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Protein

Aldehyde dehydrogenase

Gene

alkH

Organism
Pseudomonas oleovorans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway:ialkane degradation

This protein is involved in the pathway alkane degradation, which is part of Hydrocarbon metabolism.
View all proteins of this organism that are known to be involved in the pathway alkane degradation and in Hydrocarbon metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261By similarity
Active sitei260 – 2601By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi204 – 2096NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00191.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:alkH
Encoded oniPlasmid OCT0 Publication
OrganismiPseudomonas oleovorans
Taxonomic identifieri301 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas oleovorans/pseudoalcaligenes group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Aldehyde dehydrogenasePRO_0000056451Add
BLAST

Expressioni

Inductioni

Induced by AlkS.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP12693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPISLAKL NSSADTHSAL EVFNLQKVAS SARRGKFGIA ERIAALNLLK
60 70 80 90 100
ETIQRREPEI IAALAADFRK PASEVKLTEI FPVLQEINHA KRNLKDWMKP
110 120 130 140 150
RRVRAALSVA GTRAGLRYEP KGVCLIIAPW NYPFNLSFGP LVSALAAGNS
160 170 180 190 200
VVIKPSELTP HTATLIGSIV REAFSVDLVA VVEGDAAVSQ ELLALPFDHI
210 220 230 240 250
FFTGSPRVGK LVMEAASKTL ASVTLELGGK SPTIIGPTAN LPKAARNIVW
260 270 280 290 300
GKFSNNGQTC IAPDHVFVHR CIAQKFNEIL VKEIVRVYGK DFAAQRRSAD
310 320 330 340 350
YCRIVNDQHF NRINKLLTDA KAKGAKILQG GQVDATERLV VPTVLSNVTA
360 370 380 390 400
AMDINHEEIF GPLLPIIEYD DIDSVIKRVN DGDKPLALYV FSEDKQFVNN
410 420 430 440 450
IVARTSSGSV GVNLSVVHFL HPNLPFGGVN NSGIGSAHGV YGFRAFSHEK
460 470 480
PVLIDKFSIT HWLFPPYTKK VKQLIGITVK YLS
Length:483
Mass (Da):52,766
Last modified:October 1, 1989 - v1
Checksum:iE65E9D00A4E8F336
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245436 Genomic DNA. Translation: CAB54053.1.
PIRiC32850. D31266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245436 Genomic DNA. Translation: CAB54053.1.
PIRiC32850. D31266.

3D structure databases

ProteinModelPortaliP12693.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00191.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase."
    Kok M., Oldenhuis R., van der Linden M.P.G., Meulenberg C.H.C., Kingma J., Witholt B.
    J. Biol. Chem. 264:5442-5451(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GPo1.
  2. "DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans."
    van Beilen J.B., Eggink G., Enequist H., Bos R., Witholt B.
    Mol. Microbiol. 6:3121-3136(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GPo1.
  3. "A positive feedback mechanism controls expression of AlkS, the transcriptional regulator of the Pseudomonas oleovorans alkane degradation pathway."
    Canosa I., Sanchez-Romero J.M., Yuste L., Rojo F.
    Mol. Microbiol. 35:791-799(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiALDH_PSEOL
AccessioniPrimary (citable) accession number: P12693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 1, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.