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Protein

Thyrotropin subunit beta

Gene

Tshb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Indispensable for the control of thyroid structure and metabolism.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin subunit beta
Alternative name(s):
Thyroid-stimulating hormone subunit beta
Short name:
TSH-B
Short name:
TSH-beta
Thyrotropin beta chain
Gene namesi
Name:Tshb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98848. Tshb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 132112Thyrotropin subunit betaPRO_0000011750Add
BLAST
Propeptidei133 – 1386PRO_0000011751

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 72By similarity
Disulfide bondi36 ↔ 87By similarity
Disulfide bondi39 ↔ 125By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 103By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi108 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12656.
PRIDEiP12656.

PTM databases

PhosphoSiteiP12656.

Expressioni

Gene expression databases

CleanExiMM_TSHB.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029450.

Structurei

3D structure databases

ProteinModelPortaliP12656.
SMRiP12656. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP12656.
PhylomeDBiP12656.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVLLSVL FALACGQAAS FCIPTEYTMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFIYR TVEIPGCPHH VTPYFSFPVA
110 120 130
VSCKCGKCNT DNSDCIHEAV RTNYCTKPQS FYLGGFSV
Length:138
Mass (Da):15,373
Last modified:October 1, 1989 - v1
Checksum:i44386FF3E17C5BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20537, M20536 Genomic DNA. Translation: AAA40494.1.
M22740 Genomic DNA. Translation: AAA40493.1.
M35719 mRNA. Translation: AAA37307.1.
M35720 mRNA. Translation: AAA37308.1.
M35721 mRNA. Translation: AAA37309.1.
M35723 mRNA. Translation: AAA37310.1.
M54943 mRNA. Translation: AAA40492.1.
CCDSiCCDS17689.1.
PIRiA29479.
UniGeneiMm.110730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20537, M20536 Genomic DNA. Translation: AAA40494.1.
M22740 Genomic DNA. Translation: AAA40493.1.
M35719 mRNA. Translation: AAA37307.1.
M35720 mRNA. Translation: AAA37308.1.
M35721 mRNA. Translation: AAA37309.1.
M35723 mRNA. Translation: AAA37310.1.
M54943 mRNA. Translation: AAA40492.1.
CCDSiCCDS17689.1.
PIRiA29479.
UniGeneiMm.110730.

3D structure databases

ProteinModelPortaliP12656.
SMRiP12656. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029450.

PTM databases

PhosphoSiteiP12656.

Proteomic databases

PaxDbiP12656.
PRIDEiP12656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98848. Tshb.

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP12656.
PhylomeDBiP12656.

Miscellaneous databases

PROiP12656.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TSHB.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization and nucleotide sequence of the gene encoding the beta-subunit of murine thyrotropin."
    Gordon D.F., Wood W.M., Ridgway E.C.
    DNA 7:17-26(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of the gene for the beta subunit of mouse thyrotropin results in multiple mRNAs differing in their 5'-untranslated regions."
    Wolf O., Kourides I.A., Gurr J.A.
    J. Biol. Chem. 262:16596-16603(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The regulation and organization of thyroid stimulating hormone genes."
    Kourides I.A., Gurr J.A., Wolf O.
    Recent Prog. Horm. Res. 40:79-120(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Expression of the beta-subunit gene of murine thyrotropin results in multiple messenger ribonucleic acid species which are generated by alternative exon splicing."
    Wood W.M., Gordon D.F., Ridgway E.C.
    Mol. Endocrinol. 1:875-883(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-8.
    Strain: LAF1.

Entry informationi

Entry nameiTSHB_MOUSE
AccessioniPrimary (citable) accession number: P12656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 11, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.