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Protein

Fatty acid-binding protein, liver

Gene

Fabp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding, Selenium

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
R-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, liver
Alternative name(s):
14 kDa selenium-binding protein
Fatty acid-binding protein 1
Liver-type fatty acid-binding protein
Short name:
L-FABP
Gene namesi
Name:Fabp1
Synonyms:Fabpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95479. Fabp1.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: Ensembl
  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • extracellular exosome Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • peroxisomal matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi2531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Fatty acid-binding protein, liverPRO_0000067335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei11 – 111PhosphoserineCombined sources
Modified residuei31 – 311N6-succinyllysineCombined sources
Modified residuei36 – 361N6-succinyllysineCombined sources
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei46 – 461N6-succinyllysineCombined sources
Modified residuei51 – 511PhosphothreonineBy similarity
Modified residuei57 – 571N6-succinyllysineCombined sources
Modified residuei78 – 781N6-succinyllysineCombined sources
Modified residuei84 – 841N6-acetyllysine; alternateCombined sources
Modified residuei84 – 841N6-succinyllysine; alternateCombined sources
Modified residuei90 – 901N6-succinyllysineCombined sources
Modified residuei100 – 1001PhosphoserineCombined sources
Modified residuei121 – 1211N6-succinyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12710.
PaxDbiP12710.
PeptideAtlasiP12710.
PRIDEiP12710.

2D gel databases

SWISS-2DPAGEP12710.

PTM databases

iPTMnetiP12710.
PhosphoSiteiP12710.

Expressioni

Gene expression databases

BgeeiP12710.
CleanExiMM_FABP1.
ExpressionAtlasiP12710. baseline and differential.
GenevisibleiP12710. MM.

Interactioni

Protein-protein interaction databases

BioGridi199584. 2 interactions.
IntActiP12710. 4 interactions.
MINTiMINT-1868777.
STRINGi10090.ENSMUSP00000064655.

Structurei

3D structure databases

ProteinModelPortaliP12710.
SMRiP12710. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP12710.
KOiK08750.
OMAiFTLGEEC.
OrthoDBiEOG7HB5C9.
PhylomeDBiP12710.
TreeFamiTF330348.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSGKYQLQ SQENFEPFMK AIGLPEDLIQ KGKDIKGVSE IVHEGKKIKL
60 70 80 90 100
TITYGPKVVR NEFTLGEECE LETMTGEKVK AVVKLEGDNK MVTTFKGIKS
110 120
VTELNGDTIT NTMTLGDIVY KRVSKRI
Length:127
Mass (Da):14,246
Last modified:December 15, 1998 - v2
Checksum:i2C787139174DD24D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14660 mRNA. Translation: CAA74989.1.
BC009812 mRNA. Translation: AAH09812.1.
CCDSiCCDS20226.1.
PIRiA32640.
RefSeqiNP_059095.1. NM_017399.4.
UniGeneiMm.22126.

Genome annotation databases

EnsembliENSMUST00000067492; ENSMUSP00000064655; ENSMUSG00000054422.
GeneIDi14080.
KEGGimmu:14080.
UCSCiuc009cgh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14660 mRNA. Translation: CAA74989.1.
BC009812 mRNA. Translation: AAH09812.1.
CCDSiCCDS20226.1.
PIRiA32640.
RefSeqiNP_059095.1. NM_017399.4.
UniGeneiMm.22126.

3D structure databases

ProteinModelPortaliP12710.
SMRiP12710. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199584. 2 interactions.
IntActiP12710. 4 interactions.
MINTiMINT-1868777.
STRINGi10090.ENSMUSP00000064655.

Chemistry

GuidetoPHARMACOLOGYi2531.

PTM databases

iPTMnetiP12710.
PhosphoSiteiP12710.

2D gel databases

SWISS-2DPAGEP12710.

Proteomic databases

EPDiP12710.
PaxDbiP12710.
PeptideAtlasiP12710.
PRIDEiP12710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067492; ENSMUSP00000064655; ENSMUSG00000054422.
GeneIDi14080.
KEGGimmu:14080.
UCSCiuc009cgh.1. mouse.

Organism-specific databases

CTDi2168.
MGIiMGI:95479. Fabp1.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP12710.
KOiK08750.
OMAiFTLGEEC.
OrthoDBiEOG7HB5C9.
PhylomeDBiP12710.
TreeFamiTF330348.

Enzyme and pathway databases

ReactomeiR-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.
R-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

PROiP12710.
SOURCEiSearch...

Gene expression databases

BgeeiP12710.
CleanExiMM_FABP1.
ExpressionAtlasiP12710. baseline and differential.
GenevisibleiP12710. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wolfrum C., Ellinghaus P., Kannenberg F., Seedorf U., Assmann G., Boerchers T., Spener F.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "A 14-kilodalton selenium-binding protein in mouse liver is fatty acid-binding protein."
    Bansai M.P., Cook R.G., Danielson K.G., Medina D.
    J. Biol. Chem. 264:13780-13784(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-113.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung and Pancreas.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-31; LYS-36; LYS-46; LYS-57; LYS-78; LYS-84; LYS-90 AND LYS-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFABPL_MOUSE
AccessioniPrimary (citable) accession number: P12710
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 15, 1998
Last modified: July 6, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.