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Protein

54S ribosomal protein L2, mitochondrial

Gene

MRP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptidyltransferase activity Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L2, mitochondrial
Alternative name(s):
YMR6
YmL2
Gene namesi
Name:MRP7
Synonyms:MRPL2
Ordered Locus Names:YNL005C
ORF Names:N2007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL005C.
SGDiS000004950. MRP7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27Mitochondrion2 PublicationsAdd BLAST27
ChainiPRO_000003050328 – 37154S ribosomal protein L2, mitochondrialAdd BLAST344

Proteomic databases

MaxQBiP12687.
PRIDEiP12687.

PTM databases

iPTMnetiP12687.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

Protein-protein interaction databases

BioGridi35820. 33 interactors.
DIPiDIP-5620N.
IntActiP12687. 14 interactors.
MINTiMINT-476381.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20R1-371[»]
ProteinModelPortaliP12687.
SMRiP12687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L27P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000014660.
HOGENOMiHOG000248704.
InParanoidiP12687.
OMAiRYYLDPF.
OrthoDBiEOG092C546H.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
IPR018261. Ribosomal_L27_CS.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00062. L27. 1 hit.
PROSITEiPS00831. RIBOSOMAL_L27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNPILLDTS SFSFQKHVSG VFLQVRNATK RAAGSRTSMK DSAGRRLGPK
60 70 80 90 100
KYEGQDVSTG EIIMRQRGTK FYPGENVGIG KDHSIFALEP GVVRYYLDPF
110 120 130 140 150
HPKRKFIGVA LRRDLKLPSP HFEPTVRRFG RFELTNKRAA YKEENSISRK
160 170 180 190 200
DYLAKPNILK QLEVRESKRK ELQDKLSKVL RDELKLDIKD IELATSYLIR
210 220 230 240 250
VRASLKNGYP IEDARFNSRY YLKEEERLKA RRESWTNEKL SESLSKIDEC
260 270 280 290 300
SDLLNSSTSF NNKLELHQYI SEQEKQALKA KLLEDLEKSQ HLETKKDKNY
310 320 330 340 350
IKALFKDACN FLTLSEEVHL RRKYLKSVFP ETDSTVETKS GKKSIVSRRF
360 370
DYTKNKVEVI ARSRRAFLSK L
Length:371
Mass (Da):43,227
Last modified:October 1, 1989 - v1
Checksum:iF8F17EF955BB7ACF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29AT → SG AA sequence (PubMed:2693936).Curated2
Sequence conflicti350F → L in CAA54379 (PubMed:7985421).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22116 Genomic DNA. Translation: AAA34794.1.
X77114 Genomic DNA. Translation: CAA54379.1.
Z71281 Genomic DNA. Translation: CAA95864.1.
AY693088 Genomic DNA. Translation: AAT93107.1.
BK006947 Genomic DNA. Translation: DAA10538.1.
PIRiS62914. R6BYM7.
RefSeqiNP_014393.1. NM_001182844.1.

Genome annotation databases

EnsemblFungiiYNL005C; YNL005C; YNL005C.
GeneIDi855727.
KEGGisce:YNL005C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22116 Genomic DNA. Translation: AAA34794.1.
X77114 Genomic DNA. Translation: CAA54379.1.
Z71281 Genomic DNA. Translation: CAA95864.1.
AY693088 Genomic DNA. Translation: AAT93107.1.
BK006947 Genomic DNA. Translation: DAA10538.1.
PIRiS62914. R6BYM7.
RefSeqiNP_014393.1. NM_001182844.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20R1-371[»]
ProteinModelPortaliP12687.
SMRiP12687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35820. 33 interactors.
DIPiDIP-5620N.
IntActiP12687. 14 interactors.
MINTiMINT-476381.

PTM databases

iPTMnetiP12687.

Proteomic databases

MaxQBiP12687.
PRIDEiP12687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL005C; YNL005C; YNL005C.
GeneIDi855727.
KEGGisce:YNL005C.

Organism-specific databases

EuPathDBiFungiDB:YNL005C.
SGDiS000004950. MRP7.

Phylogenomic databases

GeneTreeiENSGT00390000014660.
HOGENOMiHOG000248704.
InParanoidiP12687.
OMAiRYYLDPF.
OrthoDBiEOG092C546H.

Enzyme and pathway databases

BioCyciYEAST:G3O-33047-MONOMER.

Miscellaneous databases

PROiP12687.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
IPR018261. Ribosomal_L27_CS.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00062. L27. 1 hit.
PROSITEiPS00831. RIBOSOMAL_L27. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM02_YEAST
AccessioniPrimary (citable) accession number: P12687
Secondary accession number(s): D6W1H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.