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Protein

Purkinje cell protein 2

Gene

Pcp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a cell-type specific modulator for G protein-mediated cell signaling.

GO - Molecular functioni

  • GTPase regulator activity Source: InterPro
  • guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • rhodopsin mediated signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Purkinje cell protein 2
Alternative name(s):
Protein PCD-5
Purkinje cell-specific protein L7
Gene namesi
Name:Pcp2
Synonyms:Pcp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97508. Pcp2.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582611 – 120Purkinje cell protein 2Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP12660.
PRIDEiP12660.

PTM databases

iPTMnetiP12660.
PhosphoSitePlusiP12660.

Expressioni

Tissue specificityi

Cerebellum (Purkinje cells) and retinal bipolar neurons.

Gene expression databases

BgeeiENSMUSG00000004630.
CleanExiMM_PCP2.
ExpressionAtlasiP12660. baseline and differential.
GenevisibleiP12660. MM.

Interactioni

Protein-protein interaction databases

BioGridi202055. 8 interactors.
IntActiP12660. 1 interactor.
MINTiMINT-89408.
STRINGi10090.ENSMUSP00000121079.

Structurei

3D structure databases

ProteinModelPortaliP12660.
SMRiP12660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 29GoLoco 1PROSITE-ProRule annotationAdd BLAST23
Domaini47 – 69GoLoco 2PROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Contains 2 GoLoco domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiP12660.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSPDQEGF FNLLTHVQGD RMEEQRCSLQ AGPGQNPESQ GGPAPEMDNL
60 70 80 90 100
MDMLVNTQGR RMDDQRVTVN SLPGFQPIGP KDGMQKRPGT LSPQPLLTPQ
110 120
DPAALSFRRN SSPQPQTQAP
Length:120
Mass (Da):13,054
Last modified:September 19, 2006 - v2
Checksum:iD186BF2710DCA03E
GO

Sequence cautioni

The sequence AAA02989 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB19316 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC25015 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE35767 differs from that shown. Reason: Erroneous initiation.Curated
The sequence described in PubMed:2483097 differs from that shown. Reason: Frameshift at position 77.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21532 mRNA. Translation: AAA02989.1. Different initiation.
S40022 Genomic DNA. Translation: AAB19316.1. Sequence problems.
AK003002 mRNA. Translation: BAC25015.1. Different initiation.
AK160398 mRNA. Translation: BAE35767.1. Different initiation.
CCDSiCCDS52470.1.
PIRiA40322. B34955.
RefSeqiNP_001123276.1. NM_001129804.1.
NP_032816.1. NM_008790.2.
XP_006508793.2. XM_006508730.2.
UniGeneiMm.440882.

Genome annotation databases

EnsembliENSMUST00000133459; ENSMUSP00000122902; ENSMUSG00000004630.
GeneIDi18545.
KEGGimmu:18545.
UCSCiuc009ksa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21532 mRNA. Translation: AAA02989.1. Different initiation.
S40022 Genomic DNA. Translation: AAB19316.1. Sequence problems.
AK003002 mRNA. Translation: BAC25015.1. Different initiation.
AK160398 mRNA. Translation: BAE35767.1. Different initiation.
CCDSiCCDS52470.1.
PIRiA40322. B34955.
RefSeqiNP_001123276.1. NM_001129804.1.
NP_032816.1. NM_008790.2.
XP_006508793.2. XM_006508730.2.
UniGeneiMm.440882.

3D structure databases

ProteinModelPortaliP12660.
SMRiP12660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202055. 8 interactors.
IntActiP12660. 1 interactor.
MINTiMINT-89408.
STRINGi10090.ENSMUSP00000121079.

PTM databases

iPTMnetiP12660.
PhosphoSitePlusiP12660.

Proteomic databases

PaxDbiP12660.
PRIDEiP12660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133459; ENSMUSP00000122902; ENSMUSG00000004630.
GeneIDi18545.
KEGGimmu:18545.
UCSCiuc009ksa.2. mouse.

Organism-specific databases

CTDi126006.
MGIiMGI:97508. Pcp2.

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiP12660.

Miscellaneous databases

PROiP12660.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004630.
CleanExiMM_PCP2.
ExpressionAtlasiP12660. baseline and differential.
GenevisibleiP12660. MM.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP2_MOUSE
AccessioniPrimary (citable) accession number: P12660
Secondary accession number(s): P22941, Q3TV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 19, 2006
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.