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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalSequence analysisAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 229Mitochondrial intermembraneSequence analysisAdd BLAST147

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836511 – 229Cytochrome c oxidase subunit 2Add BLAST229

Structurei

3D structure databases

ProteinModelPortaliP12701.
SMRiP12701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

P12701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATWAQFGLQ DASSPLMEEL TYFHDYALIV LTLITILVFY GLVSLLLSSS
60 70 80 90 100
TNRFFLEGQE LETIWTVVPA FILIFIALPS LQLLYLMDEV NNPFLTIKAI
110 120 130 140 150
GHQWYWSYEY TDYNDLEFDS YMVPTSDVSL GNPRLLEVDN RLILPMQNPI
160 170 180 190 200
RVLVSSADVL HSWAVPSLGV KMDAVPGRLN QTTFFAARAG LFYGQCSEIC
210 220
GANHSFMPIL IESVPFSNFE NWVAQYIEE
Length:229
Mass (Da):26,045
Last modified:October 1, 1989 - v1
Checksum:i9FEC52A0EDDB48A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → P (PubMed:3596250).Curated1
Sequence conflicti11D → H (PubMed:3596250).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04815 Genomic DNA. Translation: AAA68137.1.
M16520 Genomic DNA. Translation: AAA31991.1.
PIRiE34284.
RefSeqiNP_008125.1. NC_001572.1.

Genome annotation databases

GeneIDi807715.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX2_PARLI
AccessioniPrimary (citable) accession number: P12701
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 10, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families