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P12556 (HN_NDVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase
EC=3.2.1.18
Gene names
Name:HN
OrganismNewcastle disease virus (strain Italien/45) (NDV)
Taxonomic identifier11182 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Avulavirus ›
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Hemagglutinin-neuraminidase
PRO_0000142612

Regions

Topological domain1 – 2626Intravirion Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 571524Virion surface Potential

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...); by host Potential
Glycosylation3411N-linked (GlcNAc...); by host Potential
Glycosylation4331N-linked (GlcNAc...); by host Potential
Glycosylation4811N-linked (GlcNAc...); by host Potential
Glycosylation5081N-linked (GlcNAc...); by host Potential
Glycosylation5381N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant3 – 42RA → LP.
Natural variant521T → S.
Natural variant751S → G.
Natural variant2161T → A.
Natural variant400 – 4012PE → AD.

Sequences

Sequence LengthMass (Da)Tools
P12556 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: F1ECB12BEF46C00F

FASTA57162,605
        10         20         30         40         50         60 
MDRAVGRVAL ENEEREAKNT WRFVFRIAIF LLIVITLAIS AAALVYSMEA STPGDLVGIP 

        70         80         90        100        110        120 
TVISRAEEKI TSALSSNQDV VDRIYKQVAL ESPLALLNTE SVIMNAITSL SYQINGAANN 

       130        140        150        160        170        180 
SGCGAPVHDP DYIGGIGKEL IVDDASDVTS FYPSAFQEHL NFIPAPTTGS GCTRIPSFDI 

       190        200        210        220        230        240 
SATHYCYTHN VILSGCRDHS HSHQYLALGV LRTSATGRVF FSTLRSINLD DNQNRKSCSV 

       250        260        270        280        290        300 
SATPLGCDML CSKITETEEE DYSSVTPTSM VHGRLGFDGQ YHEKDLDVIT LFKDWVANYP 

       310        320        330        340        350        360 
GVGGGSFIDN RVWFPVYGGL KPNSPSDTAQ EGRYVIYKRY NDTCPDEQDY QIRMAKSSYK 

       370        380        390        400        410        420 
PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGP EGRVLTVGTS HFLYQRGSSY 

       430        440        450        460        470        480 
FSPALLYPMT VNNKTATLHS PYTFNAFTRP GSVPCQASAR CPNSCVTGVY TDPYPLVFHR 

       490        500        510        520        530        540 
NHTLRGVFGT MLDDKQARLN PVSAVFDNIS RSRITRVSSS STKAAYTTST CFKVVKTNKT 

       550        560        570 
YCLSIAEISN TLFGEFRIVP LLVEILKEDG V

« Hide

References

[1]"The hemagglutinin-neuraminidase (HN) gene of Newcastle disease virus strain Italien (NDV Italien): comparison with HNs of other strains and expression by a vaccinia recombinant."
Wemers C.D., de Henau S., Neyt C., Espion D., Letellier C., Meulemans G., Burny A.
Arch. Virol. 97:101-113(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M18640 Genomic RNA. Translation: AAA46671.1.
M24715 Genomic RNA. Translation: AAA46665.1.
PIRB36829. S07126.

3D structure databases

ProteinModelPortalP12556.
SMRP12556. Positions 124-571.
ModBaseSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. Sialidase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_NDVI
AccessionPrimary (citable) accession number: P12556
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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