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Protein

Bone morphogenetic protein 4

Gene

BMP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).By similarity

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • chemoattractant activity Source: UniProtKB
  • co-receptor binding Source: BHF-UCL
  • cytokine activity Source: MGI
  • heparin binding Source: Ensembl
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  • activation of MAPKK activity Source: UniProtKB
  • anterior/posterior axis specification Source: Ensembl
  • aortic valve morphogenesis Source: BHF-UCL
  • blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
  • BMP signaling pathway Source: BHF-UCL
  • BMP signaling pathway involved in heart development Source: BHF-UCL
  • BMP signaling pathway involved in heart induction Source: BHF-UCL
  • BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  • BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  • BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  • branching involved in prostate gland morphogenesis Source: Ensembl
  • branching involved in ureteric bud morphogenesis Source: UniProtKB
  • branching morphogenesis of an epithelial tube Source: UniProtKB
  • bronchus development Source: MGI
  • bud dilation involved in lung branching Source: MGI
  • bud elongation involved in lung branching Source: Ensembl
  • cardiac muscle cell differentiation Source: Ensembl
  • cardiac septum development Source: BHF-UCL
  • cellular response to BMP stimulus Source: BHF-UCL
  • chondrocyte differentiation Source: UniProtKB
  • cloacal septation Source: Ensembl
  • common-partner SMAD protein phosphorylation Source: UniProtKB
  • coronary vasculature development Source: BHF-UCL
  • cranial suture morphogenesis Source: Ensembl
  • deltoid tuberosity development Source: UniProtKB
  • dorsal/ventral neural tube patterning Source: Ensembl
  • embryonic cranial skeleton morphogenesis Source: Ensembl
  • embryonic digit morphogenesis Source: Ensembl
  • embryonic hindlimb morphogenesis Source: Ensembl
  • embryonic skeletal joint morphogenesis Source: Ensembl
  • endocardial cushion development Source: BHF-UCL
  • endochondral ossification Source: UniProtKB
  • epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • epithelial-mesenchymal cell signaling Source: Ensembl
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • erythrocyte differentiation Source: Ensembl
  • germ cell development Source: Ensembl
  • glomerular capillary formation Source: UniProtKB
  • glomerular visceral epithelial cell development Source: Ensembl
  • hematopoietic progenitor cell differentiation Source: UniProtKB
  • inner ear receptor cell differentiation Source: Ensembl
  • intermediate mesodermal cell differentiation Source: UniProtKB
  • kidney development Source: UniProtKB
  • lens induction in camera-type eye Source: Ensembl
  • lung alveolus development Source: MGI
  • lung morphogenesis Source: MGI
  • lymphoid progenitor cell differentiation Source: BHF-UCL
  • macrophage differentiation Source: DFLAT
  • mammary gland formation Source: Ensembl
  • membranous septum morphogenesis Source: BHF-UCL
  • mesenchymal cell differentiation involved in kidney development Source: Ensembl
  • mesenchymal cell proliferation involved in ureter development Source: Ensembl
  • mesenchymal cell proliferation involved in ureteric bud development Source: Ensembl
  • mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  • mesodermal cell fate determination Source: Ensembl
  • mesonephros development Source: UniProtKB
  • metanephric collecting duct development Source: UniProtKB
  • monocyte differentiation Source: DFLAT
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  • negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • negative regulation of cell cycle Source: HGNC
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  • negative regulation of chondrocyte differentiation Source: Ensembl
  • negative regulation of epithelial cell proliferation Source: Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  • negative regulation of glomerulus development Source: UniProtKB
  • negative regulation of immature T cell proliferation in thymus Source: BHF-UCL
  • negative regulation of MAP kinase activity Source: UniProtKB
  • negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  • negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  • negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  • negative regulation of mitotic nuclear division Source: UniProtKB
  • negative regulation of myoblast differentiation Source: MGI
  • negative regulation of phosphorylation Source: UniProtKB
  • negative regulation of prostatic bud formation Source: Ensembl
  • negative regulation of striated muscle tissue development Source: MGI
  • negative regulation of T cell differentiation in thymus Source: BHF-UCL
  • negative regulation of thymocyte apoptotic process Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • neural tube closure Source: Ensembl
  • neuron fate commitment Source: Ensembl
  • odontogenesis Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: Ensembl
  • osteoblast differentiation Source: BHF-UCL
  • outflow tract septum morphogenesis Source: BHF-UCL
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • pituitary gland development Source: Ensembl
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • positive regulation of bone mineralization Source: UniProtKB
  • positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  • positive regulation of cardiac muscle fiber development Source: BHF-UCL
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell death Source: MGI
  • positive regulation of cell proliferation involved in outflow tract morphogenesis Source: BHF-UCL
  • positive regulation of collagen biosynthetic process Source: BHF-UCL
  • positive regulation of DNA-dependent DNA replication Source: BHF-UCL
  • positive regulation of endothelial cell differentiation Source: Ensembl
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of epidermal cell differentiation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  • positive regulation of kidney development Source: UniProtKB
  • positive regulation of neuron differentiation Source: Ensembl
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of SMAD protein import into nucleus Source: BHF-UCL
  • positive regulation of smooth muscle cell proliferation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • post-embryonic development Source: MGI
  • protein localization to nucleus Source: UniProtKB
  • pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  • pulmonary valve morphogenesis Source: BHF-UCL
  • regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  • regulation of cell fate commitment Source: UniProtKB
  • regulation of odontogenesis of dentin-containing tooth Source: Ensembl
  • regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • regulation of protein import into nucleus Source: MGI
  • regulation of smooth muscle cell differentiation Source: Ensembl
  • renal system development Source: UniProtKB
  • renal system process Source: Ensembl
  • secondary heart field specification Source: BHF-UCL
  • SMAD protein signal transduction Source: UniProtKB
  • smoothened signaling pathway Source: UniProtKB
  • smooth muscle tissue development Source: UniProtKB
  • specification of animal organ position Source: Ensembl
  • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  • steroid hormone mediated signaling pathway Source: UniProtKB
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: Ensembl
  • tendon cell differentiation Source: UniProtKB
  • trachea development Source: MGI
  • trachea formation Source: Ensembl
  • type B pancreatic cell development Source: BHF-UCL
  • ureter epithelial cell differentiation Source: UniProtKB
  • ureteric bud development Source: MGI
  • ureter smooth muscle cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125378-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP12644.
SIGNORiP12644.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:BMP4
Synonyms:BMP2B, DVR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1071. BMP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Microphthalmia, syndromic, 6 (MCOPS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
See also OMIM:607932
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04353293E → G in MCOPS6. 1 PublicationCorresponds to variant rs121912765dbSNPEnsembl.1
Non-syndromic orofacial cleft 11 (OFC11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
See also OMIM:600625
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04353191S → C in OFC11; also found in renal hypodysplasia patients. 3 PublicationsCorresponds to variant rs121912767dbSNPEnsembl.1
Natural variantiVAR_058315162R → Q in OFC11. 1 PublicationCorresponds to variant rs770493925dbSNPEnsembl.1
Natural variantiVAR_058317287R → H in OFC11. 1 PublicationCorresponds to variant rs121912768dbSNPEnsembl.1
Natural variantiVAR_058318346A → V in OFC11. 1 PublicationCorresponds to variant rs121912766dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNETi652.
MalaCardsiBMP4.
MIMi600625. phenotype.
607932. phenotype.
OpenTargetsiENSG00000125378.
Orphaneti264200. 14q22q23 microdeletion syndrome.
1991. Cleft lip with or without cleft palate.
139471. Microphthalmia with brain and digit anomalies.
93100. Unilateral renal agenesis.
PharmGKBiPA25381.

Chemistry databases

ChEMBLiCHEMBL5350.

Polymorphism and mutation databases

BioMutaiBMP4.
DMDMi115073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003385620 – 292Add BLAST273
ChainiPRO_0000033857293 – 408Bone morphogenetic protein 4Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Phosphoserine; by FAM20C1 Publication1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi308 ↔ 373By similarity
Disulfide bondi337 ↔ 405By similarity
Disulfide bondi341 ↔ 407By similarity
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi372InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12644.
PeptideAtlasiP12644.
PRIDEiP12644.

PTM databases

iPTMnetiP12644.
PhosphoSitePlusiP12644.

Expressioni

Tissue specificityi

Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

Gene expression databases

BgeeiENSG00000125378.
CleanExiHS_BMP4.
ExpressionAtlasiP12644. baseline and differential.
GenevisibleiP12644. HS.

Organism-specific databases

HPAiCAB006863.
HPA066235.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Interacts with SOSTDC1. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR1AP368942EBI-1998134,EBI-1029237

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • co-receptor binding Source: BHF-UCL
  • cytokine activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi107120. 13 interactors.
DIPiDIP-5795N.
IntActiP12644. 8 interactors.
MINTiMINT-1184353.
STRINGi9606.ENSP00000245451.

Chemistry databases

BindingDBiP12644.

Structurei

3D structure databases

ProteinModelPortaliP12644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12644.
KOiK04662.
OMAiTRLVRHN.
OrthoDBiEOG091G0K7Z.
PhylomeDBiP12644.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH
110 120 130 140 150
STGLEYPERP ASRANTVRSF HHEEHLENIP GTSENSAFRF LFNLSSIPEN
160 170 180 190 200
EVISSAELRL FREQVDQGPD WERGFHRINI YEVMKPPAEV VPGHLITRLL
210 220 230 240 250
DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ
260 270 280 290 300
HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
310 320 330 340 350
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,555
Last modified:October 1, 1989 - v1
Checksum:i79B01179DBB98204
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04353191S → C in OFC11; also found in renal hypodysplasia patients. 3 PublicationsCorresponds to variant rs121912767dbSNPEnsembl.1
Natural variantiVAR_04353293E → G in MCOPS6. 1 PublicationCorresponds to variant rs121912765dbSNPEnsembl.1
Natural variantiVAR_058314102T → A.1 PublicationCorresponds to variant rs202159001dbSNPEnsembl.1
Natural variantiVAR_043533116T → S in a renal hypodysplasia patient. 1 PublicationCorresponds to variant rs750427266dbSNPEnsembl.1
Natural variantiVAR_043534150N → K in a renal hypodysplasia patient. 1 PublicationCorresponds to variant rs767216159dbSNPEnsembl.1
Natural variantiVAR_016174152V → A.4 PublicationsCorresponds to variant rs17563dbSNPEnsembl.1
Natural variantiVAR_058315162R → Q in OFC11. 1 PublicationCorresponds to variant rs770493925dbSNPEnsembl.1
Natural variantiVAR_058316168G → A.1 Publication1
Natural variantiVAR_043535225T → A.1 PublicationCorresponds to variant rs144556455dbSNPEnsembl.1
Natural variantiVAR_043536226R → W.1 PublicationCorresponds to variant rs140590144dbSNPEnsembl.1
Natural variantiVAR_058317287R → H in OFC11. 1 PublicationCorresponds to variant rs121912768dbSNPEnsembl.1
Natural variantiVAR_058318346A → V in OFC11. 1 PublicationCorresponds to variant rs121912766dbSNPEnsembl.1
Natural variantiVAR_043537367S → T.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22490 mRNA. Translation: AAA51835.1.
U43842 Genomic DNA. Translation: AAC72278.1.
BC020546 mRNA. Translation: AAH20546.1.
D30751 mRNA. Translation: BAA06410.1.
CCDSiCCDS9715.1.
PIRiC37278. BMHU4.
RefSeqiNP_001193.2. NM_001202.4.
NP_570911.2. NM_130850.3.
XP_005268072.1. XM_005268015.4.
XP_016877092.1. XM_017021603.1.
UniGeneiHs.68879.

Genome annotation databases

EnsembliENST00000245451; ENSP00000245451; ENSG00000125378.
ENST00000417573; ENSP00000394165; ENSG00000125378.
ENST00000558984; ENSP00000454134; ENSG00000125378.
ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneIDi652.
KEGGihsa:652.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 4 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22490 mRNA. Translation: AAA51835.1.
U43842 Genomic DNA. Translation: AAC72278.1.
BC020546 mRNA. Translation: AAH20546.1.
D30751 mRNA. Translation: BAA06410.1.
CCDSiCCDS9715.1.
PIRiC37278. BMHU4.
RefSeqiNP_001193.2. NM_001202.4.
NP_570911.2. NM_130850.3.
XP_005268072.1. XM_005268015.4.
XP_016877092.1. XM_017021603.1.
UniGeneiHs.68879.

3D structure databases

ProteinModelPortaliP12644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107120. 13 interactors.
DIPiDIP-5795N.
IntActiP12644. 8 interactors.
MINTiMINT-1184353.
STRINGi9606.ENSP00000245451.

Chemistry databases

BindingDBiP12644.
ChEMBLiCHEMBL5350.

PTM databases

iPTMnetiP12644.
PhosphoSitePlusiP12644.

Polymorphism and mutation databases

BioMutaiBMP4.
DMDMi115073.

Proteomic databases

PaxDbiP12644.
PeptideAtlasiP12644.
PRIDEiP12644.

Protocols and materials databases

DNASUi652.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245451; ENSP00000245451; ENSG00000125378.
ENST00000417573; ENSP00000394165; ENSG00000125378.
ENST00000558984; ENSP00000454134; ENSG00000125378.
ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneIDi652.
KEGGihsa:652.

Organism-specific databases

CTDi652.
DisGeNETi652.
GeneCardsiBMP4.
GeneReviewsiBMP4.
HGNCiHGNC:1071. BMP4.
HPAiCAB006863.
HPA066235.
MalaCardsiBMP4.
MIMi112262. gene.
600625. phenotype.
607932. phenotype.
neXtProtiNX_P12644.
OpenTargetsiENSG00000125378.
Orphaneti264200. 14q22q23 microdeletion syndrome.
1991. Cleft lip with or without cleft palate.
139471. Microphthalmia with brain and digit anomalies.
93100. Unilateral renal agenesis.
PharmGKBiPA25381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12644.
KOiK04662.
OMAiTRLVRHN.
OrthoDBiEOG091G0K7Z.
PhylomeDBiP12644.
TreeFamiTF351789.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125378-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP12644.
SIGNORiP12644.

Miscellaneous databases

GeneWikiiBone_morphogenetic_protein_4.
GenomeRNAii652.
PROiP12644.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125378.
CleanExiHS_BMP4.
ExpressionAtlasiP12644. baseline and differential.
GenevisibleiP12644. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP4_HUMAN
AccessioniPrimary (citable) accession number: P12644
Secondary accession number(s): Q9UM80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 190 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.