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P12611

- WHI2_YEAST

UniProt

P12611 - WHI2_YEAST

Protein

Growth regulation protein

Gene

WHI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.2 Publications

    GO - Molecular functioni

    1. phosphatase activator activity Source: SGD
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. actin filament organization Source: SGD
    2. cell cycle Source: UniProtKB-KW
    3. endocytosis Source: SGD
    4. mitochondrion degradation Source: SGD
    5. positive regulation of catalytic activity Source: GOC
    6. regulation of growth Source: SGD
    7. response to heat Source: UniProtKB
    8. response to salt stress Source: UniProtKB

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33587-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth regulation protein
    Gene namesi
    Name:WHI2
    Ordered Locus Names:YOR043W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR043w.
    SGDiS000005569. WHI2.

    Pathology & Biotechi

    Disruption phenotypei

    Negative mutants fail to enter the G0 phase under conditions of carbon limitation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Growth regulation proteinPRO_0000065967Add
    BLAST

    Proteomic databases

    MaxQBiP12611.
    PaxDbiP12611.

    Expressioni

    Gene expression databases

    GenevestigatoriP12611.

    Interactioni

    Subunit structurei

    Interacts with MSN2 and PSR1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PSR1Q078003EBI-20530,EBI-31129

    Protein-protein interaction databases

    BioGridi34444. 230 interactions.
    DIPiDIP-2573N.
    IntActiP12611. 11 interactions.
    MINTiMINT-427278.
    STRINGi4932.YOR043W.

    Structurei

    3D structure databases

    ProteinModelPortaliP12611.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the WHI2 family.Curated

    Phylogenomic databases

    eggNOGiNOG83078.
    HOGENOMiHOG000187763.
    OMAiLIHLNIQ.
    OrthoDBiEOG7DNP54.

    Family and domain databases

    Gene3Di3.30.710.10. 2 hits.
    InterProiIPR011333. BTB/POZ_fold.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P12611-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH    50
    YFITRDQLMS LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD 100
    CFEYIMEIYT KAHDDLYNHP VEKFFDRPSS SFVSNAKGFF GLSSNNSISS 150
    NNEQDILHQK PAIIVLREDL DYYCVPQEEF QFDSTNEENN EDLLRHFMAQ 200
    VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS SSNTKSTSKK 250
    LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
    FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN 350
    LTSGSTAPAT ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD 400
    LVPKPNINAK LLLFWRKPAR KCWWGEEDIE LEVEVFGSWK DESKKIIELI 450
    LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL SVIGVQ 486
    Length:486
    Mass (Da):55,346
    Last modified:November 1, 1997 - v2
    Checksum:i105419D6180207F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161F → L in AAA35218. (PubMed:3049245)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21089 Genomic DNA. Translation: AAA35218.1.
    Z74951 Genomic DNA. Translation: CAA99234.1.
    BK006948 Genomic DNA. Translation: DAA10825.1.
    PIRiS66917. COBYW2.
    RefSeqiNP_014686.1. NM_001183462.1.

    Genome annotation databases

    EnsemblFungiiYOR043W; YOR043W; YOR043W.
    GeneIDi854208.
    KEGGisce:YOR043W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21089 Genomic DNA. Translation: AAA35218.1 .
    Z74951 Genomic DNA. Translation: CAA99234.1 .
    BK006948 Genomic DNA. Translation: DAA10825.1 .
    PIRi S66917. COBYW2.
    RefSeqi NP_014686.1. NM_001183462.1.

    3D structure databases

    ProteinModelPortali P12611.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34444. 230 interactions.
    DIPi DIP-2573N.
    IntActi P12611. 11 interactions.
    MINTi MINT-427278.
    STRINGi 4932.YOR043W.

    Proteomic databases

    MaxQBi P12611.
    PaxDbi P12611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR043W ; YOR043W ; YOR043W .
    GeneIDi 854208.
    KEGGi sce:YOR043W.

    Organism-specific databases

    CYGDi YOR043w.
    SGDi S000005569. WHI2.

    Phylogenomic databases

    eggNOGi NOG83078.
    HOGENOMi HOG000187763.
    OMAi LIHLNIQ.
    OrthoDBi EOG7DNP54.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33587-MONOMER.

    Miscellaneous databases

    NextBioi 976056.

    Gene expression databases

    Genevestigatori P12611.

    Family and domain databases

    Gene3Di 3.30.710.10. 2 hits.
    InterProi IPR011333. BTB/POZ_fold.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene."
      Kelly D.E., Trevethick J., Mountain H., Sudbery P.E.
      Gene 66:205-213(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression."
      Kaida D., Yashiroda H., Toh-e A., Kikuchi Y.
      Genes Cells 7:543-552(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PSR1 AND MSN2.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWHI2_YEAST
    AccessioniPrimary (citable) accession number: P12611
    Secondary accession number(s): D6W2A9, Q08413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1800 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3