Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone morphogenetic protein 2

Gene

BMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • phosphatase activator activity Source: MGI
  • protein heterodimerization activity Source: MGI
  • receptor binding Source: ProtInc
  • retinol dehydrogenase activity Source: UniProtKB
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  • activation of MAPK activity Source: AgBase
  • atrioventricular valve morphogenesis Source: UniProtKB
  • BMP signaling pathway Source: BHF-UCL
  • BMP signaling pathway involved in heart induction Source: BHF-UCL
  • bone mineralization Source: UniProtKB
  • bone mineralization involved in bone maturation Source: BHF-UCL
  • branching involved in ureteric bud morphogenesis Source: UniProtKB
  • cardiac epithelial to mesenchymal transition Source: BHF-UCL
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue morphogenesis Source: UniProtKB
  • cardiocyte differentiation Source: BHF-UCL
  • cell-cell signaling Source: ProtInc
  • cell fate commitment Source: UniProtKB
  • cellular response to BMP stimulus Source: BHF-UCL
  • cellular response to organic cyclic compound Source: Ensembl
  • chondrocyte differentiation Source: AgBase
  • corticotropin hormone secreting cell differentiation Source: UniProtKB
  • embryo development Source: UniProtKB
  • embryonic heart tube anterior/posterior pattern specification Source: UniProtKB
  • endocardial cushion morphogenesis Source: UniProtKB
  • epithelial to mesenchymal transition Source: BHF-UCL
  • extracellular matrix organization Source: Reactome
  • growth Source: InterPro
  • heart development Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • inner ear development Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • mesenchymal cell differentiation Source: UniProtKB
  • mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  • mesenchyme development Source: BHF-UCL
  • negative regulation of aldosterone biosynthetic process Source: BHF-UCL
  • negative regulation of calcium-independent cell-cell adhesion Source: AgBase
  • negative regulation of canonical Wnt signaling pathway Source: AgBase
  • negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
  • negative regulation of cell cycle Source: HGNC
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of cortisol biosynthetic process Source: BHF-UCL
  • negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
  • negative regulation of steroid biosynthetic process Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of Wnt signaling pathway involved in heart development Source: BHF-UCL
  • Notch signaling pathway Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: UniProtKB
  • organ morphogenesis Source: UniProtKB
  • osteoblast differentiation Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • pericardium development Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of astrocyte differentiation Source: UniProtKB
  • positive regulation of bone mineralization Source: BHF-UCL
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: DFLAT
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of MAPK cascade Source: DFLAT
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of odontogenesis Source: UniProtKB
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of osteoblast proliferation Source: UniProtKB
  • positive regulation of p38MAPK cascade Source: DFLAT
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of phosphatase activity Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • positive regulation of Wnt signaling pathway by BMP signaling pathway Source: UniProtKB
  • protein destabilization Source: Ensembl
  • protein phosphorylation Source: DFLAT
  • proteoglycan metabolic process Source: Ensembl
  • regulation of odontogenesis of dentin-containing tooth Source: Ensembl
  • regulation of transcription, DNA-templated Source: HGNC
  • response to hypoxia Source: UniProtKB
  • skeletal system development Source: ProtInc
  • SMAD protein signal transduction Source: UniProtKB
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: UniProtKB
  • thyroid-stimulating hormone-secreting cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.
REACT_150331. Molecules associated with elastic fibres.
SignaLinkiP12643.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:BMP2
Synonyms:BMP2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1069. BMP2.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Organism-specific databases

Orphaneti261295. 20p12.3 microdeletion syndrome.
93396. Brachydactyly type A2.
PharmGKBiPA25379.

Polymorphism and mutation databases

BioMutaiBMP2.
DMDMi115068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 282259Cleaved by PCSK5PRO_0000033824Add
BLAST
Chaini283 – 396114Bone morphogenetic protein 2PRO_0000033825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi296 ↔ 361
Disulfide bondi325 ↔ 393
Disulfide bondi329 ↔ 395
Glycosylationi338 – 3381N-linked (GlcNAc...) (high mannose)1 Publication
Disulfide bondi360 – 360Interchain

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12643.
PRIDEiP12643.

PTM databases

PhosphoSiteiP12643.

Expressioni

Tissue specificityi

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Gene expression databases

BgeeiP12643.
CleanExiHS_BMP2.
ExpressionAtlasiP12643. baseline and differential.
GenevestigatoriP12643.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BMPR1AP3689411EBI-1029262,EBI-1029237
BMPR1BO002383EBI-1029262,EBI-7527193
FSTL1Q128412EBI-1029262,EBI-2349801
NOGQ132532EBI-1029262,EBI-1035205

Protein-protein interaction databases

BioGridi107118. 8 interactions.
DIPiDIP-5792N.
IntActiP12643. 8 interactions.
MINTiMINT-6772716.
STRINGi9606.ENSP00000368104.

Structurei

Secondary structure

1
396
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi295 – 2995Combined sources
Beta strandi302 – 3043Combined sources
Helixi305 – 3084Combined sources
Turni311 – 3133Combined sources
Beta strandi314 – 3163Combined sources
Beta strandi318 – 3214Combined sources
Beta strandi324 – 3263Combined sources
Beta strandi337 – 3393Combined sources
Helixi341 – 35212Combined sources
Beta strandi354 – 3563Combined sources
Beta strandi360 – 37415Combined sources
Beta strandi380 – 39617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES7X-ray2.90A/C283-396[»]
1REUX-ray2.65A294-396[»]
1REWX-ray1.86A/B283-396[»]
2GOOX-ray2.20A/D283-396[»]
2H62X-ray1.85A/B283-396[»]
2H64X-ray1.92A283-396[»]
2QJ9X-ray2.44A/B283-396[»]
2QJAX-ray2.60A/B283-396[»]
2QJBX-ray2.50A/B283-396[»]
3BK3X-ray2.70A/B283-396[»]
3BMPX-ray2.70A283-396[»]
4MIDX-ray2.14A283-312[»]
4N1DX-ray1.91A283-305[»]
A362-396[»]
ProteinModelPortaliP12643.
SMRiP12643. Positions 293-396.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12643.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12643.
KOiK04662.
OMAiDEHSWSQ.
OrthoDBiEOG7WHH9D.
PhylomeDBiP12643.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL
60 70 80 90 100
SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE
110 120 130 140 150
RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL
160 170 180 190 200
QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN
210 220 230 240 250
ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL
260 270 280 290 300
HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP
310 320 330 340 350
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN
360 370 380 390
SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR
Length:396
Mass (Da):44,702
Last modified:October 1, 1989 - v1
Checksum:i20653A3987B25E60
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371S → A.
Corresponds to variant rs2273073 [ dbSNP | Ensembl ].
VAR_020061
Natural varianti77 – 771P → S.
Corresponds to variant rs36105541 [ dbSNP | Ensembl ].
VAR_052568
Natural varianti106 – 1061A → T.
Corresponds to variant rs2273074 [ dbSNP | Ensembl ].
VAR_020062
Natural varianti161 – 1611L → S.
Corresponds to variant rs34183594 [ dbSNP | Ensembl ].
VAR_052569
Natural varianti190 – 1901R → S.
Corresponds to variant rs235768 [ dbSNP | Ensembl ].
VAR_024232
Natural varianti387 – 3871D → G.
Corresponds to variant rs11545591 [ dbSNP | Ensembl ].
VAR_052570

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22489 mRNA. Translation: AAA51834.1.
AF040249 Genomic DNA. Translation: AAF21646.1.
AL035668 Genomic DNA. Translation: CAB82007.1.
CCDSiCCDS13099.1.
PIRiB37278. BMHU2.
RefSeqiNP_001191.1. NM_001200.2.
UniGeneiHs.73853.

Genome annotation databases

EnsembliENST00000378827; ENSP00000368104; ENSG00000125845.
GeneIDi650.
KEGGihsa:650.
UCSCiuc002wmu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22489 mRNA. Translation: AAA51834.1.
AF040249 Genomic DNA. Translation: AAF21646.1.
AL035668 Genomic DNA. Translation: CAB82007.1.
CCDSiCCDS13099.1.
PIRiB37278. BMHU2.
RefSeqiNP_001191.1. NM_001200.2.
UniGeneiHs.73853.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES7X-ray2.90A/C283-396[»]
1REUX-ray2.65A294-396[»]
1REWX-ray1.86A/B283-396[»]
2GOOX-ray2.20A/D283-396[»]
2H62X-ray1.85A/B283-396[»]
2H64X-ray1.92A283-396[»]
2QJ9X-ray2.44A/B283-396[»]
2QJAX-ray2.60A/B283-396[»]
2QJBX-ray2.50A/B283-396[»]
3BK3X-ray2.70A/B283-396[»]
3BMPX-ray2.70A283-396[»]
4MIDX-ray2.14A283-312[»]
4N1DX-ray1.91A283-305[»]
A362-396[»]
ProteinModelPortaliP12643.
SMRiP12643. Positions 293-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107118. 8 interactions.
DIPiDIP-5792N.
IntActiP12643. 8 interactions.
MINTiMINT-6772716.
STRINGi9606.ENSP00000368104.

Chemistry

ChEMBLiCHEMBL1926496.

PTM databases

PhosphoSiteiP12643.

Polymorphism and mutation databases

BioMutaiBMP2.
DMDMi115068.

Proteomic databases

PaxDbiP12643.
PRIDEiP12643.

Protocols and materials databases

DNASUi650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378827; ENSP00000368104; ENSG00000125845.
GeneIDi650.
KEGGihsa:650.
UCSCiuc002wmu.1. human.

Organism-specific databases

CTDi650.
GeneCardsiGC20P006696.
HGNCiHGNC:1069. BMP2.
MIMi112261. gene.
neXtProtiNX_P12643.
Orphaneti261295. 20p12.3 microdeletion syndrome.
93396. Brachydactyly type A2.
PharmGKBiPA25379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG243555.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP12643.
KOiK04662.
OMAiDEHSWSQ.
OrthoDBiEOG7WHH9D.
PhylomeDBiP12643.
TreeFamiTF351789.

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.
REACT_150331. Molecules associated with elastic fibres.
SignaLinkiP12643.

Miscellaneous databases

ChiTaRSiBMP2. human.
EvolutionaryTraceiP12643.
GeneWikiiBone_morphogenetic_protein_2.
GenomeRNAii650.
NextBioi2640.
PROiP12643.
SOURCEiSearch...

Gene expression databases

BgeeiP12643.
CleanExiHS_BMP2.
ExpressionAtlasiP12643. baseline and differential.
GenevestigatoriP12643.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel regulators of bone formation: molecular clones and activities."
    Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.
    Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human bone morphogenetic protein 2 (BMP-2) genomic DNA sequence."
    Shore E.M., Xu M.-Q., Calvert G., Moriatis J., Kaplan F.S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry."
    Yeung B., Porter T.J., Vath J.E.
    Anal. Chem. 69:2510-2516(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-338.
  5. Cited for: INTERACTION WITH SOSTDC1.
  6. "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
    Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
    Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, PROPEPTIDE.
  7. "Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution."
    Scheufler C., Sebald W., Huelsmeyer M.
    J. Mol. Biol. 287:103-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 292-396.

Entry informationi

Entry nameiBMP2_HUMAN
AccessioniPrimary (citable) accession number: P12643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 27, 2015
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.