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P12611 (WHI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth regulation protein
Gene names
Name:WHI2
Ordered Locus Names:YOR043W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2. Ref.1 Ref.4

Subunit structure

Interacts with MSN2 and PSR1. Ref.4

Disruption phenotype

Negative mutants fail to enter the G0 phase under conditions of carbon limitation. Ref.1

Miscellaneous

Present with 1800 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WHI2 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PSR1Q078003EBI-20530,EBI-31129

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Growth regulation protein
PRO_0000065967

Experimental info

Sequence conflict2161F → L in AAA35218. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P12611 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 105419D6180207F2

FASTA48655,346
        10         20         30         40         50         60 
MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH YFITRDQLMS 

        70         80         90        100        110        120 
LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD CFEYIMEIYT KAHDDLYNHP 

       130        140        150        160        170        180 
VEKFFDRPSS SFVSNAKGFF GLSSNNSISS NNEQDILHQK PAIIVLREDL DYYCVPQEEF 

       190        200        210        220        230        240 
QFDSTNEENN EDLLRHFMAQ VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS 

       250        260        270        280        290        300 
SSNTKSTSKK LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 

       310        320        330        340        350        360 
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN LTSGSTAPAT 

       370        380        390        400        410        420 
ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD LVPKPNINAK LLLFWRKPAR 

       430        440        450        460        470        480 
KCWWGEEDIE LEVEVFGSWK DESKKIIELI LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL 


SVIGVQ 

« Hide

References

« Hide 'large scale' references
[1]"Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene."
Kelly D.E., Trevethick J., Mountain H., Sudbery P.E.
Gene 66:205-213(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression."
Kaida D., Yashiroda H., Toh-e A., Kikuchi Y.
Genes Cells 7:543-552(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PSR1 AND MSN2.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21089 Genomic DNA. Translation: AAA35218.1.
Z74951 Genomic DNA. Translation: CAA99234.1.
BK006948 Genomic DNA. Translation: DAA10825.1.
PIRCOBYW2. S66917.
RefSeqNP_014686.1. NM_001183462.1.

3D structure databases

ProteinModelPortalP12611.
SMRP12611. Positions 39-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34444. 229 interactions.
DIPDIP-2573N.
IntActP12611. 11 interactions.
MINTMINT-427278.
STRING4932.YOR043W.

Proteomic databases

PaxDbP12611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR043W; YOR043W; YOR043W.
GeneID854208.
KEGGsce:YOR043W.

Organism-specific databases

CYGDYOR043w.
SGDS000005569. WHI2.

Phylogenomic databases

eggNOGNOG83078.
HOGENOMHOG000187763.
OMALIHLNIQ.
OrthoDBEOG7DNP54.

Enzyme and pathway databases

BioCycYEAST:G3O-33587-MONOMER.

Gene expression databases

GenevestigatorP12611.

Family and domain databases

Gene3D3.30.710.10. 2 hits.
InterProIPR011333. BTB/POZ_fold.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio976056.

Entry information

Entry nameWHI2_YEAST
AccessionPrimary (citable) accession number: P12611
Secondary accession number(s): D6W2A9, Q08413
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families