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P12693

- ALDH_PSEOL

UniProt

P12693 - ALDH_PSEOL

Protein

Aldehyde dehydrogenase

Gene

alkH

Organism
Pseudomonas oleovorans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei226 – 2261By similarity
    Active sitei260 – 2601By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi204 – 2096NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. alkane catabolic process Source: UniProtKB-UniPathway
    2. cellular aldehyde metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00191.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Name:alkH
    Encoded oniPlasmid OCT0 Publication
    OrganismiPseudomonas oleovorans
    Taxonomic identifieri301 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas oleovorans/pseudoalcaligenes group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Aldehyde dehydrogenasePRO_0000056451Add
    BLAST

    Expressioni

    Inductioni

    Induced by AlkS.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP12693.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12693-1 [UniParc]FASTAAdd to Basket

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    MTIPISLAKL NSSADTHSAL EVFNLQKVAS SARRGKFGIA ERIAALNLLK    50
    ETIQRREPEI IAALAADFRK PASEVKLTEI FPVLQEINHA KRNLKDWMKP 100
    RRVRAALSVA GTRAGLRYEP KGVCLIIAPW NYPFNLSFGP LVSALAAGNS 150
    VVIKPSELTP HTATLIGSIV REAFSVDLVA VVEGDAAVSQ ELLALPFDHI 200
    FFTGSPRVGK LVMEAASKTL ASVTLELGGK SPTIIGPTAN LPKAARNIVW 250
    GKFSNNGQTC IAPDHVFVHR CIAQKFNEIL VKEIVRVYGK DFAAQRRSAD 300
    YCRIVNDQHF NRINKLLTDA KAKGAKILQG GQVDATERLV VPTVLSNVTA 350
    AMDINHEEIF GPLLPIIEYD DIDSVIKRVN DGDKPLALYV FSEDKQFVNN 400
    IVARTSSGSV GVNLSVVHFL HPNLPFGGVN NSGIGSAHGV YGFRAFSHEK 450
    PVLIDKFSIT HWLFPPYTKK VKQLIGITVK YLS 483
    Length:483
    Mass (Da):52,766
    Last modified:October 1, 1989 - v1
    Checksum:iE65E9D00A4E8F336
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245436 Genomic DNA. Translation: CAB54053.1.
    PIRiC32850. D31266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245436 Genomic DNA. Translation: CAB54053.1 .
    PIRi C32850. D31266.

    3D structure databases

    ProteinModelPortali P12693.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00191 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase."
      Kok M., Oldenhuis R., van der Linden M.P.G., Meulenberg C.H.C., Kingma J., Witholt B.
      J. Biol. Chem. 264:5442-5451(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GPo1.
    2. "DNA sequence determination and functional characterization of the OCT-plasmid-encoded alkJKL genes of Pseudomonas oleovorans."
      van Beilen J.B., Eggink G., Enequist H., Bos R., Witholt B.
      Mol. Microbiol. 6:3121-3136(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GPo1.
    3. "A positive feedback mechanism controls expression of AlkS, the transcriptional regulator of the Pseudomonas oleovorans alkane degradation pathway."
      Canosa I., Sanchez-Romero J.M., Yuste L., Rojo F.
      Mol. Microbiol. 35:791-799(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiALDH_PSEOL
    AccessioniPrimary (citable) accession number: P12693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3