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P12546 (CERC_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cercarial protease

EC=3.4.21.-
Alternative name(s):
Cercarial elastase
OrganismSchistosoma mansoni (Blood fluke)
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protease cleaves elastin and thus facilitates penetration of schistosome parasite larvae through elastin-rich tissue of the host.

Enzyme regulation

Activated by an autocatalytic mechanism.

Tissue specificity

Acetabular (penetration) glands.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 278 Potential
PRO_0000028440
Chain28 – 264237Cercarial protease
PRO_0000028441

Regions

Domain28 – 264237Peptidase S1

Sites

Active site681Charge relay system By similarity
Active site1261Charge relay system By similarity
Active site2181Charge relay system By similarity

Amino acid modifications

Disulfide bond53 ↔ 69 By similarity
Disulfide bond192 ↔ 202 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12546 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: E2E5129A7C5D5010

FASTA26428,545
        10         20         30         40         50         60 
MSNRWRFVVV VTLFTYCLTF ERVSTWLIRS GEPVQHPAEF PFIAFLTTER TMCTGSLVST 

        70         80         90        100        110        120 
RAVLTAGHCV CSPLPVIRVS FLTLRNGDQQ GIHHQPSGVK VAPGYMPSCM SARQRRPIAQ 

       130        140        150        160        170        180 
TLSGFDIAIV MLAQMVNLQS GIRVISLPQP SDIPPPGTGV FIVGYGRDDN DRDPSRKNGG 

       190        200        210        220        230        240 
ILKKGRATIM ECRHATNGNP ICVKAGQNFG QLPAPGDSGG PLLPSLQGPV LGVVSHGVTL 

       250        260 
PNLPDIIVEY ASVARMLDFV RSNI 

« Hide

References

[1]"Cloning of the proteinase that facilitates infection by schistosome parasites."
Newport G.R., McKerrow J.H., Hedstrom R., Petitt M., McGarrigle L., Barr P.J., Agabian N.
J. Biol. Chem. 263:13179-13184(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03946 mRNA. Translation: AAA29864.1.
PIRA28942.

3D structure databases

ProteinModelPortalP12546.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCERC_SCHMA
AccessionPrimary (citable) accession number: P12546
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries