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P12617

- DCMC_ANSAN

UniProt

P12617 - DCMC_ANSAN

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Protein
Malonyl-CoA decarboxylase, mitochondrial
Gene
MLYCD
Organism
Anser anser anser (Western graylag goose)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.

Catalytic activityi

Malonyl-CoA = acetyl-CoA + CO2.

Pathwayi

GO - Molecular functioni

  1. malonyl-CoA decarboxylase activity Source: UniProtKB

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB
  2. fatty acid biosynthetic process Source: UniProtKB-KW
  3. malonyl-CoA catabolic process Source: UniProtKB
  4. positive regulation of fatty acid oxidation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00340; UER00710.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-CoA decarboxylase, mitochondrial (EC:4.1.1.9)
Short name:
MCD
Gene namesi
Name:MLYCD
OrganismiAnser anser anser (Western graylag goose)
Taxonomic identifieri8844 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Subcellular locationi

Mitochondrion. Cytoplasm. Peroxisome
Note: Mitochondrial in liver. Cytoplasmic in uropygial gland.1 Publication

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
  2. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 504Malonyl-CoA decarboxylase, mitochondrialPRO_0000021086
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi502 – 5043Microbody targeting signal Reviewed prediction

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG000825.

Family and domain databases

InterProiIPR007956. Malonyl_CoA_deC.
[Graphical view]
PfamiPF05292. MCD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform Mitochondrial (identifier: P12617-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRGLRRGLSR LGPRLGPWAV PRSLRRVLRA AGPWRGQSSA GSVSERGGAS    50
MEEVLSRSVP LLPPYETKEK APPPAERRSA EFVRYYRGLE AGSRRAELLG 100
CLARDFGADH GRVAEFSAKV LQAREQEREQ GALLQAEDRV RYYLTPRYRA 150
LFQHLGRLEG GLRFLVELRG DLVEGLAAKA VDGPHVKEMS GVLKNMLSEW 200
FSTGFLNLER VTWQSPCEVL QKISDSEAVH PVRNWVDLKR RVGPYRRCYF 250
FSHCAIPGEP LIILHVALTS DISSSIQSIV KDVESLETED AEKITTAIFY 300
SISLAQQGLQ GVELGNHLIK RVVKELQKDL PQIEAFSSLS PIPGFTKWLV 350
GLLSSQTKEL GRNELFTESE RQEISEITED STTETLKKLL TNSEWVKSEK 400
LVKALHSPLM RLCAWYLYGE KHRGYALNPV ANFHLQNGAE LWRINWMGDT 450
SPRGIAASCG MMVNYRYFLE DTASNSAAYL GTKHIKASEQ VLSFVSQFQQ 500
NSKL 504
Length:504
Mass (Da):56,690
Last modified:November 1, 1995 - v2
Checksum:i683991C1F9773DF4
GO
Isoform Cytoplasmic+peroxisomal (identifier: P12617-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:454
Mass (Da):51,368
Checksum:i06251394595673F1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform Cytoplasmic+peroxisomal.
VSP_018815Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 13613Missing AA sequence 1 Publication
Add
BLAST
Sequence conflicti140 – 1401V → L in AAA49317. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21171 mRNA. Translation: AAA49317.1. Sequence problems.
PIRiA33313.
S27113.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21171 mRNA. Translation: AAA49317.1 . Sequence problems.
PIRi A33313.
S27113.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000825.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00710 .

Family and domain databases

InterProi IPR007956. Malonyl_CoA_deC.
[Graphical view ]
Pfami PF05292. MCD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site."
    Courchesne-Smith C., Jang S.-H., Shi Q., Dewille J., Sasaki G., Kolattukudy P.E.
    Arch. Biochem. Biophys. 298:576-586(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MITOCHONDRIAL AND CYTOPLASMIC+PEROXISOMAL), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
    Tissue: Uropygial gland.
  2. "Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase."
    Jang S.-H., Cheesbrough T.M., Kolattukudy P.E.
    J. Biol. Chem. 264:3500-3505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-504, PARTIAL PROTEIN SEQUENCE.
    Tissue: Uropygial gland.

Entry informationi

Entry nameiDCMC_ANSAN
AccessioniPrimary (citable) accession number: P12617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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