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Protein

Bone morphogenetic protein 3

Gene

BMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.2 Publications

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • receptor binding Source: ProtInc
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152785-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Alternative name(s):
Bone morphogenetic protein 3A
Short name:
BMP-3A
Osteogenin
Gene namesi
Name:BMP3
Synonyms:BMP3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1070. BMP3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi651.
OpenTargetsiENSG00000152785.
PharmGKBiPA25380.

Polymorphism and mutation databases

BioMutaiBMP3.
DMDMi215273985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003383623 – 362By similarityAdd BLAST340
ChainiPRO_0000033837363 – 472Bone morphogenetic protein 3Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi370 ↔ 4371 Publication
Disulfide bondi399 ↔ 4691 Publication
Disulfide bondi403 ↔ 4711 Publication
Disulfide bondi436Interchain1 Publication
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12645.
PeptideAtlasiP12645.
PRIDEiP12645.

PTM databases

iPTMnetiP12645.
PhosphoSitePlusiP12645.

Expressioni

Tissue specificityi

Expressed in adult and fetal cartilage.1 Publication

Inductioni

Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.1 Publication

Gene expression databases

BgeeiENSG00000152785.
CleanExiHS_BMP3.
GenevisibleiP12645. HS.

Organism-specific databases

HPAiHPA045344.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • receptor binding Source: ProtInc
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi107119. 2 interactors.
IntActiP12645. 4 interactors.
MINTiMINT-8044327.
STRINGi9606.ENSP00000282701.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi368 – 373Combined sources6
Beta strandi376 – 378Combined sources3
Turni379 – 383Combined sources5
Turni385 – 387Combined sources3
Beta strandi388 – 390Combined sources3
Beta strandi392 – 395Combined sources4
Beta strandi398 – 400Combined sources3
Helixi409 – 411Combined sources3
Helixi415 – 425Combined sources11
Beta strandi437 – 439Combined sources3
Beta strandi441 – 450Combined sources10
Beta strandi456 – 466Combined sources11
Beta strandi469 – 471Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCQX-ray2.21A/B363-472[»]
ProteinModelPortaliP12645.
SMRiP12645.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12645.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP12645.
KOiK05496.
OMAiLPFPEPY.
OrthoDBiEOG091G0WGP.
PhylomeDBiP12645.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL
60 70 80 90 100
QPQDKVSEHM LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF
110 120 130 140 150
RAAAAETLER KGLYIFNLTS LTKSENILSA TLYFCIGELG NISLSCPVSG
160 170 180 190 200
GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL GHLSVDMAKS HRDIMSWLSK
210 220 230 240 250
DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI LVYANDAAIS
260 270 280 290 300
EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN
310 320 330 340 350
ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ
360 370 380 390 400
FDEQTLKKAR RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS
410 420 430 440 450
GACQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE KMSSLSILFF
460 470
DENKNVVLKV YPNMTVESCA CR
Length:472
Mass (Da):53,372
Last modified:November 25, 2008 - v2
Checksum:i2809B7EF5E37596A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047418176Q → K.Corresponds to variant rs34213771dbSNPEnsembl.1
Natural variantiVAR_047419176Q → L.Corresponds to variant rs34847147dbSNPEnsembl.1
Natural variantiVAR_020063192R → Q.Corresponds to variant rs3733549dbSNPEnsembl.1
Natural variantiVAR_047420205L → F.3 PublicationsCorresponds to variant rs6831040dbSNPEnsembl.1
Natural variantiVAR_047421222T → M.Corresponds to variant rs34505126dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22491 mRNA. Translation: AAA51836.1.
AC093883 Genomic DNA. No translation available.
BC096269 mRNA. Translation: AAH96269.1.
BC096270 mRNA. Translation: AAH96270.1.
BC096271 mRNA. Translation: AAH96271.1.
BC117514 mRNA. Translation: AAI17515.1.
CCDSiCCDS3588.1.
PIRiD37278. BMHU3.
RefSeqiNP_001192.3. NM_001201.3.
UniGeneiHs.387411.

Genome annotation databases

EnsembliENST00000282701; ENSP00000282701; ENSG00000152785.
GeneIDi651.
KEGGihsa:651.
UCSCiuc003hmg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22491 mRNA. Translation: AAA51836.1.
AC093883 Genomic DNA. No translation available.
BC096269 mRNA. Translation: AAH96269.1.
BC096270 mRNA. Translation: AAH96270.1.
BC096271 mRNA. Translation: AAH96271.1.
BC117514 mRNA. Translation: AAI17515.1.
CCDSiCCDS3588.1.
PIRiD37278. BMHU3.
RefSeqiNP_001192.3. NM_001201.3.
UniGeneiHs.387411.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCQX-ray2.21A/B363-472[»]
ProteinModelPortaliP12645.
SMRiP12645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107119. 2 interactors.
IntActiP12645. 4 interactors.
MINTiMINT-8044327.
STRINGi9606.ENSP00000282701.

PTM databases

iPTMnetiP12645.
PhosphoSitePlusiP12645.

Polymorphism and mutation databases

BioMutaiBMP3.
DMDMi215273985.

Proteomic databases

PaxDbiP12645.
PeptideAtlasiP12645.
PRIDEiP12645.

Protocols and materials databases

DNASUi651.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282701; ENSP00000282701; ENSG00000152785.
GeneIDi651.
KEGGihsa:651.
UCSCiuc003hmg.4. human.

Organism-specific databases

CTDi651.
DisGeNETi651.
GeneCardsiBMP3.
HGNCiHGNC:1070. BMP3.
HPAiHPA045344.
MIMi112263. gene.
neXtProtiNX_P12645.
OpenTargetsiENSG00000152785.
PharmGKBiPA25380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP12645.
KOiK05496.
OMAiLPFPEPY.
OrthoDBiEOG091G0WGP.
PhylomeDBiP12645.
TreeFamiTF316134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152785-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP12645.
GeneWikiiBone_morphogenetic_protein_3.
GenomeRNAii651.
PROiP12645.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152785.
CleanExiHS_BMP3.
GenevisibleiP12645. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP3_HUMAN
AccessioniPrimary (citable) accession number: P12645
Secondary accession number(s): Q4VAS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.