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Protein

Troponin T, fast skeletal muscle isoforms

Gene

TNNT3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, fast skeletal muscle isoforms
Gene namesi
Name:TNNT3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 263262Troponin T, fast skeletal muscle isoformsPRO_0000186183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Gene expression databases

ExpressionAtlasiP12620. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiP12620. 2 interactions.
MINTiMINT-8189876.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni70 – 734Combined sources
Helixi74 – 774Combined sources
Turni78 – 847Combined sources
Beta strandi85 – 917Combined sources
Turni92 – 943Combined sources
Turni96 – 983Combined sources
Helixi164 – 18825Combined sources
Beta strandi196 – 1983Combined sources
Helixi202 – 24443Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTZX-ray3.00T157-263[»]
1YV0X-ray7.00T157-263[»]
2W49electron microscopy35.001/4/7/Y160-249[»]
2W4Uelectron microscopy35.001/4/7/Y160-249[»]
2Z5HX-ray2.89T58-112[»]
ProteinModelPortaliP12620.
SMRiP12620. Positions 66-99, 160-249.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12620.

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiP12620.

Family and domain databases

InterProiIPR027707. TNNT.
IPR027708. Tnnt3.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PTHR11521:SF4. PTHR11521:SF4. 1 hit.
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform TNT-3 (identifier: P12620-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEVEHG EEEYEEEAHE AEEVHEEEVH EPAPPPEEAP EEEEKPRIKL
60 70 80 90 100
TAPKIPEGEK VDFDDIQKKR QNKDLIELQA LIDSHFEARR KEEEELVALK
110 120 130 140 150
ERIEKRRAER AEQQRIRAEK EKERQARLAE EKARREEEDA KRKAEDDLKK
160 170 180 190 200
KKALSSMGAS YSSYLAKADQ KRGKKQTARE TKKKVLAERR KPLNIDHLNE
210 220 230 240 250
DKLRDKAKEL WDWLYQLQTE KYDFAEQIKR KKYEIVTLRN RIDQAQKHSK
260
KAGAKGKVGG RWK
Length:263
Mass (Da):31,142
Last modified:January 23, 2007 - v3
Checksum:iDBBB46419CCE6FAC
GO
Isoform TNT-1 (identifier: P12620-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-35: EEYEEEAHEAEEVHEEEVHEPAPP → AHEAEEVHEEAHHEEAHHAEAHHEEAHAHAEEVHE

Show »
Length:274
Mass (Da):32,340
Checksum:i80ABAC6B65EAF314
GO
Isoform TNT-2 (identifier: P12620-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     236-248: VTLRNRIDQAQKH → LTLRCRLQELSKF

Show »
Length:257
Mass (Da):30,361
Checksum:iF1D5F28D913FEE71
GO
Isoform TNT-4 (identifier: P12620-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     39-44: Missing.

Show »
Length:251
Mass (Da):29,649
Checksum:i898E12FC9C3D5931
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 3524EEYEE…EPAPP → AHEAEEVHEEAHHEEAHHAE AHHEEAHAHAEEVHE in isoform TNT-1. 1 PublicationVSP_006633Add
BLAST
Alternative sequencei12 – 176Missing in isoform TNT-2 and isoform TNT-4. 1 PublicationVSP_006634
Alternative sequencei39 – 446Missing in isoform TNT-4. 1 PublicationVSP_006635
Alternative sequencei236 – 24813VTLRN…QAQKH → LTLRCRLQELSKF in isoform TNT-2. 1 PublicationVSP_006636Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22156 mRNA. Translation: AAA49102.1.
M22158 mRNA. Translation: AAA49103.1.
M22155 mRNA. Translation: AAA49101.1.
M22154 mRNA. Translation: AAA49100.1.
PIRiA31957.
B31957.
C31957.
D31957.
RefSeqiXP_015142056.1. XM_015286570.1. [P12620-1]
XP_015142059.1. XM_015286573.1. [P12620-3]
XP_015142062.1. XM_015286576.1. [P12620-4]
UniGeneiGga.39779.

Genome annotation databases

GeneIDi395761.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22156 mRNA. Translation: AAA49102.1.
M22158 mRNA. Translation: AAA49103.1.
M22155 mRNA. Translation: AAA49101.1.
M22154 mRNA. Translation: AAA49100.1.
PIRiA31957.
B31957.
C31957.
D31957.
RefSeqiXP_015142056.1. XM_015286570.1. [P12620-1]
XP_015142059.1. XM_015286573.1. [P12620-3]
XP_015142062.1. XM_015286576.1. [P12620-4]
UniGeneiGga.39779.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTZX-ray3.00T157-263[»]
1YV0X-ray7.00T157-263[»]
2W49electron microscopy35.001/4/7/Y160-249[»]
2W4Uelectron microscopy35.001/4/7/Y160-249[»]
2Z5HX-ray2.89T58-112[»]
ProteinModelPortaliP12620.
SMRiP12620. Positions 66-99, 160-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12620. 2 interactions.
MINTiMINT-8189876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395761.

Phylogenomic databases

HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiP12620.

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP12620.

Gene expression databases

ExpressionAtlasiP12620. baseline and differential.

Family and domain databases

InterProiIPR027707. TNNT.
IPR027708. Tnnt3.
IPR001978. Troponin.
[Graphical view]
PANTHERiPTHR11521. PTHR11521. 1 hit.
PTHR11521:SF4. PTHR11521:SF4. 1 hit.
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences of complete cDNAs encoding four variants of chicken skeletal muscle troponin T."
    Smillie L.B., Golosinska K., Reinach F.C.
    J. Biol. Chem. 263:18816-18820(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TNT-1; TNT-2; TNT-3 AND TNT-4).
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 58-112, X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 157-262, FUNCTION.

Entry informationi

Entry nameiTNNT3_CHICK
AccessioniPrimary (citable) accession number: P12620
Secondary accession number(s): P12618, P12619, P12621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 13, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.