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P12538 (PEN3_ADE05) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Penton protein
Alternative name(s):
Penton base protein
Virion component III
pIII
Gene names
Name:PIII
OrganismHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Taxonomic identifier28285 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in virus clathrin-mediated internalization through the binding to host integrin heterodimer alphaV-beta5 (ITGAV-ITGB5). In primary receptor (CXADR)-negative cells, also mediates virus attachment to host cell. Ref.3

Subunit structure

Interacts with host WWP1 and WWP2. Interacts (via cell attachment site RGD) with host heterodimer ITGAV-ITGB5.

Sequence similarities

Belongs to the adenoviridae pIII family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Penton protein
PRO_0000221873

Secondary structure

1 ................................... 571
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P12538 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 89D77207F2786802

FASTA57163,293
        10         20         30         40         50         60 
MRRAAMYEEG PPPSYESVVS AAPVAAALGS PFDAPLDPPF VPPRYLRPTG GRNSIRYSEL 

        70         80         90        100        110        120 
APLFDTTRVY LVDNKSTDVA SLNYQNDHSN FLTTVIQNND YSPGEASTQT INLDDRSHWG 

       130        140        150        160        170        180 
GDLKTILHTN MPNVNEFMFT NKFKARVMVS RLPTKDNQVE LKYEWVEFTL PEGNYSETMT 

       190        200        210        220        230        240 
IDLMNNAIVE HYLKVGRQNG VLESDIGVKF DTRNFRLGFD PVTGLVMPGV YTNEAFHPDI 

       250        260        270        280        290        300 
ILLPGCGVDF THSRLSNLLG IRKRQPFQEG FRITYDDLEG GNIPALLDVD AYQASLKDDT 

       310        320        330        340        350        360 
EQGGGGAGGS NSSGSGAEEN SNAAAAAMQP VEDMNDHAIR GDTFATRAEE KRAEAEAAAE 

       370        380        390        400        410        420 
AAAPAAQPEV EKPQKKPVIK PLTEDSKKRS YNLISNDSTF TQYRSWYLAY NYGDPQTGIR 

       430        440        450        460        470        480 
SWTLLCTPDV TCGSEQVYWS LPDMMQDPVT FRSTRQISNF PVVGAELLPV HSKSFYNDQA 

       490        500        510        520        530        540 
VYSQLIRQFT SLTHVFNRFP ENQILARPPA PTITTVSENV PALTDHGTLP LRNSIGGVQR 

       550        560        570 
VTITDARRRT CPYVYKALGI VSPRVLSSRT F

« Hide

References

« Hide 'large scale' references
[1]"Determination of the nucleotide sequence for the penton-base gene of human adenovirus type 5."
Neumann R., Chroboczek J., Jacrot B.
Gene 69:153-157(1988) [PubMed: 3224820] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2."
Chroboczek J., Bieber F., Jacrot B.
Virology 186:280-285(1992) [PubMed: 1727603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells."
Lyle C., McCormick F.
Virol. J. 7:148-148(2010) [PubMed: 20615244] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M73260 Genomic DNA. No translation available.
M22141 Genomic DNA. Translation: AAA42519.1.
PIRXZADH5. JT0337.
RefSeqAP_000206.1. AC_000008.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VSZX-ray3.50N1-571[»]
3IYNelectron microscopy-M1-571[»]
3IZOelectron microscopy-A/B/C/D/E1-571[»]
ProteinModelPortalP12538.
SMRP12538. Positions 49-569.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002605. Adeno_Penton_B.
[Graphical view]
PfamPF01686. Adeno_Penton_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePEN3_ADE05
AccessionPrimary (citable) accession number: P12538
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 31, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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