Reviewed, UniProtKB/Swiss-Prot P12541 (TERM_ADE12)

Names and origin

Protein names

Recommended name:
    DNA terminal protein
Alternative name(s):
    Bellett protein
    pTP protein

Gene names

Name:

PTP

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	606 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein is covalently attached to the termini of replicating DNA in vivo and nascent DNA synthesized in vitro and may play some role in DNA replication.
Sequence similarities	Belongs to the adenoviridae terminal protein family.

Ontologies

Keywords
Biological process	DNA replication
PTM	Covalent protein-DNA linkage Phosphoprotein
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW protein-DNA covalent cross-linking Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 606	606	DNA terminal protein		PRO_0000221896
Amino acid modifications
	Modified residue	515	1	O-(5'-phospho-DNA)-serine By similarity
Experimental info
	Sequence conflict	248	1	L → F in AAA42480. Ref.2
	Sequence conflict	405 – 406	2	EL → DV in AAA42480. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P12541-1 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: A62C0E78DFD11A1C	FASTA	606	69,447
	10 20 30 40 50 60 MRATTTAAGI TWMSRYIYEY HRLMLEDLAP GAAATLGWPL YREPPPHFLV GYQYLVRTCN 70 80 90 100 110 120 DYVFDSRAYS RLRYTETVQP GTQTVNWSVM TNCSYTINAG AYHRFVDVDD FATTLTQIQQ 130 140 150 160 170 180 AVLAERVVAD LALLQPLQGY GSTHMADRGN REVEVERLMQ DYYKDLGRCQ SDVWGMADRL 190 200 210 220 230 240 RIQQAGPKDV VLLKTIRGLK TAYFNYIISS IAQLPGTLEE TKLSLPCDCD WLDAFLERFS 250 260 270 280 290 300 DPVDMQTLSS LRGVPTQQII KCIISAVSLP NAPRNASFPI LHETELRGGV FELRPRENGR 310 320 330 340 350 360 AVTETMRRRR GEMIERFVDR LPVRRRRRRQ PPPPVVEEEI MEVEEEEQEI VPGAFQQEVR 370 380 390 400 410 420 ETVAELIRLL EEELTVAARN SQFFNFAVDF YEAMERLEAL GDINELTLRR WILYFFVSEH 430 440 450 460 470 480 VATTLNYLFQ RLRNYGVFAR LVELNLAQVV MRARDSEGGV VYSRVWNEIG LNAFSQLMSR 490 500 510 520 530 540 ISNDLAATIE RAGHGDLQEE EIDQLMAEIA YQDNSGDVQE ILRQAAVNDT EIDSVELSFR 550 560 570 580 590 600 FKTTGPVVFT QRRQIQDINR RVVAHASQLR AQHLPLPERQ ADIPLPPLPA GPEPPLPPGA RPRRRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 12." Shu L., Hong J.S., Wei Y.-F., Engler J.A. Gene 46:187-195(1986) [PubMed: 3803925] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X73487 Genomic DNA. Translation: CAA51884.1. M14785 Genomic DNA. Translation: AAA42480.1. Different initiation.
PIR	UZAD12. B25770.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR003391. Adeno_terminal. [Graphical view]
Pfam	PF02459. Adeno_terminal. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TERM_ADE12

Accession

Primary (citable) accession number: P12541

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	June 1, 1994
Last modified:	July 28, 2009
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)