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Protein

Purkinje cell protein 2

Gene

Pcp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a cell-type specific modulator for G protein-mediated cell signaling.

GO - Molecular functioni

  • GTPase regulator activity Source: InterPro
  • guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • positive regulation of GTPase activity Source: GOC
  • rhodopsin mediated signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Purkinje cell protein 2
Alternative name(s):
Protein PCD-5
Purkinje cell-specific protein L7
Gene namesi
Name:Pcp2
Synonyms:Pcp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97508. Pcp2.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Purkinje cell protein 2PRO_0000058261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP12660.
PaxDbiP12660.
PRIDEiP12660.

PTM databases

PhosphoSiteiP12660.

Expressioni

Tissue specificityi

Cerebellum (Purkinje cells) and retinal bipolar neurons.

Gene expression databases

BgeeiP12660.
CleanExiMM_PCP2.
ExpressionAtlasiP12660. baseline and differential.
GenevisibleiP12660. MM.

Interactioni

Protein-protein interaction databases

BioGridi202055. 8 interactions.
IntActiP12660. 1 interaction.
MINTiMINT-89408.
STRINGi10090.ENSMUSP00000121079.

Structurei

3D structure databases

ProteinModelPortaliP12660.
SMRiP12660. Positions 5-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 2923GoLoco 1PROSITE-ProRule annotationAdd
BLAST
Domaini47 – 6923GoLoco 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 GoLoco domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiP12660.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSPDQEGF FNLLTHVQGD RMEEQRCSLQ AGPGQNPESQ GGPAPEMDNL
60 70 80 90 100
MDMLVNTQGR RMDDQRVTVN SLPGFQPIGP KDGMQKRPGT LSPQPLLTPQ
110 120
DPAALSFRRN SSPQPQTQAP
Length:120
Mass (Da):13,054
Last modified:September 19, 2006 - v2
Checksum:iD186BF2710DCA03E
GO

Sequence cautioni

The sequence AAA02989.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAB19316.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAC25015.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE35767.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence described in PubMed:2483097 differs from that shown. Reason: Frameshift at position 77. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21532 mRNA. Translation: AAA02989.1. Different initiation.
S40022 Genomic DNA. Translation: AAB19316.1. Sequence problems.
AK003002 mRNA. Translation: BAC25015.1. Different initiation.
AK160398 mRNA. Translation: BAE35767.1. Different initiation.
CCDSiCCDS52470.1.
PIRiA40322. B34955.
RefSeqiNP_001123276.1. NM_001129804.1.
NP_032816.1. NM_008790.2.
XP_006508793.2. XM_006508730.2.
UniGeneiMm.440882.

Genome annotation databases

EnsembliENSMUST00000133459; ENSMUSP00000122902; ENSMUSG00000004630.
GeneIDi18545.
KEGGimmu:18545.
UCSCiuc009ksa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21532 mRNA. Translation: AAA02989.1. Different initiation.
S40022 Genomic DNA. Translation: AAB19316.1. Sequence problems.
AK003002 mRNA. Translation: BAC25015.1. Different initiation.
AK160398 mRNA. Translation: BAE35767.1. Different initiation.
CCDSiCCDS52470.1.
PIRiA40322. B34955.
RefSeqiNP_001123276.1. NM_001129804.1.
NP_032816.1. NM_008790.2.
XP_006508793.2. XM_006508730.2.
UniGeneiMm.440882.

3D structure databases

ProteinModelPortaliP12660.
SMRiP12660. Positions 5-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202055. 8 interactions.
IntActiP12660. 1 interaction.
MINTiMINT-89408.
STRINGi10090.ENSMUSP00000121079.

PTM databases

PhosphoSiteiP12660.

Proteomic databases

MaxQBiP12660.
PaxDbiP12660.
PRIDEiP12660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133459; ENSMUSP00000122902; ENSMUSG00000004630.
GeneIDi18545.
KEGGimmu:18545.
UCSCiuc009ksa.2. mouse.

Organism-specific databases

CTDi126006.
MGIiMGI:97508. Pcp2.

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiP12660.

Miscellaneous databases

NextBioi294330.
PROiP12660.
SOURCEiSearch...

Gene expression databases

BgeeiP12660.
CleanExiMM_PCP2.
ExpressionAtlasiP12660. baseline and differential.
GenevisibleiP12660. MM.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons."
    Nordquist D.T., Kozak C.A., Orr H.T.
    J. Neurosci. 8:4780-4789(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "A Purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene."
    Oberdick J., Levinthal F., Levinthal C.
    Neuron 1:367-376(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Purkinje cell.
  3. "Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments."
    Vandaele S., Nordquist D.T., Feddersen R.M., Tretjakoff I., Peterson A.C., Orr H.T.
    Genes Dev. 5:1136-1148(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Cerebellum.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPCP2_MOUSE
AccessioniPrimary (citable) accession number: P12660
Secondary accession number(s): P22941, Q3TV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 19, 2006
Last modified: May 11, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.