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P12644

- BMP4_HUMAN

UniProt

P12644 - BMP4_HUMAN

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Protein

Bone morphogenetic protein 4

Gene

BMP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).By similarity

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. chemoattractant activity Source: UniProtKB
  3. cytokine activity Source: MGI
  4. heparin binding Source: Ensembl

GO - Biological processi

  1. activation of MAPKK activity Source: UniProtKB
  2. anterior/posterior axis specification Source: Ensembl
  3. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
  4. BMP signaling pathway Source: BHF-UCL
  5. BMP signaling pathway involved in heart induction Source: BHF-UCL
  6. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  7. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  8. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  9. branching involved in prostate gland morphogenesis Source: Ensembl
  10. branching involved in ureteric bud morphogenesis Source: UniProtKB
  11. branching morphogenesis of an epithelial tube Source: UniProtKB
  12. bronchus development Source: MGI
  13. bud dilation involved in lung branching Source: MGI
  14. bud elongation involved in lung branching Source: Ensembl
  15. cardiac septum development Source: BHF-UCL
  16. cellular response to growth factor stimulus Source: Ensembl
  17. chondrocyte differentiation Source: UniProtKB
  18. cloacal septation Source: Ensembl
  19. common-partner SMAD protein phosphorylation Source: UniProtKB
  20. cranial suture morphogenesis Source: Ensembl
  21. deltoid tuberosity development Source: UniProtKB
  22. dorsal/ventral neural tube patterning Source: Ensembl
  23. embryonic cranial skeleton morphogenesis Source: Ensembl
  24. embryonic digit morphogenesis Source: Ensembl
  25. embryonic hindlimb morphogenesis Source: Ensembl
  26. embryonic skeletal joint morphogenesis Source: Ensembl
  27. endocardial cushion development Source: BHF-UCL
  28. endochondral ossification Source: UniProtKB
  29. epithelial cell proliferation involved in lung morphogenesis Source: MGI
  30. epithelial-mesenchymal cell signaling Source: Ensembl
  31. epithelial tube branching involved in lung morphogenesis Source: MGI
  32. erythrocyte differentiation Source: Ensembl
  33. extracellular matrix organization Source: Reactome
  34. germ cell development Source: Ensembl
  35. glomerular capillary formation Source: UniProtKB
  36. glomerular visceral epithelial cell development Source: Ensembl
  37. hematopoietic progenitor cell differentiation Source: UniProtKB
  38. inner ear receptor cell differentiation Source: Ensembl
  39. intermediate mesodermal cell differentiation Source: UniProtKB
  40. kidney development Source: UniProtKB
  41. lens induction in camera-type eye Source: Ensembl
  42. lung alveolus development Source: MGI
  43. lung morphogenesis Source: MGI
  44. lymphoid progenitor cell differentiation Source: BHF-UCL
  45. macrophage differentiation Source: DFLAT
  46. mammary gland formation Source: Ensembl
  47. mesenchymal cell differentiation involved in kidney development Source: Ensembl
  48. mesenchymal cell proliferation involved in ureter development Source: Ensembl
  49. mesenchymal cell proliferation involved in ureteric bud development Source: Ensembl
  50. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  51. mesodermal cell fate determination Source: Ensembl
  52. mesonephros development Source: UniProtKB
  53. metanephric collecting duct development Source: UniProtKB
  54. monocyte differentiation Source: DFLAT
  55. negative regulation of apoptotic process Source: UniProtKB
  56. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  57. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  58. negative regulation of cell cycle Source: HGNC
  59. negative regulation of cell death Source: UniProtKB
  60. negative regulation of cell proliferation Source: MGI
  61. negative regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  62. negative regulation of chondrocyte differentiation Source: Ensembl
  63. negative regulation of epithelial cell proliferation Source: Ensembl
  64. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  65. negative regulation of glomerulus development Source: UniProtKB
  66. negative regulation of immature T cell proliferation in thymus Source: BHF-UCL
  67. negative regulation of MAP kinase activity Source: UniProtKB
  68. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  69. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  70. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  71. negative regulation of mitosis Source: UniProtKB
  72. negative regulation of myoblast differentiation Source: MGI
  73. negative regulation of phosphorylation Source: UniProtKB
  74. negative regulation of prostatic bud formation Source: Ensembl
  75. negative regulation of striated muscle tissue development Source: MGI
  76. negative regulation of T cell differentiation in thymus Source: BHF-UCL
  77. negative regulation of thymocyte apoptotic process Source: BHF-UCL
  78. negative regulation of transcription, DNA-templated Source: UniProtKB
  79. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  80. neural tube closure Source: Ensembl
  81. neuron fate commitment Source: Ensembl
  82. odontogenesis Source: UniProtKB
  83. odontogenesis of dentin-containing tooth Source: Ensembl
  84. osteoblast differentiation Source: BHF-UCL
  85. pituitary gland development Source: Ensembl
  86. positive chemotaxis Source: GOC
  87. positive regulation of apoptotic process Source: UniProtKB
  88. positive regulation of BMP signaling pathway Source: UniProtKB
  89. positive regulation of bone mineralization Source: UniProtKB
  90. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  91. positive regulation of cardiac muscle fiber development Source: BHF-UCL
  92. positive regulation of cartilage development Source: MGI
  93. positive regulation of cell death Source: MGI
  94. positive regulation of collagen biosynthetic process Source: BHF-UCL
  95. positive regulation of DNA-dependent DNA replication Source: BHF-UCL
  96. positive regulation of endothelial cell differentiation Source: Ensembl
  97. positive regulation of endothelial cell migration Source: UniProtKB
  98. positive regulation of endothelial cell proliferation Source: UniProtKB
  99. positive regulation of epidermal cell differentiation Source: UniProt
  100. positive regulation of epithelial cell proliferation Source: BHF-UCL
  101. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  102. positive regulation of kidney development Source: UniProtKB
  103. positive regulation of neuron differentiation Source: Ensembl
  104. positive regulation of ossification Source: MGI
  105. positive regulation of osteoblast differentiation Source: BHF-UCL
  106. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  107. positive regulation of protein binding Source: MGI
  108. positive regulation of protein phosphorylation Source: MGI
  109. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
  110. positive regulation of smooth muscle cell proliferation Source: UniProtKB
  111. positive regulation of transcription, DNA-templated Source: UniProtKB
  112. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  113. post-embryonic development Source: MGI
  114. protein localization to nucleus Source: UniProtKB
  115. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  116. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  117. regulation of cell fate commitment Source: UniProt
  118. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
  119. regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  120. regulation of smooth muscle cell differentiation Source: Ensembl
  121. renal system development Source: UniProtKB
  122. renal system process Source: Ensembl
  123. secondary heart field specification Source: BHF-UCL
  124. SMAD protein signal transduction Source: UniProtKB
  125. smoothened signaling pathway Source: UniProtKB
  126. smooth muscle tissue development Source: UniProtKB
  127. specification of organ position Source: Ensembl
  128. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  129. steroid hormone mediated signaling pathway Source: UniProtKB
  130. telencephalon development Source: MGI
  131. telencephalon regionalization Source: Ensembl
  132. tendon cell differentiation Source: UniProtKB
  133. trachea development Source: MGI
  134. trachea formation Source: Ensembl
  135. type B pancreatic cell development Source: BHF-UCL
  136. ureter epithelial cell differentiation Source: UniProtKB
  137. ureteric bud development Source: MGI
  138. ureter smooth muscle cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
SignaLinkiP12644.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:BMP4
Synonyms:BMP2B, DVR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1071. BMP4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931E → G in MCOPS6. 1 Publication
VAR_043532
Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911S → C in OFC11; also found in renal hypodysplasia patients. 3 Publications
VAR_043531
Natural varianti162 – 1621R → Q in OFC11. 1 Publication
VAR_058315
Natural varianti287 – 2871R → H in OFC11. 1 Publication
Corresponds to variant rs121912768 [ dbSNP | Ensembl ].
VAR_058317
Natural varianti346 – 3461A → V in OFC11. 1 Publication
VAR_058318

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

MIMi600625. phenotype.
607932. phenotype.
Orphaneti264200. 14q22q23 microdeletion syndrome.
1991. Cleft lip with or without cleft palate.
139471. Microphthalmia with brain and digit anomalies.
93100. Unilateral renal agenesis.
PharmGKBiPA25381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 292273PRO_0000033856Add
BLAST
Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033857Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 373By similarity
Disulfide bondi337 ↔ 405By similarity
Disulfide bondi341 ↔ 407By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi372 – 372InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12644.
PRIDEiP12644.

PTM databases

PhosphoSiteiP12644.

Expressioni

Tissue specificityi

Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

Gene expression databases

BgeeiP12644.
CleanExiHS_BMP4.
ExpressionAtlasiP12644. baseline and differential.
GenevestigatoriP12644.

Organism-specific databases

HPAiCAB006863.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Interacts with SOSTDC1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR1AP368942EBI-1998134,EBI-1029237

Protein-protein interaction databases

BioGridi107120. 7 interactions.
DIPiDIP-5795N.
IntActiP12644. 7 interactions.
MINTiMINT-1184353.
STRINGi9606.ENSP00000245451.

Structurei

3D structure databases

ProteinModelPortaliP12644.
SMRiP12644. Positions 307-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12644.
KOiK04662.
OMAiGFHHEEH.
OrthoDBiEOG7WHH9D.
PhylomeDBiP12644.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12644-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH
110 120 130 140 150
STGLEYPERP ASRANTVRSF HHEEHLENIP GTSENSAFRF LFNLSSIPEN
160 170 180 190 200
EVISSAELRL FREQVDQGPD WERGFHRINI YEVMKPPAEV VPGHLITRLL
210 220 230 240 250
DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ
260 270 280 290 300
HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
310 320 330 340 350
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,555
Last modified:October 1, 1989 - v1
Checksum:i79B01179DBB98204
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911S → C in OFC11; also found in renal hypodysplasia patients. 3 Publications
VAR_043531
Natural varianti93 – 931E → G in MCOPS6. 1 Publication
VAR_043532
Natural varianti102 – 1021T → A.1 Publication
Corresponds to variant rs202159001 [ dbSNP | Ensembl ].
VAR_058314
Natural varianti116 – 1161T → S in a renal hypodysplasia patient. 1 Publication
VAR_043533
Natural varianti150 – 1501N → K in a renal hypodysplasia patient. 1 Publication
VAR_043534
Natural varianti152 – 1521V → A.4 Publications
Corresponds to variant rs17563 [ dbSNP | Ensembl ].
VAR_016174
Natural varianti162 – 1621R → Q in OFC11. 1 Publication
VAR_058315
Natural varianti168 – 1681G → A.1 Publication
VAR_058316
Natural varianti225 – 2251T → A.1 Publication
VAR_043535
Natural varianti226 – 2261R → W.1 Publication
VAR_043536
Natural varianti287 – 2871R → H in OFC11. 1 Publication
Corresponds to variant rs121912768 [ dbSNP | Ensembl ].
VAR_058317
Natural varianti346 – 3461A → V in OFC11. 1 Publication
VAR_058318
Natural varianti367 – 3671S → T.1 Publication
VAR_043537

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22490 mRNA. Translation: AAA51835.1.
U43842 Genomic DNA. Translation: AAC72278.1.
BC020546 mRNA. Translation: AAH20546.1.
D30751 mRNA. Translation: BAA06410.1.
CCDSiCCDS9715.1.
PIRiC37278. BMHU4.
RefSeqiNP_001193.2. NM_001202.3.
NP_570911.2. NM_130850.2.
NP_570912.2. NM_130851.2.
XP_005268072.1. XM_005268015.2.
UniGeneiHs.68879.

Genome annotation databases

EnsembliENST00000245451; ENSP00000245451; ENSG00000125378.
ENST00000417573; ENSP00000394165; ENSG00000125378.
ENST00000558984; ENSP00000454134; ENSG00000125378.
ENST00000559087; ENSP00000453485; ENSG00000125378.
GeneIDi652.
KEGGihsa:652.
UCSCiuc001xal.4. human.

Polymorphism databases

DMDMi115073.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 4 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22490 mRNA. Translation: AAA51835.1 .
U43842 Genomic DNA. Translation: AAC72278.1 .
BC020546 mRNA. Translation: AAH20546.1 .
D30751 mRNA. Translation: BAA06410.1 .
CCDSi CCDS9715.1.
PIRi C37278. BMHU4.
RefSeqi NP_001193.2. NM_001202.3.
NP_570911.2. NM_130850.2.
NP_570912.2. NM_130851.2.
XP_005268072.1. XM_005268015.2.
UniGenei Hs.68879.

3D structure databases

ProteinModelPortali P12644.
SMRi P12644. Positions 307-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107120. 7 interactions.
DIPi DIP-5795N.
IntActi P12644. 7 interactions.
MINTi MINT-1184353.
STRINGi 9606.ENSP00000245451.

Chemistry

BindingDBi P12644.
ChEMBLi CHEMBL5350.

PTM databases

PhosphoSitei P12644.

Polymorphism databases

DMDMi 115073.

Proteomic databases

PaxDbi P12644.
PRIDEi P12644.

Protocols and materials databases

DNASUi 652.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245451 ; ENSP00000245451 ; ENSG00000125378 .
ENST00000417573 ; ENSP00000394165 ; ENSG00000125378 .
ENST00000558984 ; ENSP00000454134 ; ENSG00000125378 .
ENST00000559087 ; ENSP00000453485 ; ENSG00000125378 .
GeneIDi 652.
KEGGi hsa:652.
UCSCi uc001xal.4. human.

Organism-specific databases

CTDi 652.
GeneCardsi GC14M054416.
GeneReviewsi BMP4.
HGNCi HGNC:1071. BMP4.
HPAi CAB006863.
MIMi 112262. gene.
600625. phenotype.
607932. phenotype.
neXtProti NX_P12644.
Orphaneti 264200. 14q22q23 microdeletion syndrome.
1991. Cleft lip with or without cleft palate.
139471. Microphthalmia with brain and digit anomalies.
93100. Unilateral renal agenesis.
PharmGKBi PA25381.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi P12644.
KOi K04662.
OMAi GFHHEEH.
OrthoDBi EOG7WHH9D.
PhylomeDBi P12644.
TreeFami TF351789.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.
SignaLinki P12644.

Miscellaneous databases

GeneWikii Bone_morphogenetic_protein_4.
GenomeRNAii 652.
NextBioi 2648.
PROi P12644.
SOURCEi Search...

Gene expression databases

Bgeei P12644.
CleanExi HS_BMP4.
ExpressionAtlasi P12644. baseline and differential.
Genevestigatori P12644.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel regulators of bone formation: molecular clones and activities."
    Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
    Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation."
    Shore E.M., Xu M., Shah P.B., Janoff H.B., Hahn G.V., Deardorff M.A., Sovinsky L., Spinner N.B., Zasloff M.A., Wozney J.M., Kaplan F.S.
    Calcif. Tissue Int. 63:221-229(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-152.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-152.
    Tissue: Duodenum.
  4. "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library."
    Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S.
    DNA Seq. 5:273-275(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-408.
    Tissue: Placenta.
  5. Cited for: INTERACTION WITH SOSTDC1.
  6. "Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)."
    Felder B., Stegmann K., Schultealbert A., Geller F., Strehl E., Ermert A., Koch M.C.
    Eur. J. Hum. Genet. 10:753-756(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367.
  7. Cited for: VARIANT MCOPS6 GLY-93.
  8. Cited for: VARIANTS CYS-91; SER-116 AND LYS-150.
  9. Cited for: VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346, VARIANTS ALA-102; ALA-152 AND ALA-168.

Entry informationi

Entry nameiBMP4_HUMAN
AccessioniPrimary (citable) accession number: P12644
Secondary accession number(s): Q9UM80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3