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P12546

- CERC_SCHMA

UniProt

P12546 - CERC_SCHMA

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Protein

Cercarial protease

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This protease cleaves elastin and thus facilitates penetration of schistosome parasite larvae through elastin-rich tissue of the host.

Enzyme regulationi

Activated by an autocatalytic mechanism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Charge relay systemBy similarity
Active sitei126 – 1261Charge relay systemBy similarity
Active sitei218 – 2181Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.144.

Names & Taxonomyi

Protein namesi
Recommended name:
Cercarial protease (EC:3.4.21.-)
Alternative name(s):
Cercarial elastase
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 278Sequence AnalysisPRO_0000028440
Chaini28 – 264237Cercarial proteasePRO_0000028441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 69PROSITE-ProRule annotation
Disulfide bondi192 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Tissue specificityi

Acetabular (penetration) glands.

Structurei

3D structure databases

ProteinModelPortaliP12546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 264237Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12546-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSNRWRFVVV VTLFTYCLTF ERVSTWLIRS GEPVQHPAEF PFIAFLTTER
60 70 80 90 100
TMCTGSLVST RAVLTAGHCV CSPLPVIRVS FLTLRNGDQQ GIHHQPSGVK
110 120 130 140 150
VAPGYMPSCM SARQRRPIAQ TLSGFDIAIV MLAQMVNLQS GIRVISLPQP
160 170 180 190 200
SDIPPPGTGV FIVGYGRDDN DRDPSRKNGG ILKKGRATIM ECRHATNGNP
210 220 230 240 250
ICVKAGQNFG QLPAPGDSGG PLLPSLQGPV LGVVSHGVTL PNLPDIIVEY
260
ASVARMLDFV RSNI
Length:264
Mass (Da):28,545
Last modified:October 1, 1989 - v1
Checksum:iE2E5129A7C5D5010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03946 mRNA. Translation: AAA29864.1.
PIRiA28942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03946 mRNA. Translation: AAA29864.1 .
PIRi A28942.

3D structure databases

ProteinModelPortali P12546.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.144.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the proteinase that facilitates infection by schistosome parasites."
    Newport G.R., McKerrow J.H., Hedstrom R., Petitt M., McGarrigle L., Barr P.J., Agabian N.
    J. Biol. Chem. 263:13179-13184(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCERC_SCHMA
AccessioniPrimary (citable) accession number: P12546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3