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Protein

Growth regulation protein

Gene

WHI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.2 Publications

Miscellaneous

Present with 1800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatase activator activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • cell cycle Source: UniProtKB-KW
  • endocytosis Source: SGD
  • mitophagy Source: SGD
  • regulation of growth Source: SGD
  • response to heat Source: UniProtKB
  • response to salt stress Source: UniProtKB

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-33587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth regulation protein
Gene namesi
Name:WHI2
Ordered Locus Names:YOR043W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR043W.
SGDiS000005569. WHI2.

Pathology & Biotechi

Disruption phenotypei

Negative mutants fail to enter the G0 phase under conditions of carbon limitation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659671 – 486Growth regulation proteinAdd BLAST486

Proteomic databases

MaxQBiP12611.
PRIDEiP12611.

PTM databases

iPTMnetiP12611.

Interactioni

Subunit structurei

Interacts with MSN2 and PSR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSR1Q078003EBI-20530,EBI-31129

Protein-protein interaction databases

BioGridi34444. 368 interactors.
DIPiDIP-2573N.
IntActiP12611. 11 interactors.
MINTiMINT-427278.
STRINGi4932.YOR043W.

Structurei

3D structure databases

ProteinModelPortaliP12611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WHI2 family.Curated

Phylogenomic databases

HOGENOMiHOG000187763.
InParanoidiP12611.
OMAiPSRCCIS.
OrthoDBiEOG092C3WLJ.

Family and domain databases

InterProiView protein in InterPro
IPR011333. SKP1/BTB/POZ.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P12611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH
60 70 80 90 100
YFITRDQLMS LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD
110 120 130 140 150
CFEYIMEIYT KAHDDLYNHP VEKFFDRPSS SFVSNAKGFF GLSSNNSISS
160 170 180 190 200
NNEQDILHQK PAIIVLREDL DYYCVPQEEF QFDSTNEENN EDLLRHFMAQ
210 220 230 240 250
VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS SSNTKSTSKK
260 270 280 290 300
LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG
310 320 330 340 350
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN
360 370 380 390 400
LTSGSTAPAT ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD
410 420 430 440 450
LVPKPNINAK LLLFWRKPAR KCWWGEEDIE LEVEVFGSWK DESKKIIELI
460 470 480
LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL SVIGVQ
Length:486
Mass (Da):55,346
Last modified:November 1, 1997 - v2
Checksum:i105419D6180207F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216F → L in AAA35218 (PubMed:3049245).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21089 Genomic DNA. Translation: AAA35218.1.
Z74951 Genomic DNA. Translation: CAA99234.1.
BK006948 Genomic DNA. Translation: DAA10825.1.
PIRiS66917. COBYW2.
RefSeqiNP_014686.1. NM_001183462.1.

Genome annotation databases

EnsemblFungiiYOR043W; YOR043W; YOR043W.
GeneIDi854208.
KEGGisce:YOR043W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWHI2_YEAST
AccessioniPrimary (citable) accession number: P12611
Secondary accession number(s): D6W2A9, Q08413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names