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P12556

- HN_NDVI

UniProt

P12556 - HN_NDVI

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Newcastle disease virus (strain Italien/45) (NDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Italien/45) (NDV)
Taxonomic identifieri11182 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Intravirion Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 571524Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Hemagglutinin-neuraminidase
PRO_0000142612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi508 – 5081N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP12556.
SMRiP12556. Positions 124-571.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P12556-1 [UniParc]FASTAAdd to Basket

« Hide

MDRAVGRVAL ENEEREAKNT WRFVFRIAIF LLIVITLAIS AAALVYSMEA    50
STPGDLVGIP TVISRAEEKI TSALSSNQDV VDRIYKQVAL ESPLALLNTE 100
SVIMNAITSL SYQINGAANN SGCGAPVHDP DYIGGIGKEL IVDDASDVTS 150
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDI SATHYCYTHN VILSGCRDHS 200
HSHQYLALGV LRTSATGRVF FSTLRSINLD DNQNRKSCSV SATPLGCDML 250
CSKITETEEE DYSSVTPTSM VHGRLGFDGQ YHEKDLDVIT LFKDWVANYP 300
GVGGGSFIDN RVWFPVYGGL KPNSPSDTAQ EGRYVIYKRY NDTCPDEQDY 350
QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGP 400
EGRVLTVGTS HFLYQRGSSY FSPALLYPMT VNNKTATLHS PYTFNAFTRP 450
GSVPCQASAR CPNSCVTGVY TDPYPLVFHR NHTLRGVFGT MLDDKQARLN 500
PVSAVFDNIS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
TLFGEFRIVP LLVEILKEDG V 571
Length:571
Mass (Da):62,605
Last modified:October 1, 1989 - v1
Checksum:iF1ECB12BEF46C00F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 42RA → LP.
Natural varianti52 – 521T → S.
Natural varianti75 – 751S → G.
Natural varianti216 – 2161T → A.
Natural varianti400 – 4012PE → AD.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18640 Genomic RNA. Translation: AAA46671.1.
M24715 Genomic RNA. Translation: AAA46665.1.
PIRiS07126. B36829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18640 Genomic RNA. Translation: AAA46671.1 .
M24715 Genomic RNA. Translation: AAA46665.1 .
PIRi S07126. B36829.

3D structure databases

ProteinModelPortali P12556.
SMRi P12556. Positions 124-571.
ModBasei Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The hemagglutinin-neuraminidase (HN) gene of Newcastle disease virus strain Italien (NDV Italien): comparison with HNs of other strains and expression by a vaccinia recombinant."
    Wemers C.D., de Henau S., Neyt C., Espion D., Letellier C., Meulemans G., Burny A.
    Arch. Virol. 97:101-113(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
    Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
    Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_NDVI
AccessioniPrimary (citable) accession number: P12556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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