P12644 (BMP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 4
Short name=BMP-4

Alternative name(s):
Bone morphogenetic protein 2B
Short name=BMP-2B

Gene names

Name:	BMP4
Synonyms:	BMP2B, DVR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction By similarity.
Subunit structure	Homodimer; disulfide-linked By similarity. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition By similarity. Interacts with SOSTDC1. Ref.5
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Involvement in disease	Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Disease	Disease mutation Microphthalmia
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway involved in heart induction Inferred from mutant phenotype PubMed 20702560. Source: BHF-UCL BMP signaling pathway involved in nephric duct formation Inferred from direct assay PubMed 10021330. Source: UniProtKB BMP signaling pathway involved in renal system segmentation Inferred from sequence or structural similarity. Source: UniProtKB BMP signaling pathway involved in ureter morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB SMAD protein signal transduction Inferred from direct assay PubMed 17244894. Source: UniProtKB activation of MAPKK activity Inferred from direct assay PubMed 17600318PubMed 17992660. Source: UniProtKB anterior/posterior axis specification Inferred from electronic annotation. Source: Compara blood vessel endothelial cell proliferation involved in sprouting angiogenesis Inferred from direct assay PubMed 18787191. Source: BHF-UCL branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 12631064. Source: UniProtKB bronchus development Inferred from direct assay PubMed 8674409. Source: MGI bud dilation involved in lung branching Inferred from direct assay PubMed 8674409. Source: MGI bud elongation involved in lung branching Inferred from electronic annotation. Source: Compara cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara cardiac septum development Traceable author statement PubMed 18076106. Source: BHF-UCL cellular response to growth factor stimulus Inferred from electronic annotation. Source: Compara chondrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB cloacal septation Inferred from electronic annotation. Source: Compara common-partner SMAD protein phosphorylation Inferred from direct assay PubMed 20573232. Source: UniProtKB cranial suture morphogenesis Inferred from electronic annotation. Source: Compara deltoid tuberosity development Inferred from sequence or structural similarity. Source: UniProtKB dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal joint morphogenesis Inferred from electronic annotation. Source: Compara endocardial cushion development Traceable author statement PubMed 18076106. Source: BHF-UCL endochondral ossification Inferred from sequence or structural similarity. Source: UniProtKB epithelial cell proliferation involved in lung morphogenesis Inferred from direct assay PubMed 8674409. Source: MGI epithelial-mesenchymal cell signaling Inferred from electronic annotation. Source: Compara erythrocyte differentiation Inferred from electronic annotation. Source: Compara germ cell development Inferred from electronic annotation. Source: Compara glomerular capillary formation Inferred from sequence or structural similarity. Source: UniProtKB glomerular visceral epithelial cell development Inferred from electronic annotation. Source: Compara inner ear receptor cell differentiation Inferred from electronic annotation. Source: Compara intermediate mesodermal cell differentiation Inferred from direct assay PubMed 10021330. Source: UniProtKB lens induction in camera-type eye Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from direct assay PubMed 8674409. Source: MGI lymphoid progenitor cell differentiation Inferred from mutant phenotype PubMed 12421925. Source: BHF-UCL macrophage differentiation Inferred from direct assay PubMed 21149635. Source: DFLAT mammary gland formation Inferred from electronic annotation. Source: Compara mesenchymal cell differentiation involved in kidney development Inferred from electronic annotation. Source: Compara mesenchymal cell proliferation involved in ureter development Inferred from electronic annotation. Source: Compara mesenchymal cell proliferation involved in ureteric bud development Inferred from electronic annotation. Source: Compara mesenchymal to epithelial transition involved in metanephros morphogenesis Inferred from direct assay PubMed 10706139. Source: UniProtKB mesodermal cell fate determination Inferred from electronic annotation. Source: Compara mesonephros development Inferred from expression pattern PubMed 18437684. Source: UniProtKB metanephric collecting duct development Inferred from sequence or structural similarity. Source: UniProtKB monocyte differentiation Inferred from direct assay PubMed 21149635. Source: DFLAT negative regulation of MAP kinase activity Inferred from direct assay PubMed 17244894. Source: UniProtKB negative regulation of T cell differentiation in thymus Inferred from mutant phenotype PubMed 12421925. Source: BHF-UCL negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Inferred from direct assay PubMed 10706139PubMed 17118062. Source: UniProtKB negative regulation of branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 12141440PubMed 17118062. Source: UniProtKB negative regulation of cell proliferation involved in heart morphogenesis Inferred from mutant phenotype PubMed 20702560. Source: BHF-UCL negative regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of glomerular mesangial cell proliferation Inferred from direct assay PubMed 17244894. Source: UniProtKB negative regulation of glomerulus development Inferred from direct assay PubMed 12141440. Source: UniProtKB negative regulation of immature T cell proliferation in thymus Inferred from mutant phenotype PubMed 12421925. Source: BHF-UCL negative regulation of mesenchymal cell proliferation involved in ureter development Inferred from direct assay PubMed 12399320. Source: UniProtKB negative regulation of metanephric S-shaped body morphogenesis Inferred from direct assay PubMed 12141440. Source: UniProtKB negative regulation of metanephric comma-shaped body morphogenesis Inferred from direct assay PubMed 12141440. Source: UniProtKB negative regulation of mitosis Inferred from direct assay PubMed 17244894. Source: UniProtKB negative regulation of myoblast differentiation Inferred from direct assay PubMed 14749725. Source: MGI negative regulation of prostatic bud formation Inferred from electronic annotation. Source: Compara negative regulation of striated muscle tissue development Inferred from direct assay PubMed 14749725. Source: MGI negative regulation of thymocyte apoptotic process Inferred from mutant phenotype PubMed 12421925. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 9187146. Source: MGI neural tube closure Inferred from electronic annotation. Source: Compara neuron fate commitment Inferred from electronic annotation. Source: Compara odontogenesis Inferred from genetic interaction PubMed 11023873. Source: UniProtKB odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from direct assay PubMed 17720811. Source: BHF-UCL pituitary gland development Inferred from electronic annotation. Source: Compara positive regulation of BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of DNA-dependent DNA replication Inferred from direct assay PubMed 15516325. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of SMAD protein import into nucleus Inferred from direct assay PubMed 9389648. Source: BHF-UCL positive regulation of apoptotic process Inferred from direct assay PubMed 10706139. Source: UniProtKB positive regulation of bone mineralization Inferred from direct assay PubMed 14749725. Source: UniProtKB positive regulation of branching involved in lung morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cardiac muscle fiber development Inferred from mutant phenotype PubMed 20702560. Source: BHF-UCL positive regulation of cartilage development Inferred from direct assay Ref.1. Source: MGI positive regulation of collagen biosynthetic process Inferred from direct assay PubMed 17720811. Source: BHF-UCL positive regulation of endothelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell migration Inferred from direct assay PubMed 17992660. Source: UniProtKB positive regulation of endothelial cell proliferation Inferred from direct assay PubMed 17992660. Source: UniProtKB positive regulation of kidney development Inferred from direct assay PubMed 10021330. Source: UniProtKB positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from direct assay PubMed 18436533. Source: BHF-UCL positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from direct assay PubMed 16816361PubMed 17244894. Source: UniProtKB positive regulation of smooth muscle cell proliferation Inferred from direct assay PubMed 10706139PubMed 17600318. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15516325. Source: BHF-UCL post-embryonic development Inferred from direct assay PubMed 8674409. Source: MGI protein localization to nucleus Inferred from direct assay PubMed 17244894. Source: UniProtKB pulmonary artery endothelial tube morphogenesis Inferred from direct assay PubMed 17992660. Source: UniProtKB regulation of branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara regulation of odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara regulation of smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara renal system process Inferred from electronic annotation. Source: Compara secondary heart field specification Inferred from mutant phenotype PubMed 20702560. Source: BHF-UCL smoothened signaling pathway Inferred from expression pattern PubMed 17850284. Source: UniProtKB specification of organ position Inferred from electronic annotation. Source: Compara specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Inferred from direct assay PubMed 10706139PubMed 17118062. Source: UniProtKB steroid hormone mediated signaling pathway Inferred from mutant phenotype PubMed 17244894. Source: UniProtKB telencephalon development Inferred from direct assay PubMed 9187146. Source: MGI telencephalon regionalization Inferred from electronic annotation. Source: Compara tendon cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB trachea development Inferred from direct assay PubMed 8674409. Source: MGI trachea formation Inferred from electronic annotation. Source: Compara type B pancreatic cell development Inferred from direct assay PubMed 11865031. Source: BHF-UCL ureter epithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB ureter smooth muscle cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	BMP receptor binding Inferred from direct assay PubMed 7811286. Source: MGI chemoattractant activity Inferred from direct assay PubMed 12631064. Source: UniProtKB cytokine activity Inferred from direct assay PubMed 14749725. Source: MGI heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 292	273			PRO_0000033856
	Chain	293 – 408	116	Bone morphogenetic protein 4		PRO_0000033857
Amino acid modifications
	Glycosylation	143	1	N-linked (GlcNAc...) Potential
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	365	1	N-linked (GlcNAc...) Potential
	Disulfide bond	308 ↔ 373		By similarity
	Disulfide bond	337 ↔ 405		By similarity
	Disulfide bond	341 ↔ 407		By similarity
	Disulfide bond	372		Interchain By similarity
Natural variations
	Natural variant	91	1	S → C in OFC11; also found in renal hypodysplasia patients. Ref.6 Ref.8 Ref.9		VAR_043531
	Natural variant	93	1	E → G in MCOPS6. Ref.7		VAR_043532
	Natural variant	102	1	T → A. Ref.9		VAR_058314
	Natural variant	116	1	T → S in a renal hypodysplasia patient. Ref.8		VAR_043533
	Natural variant	150	1	N → K in a renal hypodysplasia patient. Ref.8		VAR_043534
	Natural variant	152	1	V → A. Ref.2 Ref.3 Ref.6 Ref.9 Corresponds to variant rs17563 [ dbSNP | Ensembl ].		VAR_016174
	Natural variant	162	1	R → Q in OFC11. Ref.9		VAR_058315
	Natural variant	168	1	G → A. Ref.9		VAR_058316
	Natural variant	225	1	T → A. Ref.6		VAR_043535
	Natural variant	226	1	R → W. Ref.6		VAR_043536
	Natural variant	287	1	R → H in OFC11. Ref.9		VAR_058317
	Natural variant	346	1	A → V in OFC11. Ref.9		VAR_058318
	Natural variant	367	1	S → T. Ref.6		VAR_043537

Sequences

	Sequence		Length	Mass (Da)
	P12644 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 79B01179DBB98204	FASTA	408	46,555
	10 20 30 40 50 60 MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 70 80 90 100 110 120 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF 130 140 150 160 170 180 HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI 190 200 210 220 230 240 YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH 250 260 270 280 290 300 LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 310 320 330 340 350 360 ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 370 380 390 400 VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel regulators of bone formation: molecular clones and activities." Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A. Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation." Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A., Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S. Calcif. Tissue Int. 63:221-229(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-152.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-152. Tissue: Duodenum.
[4]	"Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S. DNA Seq. 5:273-275(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-408. Tissue: Placenta.
[5]	"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney." Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S., Akiyama T., Miyazono K., Yanagisawa M., Sakurai T. Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SOSTDC1.
[6]	"Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)." Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E., Ermert A., Koch M.C. Eur. J. Hum. Genet. 10:753-756(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367.
[7]	"Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways." Bakrania P., Efthymiou M., Klein J.C., Salt A., Bunyan D.J., Wyatt A., Ponting C.P., Martin A., Williams S., Lindley V., Gilmore J., Restori M., Robson A.G., Neveu M.M., Holder G.E., Collin J.R.O., Robinson D.O., Farndon P. , Johansen-Berg H., Gerrelli D., Ragge N.K. Am. J. Hum. Genet. 82d:304-319(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MCOPS6 GLY-93.
[8]	"SIX2 and BMP4 mutations associate with anomalous kidney development." Weber S., Taylor J.C., Winyard P., Baker K.F., Sullivan-Brown J., Schild R., Knueppel T., Zurowska A.M., Caldas-Alfonso A., Litwin M., Emre S., Ghiggeri G.M., Bakkaloglu A., Mehls O., Antignac C., Schaefer F., Burdine R.D. J. Am. Soc. Nephrol. 19:891-903(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CYS-91; SER-116 AND LYS-150.
[9]	"Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip." Suzuki S., Marazita M.L., Cooper M.E., Miwa N., Hing A., Jugessur A., Natsume N., Shimozato K., Ohbayashi N., Suzuki Y., Niimi T., Minami K., Yamamoto M., Altannamar T.J., Erkhembaatar T., Furukawa H., Daack-Hirsch S., L'heureux J. , Brandon C.A., Weinberg S.M., Neiswanger K., Deleyiannis F.W., de Salamanca J.E., Vieira A.R., Lidral A.C., Martin J.F., Murray J.C. Am. J. Hum. Genet. 84:406-411(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346, VARIANTS ALA-102; ALA-152 AND ALA-168.
+	Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 4 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22490 mRNA. Translation: AAA51835.1. U43842 Genomic DNA. Translation: AAC72278.1. BC020546 mRNA. Translation: AAH20546.1. D30751 mRNA. Translation: BAA06410.1.
IPI	IPI00292640.
PIR	BMHU4. C37278.
RefSeq	NP_001193.2. NM_001202.3. NP_570911.2. NM_130850.2. NP_570912.2. NM_130851.2.
UniGene	Hs.68879.
3D structure databases
ProteinModelPortal	P12644.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5795N.
IntAct	P12644. 2 interactions.
MINT	MINT-1184353.
STRING	9606.ENSP00000245451.
PTM databases
PhosphoSite	P12644.
Polymorphism databases
DMDM	115073.
Proteomic databases
PaxDb	P12644.
PRIDE	P12644.
Protocols and materials databases
DNASU	652.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245451; ENSP00000245451; ENSG00000125378. ENST00000417573; ENSP00000394165; ENSG00000125378. ENST00000558984; ENSP00000454134; ENSG00000125378. ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneID	652.
KEGG	hsa:652.
UCSC	uc001xal.4. human.
Organism-specific databases
CTD	652.
GeneCards	GC14M054416.
HGNC	HGNC:1071. BMP4.
HPA	CAB006863.
MIM	112262. gene. 600625. phenotype. 607932. phenotype.
neXtProt	NX_P12644.
Orphanet	264200. 14q22q23 microdeletion syndrome. 1991. Cleft lip with or without cleft palate. 139471. Microphthalmia with brain and digit anomalies.
PharmGKB	PA25381.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG243555.
HOGENOM	HOG000249478.
HOVERGEN	HBG004860.
InParanoid	P12644.
KO	K04662.
OMA	QGFHRIN.
OrthoDB	EOG4JT05K.
PhylomeDB	P12644.
Enzyme and pathway databases
Pathway_Interaction_DB	bmppathway. BMP receptor signaling. glypican_3pathway. Glypican 3 network.
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	P12644.
Bgee	P12644.
CleanEx	HS_BMP4.
Genevestigator	P12644.
GermOnline	ENSG00000125378. Homo sapiens.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P12644.
ChEMBL	CHEMBL5350.
GenomeRNAi	652.
NextBio	2648.
SOURCE	Search...

Entry information

Entry name

BMP4_HUMAN

Accession

Primary (citable) accession number: P12644
Secondary accession number(s): Q9UM80

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 1, 2013
This is version 154 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.