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Protein

Calbindin

Gene

Calb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351Add BLAST12
Calcium bindingi111 – 1222Add BLAST12
Calcium bindingi155 – 1663Add BLAST12
Calcium bindingi199 – 2104Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: SynGO
  • calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration Source: SynGO
  • vitamin D binding Source: UniProtKB-KW
  • zinc ion binding Source: MGI

GO - Biological processi

  • cellular response to organic substance Source: MGI
  • locomotory behavior Source: MGI
  • long-term memory Source: MGI
  • metanephric collecting duct development Source: UniProtKB
  • metanephric connecting tubule development Source: UniProtKB
  • metanephric distal convoluted tubule development Source: UniProtKB
  • metanephric part of ureteric bud development Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: GO_Central
  • regulation of long-term synaptic potentiation Source: SynGO
  • regulation of presynaptic cytosolic calcium ion concentration Source: Ensembl
  • retina development in camera-type eye Source: UniProtKB
  • retina layer formation Source: UniProtKB
  • short-term memory Source: MGI

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
PCD-29
Spot 35 protein
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:Calb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88248. Calb1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000734732 – 261CalbindinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP12658.
PaxDbiP12658.
PeptideAtlasiP12658.
PRIDEiP12658.

PTM databases

iPTMnetiP12658.
PhosphoSitePlusiP12658.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028222.
CleanExiMM_CALB1.
GenevisibleiP12658. MM.

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

IntActiP12658. 1 interactor.
MINTiMINT-4996422.
STRINGi10090.ENSMUSP00000029876.

Structurei

3D structure databases

ProteinModelPortaliP12658.
SMRiP12658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1Add BLAST36
Domaini53 – 88EF-hand 2Add BLAST36
Domaini98 – 133EF-hand 3Add BLAST36
Domaini142 – 177EF-hand 4Add BLAST36
Domaini186 – 221EF-hand 5Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 7Interaction with RANBP9By similarity6

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP12658.
KOiK14757.
OMAiMQTWRKY.
OrthoDBiEOG091G0GNH.
PhylomeDBiP12658.
TreeFamiTF325083.

Family and domain databases

InterProiView protein in InterPro
IPR029634. Calbindin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PANTHERiPTHR19972:SF3. PTHR19972:SF3. 1 hit.
PfamiView protein in Pfam
PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELLQARKKA
60 70 80 90 100
GLELSPEMKS FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQELDINN ITTYKKNIMA LSDGGKLYRT
260
DLALILSAGD N
Length:261
Mass (Da):29,994
Last modified:January 23, 2007 - v2
Checksum:iBCC600FD1A86AF3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21531 mRNA. Translation: AAA39898.1.
D26352 Genomic DNA. Translation: BAA05386.1.
AK002635 mRNA. Translation: BAB22249.1.
AK005081 mRNA. Translation: BAB23805.1.
AK005243 mRNA. Translation: BAB23900.1.
AK028050 mRNA. Translation: BAC25721.1.
AK048517 mRNA. Translation: BAC33354.1.
AK077499 mRNA. Translation: BAC36831.1.
BC016421 mRNA. Translation: AAH16421.1.
M23663 mRNA. Translation: AAA53198.1.
CCDSiCCDS17984.1.
PIRiA34955.
RefSeqiNP_033918.1. NM_009788.4.
UniGeneiMm.277665.

Genome annotation databases

EnsembliENSMUST00000029876; ENSMUSP00000029876; ENSMUSG00000028222.
GeneIDi12307.
KEGGimmu:12307.
UCSCiuc008sbl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCALB1_MOUSE
AccessioniPrimary (citable) accession number: P12658
Secondary accession number(s): Q545N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families