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P12564 (HN_PI3HV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismHuman parainfluenza 3 virus (strain Tex/12677/83) (HPIV-3)
Taxonomic identifier11221 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Hemagglutinin-neuraminidase
PRO_0000142629

Regions

Topological domain1 – 3131Intravirion Potential
Transmembrane32 – 5221Helical; Potential
Topological domain53 – 572520Virion surface Potential

Amino acid modifications

Glycosylation3081N-linked (GlcNAc...); by host Potential
Glycosylation3511N-linked (GlcNAc...); by host Potential
Glycosylation5231N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P12564 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 57875F74AC568ECD

FASTA57264,330
        10         20         30         40         50         60 
MEYWKHTNHG KDAGNELETS MATHGNKLTN KIIYILWTII LVLLSIVFII VLINSIKSEK 

        70         80         90        100        110        120 
AHESLLRDIN NEFMEITGKI QMASDNTNDL IQSGVNTRLL TIQSHVQNYI PISLTQQMSD 

       130        140        150        160        170        180 
LRKFISEITI RNDNQEVLPQ RITHDVGIKP LNPDDFWRCT SGLPSLMKTP KIRLMPGPGL 

       190        200        210        220        230        240 
LAMPTTDDGC IRTPSLVIND LIYAYTSNLI TRGCQDIGKS YQVLQIGIIT VNSDLVPDLN 

       250        260        270        280        290        300 
PRISHTFNIN DNRKSCSLAL LNTDVYQLCS TPKVDERSDY ASSGIEDIVL DIVNYDGSIS 

       310        320        330        340        350        360 
TTRFKNNNIS FDQPYAALYP SVGPGIYYKG KIIFLGYGGL EHPINENVIC NTTGCPGKTQ 

       370        380        390        400        410        420 
RDCNQASHSP WFSDRRMVNS IIVVDKGLNS TPKLKVWTIS MRQNYWGSEG RLLLLGNKIY 

       430        440        450        460        470        480 
IYTRSTSWHS KLQLGIIDIT DYSDIRIKWT WHNVLSRPGN NECPWGHSCP DGCITGVYTD 

       490        500        510        520        530        540 
AYPLNPTGSI VSSVILDSQK SRVNPVITYS TATERVNELA IRNRTLSAGY TTTSCITHYN 

       550        560        570 
KGYCFHIVEI NHKSLNTFQP MLFKTEIPKS CS 

« Hide

References

[1]"Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983."
van Wyke Coelingh K.L., Winter C.C., Murphy B.R.
Virology 162:137-143(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18764 Genomic RNA. Translation: AAA46851.1.
PIRHNNZ83. F29970.

3D structure databases

ProteinModelPortalP12564.
SMRP12564. Positions 142-572.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_PI3HV
AccessionPrimary (citable) accession number: P12564
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries