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Protein

Glutathione S-transferase 1

Gene

GST1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: AgBase

GO - Biological processi

  • response to herbicide Source: AgBase
  • response to hydrogen peroxide Source: AgBase
  • response to reactive oxygen species Source: AgBase
  • response to salicylic acid Source: AgBase
  • response to xenobiotic stimulus Source: AgBase

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 6752
SABIO-RKP12653

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST class-phi member 1
GST-29
GST-I
Gene namesi
Name:GST1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi65344

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001858412 – 214Glutathione S-transferase 1Add BLAST213

Proteomic databases

PaxDbiP12653
PRIDEiP12653

Expressioni

Tissue specificityi

Expressed in the stem and leaves, lower levels are seen in the pollen and endosperm.

Gene expression databases

ExpressionAtlasiP12653 differential

Interactioni

Subunit structurei

Homodimer or heterodimer of GST-I and GST-IV (=GST-II).2 Publications

Protein-protein interaction databases

STRINGi4577.GRMZM2G116273_P01

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Beta strandi10 – 14Combined sources5
Helixi15 – 25Combined sources11
Beta strandi29 – 32Combined sources4
Turni36 – 39Combined sources4
Helixi40 – 42Combined sources3
Helixi44 – 47Combined sources4
Beta strandi57 – 60Combined sources4
Beta strandi63 – 67Combined sources5
Helixi68 – 79Combined sources12
Helixi81 – 84Combined sources4
Turni85 – 87Combined sources3
Helixi89 – 104Combined sources16
Helixi106 – 117Combined sources12
Helixi119 – 122Combined sources4
Helixi129 – 152Combined sources24
Beta strandi154 – 160Combined sources7
Helixi163 – 166Combined sources4
Helixi169 – 175Combined sources7
Helixi179 – 186Combined sources8
Helixi188 – 199Combined sources12
Helixi201 – 209Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXDX-ray2.50A/B2-210[»]
1BYEX-ray2.80A/B/C/D2-214[»]
ProteinModelPortaliP12653
SMRiP12653
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12653

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini88 – 214GST C-terminalAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 42Glutathione binding2
Regioni54 – 55Glutathione binding2
Regioni67 – 68Glutathione binding2

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000125746
KOiK00799

Family and domain databases

CDDicd03187 GST_C_Phi, 1 hit
InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR034347 GST_Phi_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPMKLYGAV MSWNLTRCAT ALEEAGSDYE IVPINFATAE HKSPEHLVRN
60 70 80 90 100
PFGQVPALQD GDLYLFESRA ICKYAARKNK PELLREGNLE EAAMVDVWIE
110 120 130 140 150
VEANQYTAAL NPILFQVLIS PMLGGTTDQK VVDENLEKLK KVLEVYEARL
160 170 180 190 200
TKCKYLAGDF LSLADLNHVS VTLCLFATPY ASVLDAYPHV KAWWSGLMER
210
PSVQKVAALM KPSA
Length:214
Mass (Da):23,822
Last modified:January 23, 2007 - v4
Checksum:i97DA6337ADF03CB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → V in AAA33470 (Ref. 2) Curated1
Sequence conflicti15L → V in AAA33469 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06754 mRNA Translation: CAA29928.1
M16901 mRNA Translation: AAA33470.1
M16902, M16900 Genomic DNA Translation: AAA33469.1
PIRiS03726 XUZM1
RefSeqiNP_001105412.1, NM_001111942.1
UniGeneiZm.9

Genome annotation databases

GeneIDi542366
KEGGizma:542366

Similar proteinsi

Entry informationi

Entry nameiGSTF1_MAIZE
AccessioniPrimary (citable) accession number: P12653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 119 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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