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Protein

Troponin T, fast skeletal muscle isoforms

Gene

TNNT3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.1 Publication

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-GGA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, fast skeletal muscle isoforms
Gene namesi
Name:TNNT3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001861832 – 263Troponin T, fast skeletal muscle isoformsAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSGALG00000006572
ExpressionAtlasiP12620 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiP12620, 2 interactors
MINTiP12620

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni70 – 73Combined sources4
Helixi74 – 77Combined sources4
Turni78 – 84Combined sources7
Beta strandi85 – 91Combined sources7
Turni92 – 94Combined sources3
Turni96 – 98Combined sources3
Helixi164 – 188Combined sources25
Beta strandi196 – 198Combined sources3
Helixi202 – 244Combined sources43

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTZX-ray3.00T157-263[»]
1YV0X-ray7.00T157-263[»]
2W49electron microscopy35.001/4/7/Y160-249[»]
2W4Uelectron microscopy35.001/4/7/Y160-249[»]
2Z5HX-ray2.89T58-112[»]
ProteinModelPortaliP12620
SMRiP12620
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12620

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP12620

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR027708 Tnnt3
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PTHR11521:SF4 PTHR11521:SF4, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform TNT-3 (identifier: P12620-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEVEHG EEEYEEEAHE AEEVHEEEVH EPAPPPEEAP EEEEKPRIKL
60 70 80 90 100
TAPKIPEGEK VDFDDIQKKR QNKDLIELQA LIDSHFEARR KEEEELVALK
110 120 130 140 150
ERIEKRRAER AEQQRIRAEK EKERQARLAE EKARREEEDA KRKAEDDLKK
160 170 180 190 200
KKALSSMGAS YSSYLAKADQ KRGKKQTARE TKKKVLAERR KPLNIDHLNE
210 220 230 240 250
DKLRDKAKEL WDWLYQLQTE KYDFAEQIKR KKYEIVTLRN RIDQAQKHSK
260
KAGAKGKVGG RWK
Length:263
Mass (Da):31,142
Last modified:January 23, 2007 - v3
Checksum:iDBBB46419CCE6FAC
GO
Isoform TNT-1 (identifier: P12620-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-35: EEYEEEAHEAEEVHEEEVHEPAPP → AHEAEEVHEEAHHEEAHHAEAHHEEAHAHAEEVHE

Show »
Length:274
Mass (Da):32,340
Checksum:i80ABAC6B65EAF314
GO
Isoform TNT-2 (identifier: P12620-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     236-248: VTLRNRIDQAQKH → LTLRCRLQELSKF

Show »
Length:257
Mass (Da):30,361
Checksum:iF1D5F28D913FEE71
GO
Isoform TNT-4 (identifier: P12620-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     39-44: Missing.

Show »
Length:251
Mass (Da):29,649
Checksum:i898E12FC9C3D5931
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00663312 – 35EEYEE…EPAPP → AHEAEEVHEEAHHEEAHHAE AHHEEAHAHAEEVHE in isoform TNT-1. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_00663412 – 17Missing in isoform TNT-2 and isoform TNT-4. 1 Publication6
Alternative sequenceiVSP_00663539 – 44Missing in isoform TNT-4. 1 Publication6
Alternative sequenceiVSP_006636236 – 248VTLRN…QAQKH → LTLRCRLQELSKF in isoform TNT-2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22156 mRNA Translation: AAA49102.1
M22158 mRNA Translation: AAA49103.1
M22155 mRNA Translation: AAA49101.1
M22154 mRNA Translation: AAA49100.1
PIRiA31957
B31957
C31957
D31957
RefSeqiXP_015142056.1, XM_015286570.1 [P12620-1]
XP_015142059.1, XM_015286573.1 [P12620-3]
XP_015142062.1, XM_015286576.1 [P12620-4]
UniGeneiGga.39779

Genome annotation databases

EnsembliENSGALT00000085510; ENSGALP00000061928; ENSGALG00000006572 [P12620-1]
GeneIDi395761

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT3_CHICK
AccessioniPrimary (citable) accession number: P12620
Secondary accession number(s): P12618, P12619, P12621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health