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Protein

Growth regulation protein

Gene

WHI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.2 Publications

GO - Molecular functioni

  • phosphatase activator activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • cell cycle Source: UniProtKB-KW
  • endocytosis Source: SGD
  • mitochondrion degradation Source: SGD
  • positive regulation of catalytic activity Source: GOC
  • regulation of growth Source: SGD
  • response to heat Source: UniProtKB
  • response to salt stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-33587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth regulation protein
Gene namesi
Name:WHI2
Ordered Locus Names:YOR043W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOR043w.
EuPathDBiFungiDB:YOR043W.
SGDiS000005569. WHI2.

Pathology & Biotechi

Disruption phenotypei

Negative mutants fail to enter the G0 phase under conditions of carbon limitation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Growth regulation proteinPRO_0000065967Add
BLAST

Proteomic databases

MaxQBiP12611.
PaxDbiP12611.

Interactioni

Subunit structurei

Interacts with MSN2 and PSR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSR1Q078003EBI-20530,EBI-31129

Protein-protein interaction databases

BioGridi34444. 232 interactions.
DIPiDIP-2573N.
IntActiP12611. 11 interactions.
MINTiMINT-427278.
STRINGi4932.YOR043W.

Structurei

3D structure databases

ProteinModelPortaliP12611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WHI2 family.Curated

Phylogenomic databases

eggNOGiNOG83078.
HOGENOMiHOG000187763.
InParanoidiP12611.
OMAiLIHLNIQ.
OrthoDBiEOG7DNP54.

Family and domain databases

InterProiIPR011333. BTB/POZ_fold.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P12611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH
60 70 80 90 100
YFITRDQLMS LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD
110 120 130 140 150
CFEYIMEIYT KAHDDLYNHP VEKFFDRPSS SFVSNAKGFF GLSSNNSISS
160 170 180 190 200
NNEQDILHQK PAIIVLREDL DYYCVPQEEF QFDSTNEENN EDLLRHFMAQ
210 220 230 240 250
VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS SSNTKSTSKK
260 270 280 290 300
LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG
310 320 330 340 350
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN
360 370 380 390 400
LTSGSTAPAT ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD
410 420 430 440 450
LVPKPNINAK LLLFWRKPAR KCWWGEEDIE LEVEVFGSWK DESKKIIELI
460 470 480
LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL SVIGVQ
Length:486
Mass (Da):55,346
Last modified:November 1, 1997 - v2
Checksum:i105419D6180207F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161F → L in AAA35218 (PubMed:3049245).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21089 Genomic DNA. Translation: AAA35218.1.
Z74951 Genomic DNA. Translation: CAA99234.1.
BK006948 Genomic DNA. Translation: DAA10825.1.
PIRiS66917. COBYW2.
RefSeqiNP_014686.1. NM_001183462.1.

Genome annotation databases

EnsemblFungiiYOR043W; YOR043W; YOR043W.
GeneIDi854208.
KEGGisce:YOR043W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21089 Genomic DNA. Translation: AAA35218.1.
Z74951 Genomic DNA. Translation: CAA99234.1.
BK006948 Genomic DNA. Translation: DAA10825.1.
PIRiS66917. COBYW2.
RefSeqiNP_014686.1. NM_001183462.1.

3D structure databases

ProteinModelPortaliP12611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34444. 232 interactions.
DIPiDIP-2573N.
IntActiP12611. 11 interactions.
MINTiMINT-427278.
STRINGi4932.YOR043W.

Proteomic databases

MaxQBiP12611.
PaxDbiP12611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR043W; YOR043W; YOR043W.
GeneIDi854208.
KEGGisce:YOR043W.

Organism-specific databases

CYGDiYOR043w.
EuPathDBiFungiDB:YOR043W.
SGDiS000005569. WHI2.

Phylogenomic databases

eggNOGiNOG83078.
HOGENOMiHOG000187763.
InParanoidiP12611.
OMAiLIHLNIQ.
OrthoDBiEOG7DNP54.

Enzyme and pathway databases

BioCyciYEAST:G3O-33587-MONOMER.

Miscellaneous databases

NextBioi976056.
PROiP12611.

Family and domain databases

InterProiIPR011333. BTB/POZ_fold.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene."
    Kelly D.E., Trevethick J., Mountain H., Sudbery P.E.
    Gene 66:205-213(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression."
    Kaida D., Yashiroda H., Toh-e A., Kikuchi Y.
    Genes Cells 7:543-552(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PSR1 AND MSN2.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWHI2_YEAST
AccessioniPrimary (citable) accession number: P12611
Secondary accession number(s): D6W2A9, Q08413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.