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P12693 (ALDH_PSEOL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

EC=1.2.1.3
Gene names
Name:alkH
Encoded onPlasmid OCT
OrganismPseudomonas oleovorans
Taxonomic identifier301 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas oleovorans/pseudoalcaligenes group

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Hydrocarbon metabolism; alkane degradation.

Induction

Induced by AlkS. Ref.3

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processalkane catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

cellular aldehyde metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

aldehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Aldehyde dehydrogenase
PRO_0000056451

Regions

Nucleotide binding204 – 2096NAD By similarity

Sites

Active site2261 By similarity
Active site2601 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12693 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: E65E9D00A4E8F336

FASTA48352,766
        10         20         30         40         50         60 
MTIPISLAKL NSSADTHSAL EVFNLQKVAS SARRGKFGIA ERIAALNLLK ETIQRREPEI 

        70         80         90        100        110        120 
IAALAADFRK PASEVKLTEI FPVLQEINHA KRNLKDWMKP RRVRAALSVA GTRAGLRYEP 

       130        140        150        160        170        180 
KGVCLIIAPW NYPFNLSFGP LVSALAAGNS VVIKPSELTP HTATLIGSIV REAFSVDLVA 

       190        200        210        220        230        240 
VVEGDAAVSQ ELLALPFDHI FFTGSPRVGK LVMEAASKTL ASVTLELGGK SPTIIGPTAN 

       250        260        270        280        290        300 
LPKAARNIVW GKFSNNGQTC IAPDHVFVHR CIAQKFNEIL VKEIVRVYGK DFAAQRRSAD 

       310        320        330        340        350        360 
YCRIVNDQHF NRINKLLTDA KAKGAKILQG GQVDATERLV VPTVLSNVTA AMDINHEEIF 

       370        380        390        400        410        420 
GPLLPIIEYD DIDSVIKRVN DGDKPLALYV FSEDKQFVNN IVARTSSGSV GVNLSVVHFL 

       430        440        450        460        470        480 
HPNLPFGGVN NSGIGSAHGV YGFRAFSHEK PVLIDKFSIT HWLFPPYTKK VKQLIGITVK 


YLS 

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References

[1]"The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase."
Kok M., Oldenhuis R., van der Linden M.P.G., Meulenberg C.H.C., Kingma J., Witholt B.
J. Biol. Chem. 264:5442-5451(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GPo1.
[2]"DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans."
van Beilen J.B., Eggink G., Enequist H., Bos R., Witholt B.
Mol. Microbiol. 6:3121-3136(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GPo1.
[3]"A positive feedback mechanism controls expression of AlkS, the transcriptional regulator of the Pseudomonas oleovorans alkane degradation pathway."
Canosa I., Sanchez-Romero J.M., Yuste L., Rojo F.
Mol. Microbiol. 35:791-799(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ245436 Genomic DNA. Translation: CAB54053.1.
PIRD31266. C32850.

3D structure databases

ProteinModelPortalP12693.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00191.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_PSEOL
AccessionPrimary (citable) accession number: P12693
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways