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P12644

- BMP4_HUMAN

UniProt

P12644 - BMP4_HUMAN

Protein

Bone morphogenetic protein 4

Gene

BMP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 170 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction By similarity.By similarity

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. chemoattractant activity Source: UniProtKB
    3. cytokine activity Source: MGI
    4. heparin binding Source: Ensembl
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: UniProtKB
    2. anterior/posterior axis specification Source: Ensembl
    3. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
    4. BMP signaling pathway Source: BHF-UCL
    5. BMP signaling pathway involved in heart induction Source: BHF-UCL
    6. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
    7. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
    8. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
    9. branching involved in prostate gland morphogenesis Source: Ensembl
    10. branching involved in ureteric bud morphogenesis Source: UniProtKB
    11. branching morphogenesis of an epithelial tube Source: UniProtKB
    12. bronchus development Source: MGI
    13. bud dilation involved in lung branching Source: MGI
    14. bud elongation involved in lung branching Source: Ensembl
    15. cardiac septum development Source: BHF-UCL
    16. cellular response to growth factor stimulus Source: Ensembl
    17. chondrocyte differentiation Source: UniProtKB
    18. cloacal septation Source: Ensembl
    19. common-partner SMAD protein phosphorylation Source: UniProtKB
    20. cranial suture morphogenesis Source: Ensembl
    21. deltoid tuberosity development Source: UniProtKB
    22. dorsal/ventral neural tube patterning Source: Ensembl
    23. embryonic cranial skeleton morphogenesis Source: Ensembl
    24. embryonic digit morphogenesis Source: Ensembl
    25. embryonic hindlimb morphogenesis Source: Ensembl
    26. embryonic skeletal joint morphogenesis Source: Ensembl
    27. endocardial cushion development Source: BHF-UCL
    28. endochondral ossification Source: UniProtKB
    29. epithelial cell proliferation involved in lung morphogenesis Source: MGI
    30. epithelial-mesenchymal cell signaling Source: Ensembl
    31. epithelial tube branching involved in lung morphogenesis Source: MGI
    32. erythrocyte differentiation Source: Ensembl
    33. extracellular matrix organization Source: Reactome
    34. germ cell development Source: Ensembl
    35. glomerular capillary formation Source: UniProtKB
    36. glomerular visceral epithelial cell development Source: Ensembl
    37. hematopoietic progenitor cell differentiation Source: UniProtKB
    38. inner ear receptor cell differentiation Source: Ensembl
    39. intermediate mesodermal cell differentiation Source: UniProtKB
    40. kidney development Source: UniProtKB
    41. lens induction in camera-type eye Source: Ensembl
    42. lung alveolus development Source: MGI
    43. lung morphogenesis Source: MGI
    44. lymphoid progenitor cell differentiation Source: BHF-UCL
    45. macrophage differentiation Source: DFLAT
    46. mammary gland formation Source: Ensembl
    47. mesenchymal cell differentiation involved in kidney development Source: Ensembl
    48. mesenchymal cell proliferation involved in ureter development Source: Ensembl
    49. mesenchymal cell proliferation involved in ureteric bud development Source: Ensembl
    50. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    51. mesodermal cell fate determination Source: Ensembl
    52. mesonephros development Source: UniProtKB
    53. metanephric collecting duct development Source: UniProtKB
    54. monocyte differentiation Source: DFLAT
    55. negative regulation of apoptotic process Source: UniProtKB
    56. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
    57. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    58. negative regulation of cell cycle Source: HGNC
    59. negative regulation of cell death Source: UniProtKB
    60. negative regulation of cell proliferation Source: MGI
    61. negative regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
    62. negative regulation of chondrocyte differentiation Source: Ensembl
    63. negative regulation of epithelial cell proliferation Source: Ensembl
    64. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
    65. negative regulation of glomerulus development Source: UniProtKB
    66. negative regulation of immature T cell proliferation in thymus Source: BHF-UCL
    67. negative regulation of MAP kinase activity Source: UniProtKB
    68. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
    69. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
    70. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
    71. negative regulation of mitosis Source: UniProtKB
    72. negative regulation of myoblast differentiation Source: MGI
    73. negative regulation of phosphorylation Source: UniProtKB
    74. negative regulation of prostatic bud formation Source: Ensembl
    75. negative regulation of striated muscle tissue development Source: MGI
    76. negative regulation of T cell differentiation in thymus Source: BHF-UCL
    77. negative regulation of thymocyte apoptotic process Source: BHF-UCL
    78. negative regulation of transcription, DNA-templated Source: UniProtKB
    79. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    80. neural tube closure Source: Ensembl
    81. neuron fate commitment Source: Ensembl
    82. odontogenesis Source: UniProtKB
    83. odontogenesis of dentin-containing tooth Source: Ensembl
    84. osteoblast differentiation Source: BHF-UCL
    85. pituitary gland development Source: Ensembl
    86. positive chemotaxis Source: GOC
    87. positive regulation of apoptotic process Source: UniProtKB
    88. positive regulation of BMP signaling pathway Source: UniProtKB
    89. positive regulation of bone mineralization Source: UniProtKB
    90. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
    91. positive regulation of cardiac muscle fiber development Source: BHF-UCL
    92. positive regulation of cartilage development Source: MGI
    93. positive regulation of cell death Source: MGI
    94. positive regulation of collagen biosynthetic process Source: BHF-UCL
    95. positive regulation of DNA-dependent DNA replication Source: BHF-UCL
    96. positive regulation of endothelial cell differentiation Source: Ensembl
    97. positive regulation of endothelial cell migration Source: UniProtKB
    98. positive regulation of endothelial cell proliferation Source: UniProtKB
    99. positive regulation of epidermal cell differentiation Source: UniProt
    100. positive regulation of epithelial cell proliferation Source: BHF-UCL
    101. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    102. positive regulation of kidney development Source: UniProtKB
    103. positive regulation of neuron differentiation Source: Ensembl
    104. positive regulation of ossification Source: MGI
    105. positive regulation of osteoblast differentiation Source: BHF-UCL
    106. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    107. positive regulation of protein binding Source: MGI
    108. positive regulation of protein phosphorylation Source: MGI
    109. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
    110. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    111. positive regulation of transcription, DNA-templated Source: UniProtKB
    112. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    113. post-embryonic development Source: MGI
    114. protein localization to nucleus Source: UniProtKB
    115. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
    116. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    117. regulation of cell fate commitment Source: UniProt
    118. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
    119. regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    120. regulation of smooth muscle cell differentiation Source: Ensembl
    121. renal system development Source: UniProtKB
    122. renal system process Source: Ensembl
    123. secondary heart field specification Source: BHF-UCL
    124. SMAD protein signal transduction Source: UniProtKB
    125. smoothened signaling pathway Source: UniProtKB
    126. smooth muscle tissue development Source: UniProtKB
    127. specification of organ position Source: Ensembl
    128. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
    129. steroid hormone mediated signaling pathway Source: UniProtKB
    130. telencephalon development Source: MGI
    131. telencephalon regionalization Source: Ensembl
    132. tendon cell differentiation Source: UniProtKB
    133. trachea development Source: MGI
    134. trachea formation Source: Ensembl
    135. type B pancreatic cell development Source: BHF-UCL
    136. ureter epithelial cell differentiation Source: UniProtKB
    137. ureteric bud development Source: MGI
    138. ureter smooth muscle cell differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.
    SignaLinkiP12644.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 4
    Short name:
    BMP-4
    Alternative name(s):
    Bone morphogenetic protein 2B
    Short name:
    BMP-2B
    Gene namesi
    Name:BMP4
    Synonyms:BMP2B, DVR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1071. BMP4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti93 – 931E → G in MCOPS6. 1 Publication
    VAR_043532
    Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911S → C in OFC11; also found in renal hypodysplasia patients. 3 Publications
    VAR_043531
    Natural varianti162 – 1621R → Q in OFC11. 1 Publication
    VAR_058315
    Natural varianti287 – 2871R → H in OFC11. 1 Publication
    Corresponds to variant rs121912768 [ dbSNP | Ensembl ].
    VAR_058317
    Natural varianti346 – 3461A → V in OFC11. 1 Publication
    VAR_058318

    Keywords - Diseasei

    Disease mutation, Microphthalmia

    Organism-specific databases

    MIMi600625. phenotype.
    607932. phenotype.
    Orphaneti264200. 14q22q23 microdeletion syndrome.
    1991. Cleft lip with or without cleft palate.
    139471. Microphthalmia with brain and digit anomalies.
    PharmGKBiPA25381.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 292273PRO_0000033856Add
    BLAST
    Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033857Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi308 ↔ 373By similarity
    Disulfide bondi337 ↔ 405By similarity
    Disulfide bondi341 ↔ 407By similarity
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi372 – 372InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP12644.
    PRIDEiP12644.

    PTM databases

    PhosphoSiteiP12644.

    Expressioni

    Tissue specificityi

    Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

    Gene expression databases

    ArrayExpressiP12644.
    BgeeiP12644.
    CleanExiHS_BMP4.
    GenevestigatoriP12644.

    Organism-specific databases

    HPAiCAB006863.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked By similarity. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition By similarity. Interacts with SOSTDC1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BMPR1AP368942EBI-1998134,EBI-1029237

    Protein-protein interaction databases

    BioGridi107120. 7 interactions.
    DIPiDIP-5795N.
    IntActiP12644. 7 interactions.
    MINTiMINT-1184353.
    STRINGi9606.ENSP00000245451.

    Structurei

    3D structure databases

    ProteinModelPortaliP12644.
    SMRiP12644. Positions 307-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG243555.
    HOGENOMiHOG000249478.
    HOVERGENiHBG004860.
    InParanoidiP12644.
    KOiK04662.
    OMAiGFHHEEH.
    OrthoDBiEOG7WHH9D.
    PhylomeDBiP12644.
    TreeFamiTF351789.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12644-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS    50
    HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH 100
    STGLEYPERP ASRANTVRSF HHEEHLENIP GTSENSAFRF LFNLSSIPEN 150
    EVISSAELRL FREQVDQGPD WERGFHRINI YEVMKPPAEV VPGHLITRLL 200
    DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ 250
    HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 300
    ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN 350
    STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM 400
    VVEGCGCR 408
    Length:408
    Mass (Da):46,555
    Last modified:October 1, 1989 - v1
    Checksum:i79B01179DBB98204
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911S → C in OFC11; also found in renal hypodysplasia patients. 3 Publications
    VAR_043531
    Natural varianti93 – 931E → G in MCOPS6. 1 Publication
    VAR_043532
    Natural varianti102 – 1021T → A.1 Publication
    Corresponds to variant rs202159001 [ dbSNP | Ensembl ].
    VAR_058314
    Natural varianti116 – 1161T → S in a renal hypodysplasia patient. 1 Publication
    VAR_043533
    Natural varianti150 – 1501N → K in a renal hypodysplasia patient. 1 Publication
    VAR_043534
    Natural varianti152 – 1521V → A.4 Publications
    Corresponds to variant rs17563 [ dbSNP | Ensembl ].
    VAR_016174
    Natural varianti162 – 1621R → Q in OFC11. 1 Publication
    VAR_058315
    Natural varianti168 – 1681G → A.1 Publication
    VAR_058316
    Natural varianti225 – 2251T → A.1 Publication
    VAR_043535
    Natural varianti226 – 2261R → W.1 Publication
    VAR_043536
    Natural varianti287 – 2871R → H in OFC11. 1 Publication
    Corresponds to variant rs121912768 [ dbSNP | Ensembl ].
    VAR_058317
    Natural varianti346 – 3461A → V in OFC11. 1 Publication
    VAR_058318
    Natural varianti367 – 3671S → T.1 Publication
    VAR_043537

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22490 mRNA. Translation: AAA51835.1.
    U43842 Genomic DNA. Translation: AAC72278.1.
    BC020546 mRNA. Translation: AAH20546.1.
    D30751 mRNA. Translation: BAA06410.1.
    CCDSiCCDS9715.1.
    PIRiC37278. BMHU4.
    RefSeqiNP_001193.2. NM_001202.3.
    NP_570911.2. NM_130850.2.
    NP_570912.2. NM_130851.2.
    XP_005268072.1. XM_005268015.2.
    UniGeneiHs.68879.

    Genome annotation databases

    EnsembliENST00000245451; ENSP00000245451; ENSG00000125378.
    ENST00000417573; ENSP00000394165; ENSG00000125378.
    ENST00000558984; ENSP00000454134; ENSG00000125378.
    ENST00000559087; ENSP00000453485; ENSG00000125378.
    GeneIDi652.
    KEGGihsa:652.
    UCSCiuc001xal.4. human.

    Polymorphism databases

    DMDMi115073.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 4 entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22490 mRNA. Translation: AAA51835.1 .
    U43842 Genomic DNA. Translation: AAC72278.1 .
    BC020546 mRNA. Translation: AAH20546.1 .
    D30751 mRNA. Translation: BAA06410.1 .
    CCDSi CCDS9715.1.
    PIRi C37278. BMHU4.
    RefSeqi NP_001193.2. NM_001202.3.
    NP_570911.2. NM_130850.2.
    NP_570912.2. NM_130851.2.
    XP_005268072.1. XM_005268015.2.
    UniGenei Hs.68879.

    3D structure databases

    ProteinModelPortali P12644.
    SMRi P12644. Positions 307-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107120. 7 interactions.
    DIPi DIP-5795N.
    IntActi P12644. 7 interactions.
    MINTi MINT-1184353.
    STRINGi 9606.ENSP00000245451.

    Chemistry

    BindingDBi P12644.
    ChEMBLi CHEMBL5350.

    PTM databases

    PhosphoSitei P12644.

    Polymorphism databases

    DMDMi 115073.

    Proteomic databases

    PaxDbi P12644.
    PRIDEi P12644.

    Protocols and materials databases

    DNASUi 652.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245451 ; ENSP00000245451 ; ENSG00000125378 .
    ENST00000417573 ; ENSP00000394165 ; ENSG00000125378 .
    ENST00000558984 ; ENSP00000454134 ; ENSG00000125378 .
    ENST00000559087 ; ENSP00000453485 ; ENSG00000125378 .
    GeneIDi 652.
    KEGGi hsa:652.
    UCSCi uc001xal.4. human.

    Organism-specific databases

    CTDi 652.
    GeneCardsi GC14M054416.
    GeneReviewsi BMP4.
    HGNCi HGNC:1071. BMP4.
    HPAi CAB006863.
    MIMi 112262. gene.
    600625. phenotype.
    607932. phenotype.
    neXtProti NX_P12644.
    Orphaneti 264200. 14q22q23 microdeletion syndrome.
    1991. Cleft lip with or without cleft palate.
    139471. Microphthalmia with brain and digit anomalies.
    PharmGKBi PA25381.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243555.
    HOGENOMi HOG000249478.
    HOVERGENi HBG004860.
    InParanoidi P12644.
    KOi K04662.
    OMAi GFHHEEH.
    OrthoDBi EOG7WHH9D.
    PhylomeDBi P12644.
    TreeFami TF351789.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.
    SignaLinki P12644.

    Miscellaneous databases

    GeneWikii Bone_morphogenetic_protein_4.
    GenomeRNAii 652.
    NextBioi 2648.
    PROi P12644.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12644.
    Bgeei P12644.
    CleanExi HS_BMP4.
    Genevestigatori P12644.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel regulators of bone formation: molecular clones and activities."
      Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
      Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation."
      Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A., Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S.
      Calcif. Tissue Int. 63:221-229(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-152.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-152.
      Tissue: Duodenum.
    4. "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library."
      Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S.
      DNA Seq. 5:273-275(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-408.
      Tissue: Placenta.
    5. Cited for: INTERACTION WITH SOSTDC1.
    6. "Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)."
      Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E., Ermert A., Koch M.C.
      Eur. J. Hum. Genet. 10:753-756(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367.
    7. Cited for: VARIANT MCOPS6 GLY-93.
    8. Cited for: VARIANTS CYS-91; SER-116 AND LYS-150.
    9. Cited for: VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346, VARIANTS ALA-102; ALA-152 AND ALA-168.

    Entry informationi

    Entry nameiBMP4_HUMAN
    AccessioniPrimary (citable) accession number: P12644
    Secondary accession number(s): Q9UM80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 170 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3