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P12645

- BMP3_HUMAN

UniProt

P12645 - BMP3_HUMAN

Protein

Bone morphogenetic protein 3

Gene

BMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.2 Publications

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. cell-cell signaling Source: ProtInc
    3. cell differentiation Source: UniProtKB-KW
    4. growth Source: InterPro
    5. ossification Source: UniProtKB-KW
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 3
    Short name:
    BMP-3
    Alternative name(s):
    Bone morphogenetic protein 3A
    Short name:
    BMP-3A
    Osteogenin
    Gene namesi
    Name:BMP3
    Synonyms:BMP3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:1070. BMP3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 362340By similarityPRO_0000033836Add
    BLAST
    Chaini363 – 472110Bone morphogenetic protein 3PRO_0000033837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi370 ↔ 4371 Publication
    Disulfide bondi399 ↔ 4691 Publication
    Disulfide bondi403 ↔ 4711 Publication
    Disulfide bondi436 – 436Interchain1 Publication
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP12645.
    PRIDEiP12645.

    PTM databases

    PhosphoSiteiP12645.

    Expressioni

    Tissue specificityi

    Expressed in adult and fetal cartilage.1 Publication

    Inductioni

    Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.1 Publication

    Gene expression databases

    ArrayExpressiP12645.
    BgeeiP12645.
    CleanExiHS_BMP3.
    GenevestigatoriP12645.

    Organism-specific databases

    HPAiHPA045344.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi107119. 2 interactions.
    IntActiP12645. 4 interactions.
    MINTiMINT-8044327.
    STRINGi9606.ENSP00000282701.

    Structurei

    Secondary structure

    1
    472
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi368 – 3736
    Beta strandi376 – 3783
    Turni379 – 3835
    Turni385 – 3873
    Beta strandi388 – 3903
    Beta strandi392 – 3954
    Beta strandi398 – 4003
    Helixi409 – 4113
    Helixi415 – 42511
    Beta strandi437 – 4393
    Beta strandi441 – 45010
    Beta strandi456 – 46611
    Beta strandi469 – 4713

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QCQX-ray2.21A/B363-472[»]
    ProteinModelPortaliP12645.
    SMRiP12645. Positions 365-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12645.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG300136.
    HOGENOMiHOG000232003.
    HOVERGENiHBG004857.
    InParanoidiP12645.
    KOiK05496.
    OMAiLPFPEPY.
    OrthoDBiEOG70CR76.
    PhylomeDBiP12645.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR017197. BMP3/GDF10.
    IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL    50
    QPQDKVSEHM LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF 100
    RAAAAETLER KGLYIFNLTS LTKSENILSA TLYFCIGELG NISLSCPVSG 150
    GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL GHLSVDMAKS HRDIMSWLSK 200
    DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI LVYANDAAIS 250
    EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN 300
    ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ 350
    FDEQTLKKAR RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS 400
    GACQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE KMSSLSILFF 450
    DENKNVVLKV YPNMTVESCA CR 472
    Length:472
    Mass (Da):53,372
    Last modified:November 25, 2008 - v2
    Checksum:i2809B7EF5E37596A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti176 – 1761Q → K.
    Corresponds to variant rs34213771 [ dbSNP | Ensembl ].
    VAR_047418
    Natural varianti176 – 1761Q → L.
    Corresponds to variant rs34847147 [ dbSNP | Ensembl ].
    VAR_047419
    Natural varianti192 – 1921R → Q.
    Corresponds to variant rs3733549 [ dbSNP | Ensembl ].
    VAR_020063
    Natural varianti205 – 2051L → F.3 Publications
    Corresponds to variant rs6831040 [ dbSNP | Ensembl ].
    VAR_047420
    Natural varianti222 – 2221T → M.
    Corresponds to variant rs34505126 [ dbSNP | Ensembl ].
    VAR_047421

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22491 mRNA. Translation: AAA51836.1.
    AC093883 Genomic DNA. No translation available.
    BC096269 mRNA. Translation: AAH96269.1.
    BC096270 mRNA. Translation: AAH96270.1.
    BC096271 mRNA. Translation: AAH96271.1.
    BC117514 mRNA. Translation: AAI17515.1.
    CCDSiCCDS3588.1.
    PIRiD37278. BMHU3.
    RefSeqiNP_001192.2. NM_001201.2.
    UniGeneiHs.387411.

    Genome annotation databases

    EnsembliENST00000282701; ENSP00000282701; ENSG00000152785.
    GeneIDi651.
    KEGGihsa:651.
    UCSCiuc003hmg.4. human.

    Polymorphism databases

    DMDMi215273985.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 3 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22491 mRNA. Translation: AAA51836.1 .
    AC093883 Genomic DNA. No translation available.
    BC096269 mRNA. Translation: AAH96269.1 .
    BC096270 mRNA. Translation: AAH96270.1 .
    BC096271 mRNA. Translation: AAH96271.1 .
    BC117514 mRNA. Translation: AAI17515.1 .
    CCDSi CCDS3588.1.
    PIRi D37278. BMHU3.
    RefSeqi NP_001192.2. NM_001201.2.
    UniGenei Hs.387411.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QCQ X-ray 2.21 A/B 363-472 [» ]
    ProteinModelPortali P12645.
    SMRi P12645. Positions 365-472.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107119. 2 interactions.
    IntActi P12645. 4 interactions.
    MINTi MINT-8044327.
    STRINGi 9606.ENSP00000282701.

    PTM databases

    PhosphoSitei P12645.

    Polymorphism databases

    DMDMi 215273985.

    Proteomic databases

    PaxDbi P12645.
    PRIDEi P12645.

    Protocols and materials databases

    DNASUi 651.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282701 ; ENSP00000282701 ; ENSG00000152785 .
    GeneIDi 651.
    KEGGi hsa:651.
    UCSCi uc003hmg.4. human.

    Organism-specific databases

    CTDi 651.
    GeneCardsi GC04P081952.
    HGNCi HGNC:1070. BMP3.
    HPAi HPA045344.
    MIMi 112263. gene.
    neXtProti NX_P12645.
    PharmGKBi PA25380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300136.
    HOGENOMi HOG000232003.
    HOVERGENi HBG004857.
    InParanoidi P12645.
    KOi K05496.
    OMAi LPFPEPY.
    OrthoDBi EOG70CR76.
    PhylomeDBi P12645.
    TreeFami TF316134.

    Miscellaneous databases

    EvolutionaryTracei P12645.
    GeneWikii Bone_morphogenetic_protein_3.
    GenomeRNAii 651.
    NextBioi 2644.
    PROi P12645.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12645.
    Bgeei P12645.
    CleanExi HS_BMP3.
    Genevestigatori P12645.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR017197. BMP3/GDF10.
    IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037403. BMP3/GDF10. 1 hit.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel regulators of bone formation: molecular clones and activities."
      Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
      Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-205.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-205.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-205.
    4. "Bone morphogenetic protein-3 is a negative regulator of bone density."
      Daluiski A., Engstrand T., Bahamonde M.E., Gamer L.W., Agius E., Stevenson S.L., Cox K., Rosen V., Lyons K.M.
      Nat. Genet. 27:84-88(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "BMP signaling components are expressed in human fracture callus."
      Kloen P., Di Paola M., Borens O., Richmond J., Perino G., Helfet D.L., Goumans M.J.
      Bone 33:362-371(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery."
      Kang Q., Sun M.H., Cheng H., Peng Y., Montag A.G., Deyrup A.T., Jiang W., Luu H.H., Luo J., Szatkowski J.P., Vanichakarn P., Park J.Y., Li Y., Haydon R.C., He T.-C.
      Gene Ther. 11:1312-1320(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage."
      Chen A.L., Fang C., Liu C., Leslie M.P., Chang E., Di Cesare P.E.
      J. Orthop. Res. 22:1188-1192(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."
      Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S.
      Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 363-472, DISULFIDE BONDS.

    Entry informationi

    Entry nameiBMP3_HUMAN
    AccessioniPrimary (citable) accession number: P12645
    Secondary accession number(s): Q4VAS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3