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P12617 (DCMC_ANSAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malonyl-CoA decarboxylase, mitochondrial

Short name=MCD
EC=4.1.1.9
Gene names
Name:MLYCD
OrganismAnser anser anser (Western graylag goose)
Taxonomic identifier8844 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.

Catalytic activity

Malonyl-CoA = acetyl-CoA + CO2.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.

Subcellular location

Mitochondrion. Cytoplasm. Peroxisome. Note: Mitochondrial in liver. Cytoplasmic in uropygial gland. Ref.1

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform Mitochondrial (identifier: P12617-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Cytoplasmic+peroxisomal (identifier: P12617-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 504Malonyl-CoA decarboxylase, mitochondrialPRO_0000021086

Regions

Motif502 – 5043Microbody targeting signal Potential

Natural variations

Alternative sequence1 – 5050Missing in isoform Cytoplasmic+peroxisomal.
VSP_018815

Experimental info

Sequence conflict124 – 13613Missing AA sequence Ref.2
Sequence conflict1401V → L in AAA49317. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Mitochondrial [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 683991C1F9773DF4

FASTA50456,690
        10         20         30         40         50         60 
MRGLRRGLSR LGPRLGPWAV PRSLRRVLRA AGPWRGQSSA GSVSERGGAS MEEVLSRSVP 

        70         80         90        100        110        120 
LLPPYETKEK APPPAERRSA EFVRYYRGLE AGSRRAELLG CLARDFGADH GRVAEFSAKV 

       130        140        150        160        170        180 
LQAREQEREQ GALLQAEDRV RYYLTPRYRA LFQHLGRLEG GLRFLVELRG DLVEGLAAKA 

       190        200        210        220        230        240 
VDGPHVKEMS GVLKNMLSEW FSTGFLNLER VTWQSPCEVL QKISDSEAVH PVRNWVDLKR 

       250        260        270        280        290        300 
RVGPYRRCYF FSHCAIPGEP LIILHVALTS DISSSIQSIV KDVESLETED AEKITTAIFY 

       310        320        330        340        350        360 
SISLAQQGLQ GVELGNHLIK RVVKELQKDL PQIEAFSSLS PIPGFTKWLV GLLSSQTKEL 

       370        380        390        400        410        420 
GRNELFTESE RQEISEITED STTETLKKLL TNSEWVKSEK LVKALHSPLM RLCAWYLYGE 

       430        440        450        460        470        480 
KHRGYALNPV ANFHLQNGAE LWRINWMGDT SPRGIAASCG MMVNYRYFLE DTASNSAAYL 

       490        500 
GTKHIKASEQ VLSFVSQFQQ NSKL 

« Hide

Isoform Cytoplasmic+peroxisomal [UniParc].

Checksum: 06251394595673F1
Show »

FASTA45451,368

References

[1]"Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site."
Courchesne-Smith C., Jang S.-H., Shi Q., Dewille J., Sasaki G., Kolattukudy P.E.
Arch. Biochem. Biophys. 298:576-586(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MITOCHONDRIAL AND CYTOPLASMIC+PEROXISOMAL), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
Tissue: Uropygial gland.
[2]"Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase."
Jang S.-H., Cheesbrough T.M., Kolattukudy P.E.
J. Biol. Chem. 264:3500-3505(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-504, PARTIAL PROTEIN SEQUENCE.
Tissue: Uropygial gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L21171 mRNA. Translation: AAA49317.1. Sequence problems.
PIRA33313.
S27113.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000825.

Enzyme and pathway databases

UniPathwayUPA00340; UER00710.

Family and domain databases

InterProIPR007956. Malonyl_CoA_deC.
[Graphical view]
PfamPF05292. MCD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCMC_ANSAN
AccessionPrimary (citable) accession number: P12617
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways