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P12611

- WHI2_YEAST

UniProt

P12611 - WHI2_YEAST

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Protein
Growth regulation protein
Gene
WHI2, YOR043W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.2 Publications

GO - Molecular functioni

  1. phosphatase activator activity Source: SGD
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. actin filament organization Source: SGD
  2. cell cycle Source: UniProtKB-KW
  3. endocytosis Source: SGD
  4. mitochondrion degradation Source: SGD
  5. positive regulation of catalytic activity Source: GOC
  6. regulation of growth Source: SGD
  7. response to heat Source: UniProtKB
  8. response to salt stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-33587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth regulation protein
Gene namesi
Name:WHI2
Ordered Locus Names:YOR043W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR043w.
SGDiS000005569. WHI2.

Pathology & Biotechi

Disruption phenotypei

Negative mutants fail to enter the G0 phase under conditions of carbon limitation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Growth regulation protein
PRO_0000065967Add
BLAST

Proteomic databases

MaxQBiP12611.
PaxDbiP12611.

Expressioni

Gene expression databases

GenevestigatoriP12611.

Interactioni

Subunit structurei

Interacts with MSN2 and PSR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSR1Q078003EBI-20530,EBI-31129

Protein-protein interaction databases

BioGridi34444. 229 interactions.
DIPiDIP-2573N.
IntActiP12611. 11 interactions.
MINTiMINT-427278.
STRINGi4932.YOR043W.

Structurei

3D structure databases

ProteinModelPortaliP12611.

Family & Domainsi

Sequence similaritiesi

Belongs to the WHI2 family.

Phylogenomic databases

eggNOGiNOG83078.
HOGENOMiHOG000187763.
OMAiLIHLNIQ.
OrthoDBiEOG7DNP54.

Family and domain databases

Gene3Di3.30.710.10. 2 hits.
InterProiIPR011333. BTB/POZ_fold.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P12611-1 [UniParc]FASTAAdd to Basket

« Hide

MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH    50
YFITRDQLMS LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD 100
CFEYIMEIYT KAHDDLYNHP VEKFFDRPSS SFVSNAKGFF GLSSNNSISS 150
NNEQDILHQK PAIIVLREDL DYYCVPQEEF QFDSTNEENN EDLLRHFMAQ 200
VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS SSNTKSTSKK 250
LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN 350
LTSGSTAPAT ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD 400
LVPKPNINAK LLLFWRKPAR KCWWGEEDIE LEVEVFGSWK DESKKIIELI 450
LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL SVIGVQ 486
Length:486
Mass (Da):55,346
Last modified:November 1, 1997 - v2
Checksum:i105419D6180207F2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161F → L in AAA35218. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21089 Genomic DNA. Translation: AAA35218.1.
Z74951 Genomic DNA. Translation: CAA99234.1.
BK006948 Genomic DNA. Translation: DAA10825.1.
PIRiS66917. COBYW2.
RefSeqiNP_014686.1. NM_001183462.1.

Genome annotation databases

EnsemblFungiiYOR043W; YOR043W; YOR043W.
GeneIDi854208.
KEGGisce:YOR043W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21089 Genomic DNA. Translation: AAA35218.1 .
Z74951 Genomic DNA. Translation: CAA99234.1 .
BK006948 Genomic DNA. Translation: DAA10825.1 .
PIRi S66917. COBYW2.
RefSeqi NP_014686.1. NM_001183462.1.

3D structure databases

ProteinModelPortali P12611.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34444. 229 interactions.
DIPi DIP-2573N.
IntActi P12611. 11 interactions.
MINTi MINT-427278.
STRINGi 4932.YOR043W.

Proteomic databases

MaxQBi P12611.
PaxDbi P12611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR043W ; YOR043W ; YOR043W .
GeneIDi 854208.
KEGGi sce:YOR043W.

Organism-specific databases

CYGDi YOR043w.
SGDi S000005569. WHI2.

Phylogenomic databases

eggNOGi NOG83078.
HOGENOMi HOG000187763.
OMAi LIHLNIQ.
OrthoDBi EOG7DNP54.

Enzyme and pathway databases

BioCyci YEAST:G3O-33587-MONOMER.

Miscellaneous databases

NextBioi 976056.

Gene expression databases

Genevestigatori P12611.

Family and domain databases

Gene3Di 3.30.710.10. 2 hits.
InterProi IPR011333. BTB/POZ_fold.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene."
    Kelly D.E., Trevethick J., Mountain H., Sudbery P.E.
    Gene 66:205-213(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression."
    Kaida D., Yashiroda H., Toh-e A., Kikuchi Y.
    Genes Cells 7:543-552(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PSR1 AND MSN2.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWHI2_YEAST
AccessioniPrimary (citable) accession number: P12611
Secondary accession number(s): D6W2A9, Q08413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1800 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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