Chrm1

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functionⁱ

drug binding Source: Ensembl
G-protein coupled acetylcholine receptor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
cognition Source: InterPro
neuromuscular synaptic transmission Source: Ensembl
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
positive regulation of intracellular protein transport Source: Ensembl
positive regulation of ion transport
Source: MGI
Inferred from sequence orthologyⁱ
- 14657398
regulation of locomotion
Source: MGI
Inferred from mutant phenotypeⁱ
- 11752469
regulation of vascular smooth muscle contraction Source: GO_Central
saliva secretion Source: InterPro
synaptic transmission, cholinergic Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390648. Muscarinic acetylcholine receptors. R-MMU-416476. G alpha (q) signalling events.

Reactomeⁱ

R-MMU-390648. Muscarinic acetylcholine receptors.
R-MMU-416476. G alpha (q) signalling events.

Protein family/group databases

TCDBⁱ

9.A.14.3.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M1
Gene namesⁱ	Name:Chrm1 Synonyms:Chrm-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:88396. Chrm1.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 47	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	48 – 61	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	62 – 82	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	83 – 99	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	100 – 121	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	122 – 141	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	142 – 164	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	165 – 186	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	187 – 209	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	210 – 366	CytoplasmicSequence analysisAdd BLAST	157
Transmembraneⁱ	367 – 387	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	388 – 401	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	402 – 421	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	422 – 460	CytoplasmicSequence analysisAdd BLAST	39

GO - Cellular componentⁱ

axon terminus Source: Ensembl
cell junction Source: UniProtKB-KW
dendrite Source: Ensembl
integral component of plasma membrane Source: InterPro
postsynaptic density Source: Ensembl
postsynaptic membrane Source: UniProtKB-SubCell
synapse Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3733.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	13.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069017	1 – 460	Muscarinic acetylcholine receptor M1Add BLAST		460

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	2	N-linked (GlcNAc...) asparagineCurated	1
Glycosylationⁱ	12	N-linked (GlcNAc...) asparagineCurated	1
Disulfide bondⁱ	98 ↔ 178	PROSITE-ProRule annotation
Modified residueⁱ	230	PhosphothreonineCombined sources	1
Modified residueⁱ	254	PhosphoserineBy similarity	1
Modified residueⁱ	451	PhosphoserineSequence analysis	1
Modified residueⁱ	455	PhosphothreonineSequence analysis	1
Modified residueⁱ	457	PhosphoserineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P12657.
PRIDEⁱ	P12657.

PTM databases

iPTMnetⁱ	P12657.
PhosphoSitePlusⁱ	P12657.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032773.
CleanExⁱ	MM_CHRM1.
ExpressionAtlasⁱ	P12657. baseline and differential.
Genevisibleⁱ	P12657. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000042632.

STRINGⁱ

10090.ENSMUSP00000042632.

Chemistry databases

BindingDBⁱ

P12657.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P12657.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874.
HOGENOMⁱ	HOG000231484.
HOVERGENⁱ	HBG105720.
InParanoidⁱ	P12657.
KEGG Orthology (KO) More...KOⁱ	K04129.
OMAⁱ	RCCRTPR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.
PhylomeDBⁱ	P12657.
TreeFamⁱ	TF320495.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002228. Musac_Ach_M1_rcpt. IPR000995. Musac_Ach_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00538. MUSCRINICM1R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P12657-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNTSVPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF 
        60         70         80         90        100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 
       110        120        130        140        150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 
       160        170        180        190        200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 
       210        220        230        240        250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 
       260        270        280        290        300
SPESPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
       310        320        330        340        350
VIKMPMVDPE AQAPTKQPPK SSPNTVKRPT KKGRDRGGKG QKPRGKEQLA 
       360        370        380        390        400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 
       410        420        430        440        450
ELGYWLCYVN STVNPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 
       460
SVHRTPSRQC

Length:460

Mass (Da):51,379

Last modified:October 3, 2012 - v2

Checksum:ⁱ2F6A93DE8FF4F325

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	I → S in AAA37158 (PubMed:2848036).Curated	1
Sequence conflictⁱ	50	F → I in AAA37158 (PubMed:2848036).Curated	1
Sequence conflictⁱ	420	L → S in AAA37158 (PubMed:2848036).Curated	1
Sequence conflictⁱ	428	T → H in AAA37158 (PubMed:2848036).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04192 Genomic DNA. Translation: AAA37158.1. AK081248 mRNA. Translation: BAC38175.1. AK138282 mRNA. Translation: BAE23612.1. AC025794 Genomic DNA. No translation available. CH466612 Genomic DNA. Translation: EDL33348.1. CH466612 Genomic DNA. Translation: EDL33349.1. BC094242 mRNA. Translation: AAH94242.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29539.1.
PIRⁱ	A31897.
NCBI Reference Sequences More...RefSeqⁱ	NP_001106167.1. NM_001112697.1. NP_031724.2. NM_007698.3.
UniGeneⁱ	Mm.240607.

Genome annotation databases

Ensemblⁱ	ENSMUST00000035444; ENSMUSP00000042632; ENSMUSG00000032773. ENSMUST00000163785; ENSMUSP00000126103; ENSMUSG00000032773.
GeneIDⁱ	12669.
KEGGⁱ	mmu:12669.
UCSC genome browser More...UCSCⁱ	uc008gmf.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04192 Genomic DNA. Translation: AAA37158.1. AK081248 mRNA. Translation: BAC38175.1. AK138282 mRNA. Translation: BAE23612.1. AC025794 Genomic DNA. No translation available. CH466612 Genomic DNA. Translation: EDL33348.1. CH466612 Genomic DNA. Translation: EDL33349.1. BC094242 mRNA. Translation: AAH94242.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29539.1.
PIRⁱ	A31897.
NCBI Reference Sequences More...RefSeqⁱ	NP_001106167.1. NM_001112697.1. NP_031724.2. NM_007698.3.
UniGeneⁱ	Mm.240607.

3D structure databases

ProteinModelPortalⁱ	P12657.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000042632.

STRINGⁱ

10090.ENSMUSP00000042632.

Chemistry databases

BindingDBⁱ	P12657.
ChEMBLⁱ	CHEMBL3733.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	13.

Protein family/group databases

TCDBⁱ	9.A.14.3.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P12657.
PhosphoSitePlusⁱ	P12657.

Proteomic databases

PaxDbⁱ	P12657.
PRIDEⁱ	P12657.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035444; ENSMUSP00000042632; ENSMUSG00000032773. ENSMUST00000163785; ENSMUSP00000126103; ENSMUSG00000032773.
GeneIDⁱ	12669.
KEGGⁱ	mmu:12669.
UCSC genome browser More...UCSCⁱ	uc008gmf.2. mouse.

Organism-specific databases

CTDⁱ	1128.
MGIⁱ	MGI:88396. Chrm1.

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874.
HOGENOMⁱ	HOG000231484.
HOVERGENⁱ	HBG105720.
InParanoidⁱ	P12657.
KEGG Orthology (KO) More...KOⁱ	K04129.
OMAⁱ	RCCRTPR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.
PhylomeDBⁱ	P12657.
TreeFamⁱ	TF320495.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390648. Muscarinic acetylcholine receptors. R-MMU-416476. G alpha (q) signalling events.

Reactomeⁱ

R-MMU-390648. Muscarinic acetylcholine receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P12657.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032773.
CleanExⁱ	MM_CHRM1.
ExpressionAtlasⁱ	P12657. baseline and differential.
Genevisibleⁱ	P12657. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002228. Musac_Ach_M1_rcpt. IPR000995. Musac_Ach_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00538. MUSCRINICM1R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM1_MOUSE
Accessionⁱ	P12657Primary (citable) accession number: P12657 Secondary accession number(s): Q52KQ0, Q8BJN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	October 3, 2012
	Last modified:	May 10, 2017
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P12657 (ACM1_MOUSE)

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Muscarinic acetylcholine receptor M1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ