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Protein

High-affinity potassium transport protein

Gene

TRK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is required for high-affinity potassium transport.

GO - Molecular functioni

  • potassium ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular potassium ion homeostasis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciYEAST:G3O-31579-MONOMER.

Protein family/group databases

TCDBi2.A.38.2.1. the k(+) transporter (trk) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity potassium transport protein
Gene namesi
Name:TRK1
Ordered Locus Names:YJL129C
ORF Names:J0693
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL129C.
SGDiS000003665. TRK1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 70HelicalSequence analysisAdd BLAST22
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei778 – 800HelicalSequence analysisAdd BLAST23
Transmembranei813 – 834HelicalSequence analysisAdd BLAST22
Transmembranei838 – 858HelicalSequence analysisAdd BLAST21
Transmembranei862 – 882HelicalSequence analysisAdd BLAST21
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Transmembranei923 – 943HelicalSequence analysisAdd BLAST21
Transmembranei971 – 991HelicalSequence analysisAdd BLAST21
Transmembranei1078 – 1098HelicalSequence analysisAdd BLAST21
Transmembranei1111 – 1131HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • membrane raft Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704621 – 1235High-affinity potassium transport proteinAdd BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Modified residuei414PhosphoserineCombined sources1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1
Glycosylationi532N-linked (GlcNAc...)Sequence analysis1
Modified residuei534PhosphoserineCombined sources1
Glycosylationi580N-linked (GlcNAc...)Sequence analysis1
Glycosylationi677N-linked (GlcNAc...)Sequence analysis1
Glycosylationi919N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1030N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1135N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP12685.

PTM databases

iPTMnetiP12685.

Interactioni

Protein-protein interaction databases

BioGridi33627. 55 interactors.
DIPiDIP-7454N.
IntActiP12685. 1 interactor.
MINTiMINT-2784460.

Structurei

3D structure databases

ProteinModelPortaliP12685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP12685.
OMAiNITDWIL.
OrthoDBiEOG092C1608.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P12685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFRRTMSRV PTLASLEIRY KKSFGHKFRD FIALCGHYFA PVKKYIFPSF
60 70 80 90 100
IAVHYFYTIS LTLITSILLY PIKNTRYIDT LFLAAGAVTQ GGLNTVDINN
110 120 130 140 150
LSLYQQIVLY IVCCISTPIA VHSCLAFVRL YWFERYFDGI RDSSRRNFKM
160 170 180 190 200
RRTKTILERE LTARTMTKNR TGTQRTSYPR KQAKTDDFQE KLFSGEMVNR
210 220 230 240 250
DEQDSVHSDQ NSHDISRDSS NNNTNHNGSS GSLDDFVKED ETDDNGEYQE
260 270 280 290 300
NNSYSTVGSS SNTVADESLN QKPKPSSLRF DEPHSKQRPA RVPSEKFAKR
310 320 330 340 350
RGSRDISPAD MYRSIMMLQG KHEATAEDEG PPLVIGSPAD GTRYKSNVNK
360 370 380 390 400
LKKATGINGN KIKIRDKGNE SNTDQNSVSS EANSTASVSD ESSLHTNFGN
410 420 430 440 450
KVPSLRTNTH RSNSGPIAIT DNAETDKKHG PSIQFDITKP PRKISKRVST
460 470 480 490 500
FDDLNPKSSV LYRKKASKKY LMKHFPKARR IRQQIKRRLS TGSIEKNSSN
510 520 530 540 550
NVSDRKPITD MDDDDDDDDN DGDNNEEYFA DNESGDEDER VQQSEPHSDS
560 570 580 590 600
ELKSHQQQQE KHQLQQNLHR MYKTKSFDDN RSRAVPMERS RTIDMAEAKD
610 620 630 640 650
LNELARTPDF QKMVYQNWKA HHRKKPNFRK RGWNNKIFEH GPYASDSDRN
660 670 680 690 700
YPDNSNTGNS ILHYAESILH HDGSHKNGSE EASSDSNENI YSTNGGSDHN
710 720 730 740 750
GLNNYPTYND DEEGYYGLHF DTDYDLDPRH DLSKGSGKTY LSWQPTIGRN
760 770 780 790 800
SNFLGLTRAQ KDELGGVEYR AIKLLCTILV VYYVGWHIVA FVMLVPWIIL
810 820 830 840 850
KKHYSEVVRD DGVSPTWWGF WTAMSAFNDL GLTLTPNSMM SFNKAVYPLI
860 870 880 890 900
VMIWFIIIGN TGFPILLRCI IWIMFKISPD LSQMRESLGF LLDHPRRCFT
910 920 930 940 950
LLFPKAATWW LLLTLAGLNI TDWILFIILD FGSTVVKSLS KGYRVLVGLF
960 970 980 990 1000
QSVSTRTAGF SVVDLSQLHP SIQVSYMLMM YVSVLPLAIS IRRTNVYEEQ
1010 1020 1030 1040 1050
SLGLYGDMGG EPEDTDTEDD GNDEDDDEEN ESHEGQSSQR SSSNNNNNNN
1060 1070 1080 1090 1100
RKKKKKKKTE NPNEISTKSF IGAHLRKQLS FDLWFLFLGL FIICICEGDK
1110 1120 1130 1140 1150
IKDVQEPNFN IFAILFEIVS AYGTVGLSLG YPDTNQSFSR QFTTLSKLVI
1160 1170 1180 1190 1200
IAMLIRGKNR GLPYSLDRAI ILPSDRLEHI DHLEGMKLKR QARTNTEDPM
1210 1220 1230
TEHFKRSFTD VKHRWGALKR KTTHSRNPKR SSTTL
Length:1,235
Mass (Da):141,073
Last modified:October 1, 1989 - v1
Checksum:iBCE9FDBA0BA0982B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21328 Genomic DNA. Translation: AAA34728.1.
Z49404 Genomic DNA. Translation: CAA89424.1.
BK006943 Genomic DNA. Translation: DAA08672.1.
PIRiS05849. PWBYH.
RefSeqiNP_012406.1. NM_001181562.1.

Genome annotation databases

EnsemblFungiiYJL129C; YJL129C; YJL129C.
GeneIDi853312.
KEGGisce:YJL129C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21328 Genomic DNA. Translation: AAA34728.1.
Z49404 Genomic DNA. Translation: CAA89424.1.
BK006943 Genomic DNA. Translation: DAA08672.1.
PIRiS05849. PWBYH.
RefSeqiNP_012406.1. NM_001181562.1.

3D structure databases

ProteinModelPortaliP12685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33627. 55 interactors.
DIPiDIP-7454N.
IntActiP12685. 1 interactor.
MINTiMINT-2784460.

Protein family/group databases

TCDBi2.A.38.2.1. the k(+) transporter (trk) family.

PTM databases

iPTMnetiP12685.

Proteomic databases

PRIDEiP12685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL129C; YJL129C; YJL129C.
GeneIDi853312.
KEGGisce:YJL129C.

Organism-specific databases

EuPathDBiFungiDB:YJL129C.
SGDiS000003665. TRK1.

Phylogenomic databases

GeneTreeiENSGT00530000069355.
HOGENOMiHOG000161114.
InParanoidiP12685.
OMAiNITDWIL.
OrthoDBiEOG092C1608.

Enzyme and pathway databases

BioCyciYEAST:G3O-31579-MONOMER.

Miscellaneous databases

PROiP12685.

Family and domain databases

InterProiIPR003445. Cat_transpt.
IPR004773. K/Na_transp_Trk/HKT.
IPR015958. Ktransp_fun.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]
PIRSFiPIRSF002450. K+_transpter_TRK. 1 hit.
TIGRFAMsiTIGR00934. 2a38euk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRK1_YEAST
AccessioniPrimary (citable) accession number: P12685
Secondary accession number(s): D6VW56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.