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P12546

- CERC_SCHMA

UniProt

P12546 - CERC_SCHMA

Protein

Cercarial protease

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    • Comment

    Functioni

    This protease cleaves elastin and thus facilitates penetration of schistosome parasite larvae through elastin-rich tissue of the host.

    Enzyme regulationi

    Activated by an autocatalytic mechanism.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Charge relay systemBy similarity
    Active sitei126 – 1261Charge relay systemBy similarity
    Active sitei218 – 2181Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.144.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cercarial protease (EC:3.4.21.-)
    Alternative name(s):
    Cercarial elastase
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 278Sequence AnalysisPRO_0000028440
    Chaini28 – 264237Cercarial proteasePRO_0000028441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 69PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 202PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Expressioni

    Tissue specificityi

    Acetabular (penetration) glands.

    Structurei

    3D structure databases

    ProteinModelPortaliP12546.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 264237Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12546-1 [UniParc]FASTAAdd to Basket

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    MSNRWRFVVV VTLFTYCLTF ERVSTWLIRS GEPVQHPAEF PFIAFLTTER    50
    TMCTGSLVST RAVLTAGHCV CSPLPVIRVS FLTLRNGDQQ GIHHQPSGVK 100
    VAPGYMPSCM SARQRRPIAQ TLSGFDIAIV MLAQMVNLQS GIRVISLPQP 150
    SDIPPPGTGV FIVGYGRDDN DRDPSRKNGG ILKKGRATIM ECRHATNGNP 200
    ICVKAGQNFG QLPAPGDSGG PLLPSLQGPV LGVVSHGVTL PNLPDIIVEY 250
    ASVARMLDFV RSNI 264
    Length:264
    Mass (Da):28,545
    Last modified:October 1, 1989 - v1
    Checksum:iE2E5129A7C5D5010
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03946 mRNA. Translation: AAA29864.1.
    PIRiA28942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03946 mRNA. Translation: AAA29864.1 .
    PIRi A28942.

    3D structure databases

    ProteinModelPortali P12546.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.144.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the proteinase that facilitates infection by schistosome parasites."
      Newport G.R., McKerrow J.H., Hedstrom R., Petitt M., McGarrigle L., Barr P.J., Agabian N.
      J. Biol. Chem. 263:13179-13184(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCERC_SCHMA
    AccessioniPrimary (citable) accession number: P12546
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3