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Protein

T-complex protein 1 subunit alpha

Gene

CCT1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • ovarian follicle cell development Source: FlyBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-390471 Association of TriC/CCT with target proteins during biosynthesis
R-DME-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Chaperonin containing TCP1 subunit 1Imported
Gene namesi
Name:CCT1Imported
Synonyms:CCT-1, T-cp1, Tcp-11 Publication
ORF Names:CG5374Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003676 CCT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283101 – 557T-complex protein 1 subunit alphaAdd BLAST557

Proteomic databases

PaxDbiP12613
PRIDEiP12613

Expressioni

Gene expression databases

BgeeiFBgn0003676
ExpressionAtlasiP12613 differential
GenevisibleiP12613 DM

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi6760438 interactors.
DIPiDIP-22081N
IntActiP12613 3 interactors.
STRINGi7227.FBpp0083683

Structurei

3D structure databases

ProteinModelPortaliP12613
SMRiP12613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074878
InParanoidiP12613
KOiK09493
OMAiIMRIDTL
OrthoDBiEOG091G04HL
PhylomeDBiP12613

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.102 hits
3.30.260.102 hits
3.50.7.101 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P12613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLASPLSI AGTRQSGASV RTQNVMAALS ISNIVKSSLG PVGLDKMLVD
60 70 80 90 100
DIGDVTVTND GATILRLLEV EHPAAKVLVE LAQLQDEEVG DGTTSVVILA
110 120 130 140 150
AELLKNADEL VKQKIHPTSI ISGYRIACKE ACKYISEHLT APVDELGRDS
160 170 180 190 200
LINIAKTSMS SKIIGADAEF FSAMVVDAAQ SVKITDPRGQ AAYSIKAINV
210 220 230 240 250
LKAHGKSARE SVLIPGYALN CTIASQQMPK KIVNAKIACL DFSLQKTKMK
260 270 280 290 300
MGVQVLINDP DKLEAIRARE LDITKERINM ILGTGVNVVL VSGGVDDLCM
310 320 330 340 350
KYFVEAGAMA VRRVKKSDLK IIAKATGAAF ITSLTNMDGE ESFDASMVGE
360 370 380 390 400
AAEVAQERIC DDELILIKGT KARAAASIIL RGPNDFYCDE MERSVHDALC
410 420 430 440 450
VVKRVLESKK VVAGGGCVEA ALSIYLENFA TSLASREQLA IAEFAKSLLV
460 470 480 490 500
IPKTLSVNAA KDATDLVAKL RSYHNSSQTK PERSDLKWTG LDLIEGVVRD
510 520 530 540 550
NKKAGVLEPA MSKIKSLKFA TEAAITILRI DDMIKLNPED KSGKSYADAC

AAGELDG
Length:557
Mass (Da):59,557
Last modified:May 4, 2001 - v2
Checksum:i6F4A28237456F3A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 19GAS → RRI in AAA28927 (PubMed:3146529).Curated3
Sequence conflicti192A → V in AAA28927 (PubMed:3146529).Curated1
Sequence conflicti198I → V in AAA28927 (PubMed:3146529).Curated1
Sequence conflicti240L → H in AAA28927 (PubMed:3146529).Curated1
Sequence conflicti413A → R in AAA28927 (PubMed:3146529).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21159 mRNA Translation: AAA28927.1
AE014297 Genomic DNA Translation: AAF56009.1
AY118416 mRNA Translation: AAM48445.1
PIRiJT0367
RefSeqiNP_524450.2, NM_079726.4
NP_732748.1, NM_170016.2
UniGeneiDm.1279

Genome annotation databases

EnsemblMetazoaiFBtr0084290; FBpp0083683; FBgn0003676
FBtr0084291; FBpp0083684; FBgn0003676
GeneIDi42649
KEGGidme:Dmel_CG5374

Similar proteinsi

Entry informationi

Entry nameiTCPA_DROME
AccessioniPrimary (citable) accession number: P12613
Secondary accession number(s): Q9VCZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 4, 2001
Last modified: March 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome