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P12702 (COX3_PARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismParacentrotus lividus (Common sea urchin)
Taxonomic identifier7656 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence caution

The sequence AAA68140.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183826

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P12702 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 27538CE39B4F155D

FASTA26129,627
        10         20         30         40         50         60 
MMAHQHPYYL VEQSPWPLTG AISGLMMNLG LVLWFHTGNI ILLFTGLLLL ILTLVNWWRD 

        70         80         90        100        110        120 
IVREATFQGS HTAIVENGLR YPMILFITSE VCFFFAFFWA FFHSSLAPAV EIGVTWPPSG 

       130        140        150        160        170        180 
ITPLNPFLVP LLNTAVLLSS GVTITWSHHS ILAGNRNEAI QALFLTVVLG IYFTILQAWE 

       190        200        210        220        230        240 
YIDAPFTIAD SVYGSTFFVA TGFHGLHVII GTTFLLVCLI RLSGHHFSTH HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVCIYWWG S 

« Hide

References

[1]"The complete nucleotide sequence, gene organization, and genetic code of the mitochondrial genome of Paracentrotus lividus."
Cantatore P., Roberti M., Rainaldi G., Gadaleta M.N., Saccone C.
J. Biol. Chem. 264:10965-10975(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04815 Genomic DNA. Translation: AAA68140.1. Different initiation.
PIRH34284.
RefSeqNP_008128.1. NC_001572.1.

3D structure databases

ProteinModelPortalP12702.
SMRP12702. Positions 2-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807705.

Organism-specific databases

CTD4514.

Phylogenomic databases

ProtClustDBMTH00039.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_PARLI
AccessionPrimary (citable) accession number: P12702
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families