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P12645

- BMP3_HUMAN

UniProt

P12645 - BMP3_HUMAN

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Protein

Bone morphogenetic protein 3

Gene

BMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.2 Publications

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. cell-cell signaling Source: ProtInc
  3. cell differentiation Source: UniProtKB-KW
  4. growth Source: InterPro
  5. ossification Source: UniProtKB-KW
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Alternative name(s):
Bone morphogenetic protein 3A
Short name:
BMP-3A
Osteogenin
Gene namesi
Name:BMP3
Synonyms:BMP3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1070. BMP3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 362340By similarityPRO_0000033836Add
BLAST
Chaini363 – 472110Bone morphogenetic protein 3PRO_0000033837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi370 ↔ 4371 Publication
Disulfide bondi399 ↔ 4691 Publication
Disulfide bondi403 ↔ 4711 Publication
Disulfide bondi436 – 436Interchain1 Publication
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12645.
PRIDEiP12645.

PTM databases

PhosphoSiteiP12645.

Expressioni

Tissue specificityi

Expressed in adult and fetal cartilage.1 Publication

Inductioni

Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.1 Publication

Gene expression databases

BgeeiP12645.
CleanExiHS_BMP3.
ExpressionAtlasiP12645. baseline and differential.
GenevestigatoriP12645.

Organism-specific databases

HPAiHPA045344.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi107119. 2 interactions.
IntActiP12645. 4 interactions.
MINTiMINT-8044327.
STRINGi9606.ENSP00000282701.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi368 – 3736
Beta strandi376 – 3783
Turni379 – 3835
Turni385 – 3873
Beta strandi388 – 3903
Beta strandi392 – 3954
Beta strandi398 – 4003
Helixi409 – 4113
Helixi415 – 42511
Beta strandi437 – 4393
Beta strandi441 – 45010
Beta strandi456 – 46611
Beta strandi469 – 4713

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QCQX-ray2.21A/B363-472[»]
ProteinModelPortaliP12645.
SMRiP12645. Positions 365-472.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12645.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300136.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP12645.
KOiK05496.
OMAiLPFPEPY.
OrthoDBiEOG70CR76.
PhylomeDBiP12645.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/GDF10.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL
60 70 80 90 100
QPQDKVSEHM LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF
110 120 130 140 150
RAAAAETLER KGLYIFNLTS LTKSENILSA TLYFCIGELG NISLSCPVSG
160 170 180 190 200
GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL GHLSVDMAKS HRDIMSWLSK
210 220 230 240 250
DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI LVYANDAAIS
260 270 280 290 300
EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN
310 320 330 340 350
ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ
360 370 380 390 400
FDEQTLKKAR RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS
410 420 430 440 450
GACQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE KMSSLSILFF
460 470
DENKNVVLKV YPNMTVESCA CR
Length:472
Mass (Da):53,372
Last modified:November 25, 2008 - v2
Checksum:i2809B7EF5E37596A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti176 – 1761Q → K.
Corresponds to variant rs34213771 [ dbSNP | Ensembl ].
VAR_047418
Natural varianti176 – 1761Q → L.
Corresponds to variant rs34847147 [ dbSNP | Ensembl ].
VAR_047419
Natural varianti192 – 1921R → Q.
Corresponds to variant rs3733549 [ dbSNP | Ensembl ].
VAR_020063
Natural varianti205 – 2051L → F.3 Publications
Corresponds to variant rs6831040 [ dbSNP | Ensembl ].
VAR_047420
Natural varianti222 – 2221T → M.
Corresponds to variant rs34505126 [ dbSNP | Ensembl ].
VAR_047421

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22491 mRNA. Translation: AAA51836.1.
AC093883 Genomic DNA. No translation available.
BC096269 mRNA. Translation: AAH96269.1.
BC096270 mRNA. Translation: AAH96270.1.
BC096271 mRNA. Translation: AAH96271.1.
BC117514 mRNA. Translation: AAI17515.1.
CCDSiCCDS3588.1.
PIRiD37278. BMHU3.
RefSeqiNP_001192.2. NM_001201.2.
UniGeneiHs.387411.

Genome annotation databases

EnsembliENST00000282701; ENSP00000282701; ENSG00000152785.
GeneIDi651.
KEGGihsa:651.
UCSCiuc003hmg.4. human.

Polymorphism databases

DMDMi215273985.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 3 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22491 mRNA. Translation: AAA51836.1 .
AC093883 Genomic DNA. No translation available.
BC096269 mRNA. Translation: AAH96269.1 .
BC096270 mRNA. Translation: AAH96270.1 .
BC096271 mRNA. Translation: AAH96271.1 .
BC117514 mRNA. Translation: AAI17515.1 .
CCDSi CCDS3588.1.
PIRi D37278. BMHU3.
RefSeqi NP_001192.2. NM_001201.2.
UniGenei Hs.387411.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QCQ X-ray 2.21 A/B 363-472 [» ]
ProteinModelPortali P12645.
SMRi P12645. Positions 365-472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107119. 2 interactions.
IntActi P12645. 4 interactions.
MINTi MINT-8044327.
STRINGi 9606.ENSP00000282701.

PTM databases

PhosphoSitei P12645.

Polymorphism databases

DMDMi 215273985.

Proteomic databases

PaxDbi P12645.
PRIDEi P12645.

Protocols and materials databases

DNASUi 651.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282701 ; ENSP00000282701 ; ENSG00000152785 .
GeneIDi 651.
KEGGi hsa:651.
UCSCi uc003hmg.4. human.

Organism-specific databases

CTDi 651.
GeneCardsi GC04P081952.
HGNCi HGNC:1070. BMP3.
HPAi HPA045344.
MIMi 112263. gene.
neXtProti NX_P12645.
PharmGKBi PA25380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300136.
GeneTreei ENSGT00740000114888.
HOGENOMi HOG000232003.
HOVERGENi HBG004857.
InParanoidi P12645.
KOi K05496.
OMAi LPFPEPY.
OrthoDBi EOG70CR76.
PhylomeDBi P12645.
TreeFami TF316134.

Miscellaneous databases

EvolutionaryTracei P12645.
GeneWikii Bone_morphogenetic_protein_3.
GenomeRNAii 651.
NextBioi 2644.
PROi P12645.
SOURCEi Search...

Gene expression databases

Bgeei P12645.
CleanExi HS_BMP3.
ExpressionAtlasi P12645. baseline and differential.
Genevestigatori P12645.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR017197. BMP3/GDF10.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PIRSFi PIRSF037403. BMP3/GDF10. 1 hit.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel regulators of bone formation: molecular clones and activities."
    Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
    Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-205.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-205.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-205.
  4. "Bone morphogenetic protein-3 is a negative regulator of bone density."
    Daluiski A., Engstrand T., Bahamonde M.E., Gamer L.W., Agius E., Stevenson S.L., Cox K., Rosen V., Lyons K.M.
    Nat. Genet. 27:84-88(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "BMP signaling components are expressed in human fracture callus."
    Kloen P., Di Paola M., Borens O., Richmond J., Perino G., Helfet D.L., Goumans M.J.
    Bone 33:362-371(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery."
    Kang Q., Sun M.H., Cheng H., Peng Y., Montag A.G., Deyrup A.T., Jiang W., Luu H.H., Luo J., Szatkowski J.P., Vanichakarn P., Park J.Y., Li Y., Haydon R.C., He T.-C.
    Gene Ther. 11:1312-1320(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage."
    Chen A.L., Fang C., Liu C., Leslie M.P., Chang E., Di Cesare P.E.
    J. Orthop. Res. 22:1188-1192(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."
    Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S.
    Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 363-472, DISULFIDE BONDS.

Entry informationi

Entry nameiBMP3_HUMAN
AccessioniPrimary (citable) accession number: P12645
Secondary accession number(s): Q4VAS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3