ6X-ray2.70S1-85[»]
    1VQ7X-ray2.50S1-85[»]
    1VQ8X-ray2.20S1-85[»]
    1VQ9X-ray2.40S1-85[»]
    1VQKX-ray2.30S1-85[»]
    1VQLX-ray2.30S1-85[»]
    1VQMX-ray2.30S1-85[»]
    1VQNX-ray2.40S1-85[»]
    1VQOX-ray2.20S1-85[»]
    1VQPX-ray2.25S1-85[»]
    1W2BX-ray3.50R2-85[»]
    1YHQX-ray2.40S1-85[»]
    1YI2X-ray2.65S1-85[»]
    1YIJX-ray2.60S1-85[»]
    1YITX-ray2.80S1-85[»]
    1YJ9X-ray2.90S1-85[»]
    1YJNX-ray3.00S1-85[»]
    1YJWX-ray2.90S1-85[»]
    2B9NX-ray6.76X2-85[»]
    2B9PX-ray6.46X2-85[»]
    2OTJX-ray2.90S1-85[»]
    2OTLX-ray2.70S1-85[»]
    2QA4X-ray3.00S1-85[»]
    2QEXX-ray2.90S1-85[»]
    3CC2X-ray2.40S1-85[»]
    3CC4X-ray2.70S1-85[»]
    3CC7X-ray2.70S1-85[»]
    3CCEX-ray2.75S1-85[»]
    3CCJX-ray2.70S1-85[»]
    3CCLX-ray2.90S1-85[»]
    3CCMX-ray2.55S1-85[»]
    3CCQX-ray2.90S1-85[»]
    3CCRX-ray3.00S1-85[»]
    3CCSX-ray2.95S1-85[»]
    3CCUX-ray2.80S1-85[»]
    3CCVX-ray2.90S1-85[»]
    3CD6X-ray2.75S1-85[»]
    3CMAX-ray2.80S1-85[»]
    3CMEX-ray2.95S1-85[»]
    3CPWX-ray2.70R1-85[»]
    3CXCX-ray3.00R2-85[»]
    3G4SX-ray3.20S2-82[»]
    3G6EX-ray2.70S2-82[»]
    3G71X-ray2.85S2-82[»]
    3I55X-ray3.11S1-85[»]
    3I56X-ray2.90S1-85[»]
    3OW2X-ray2.70R2-82[»]
    4ADXelectron microscopy6.60S1-85[»]
    4HUBX-ray2.40S1-85[»]
    ProteinModelPortaliP12732.
    SMRiP12732. Positions 2-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12732.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L23P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0089.
    HOGENOMiHOG000231364.
    KOiK02892.
    OMAiQNTLTFI.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    HAMAPiMF_01369_A. Ribosomal_L23_A.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR019985. Ribosomal_L23.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR001014. Ribosomal_L23/L25_CS.
    IPR013025. Ribosomal_L25/23.
    [Graphical view]
    PfamiPF00276. Ribosomal_L23. 1 hit.
    [Graphical view]
    SUPFAMiSSF54189. SSF54189. 1 hit.
    TIGRFAMsiTIGR03636. L23_arch. 1 hit.
    PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12732-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWDVIKHPH VTEKAMNDMD FQNKLQFAVD DRASKGEVAD AVEEQYDVTV   50
    EQVNTQNTMD GEKKAVVRLS EDDDAQEVAS RIGVF 85
    Length:85
    Mass (Da):9,602
    Last modified:January 23, 2007 - v2
    Checksum:i2A2E869D640D5B60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05222 Genomic DNA. Translation: AAA86861.1.
    AY596297 Genomic DNA. Translation: AAV46526.1.
    PIRiE35063. R5HS23.
    RefSeqiYP_136232.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46526; AAV46526; rrnAC1609.
    GeneIDi3128415.
    KEGGihma:rrnAC1609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05222 Genomic DNA. Translation: AAA86861.1 .
    AY596297 Genomic DNA. Translation: AAV46526.1 .
    PIRi E35063. R5HS23.
    RefSeqi YP_136232.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 P 2-85 [» ]
    1JJ2 X-ray 2.40 R 2-85 [» ]
    1K73 X-ray 3.01 T 2-85 [» ]
    1K8A X-ray 3.00 T 2-85 [» ]
    1K9M X-ray 3.00 T 2-85 [» ]
    1KC8 X-ray 3.01 T 2-85 [» ]
    1KD1 X-ray 3.00 T 2-85 [» ]
    1KQS X-ray 3.10 R 2-85 [» ]
    1M1K X-ray 3.20 T 2-85 [» ]
    1M90 X-ray 2.80 T 2-85 [» ]
    1N8R X-ray 3.00 T 2-85 [» ]
    1NJI X-ray 3.00 T 2-85 [» ]
    1Q7Y X-ray 3.20 T 2-85 [» ]
    1Q81 X-ray 2.95 T 2-85 [» ]
    1Q82 X-ray 2.98 T 2-85 [» ]
    1Q86 X-ray 3.00 T 2-85 [» ]
    1QVF X-ray 3.10 R 2-85 [» ]
    1QVG X-ray 2.90 R 2-85 [» ]
    1S72 X-ray 2.40 S 1-85 [» ]
    1VQ4 X-ray 2.70 S 1-85 [» ]
    1VQ5 X-ray 2.60 S 1-85 [» ]
    1VQ6 X-ray 2.70 S 1-85 [» ]
    1VQ7 X-ray 2.50 S 1-85 [» ]
    1VQ8 X-ray 2.20 S 1-85 [» ]
    1VQ9 X-ray 2.40 S 1-85 [» ]
    1VQK X-ray 2.30 S 1-85 [» ]
    1VQL X-ray 2.30 S 1-85 [» ]
    1VQM X-ray 2.30 S 1-85 [» ]
    1VQN X-ray 2.40 S 1-85 [» ]
    1VQO X-ray 2.20 S 1-85 [» ]
    1VQP X-ray 2.25 S 1-85 [» ]
    1W2B X-ray 3.50 R 2-85 [» ]
    1YHQ X-ray 2.40 S 1-85 [» ]
    1YI2 X-ray 2.65 S 1-85 [» ]
    1YIJ X-ray 2.60 S 1-85 [» ]
    1YIT X-ray 2.80 S 1-85 [» ]
    1YJ9 X-ray 2.90 S 1-85 [» ]
    1YJN X-ray 3.00 S 1-85 [» ]
    1YJW X-ray 2.90 S 1-85 [» ]
    2B9N X-ray 6.76 X 2-85 [» ]
    2B9P X-ray 6.46 X 2-85 [» ]
    2OTJ X-ray 2.90 S 1-85 [» ]
    2OTL X-ray 2.70 S 1-85 [» ]
    2QA4 X-ray 3.00 S 1-85 [» ]
    2QEX X-ray 2.90 S 1-85 [» ]
    3CC2 X-ray 2.40 S 1-85 [» ]
    3CC4 X-ray 2.70 S 1-85 [» ]
    3CC7 X-ray 2.70 S 1-85 [» ]
    3CCE X-ray 2.75 S 1-85 [» ]
    3CCJ X-ray 2.70 S 1-85 [» ]
    3CCL X-ray 2.90 S 1-85 [» ]
    3CCM X-ray 2.55 S 1-85 [» ]
    3CCQ X-ray 2.90 S 1-85 [» ]
    3CCR X-ray 3.00 S 1-85 [» ]
    3CCS X-ray 2.95 S 1-85 [» ]
    3CCU X-ray 2.80 S 1-85 [» ]
    3CCV X-ray 2.90 S 1-85 [» ]
    3CD6 X-ray 2.75 S 1-85 [» ]
    3CMA X-ray 2.80 S 1-85 [» ]
    3CME X-ray 2.95 S 1-85 [» ]
    3CPW X-ray 2.70 R 1-85 [» ]
    3CXC X-ray 3.00 R 2-85 [» ]
    3G4S X-ray 3.20 S 2-82 [» ]
    3G6E X-ray 2.70 S 2-82 [» ]
    3G71 X-ray 2.85 S 2-82 [» ]
    3I55 X-ray 3.11 S 1-85 [» ]
    3I56 X-ray 2.90 S 1-85 [» ]
    3OW2 X-ray 2.70 R 2-82 [» ]
    4ADX electron microscopy 6.60 S 1-85 [» ]
    4HUB X-ray 2.40 S 1-85 [» ]
    ProteinModelPortali P12732.
    SMRi P12732. Positions 2-85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC1609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46526 ; AAV46526 ; rrnAC1609 .
    GeneIDi 3128415.
    KEGGi hma:rrnAC1609.

    Phylogenomic databases

    eggNOGi COG0089.
    HOGENOMi HOG000231364.
    KOi K02892.
    OMAi QNTLTFI.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1465-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P12732.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    HAMAPi MF_01369_A. Ribosomal_L23_A.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR019985. Ribosomal_L23.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR001014. Ribosomal_L23/L25_CS.
    IPR013025. Ribosomal_L25/23.
    [Graphical view ]
    Pfami PF00276. Ribosomal_L23. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54189. SSF54189. 1 hit.
    TIGRFAMsi TIGR03636. L23_arch. 1 hit.
    PROSITEi PS00050. RIBOSOMAL_L23. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete amino acid sequences of the ribosomal proteins L25, L29 and L31 from the archaebacterium Halobacterium marismortui."
      Hatakeyama T., Kimura M.
      Eur. J. Biochem. 172:703-711(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-85.
    2. "Organization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui."
      Arndt E., Kroemer W., Hatakeyama T.
      J. Biol. Chem. 265:3034-3039(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "Extended N-terminal sequencing of proteins of archaebacterial ribosomes blotted from two-dimensional gels onto glass fiber and poly(vinylidene difluoride) membrane."
      Walsh M.J., McDougall J., Wittmann-Liebold B.
      Biochemistry 27:6867-6876(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-23.
    5. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    11. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    12. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    13. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL23_HALMA
    AccessioniPrimary (citable) accession number: P12732
    Secondary accession number(s): Q5V1S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3