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P12558

- HN_NDVU

UniProt

P12558 - HN_NDVU

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiNewcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)
    Taxonomic identifieri11190 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616Hemagglutinin-neuraminidasePRO_0000142618Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FZHX-ray3.50A/B/C/D124-616[»]
    ProteinModelPortaliP12558.
    SMRiP12558. Positions 124-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini48 – 616569Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P12558-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRAVSQVAL ENDEREAKNT WRLVFRIAIL LLTVVTLAIS AAALAYSMEA    50
    STPSDLIGIP TAISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
    STIMNAITSL SYQINGAANS SGCGAPIHDP DYIGGIGKEL IVDDASDVTS 150
    FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS 200
    HSHQYLALGV LRTSATGRVF FSTLHSINLD DTQNRKSCSV SATPLGCDML 250
    CSKVTETEEE DYNSAVPTSM VHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
    GVGGGSFIDN RVWFPVYGGL KPNSPSDTAQ EGKYVIYKRY NDTCPDEQDY 350
    QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
    EGRVLTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFDAFTRP 450
    GSVPCQASAR CPNSCVTGVY TDPYPLVFYR NHTLRGVFGT MLDDKQARLN 500
    PVSAVFDSIS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
    TLFGEFRIVP LLVEILKDDG VREARAGRLS QLREGWKDDI VSPIFCDAKN 600
    QTEYRRELES YAASWP 616
    Length:616
    Mass (Da):67,590
    Last modified:October 1, 1989 - v1
    Checksum:iE70D67796F6DDA36
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741L → H.
    Natural varianti74 – 741L → S.
    Natural varianti259 – 2591E → K.
    Natural varianti438 – 4381L → R.
    Natural varianti495 – 4951K → E.
    Natural varianti555 – 5562EF → GI.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00243 Genomic RNA. Translation: BAA00174.1.
    M19478 Genomic RNA. Translation: AAA46677.1.
    M24707 Genomic RNA. Translation: AAA46657.1.
    PIRiB29823. HNNZU1.
    C46328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00243 Genomic RNA. Translation: BAA00174.1 .
    M19478 Genomic RNA. Translation: AAA46677.1 .
    M24707 Genomic RNA. Translation: AAA46657.1 .
    PIRi B29823. HNNZU1.
    C46328.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FZH X-ray 3.50 A/B/C/D 124-616 [» ]
    ProteinModelPortali P12558.
    SMRi P12558. Positions 124-572.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the fusion and haemagglutinin-neuraminidase glycoprotein genes of Newcastle disease virus, strain Ulster: molecular basis for variations in pathogenicity between strains."
      Millar N.S., Chambers P., Emmerson P.T.
      J. Gen. Virol. 69:613-620(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus."
      Gotoh B., Sakaguchi T., Nishikawa K., Inocencio N.M., Hamaguchi M., Toyoda T., Nagai Y.
      Virology 163:174-182(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
      Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
      Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiHN_NDVU
    AccessioniPrimary (citable) accession number: P12558
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3