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P12555

- HN_NDVD

UniProt

P12555 - HN_NDVD

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Protein

Hemagglutinin-neuraminidase

Gene
HN
Organism
Newcastle disease virus (strain D26/76) (NDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain D26/76) (NDV)
Taxonomic identifieri11180 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Intravirion Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Reviewed predictionAdd
BLAST
Topological domaini48 – 616569Virion surface Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Hemagglutinin-neuraminidasePRO_0000142609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi600 – 6001N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP12555.
SMRiP12555. Positions 124-572.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P12555-1 [UniParc]FASTAAdd to Basket

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MDRAVSQVAL ENDEREAKNT WRLVFRIAIL LLTVVTLAIS AAALAYSMEA    50
STPSDLVGIP TAISRTEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
STIMNAITSL SYQINGAANS SGCGAPIHDP DYIGGIGKEL IVDDASDVTS 150
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDRS 200
HSHQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV SATPLGCDML 250
CSKVTETEEE DYNSAIPTSM VHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
GVGGGSFIDN RVWFPVYGGL KPNSPSDTAQ EGKYVIYKRY NDTCPDEQDY 350
QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
EGRVLTVGTS HFFYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP 450
GSVPCQASAR CPNSCVTGVY TDPYPLVFYR NHTLRGVFGT MLDDEQARLN 500
PVSAVFDSIS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
TLFGEFRIVP LLVEILKDDG VREARSGRLS QLQEGWKDDI VSPIFCDAKN 600
QTEYRRELES YAASWP 616
Length:616
Mass (Da):67,680
Last modified:October 1, 1989 - v1
Checksum:i2FDF7785C5DA62AA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991R → H in AAA46655. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19432 Genomic RNA. Translation: AAA46638.1.
M24705 Genomic RNA. Translation: AAA46655.1.
PIRiA46328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19432 Genomic RNA. Translation: AAA46638.1 .
M24705 Genomic RNA. Translation: AAA46655.1 .
PIRi A46328.

3D structure databases

ProteinModelPortali P12555.
SMRi P12555. Positions 124-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus."
    Gotoh B., Sakaguchi T., Nishikawa K., Inocencio N.M., Hamaguchi M., Toyoda T., Nagai Y.
    Virology 163:174-182(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
    Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
    Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_NDVD
AccessioniPrimary (citable) accession number: P12555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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