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P12557 (HN_NDVM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismNewcastle disease virus (strain Miyadera/51) (NDV)
Taxonomic identifier11185 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Hemagglutinin-neuraminidase
PRO_0000142616

Regions

Topological domain1 – 2626Intravirion Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 571523Virion surface Potential

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...); by host Potential
Glycosylation3411N-linked (GlcNAc...); by host Potential
Glycosylation4331N-linked (GlcNAc...); by host Potential
Glycosylation4811N-linked (GlcNAc...); by host Potential
Glycosylation5081N-linked (GlcNAc...); by host Potential
Glycosylation5381N-linked (GlcNAc...); by host Potential

Experimental info

Sequence conflict1671T → P in AAA46663. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P12557 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: F2891CE5137937D5

FASTA57162,523
        10         20         30         40         50         60 
MDRTVNQVAL ENDEREAKNT WRLVFRIATL LLIVMTLAFS AAALAYSMEA STPGDLVGIP 

        70         80         90        100        110        120 
TAISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE SIIMNAITSL SYQINGAANN 

       130        140        150        160        170        180 
SGCGAPVHDP DYIGGIGKEL IVDDASDVTS FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM 

       190        200        210        220        230        240 
SATHYCYTHN VILSGCRDHS QSHQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV 

       250        260        270        280        290        300 
SATPLGCDML CSKVTETEEE DYNSVTPTSM VHGRLGFDGQ YHEKDLDVTT LFGDWVANYP 

       310        320        330        340        350        360 
GVGGGSFIDS RVWFPIYGGL KPNSPSDTAQ EGRYVIYKRY NDTCPDEQDY QIRMAKSSYK 

       370        380        390        400        410        420 
PRRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA EGRVLTVGTS HFLYQRGSSY 

       430        440        450        460        470        480 
FSPALLYPMT VNNKTATLHS PYTFNAFTRP GSVPCQASAR CPNSCVTGVY TDPYPLVFHA 

       490        500        510        520        530        540 
NHTLRGVFGT MLDDERARLN PVSAVFDNVS RSRITRVSSS STKAAYTTST CFKVVKTNKT 

       550        560        570 
YCLSIAEISN TLFGEFRIVP LLVEILKDDK V 

« Hide

References

[1]"Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus."
Gotoh B., Sakaguchi T., Nishikawa K., Inocencio N.M., Hamaguchi M., Toyoda T., Nagai Y.
Virology 163:174-182(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19479 Genomic RNA. Translation: AAA46674.1.
M24713 Genomic RNA. Translation: AAA46663.1.

3D structure databases

ProteinModelPortalP12557.
SMRP12557. Positions 124-569.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_NDVM
AccessionPrimary (citable) accession number: P12557
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries