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P12617

- DCMC_ANSAN

UniProt

P12617 - DCMC_ANSAN

Protein

Malonyl-CoA decarboxylase, mitochondrial

Gene

MLYCD

Organism
Anser anser anser (Western graylag goose)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.

    Catalytic activityi

    Malonyl-CoA = acetyl-CoA + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei222 – 2221Essential for catalytic activityBy similarity
    Active sitei340 – 3401Proton acceptorBy similarity
    Active sitei434 – 4341Proton donorBy similarity

    GO - Molecular functioni

    1. malonyl-CoA decarboxylase activity Source: UniProtKB

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB
    2. fatty acid biosynthetic process Source: UniProtKB-KW
    3. malonyl-CoA catabolic process Source: UniProtKB
    4. positive regulation of fatty acid oxidation Source: UniProtKB

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00340; UER00710.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl-CoA decarboxylase, mitochondrial (EC:4.1.1.9)
    Short name:
    MCD
    Gene namesi
    Name:MLYCD
    OrganismiAnser anser anser (Western graylag goose)
    Taxonomic identifieri8844 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

    Subcellular locationi

    Mitochondrion 1 Publication. Cytoplasm 1 Publication. Peroxisome 1 Publication
    Note: Mitochondrial in liver. Cytoplasmic in uropygial gland.

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5050MitochondrionSequence AnalysisAdd
    BLAST
    Chaini51 – 504454Malonyl-CoA decarboxylase, mitochondrialPRO_0000021086Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 201151Alpha-helical domainBy similarityAdd
    BLAST
    Regioni202 – 504303Catalytic domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi502 – 5043Microbody targeting signalSequence Analysis

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG000825.

    Family and domain databases

    InterProiIPR007956. Malonyl_CoA_deC.
    [Graphical view]
    PfamiPF05292. MCD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform Mitochondrial (identifier: P12617-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGLRRGLSR LGPRLGPWAV PRSLRRVLRA AGPWRGQSSA GSVSERGGAS    50
    MEEVLSRSVP LLPPYETKEK APPPAERRSA EFVRYYRGLE AGSRRAELLG 100
    CLARDFGADH GRVAEFSAKV LQAREQEREQ GALLQAEDRV RYYLTPRYRA 150
    LFQHLGRLEG GLRFLVELRG DLVEGLAAKA VDGPHVKEMS GVLKNMLSEW 200
    FSTGFLNLER VTWQSPCEVL QKISDSEAVH PVRNWVDLKR RVGPYRRCYF 250
    FSHCAIPGEP LIILHVALTS DISSSIQSIV KDVESLETED AEKITTAIFY 300
    SISLAQQGLQ GVELGNHLIK RVVKELQKDL PQIEAFSSLS PIPGFTKWLV 350
    GLLSSQTKEL GRNELFTESE RQEISEITED STTETLKKLL TNSEWVKSEK 400
    LVKALHSPLM RLCAWYLYGE KHRGYALNPV ANFHLQNGAE LWRINWMGDT 450
    SPRGIAASCG MMVNYRYFLE DTASNSAAYL GTKHIKASEQ VLSFVSQFQQ 500
    NSKL 504
    Length:504
    Mass (Da):56,690
    Last modified:November 1, 1995 - v2
    Checksum:i683991C1F9773DF4
    GO
    Isoform Cytoplasmic+peroxisomal (identifier: P12617-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.

    Show »
    Length:454
    Mass (Da):51,368
    Checksum:i06251394595673F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 13613Missing AA sequence (PubMed:2914961)CuratedAdd
    BLAST
    Sequence conflicti140 – 1401V → L in AAA49317. (PubMed:2914961)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5050Missing in isoform Cytoplasmic+peroxisomal. 1 PublicationVSP_018815Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21171 mRNA. Translation: AAA49317.1. Sequence problems.
    PIRiA33313.
    S27113.

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21171 mRNA. Translation: AAA49317.1 . Sequence problems.
    PIRi A33313.
    S27113.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000825.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00710 .

    Family and domain databases

    InterProi IPR007956. Malonyl_CoA_deC.
    [Graphical view ]
    Pfami PF05292. MCD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site."
      Courchesne-Smith C., Jang S.-H., Shi Q., Dewille J., Sasaki G., Kolattukudy P.E.
      Arch. Biochem. Biophys. 298:576-586(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MITOCHONDRIAL AND CYTOPLASMIC+PEROXISOMAL), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
      Tissue: Uropygial gland.
    2. "Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase."
      Jang S.-H., Cheesbrough T.M., Kolattukudy P.E.
      J. Biol. Chem. 264:3500-3505(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-504, PARTIAL PROTEIN SEQUENCE.
      Tissue: Uropygial gland.

    Entry informationi

    Entry nameiDCMC_ANSAN
    AccessioniPrimary (citable) accession number: P12617
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3