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P12614

- BGLS_AGRSA

UniProt

P12614 - BGLS_AGRSA

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Protein

Beta-glucosidase

Gene

abg

Organism
Agrobacterium sp. (strain ATCC 21400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711Proton donorSequence Analysis
Active sitei359 – 3591Nucleophile1 PublicationPROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3714-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase (EC:3.2.1.21)
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:abg
OrganismiAgrobacterium sp. (strain ATCC 21400)
Taxonomic identifieri74562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Beta-glucosidasePRO_0000063869Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP12614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12614 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDPNTLAAR FPGDFLFGVA TASFQIEGST KADGRKPSIW DAFCNMPGHV
60 70 80 90 100
FGRHNGDIAC DHYNRWEEDL DLIKEMGVEA YRFSLAWPRI IPDGFGPINE
110 120 130 140 150
KGLDFYDRLV DGCKARGIKT YATLYHWDLP LTLMGDGGWA SRSTAHAFQR
160 170 180 190 200
YAKTVMARLG DRLDAVATFN EPWCAVWLSH LYGVHAPGER NMEAALAAMH
210 220 230 240 250
HINLAHGFGV EASRHVAPKV PVGLVLNAHS AIPASDGEAD LKAAERAFQF
260 270 280 290 300
HNGAFFDPVF KGEYPAEMME ALGDRMPVVE AEDLGIISQK LDWWGLNYYT
310 320 330 340 350
PMRVADDATP GVEFPATMPA PAVSDVKTDI GWEVYAPALH TLVETLYERY
360 370 380 390 400
DLPECYITEN GACYNMGVEN GQVNDQPRLD YYAEHLGIVA DLIRDGYPMR
410 420 430 440 450
GYFAWSLMDN FEWAEGYRMR FGLVHVDYQT QVRTVKNSGK WYSALASGFP

KGNHGVAKG
Length:459
Mass (Da):51,170
Last modified:October 1, 1989 - v1
Checksum:iAAB799153493A682
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19033 Genomic DNA. Translation: AAA22085.1.
PIRiA28673. GLAG.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19033 Genomic DNA. Translation: AAA22085.1 .
PIRi A28673. GLAG.

3D structure databases

ProteinModelPortali P12614.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075038.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3714-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and transcription analysis of the gene encoding a cellobiase from Agrobacterium sp. strain ATCC 21400."
    Wakarchuk W.W., Greenberg N.M., Kilburn D.G., Miller R.C. Jr., Warren R.A.J.
    J. Bacteriol. 170:301-307(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a 'retaining' glycosidase."
    Withers S.G., Warren R.A.J., Street I.P., Rupitz K., Kempton J.B., Aebersold R.
    J. Am. Chem. Soc. 112:5887-5889(1990)
    Cited for: ACTIVE SITE GLU-359.

Entry informationi

Entry nameiBGLS_AGRSA
AccessioniPrimary (citable) accession number: P12614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3