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P12700

- COX1_PARLI

UniProt

P12700 - COX1_PARLI

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Cytochrome c oxidase subunit 1
PRO_0000183382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP12700.
SMRiP12700. Positions 3-508.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12700-1 [UniParc]FASTAAdd to Basket

« Hide

MQLSRWLFST NHKDIGTLYL IFGAWAGMVG TAMSVIIRAE LAQPGSLLND    50
DQIYNVVVTA HALVMIFFMV MPIMIGGFGN WLIPLMIGAP DMAFPRMNNM 100
SFWLIPPSFI LLLASAGVES GAGTGWTIYP PLSSNIAHAG GSVDLAIFSL 150
HLAGASSILA SINFITTIIN MRTPGMSFDR LPLFVWSVFV TAFLLLLSLP 200
VLAGAITMLL TDRNINTTFF DPAGGGDPIL FQHLFWFFGH PEVYILILPG 250
FGMISHVIAH YSGKREPFGY LGMVYAMIAI GVLGFLVWAH HMFTVGMDVD 300
TRAYFTAATM IIAVPTGIKV FSWMATLQGS NLQWETPLLW ALGFVFLFTL 350
GGLTGIVLAN SSIDVVLHDT YYVVAHFHYV LSMGAVFAIF AGFTHWFPLF 400
CGYNLHPLWG KAHFFMMFVG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW 450
NTVSSIGSTI SLVAMLFFIF LIWEAFASQR EGVTPEFANA SLEWQYNSFP 500
PSHHTFDETP STVVIVK 517
Length:517
Mass (Da):57,217
Last modified:October 1, 1989 - v1
Checksum:iB42A1F1D5789A856
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04815 Genomic DNA. Translation: AAA68135.1.
M16519 Genomic DNA. Translation: AAA31989.2.
PIRiC34284.
RefSeqiNP_008123.1. NC_001572.1.

Genome annotation databases

GeneIDi807707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04815 Genomic DNA. Translation: AAA68135.1 .
M16519 Genomic DNA. Translation: AAA31989.2 .
PIRi C34284.
RefSeqi NP_008123.1. NC_001572.1.

3D structure databases

ProteinModelPortali P12700.
SMRi P12700. Positions 3-508.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807707.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence, gene organization, and genetic code of the mitochondrial genome of Paracentrotus lividus."
    Cantatore P., Roberti M., Rainaldi G., Gadaleta M.N., Saccone C.
    J. Biol. Chem. 264:10965-10975(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel gene order in the Paracentrotus lividus mitochondrial genome."
    Cantatore P., Roberti M., Morisco P., Rainaldi G., Gadaleta M.N., Saccone C.
    Gene 53:41-54(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 469-517.
    Tissue: Egg.

Entry informationi

Entry nameiCOX1_PARLI
AccessioniPrimary (citable) accession number: P12700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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