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P12643

- BMP2_HUMAN

UniProt

P12643 - BMP2_HUMAN

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Protein
Bone morphogenetic protein 2
Gene
BMP2, BMP2A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. SMAD binding Source: BHF-UCL
  3. phosphatase activator activity Source: MGI
  4. protein binding Source: UniProtKB
  5. protein heterodimerization activity Source: MGI
  6. receptor binding Source: ProtInc
  7. retinol dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. BMP signaling pathway Source: BHF-UCL
  2. BMP signaling pathway involved in heart induction Source: BHF-UCL
  3. Notch signaling pathway Source: UniProtKB
  4. SMAD protein signal transduction Source: UniProtKB
  5. activation of MAPK activity Source: AgBase
  6. atrioventricular valve morphogenesis Source: UniProtKB
  7. bone mineralization Source: UniProtKB
  8. bone mineralization involved in bone maturation Source: BHF-UCL
  9. branching involved in ureteric bud morphogenesis Source: UniProtKB
  10. cardiac epithelial to mesenchymal transition Source: BHF-UCL
  11. cardiac muscle cell differentiation Source: BHF-UCL
  12. cardiac muscle tissue morphogenesis Source: UniProtKB
  13. cardiocyte differentiation Source: BHF-UCL
  14. cell fate commitment Source: UniProtKB
  15. cell-cell signaling Source: ProtInc
  16. cellular response to BMP stimulus Source: BHF-UCL
  17. cellular response to organic cyclic compound Source: Ensembl
  18. chondrocyte differentiation Source: AgBase
  19. corticotropin hormone secreting cell differentiation Source: UniProtKB
  20. embryo development Source: UniProtKB
  21. embryonic heart tube anterior/posterior pattern specification Source: UniProtKB
  22. endocardial cushion morphogenesis Source: UniProtKB
  23. epithelial to mesenchymal transition Source: BHF-UCL
  24. extracellular matrix organization Source: Reactome
  25. growth Source: InterPro
  26. heart development Source: UniProtKB
  27. in utero embryonic development Source: UniProtKB
  28. inflammatory response Source: UniProtKB
  29. inner ear development Source: UniProtKB
  30. mesenchymal cell differentiation Source: UniProtKB
  31. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  32. mesenchyme development Source: BHF-UCL
  33. negative regulation of Wnt signaling pathway involved in heart development Source: BHF-UCL
  34. negative regulation of aldosterone biosynthetic process Source: BHF-UCL
  35. negative regulation of calcium-independent cell-cell adhesion Source: AgBase
  36. negative regulation of canonical Wnt signaling pathway Source: AgBase
  37. negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
  38. negative regulation of cell cycle Source: HGNC
  39. negative regulation of cell proliferation Source: BHF-UCL
  40. negative regulation of cortisol biosynthetic process Source: BHF-UCL
  41. negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
  42. negative regulation of steroid biosynthetic process Source: BHF-UCL
  43. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  44. negative regulation of transcription, DNA-templated Source: BHF-UCL
  45. odontogenesis of dentin-containing tooth Source: UniProtKB
  46. organ morphogenesis Source: UniProtKB
  47. osteoblast differentiation Source: MGI
  48. oxidation-reduction process Source: GOC
  49. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  50. pericardium development Source: UniProtKB
  51. positive regulation of ERK1 and ERK2 cascade Source: DFLAT
  52. positive regulation of MAPK cascade Source: DFLAT
  53. positive regulation of Wnt signaling pathway Source: UniProtKB
  54. positive regulation of Wnt signaling pathway by BMP signaling pathway Source: UniProtKB
  55. positive regulation of apoptotic process Source: MGI
  56. positive regulation of astrocyte differentiation Source: UniProtKB
  57. positive regulation of bone mineralization Source: BHF-UCL
  58. positive regulation of cartilage development Source: MGI
  59. positive regulation of cell migration Source: UniProtKB
  60. positive regulation of endothelial cell proliferation Source: UniProtKB
  61. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  62. positive regulation of fat cell differentiation Source: UniProtKB
  63. positive regulation of gene expression Source: UniProtKB
  64. positive regulation of neuron differentiation Source: UniProtKB
  65. positive regulation of odontogenesis Source: UniProtKB
  66. positive regulation of ossification Source: MGI
  67. positive regulation of osteoblast differentiation Source: BHF-UCL
  68. positive regulation of osteoblast proliferation Source: UniProtKB
  69. positive regulation of p38MAPK cascade Source: DFLAT
  70. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  71. positive regulation of phosphatase activity Source: MGI
  72. positive regulation of protein phosphorylation Source: MGI
  73. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  74. positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
  75. positive regulation of transcription, DNA-templated Source: UniProtKB
  76. protein destabilization Source: Ensembl
  77. protein phosphorylation Source: DFLAT
  78. proteoglycan metabolic process Source: Ensembl
  79. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
  80. regulation of transcription, DNA-templated Source: HGNC
  81. response to hypoxia Source: UniProtKB
  82. skeletal system development Source: ProtInc
  83. telencephalon development Source: MGI
  84. telencephalon regionalization Source: UniProtKB
  85. thyroid-stimulating hormone-secreting cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.
REACT_150331. Molecules associated with elastic fibres.
SignaLinkiP12643.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:BMP2
Synonyms:BMP2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:1069. BMP2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Organism-specific databases

Orphaneti261295. 20p12.3 microdeletion syndrome.
93396. Brachydactyly type A2.
907. Wolff-Parkinson-White syndrome.
PharmGKBiPA25379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 282259Cleaved by PCSK5
PRO_0000033824Add
BLAST
Chaini283 – 396114Bone morphogenetic protein 2
PRO_0000033825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi296 ↔ 361
Disulfide bondi325 ↔ 393
Disulfide bondi329 ↔ 395
Glycosylationi338 – 3381N-linked (GlcNAc...) (high mannose)1 Publication
Disulfide bondi360 – 360Interchain

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12643.
PRIDEiP12643.

PTM databases

PhosphoSiteiP12643.

Expressioni

Tissue specificityi

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Gene expression databases

ArrayExpressiP12643.
BgeeiP12643.
CleanExiHS_BMP2.
GenevestigatoriP12643.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR1AP3689413EBI-1029262,EBI-1029237
BMPR1BO002383EBI-1029262,EBI-7527193
FSTL1Q128412EBI-1029262,EBI-2349801
NOGQ132532EBI-1029262,EBI-1035205

Protein-protein interaction databases

BioGridi107118. 8 interactions.
DIPiDIP-5792N.
IntActiP12643. 7 interactions.
MINTiMINT-6772716.
STRINGi9606.ENSP00000368104.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi295 – 2995
Beta strandi302 – 3043
Helixi305 – 3084
Turni311 – 3133
Beta strandi314 – 3163
Beta strandi318 – 3214
Beta strandi324 – 3263
Beta strandi337 – 3393
Helixi341 – 35212
Beta strandi354 – 3563
Beta strandi360 – 37415
Beta strandi380 – 39617

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES7X-ray2.90A/C283-396[»]
1REUX-ray2.65A294-396[»]
1REWX-ray1.86A/B283-396[»]
2GOOX-ray2.20A/D283-396[»]
2H62X-ray1.85A/B283-396[»]
2H64X-ray1.92A283-396[»]
2QJ9X-ray2.44A/B283-396[»]
2QJAX-ray2.60A/B283-396[»]
2QJBX-ray2.50A/B283-396[»]
3BK3X-ray2.70A/B283-396[»]
3BMPX-ray2.70A283-396[»]
4MIDX-ray2.14A283-312[»]
4N1DX-ray1.91A283-305[»]
A362-396[»]
ProteinModelPortaliP12643.
SMRiP12643. Positions 293-396.

Miscellaneous databases

EvolutionaryTraceiP12643.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12643.
KOiK04662.
OMAiDEHSWSQ.
OrthoDBiEOG7WHH9D.
PhylomeDBiP12643.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12643-1 [UniParc]FASTAAdd to Basket

« Hide

MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL    50
SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE 100
RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL 150
QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN 200
ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL 250
HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP 300
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN 350
SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR 396
Length:396
Mass (Da):44,702
Last modified:October 1, 1989 - v1
Checksum:i20653A3987B25E60
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371S → A.
Corresponds to variant rs2273073 [ dbSNP | Ensembl ].
VAR_020061
Natural varianti77 – 771P → S.
Corresponds to variant rs36105541 [ dbSNP | Ensembl ].
VAR_052568
Natural varianti106 – 1061A → T.
Corresponds to variant rs2273074 [ dbSNP | Ensembl ].
VAR_020062
Natural varianti161 – 1611L → S.
Corresponds to variant rs34183594 [ dbSNP | Ensembl ].
VAR_052569
Natural varianti190 – 1901R → S.
Corresponds to variant rs235768 [ dbSNP | Ensembl ].
VAR_024232
Natural varianti387 – 3871D → G.
Corresponds to variant rs11545591 [ dbSNP | Ensembl ].
VAR_052570

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22489 mRNA. Translation: AAA51834.1.
AF040249 Genomic DNA. Translation: AAF21646.1.
AL035668 Genomic DNA. Translation: CAB82007.1.
CCDSiCCDS13099.1.
PIRiB37278. BMHU2.
RefSeqiNP_001191.1. NM_001200.2.
UniGeneiHs.73853.

Genome annotation databases

EnsembliENST00000378827; ENSP00000368104; ENSG00000125845.
GeneIDi650.
KEGGihsa:650.
UCSCiuc002wmu.1. human.

Polymorphism databases

DMDMi115068.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 2 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22489 mRNA. Translation: AAA51834.1 .
AF040249 Genomic DNA. Translation: AAF21646.1 .
AL035668 Genomic DNA. Translation: CAB82007.1 .
CCDSi CCDS13099.1.
PIRi B37278. BMHU2.
RefSeqi NP_001191.1. NM_001200.2.
UniGenei Hs.73853.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ES7 X-ray 2.90 A/C 283-396 [» ]
1REU X-ray 2.65 A 294-396 [» ]
1REW X-ray 1.86 A/B 283-396 [» ]
2GOO X-ray 2.20 A/D 283-396 [» ]
2H62 X-ray 1.85 A/B 283-396 [» ]
2H64 X-ray 1.92 A 283-396 [» ]
2QJ9 X-ray 2.44 A/B 283-396 [» ]
2QJA X-ray 2.60 A/B 283-396 [» ]
2QJB X-ray 2.50 A/B 283-396 [» ]
3BK3 X-ray 2.70 A/B 283-396 [» ]
3BMP X-ray 2.70 A 283-396 [» ]
4MID X-ray 2.14 A 283-312 [» ]
4N1D X-ray 1.91 A 283-305 [» ]
A 362-396 [» ]
ProteinModelPortali P12643.
SMRi P12643. Positions 293-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107118. 8 interactions.
DIPi DIP-5792N.
IntActi P12643. 7 interactions.
MINTi MINT-6772716.
STRINGi 9606.ENSP00000368104.

Chemistry

ChEMBLi CHEMBL1926496.
DrugBanki DB00641. Simvastatin.

PTM databases

PhosphoSitei P12643.

Polymorphism databases

DMDMi 115068.

Proteomic databases

PaxDbi P12643.
PRIDEi P12643.

Protocols and materials databases

DNASUi 650.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378827 ; ENSP00000368104 ; ENSG00000125845 .
GeneIDi 650.
KEGGi hsa:650.
UCSCi uc002wmu.1. human.

Organism-specific databases

CTDi 650.
GeneCardsi GC20P006696.
HGNCi HGNC:1069. BMP2.
MIMi 112261. gene.
neXtProti NX_P12643.
Orphaneti 261295. 20p12.3 microdeletion syndrome.
93396. Brachydactyly type A2.
907. Wolff-Parkinson-White syndrome.
PharmGKBi PA25379.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi P12643.
KOi K04662.
OMAi DEHSWSQ.
OrthoDBi EOG7WHH9D.
PhylomeDBi P12643.
TreeFami TF351789.

Enzyme and pathway databases

Reactomei REACT_12034. Signaling by BMP.
REACT_150331. Molecules associated with elastic fibres.
SignaLinki P12643.

Miscellaneous databases

EvolutionaryTracei P12643.
GeneWikii Bone_morphogenetic_protein_2.
GenomeRNAii 650.
NextBioi 2640.
PROi P12643.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12643.
Bgeei P12643.
CleanExi HS_BMP2.
Genevestigatori P12643.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel regulators of bone formation: molecular clones and activities."
    Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
    Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human bone morphogenetic protein 2 (BMP-2) genomic DNA sequence."
    Shore E.M., Xu M.-Q., Calvert G., Moriatis J., Kaplan F.S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry."
    Yeung B., Porter T.J., Vath J.E.
    Anal. Chem. 69:2510-2516(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-338.
  5. Cited for: INTERACTION WITH SOSTDC1.
  6. "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
    Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
    Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, PROPEPTIDE.
  7. "Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution."
    Scheufler C., Sebald W., Huelsmeyer M.
    J. Mol. Biol. 287:103-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 292-396.

Entry informationi

Entry nameiBMP2_HUMAN
AccessioniPrimary (citable) accession number: P12643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi