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P12687

- RM02_YEAST

UniProt

P12687 - RM02_YEAST

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Protein
54S ribosomal protein L2, mitochondrial
Gene
MRP7, MRPL2, YNL005C, N2007
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. peptidyltransferase activity Source: SGD
  2. structural constituent of ribosome Source: SGD
Complete GO annotation...

GO - Biological processi

  1. mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L2, mitochondrial
Alternative name(s):
YMR6
YmL2
Gene namesi
Name:MRP7
Synonyms:MRPL2
Ordered Locus Names:YNL005C
ORF Names:N2007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL005c.
SGDiS000004950. MRP7.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion2 Publications
Add
BLAST
Chaini28 – 37134454S ribosomal protein L2, mitochondrial
PRO_0000030503Add
BLAST

Proteomic databases

MaxQBiP12687.
PaxDbiP12687.
PeptideAtlasiP12687.

Expressioni

Gene expression databases

GenevestigatoriP12687.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

Protein-protein interaction databases

BioGridi35820. 45 interactions.
DIPiDIP-5620N.
IntActiP12687. 13 interactions.
MINTiMINT-476381.
STRINGi4932.YNL005C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW4electron microscopy3.20R1-371[»]
ProteinModelPortaliP12687.
SMRiP12687. Positions 46-95.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0211.
GeneTreeiENSGT00390000014660.
HOGENOMiHOG000248704.
OMAiYLDPFHP.
OrthoDBiEOG75MW7P.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
IPR018261. Ribosomal_L27_CS.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00062. L27. 1 hit.
PROSITEiPS00831. RIBOSOMAL_L27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12687-1 [UniParc]FASTAAdd to Basket

« Hide

MWNPILLDTS SFSFQKHVSG VFLQVRNATK RAAGSRTSMK DSAGRRLGPK    50
KYEGQDVSTG EIIMRQRGTK FYPGENVGIG KDHSIFALEP GVVRYYLDPF 100
HPKRKFIGVA LRRDLKLPSP HFEPTVRRFG RFELTNKRAA YKEENSISRK 150
DYLAKPNILK QLEVRESKRK ELQDKLSKVL RDELKLDIKD IELATSYLIR 200
VRASLKNGYP IEDARFNSRY YLKEEERLKA RRESWTNEKL SESLSKIDEC 250
SDLLNSSTSF NNKLELHQYI SEQEKQALKA KLLEDLEKSQ HLETKKDKNY 300
IKALFKDACN FLTLSEEVHL RRKYLKSVFP ETDSTVETKS GKKSIVSRRF 350
DYTKNKVEVI ARSRRAFLSK L 371
Length:371
Mass (Da):43,227
Last modified:October 1, 1989 - v1
Checksum:iF8F17EF955BB7ACF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292AT → SG AA sequence 1 Publication
Sequence conflicti350 – 3501F → L in CAA54379. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22116 Genomic DNA. Translation: AAA34794.1.
X77114 Genomic DNA. Translation: CAA54379.1.
Z71281 Genomic DNA. Translation: CAA95864.1.
AY693088 Genomic DNA. Translation: AAT93107.1.
BK006947 Genomic DNA. Translation: DAA10538.1.
PIRiS62914. R6BYM7.
RefSeqiNP_014393.1. NM_001182844.1.

Genome annotation databases

EnsemblFungiiYNL005C; YNL005C; YNL005C.
GeneIDi855727.
KEGGisce:YNL005C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22116 Genomic DNA. Translation: AAA34794.1 .
X77114 Genomic DNA. Translation: CAA54379.1 .
Z71281 Genomic DNA. Translation: CAA95864.1 .
AY693088 Genomic DNA. Translation: AAT93107.1 .
BK006947 Genomic DNA. Translation: DAA10538.1 .
PIRi S62914. R6BYM7.
RefSeqi NP_014393.1. NM_001182844.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW4 electron microscopy 3.20 R 1-371 [» ]
ProteinModelPortali P12687.
SMRi P12687. Positions 46-95.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35820. 45 interactions.
DIPi DIP-5620N.
IntActi P12687. 13 interactions.
MINTi MINT-476381.
STRINGi 4932.YNL005C.

Proteomic databases

MaxQBi P12687.
PaxDbi P12687.
PeptideAtlasi P12687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL005C ; YNL005C ; YNL005C .
GeneIDi 855727.
KEGGi sce:YNL005C.

Organism-specific databases

CYGDi YNL005c.
SGDi S000004950. MRP7.

Phylogenomic databases

eggNOGi COG0211.
GeneTreei ENSGT00390000014660.
HOGENOMi HOG000248704.
OMAi YLDPFHP.
OrthoDBi EOG75MW7P.

Enzyme and pathway databases

BioCyci YEAST:G3O-33047-MONOMER.

Miscellaneous databases

NextBioi 980102.
PROi P12687.

Gene expression databases

Genevestigatori P12687.

Family and domain databases

InterProi IPR001684. Ribosomal_L27.
IPR018261. Ribosomal_L27_CS.
[Graphical view ]
PANTHERi PTHR15893. PTHR15893. 1 hit.
Pfami PF01016. Ribosomal_L27. 1 hit.
[Graphical view ]
PRINTSi PR00063. RIBOSOMALL27.
ProDomi PD003114. Ribosomal_L27. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00062. L27. 1 hit.
PROSITEi PS00831. RIBOSOMAL_L27. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and regulation of a nuclear gene in Saccharomyces cerevisiae that specifies MRP7, a protein of the large subunit of the mitochondrial ribosome."
    Fearon K., Mason T.L.
    Mol. Cell. Biol. 8:3636-3646(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26109 / X2180 / NCYC 826.
  2. "Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae."
    Lalo D., Stettler S., Mariotte S., Gendreau E., Thuriaux P.
    Yeast 10:523-533(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  3. "Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence."
    Verhasselt P., Aert R., Voet M., Volckaert G.
    Yeast 10:945-951(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. "Cloning and analysis of the nuclear genes for two mitochondrial ribosomal proteins in yeast."
    Matsushita Y., Kitakawa M., Isono K.
    Mol. Gen. Genet. 219:119-124(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS.
  8. "Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria."
    Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M.
    FEBS Lett. 284:51-56(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-50, SUBUNIT.
    Strain: 07173.
  9. "Transport of mitoribosomal proteins, YmL13 and MRP7, into isolated mitochondria of Saccharomyces cerevisiae."
    Matsushita Y., Isono K.
    Biochem. Mol. Biol. Int. 30:911-919(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSPORT INTO MITOCHONDRIA.
  10. "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components."
    Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K.
    Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  11. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  12. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  13. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiRM02_YEAST
AccessioniPrimary (citable) accession number: P12687
Secondary accession number(s): D6W1H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 11, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2300 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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