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Protein

Cercarial protease

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protease cleaves elastin and thus facilitates penetration of schistosome parasite larvae through elastin-rich tissue of the host.

Enzyme regulationi

Activated by an autocatalytic mechanism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Charge relay systemBy similarity1
Active sitei126Charge relay systemBy similarity1
Active sitei218Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.144.

Names & Taxonomyi

Protein namesi
Recommended name:
Cercarial protease (EC:3.4.21.-)
Alternative name(s):
Cercarial elastase
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002844020 – 27Sequence analysis8
ChainiPRO_000002844128 – 264Cercarial proteaseAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 69PROSITE-ProRule annotation
Disulfide bondi192 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiP12546.

Expressioni

Tissue specificityi

Acetabular (penetration) glands.

Structurei

3D structure databases

ProteinModelPortaliP12546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 264Peptidase S1PROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410YYW0. LUCA.
OrthoDBiEOG091G0DF7.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRWRFVVV VTLFTYCLTF ERVSTWLIRS GEPVQHPAEF PFIAFLTTER
60 70 80 90 100
TMCTGSLVST RAVLTAGHCV CSPLPVIRVS FLTLRNGDQQ GIHHQPSGVK
110 120 130 140 150
VAPGYMPSCM SARQRRPIAQ TLSGFDIAIV MLAQMVNLQS GIRVISLPQP
160 170 180 190 200
SDIPPPGTGV FIVGYGRDDN DRDPSRKNGG ILKKGRATIM ECRHATNGNP
210 220 230 240 250
ICVKAGQNFG QLPAPGDSGG PLLPSLQGPV LGVVSHGVTL PNLPDIIVEY
260
ASVARMLDFV RSNI
Length:264
Mass (Da):28,545
Last modified:October 1, 1989 - v1
Checksum:iE2E5129A7C5D5010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03946 mRNA. Translation: AAA29864.1.
PIRiA28942.

Genome annotation databases

GeneDBiSmp_119130.1:pep.
Smp_185190.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03946 mRNA. Translation: AAA29864.1.
PIRiA28942.

3D structure databases

ProteinModelPortaliP12546.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.144.

Proteomic databases

PRIDEiP12546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiSmp_119130.1:pep.
Smp_185190.1:pep.

Phylogenomic databases

eggNOGiENOG410YYW0. LUCA.
OrthoDBiEOG091G0DF7.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERC_SCHMA
AccessioniPrimary (citable) accession number: P12546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.