Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proto-oncogene Mas

Gene

Mas1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity).By similarity

GO - Molecular functioni

  • angiotensin receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: Ensembl
  • cellular response to peptide hormone stimulus Source: RGD
  • hippocampus development Source: RGD
  • male gonad development Source: RGD
  • negative regulation of protein phosphorylation Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of inositol phosphate biosynthetic process Source: RGD
  • protein kinase C signaling Source: Ensembl
  • regulation of inflammatory response Source: Ensembl
  • response to activity Source: RGD
  • response to drug Source: RGD
  • response to gonadotropin Source: RGD
  • response to peptide hormone Source: RGD
  • spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Mas
Gene namesi
Name:Mas1
Synonyms:Mas, Mas-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3049. Mas1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 60Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini61 – 64CytoplasmicSequence analysis4
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 103ExtracellularSequence analysisAdd BLAST17
Transmembranei104 – 127Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini128 – 148CytoplasmicSequence analysisAdd BLAST21
Transmembranei149 – 171Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini172 – 184ExtracellularSequence analysisAdd BLAST13
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 223CytoplasmicSequence analysisAdd BLAST18
Transmembranei224 – 244Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini245 – 262ExtracellularSequence analysisAdd BLAST18
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 324CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

GuidetoPHARMACOLOGYi150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697161 – 324Proto-oncogene MasAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12526.
PRIDEiP12526.

PTM databases

PhosphoSitePlusiP12526.

Expressioni

Tissue specificityi

Expressed in platelets.1 Publication

Gene expression databases

BgeeiENSRNOG00000014971.
ExpressionAtlasiP12526. baseline and differential.
GenevisibleiP12526. RN.

Interactioni

Subunit structurei

Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020100.

Structurei

3D structure databases

ProteinModelPortaliP12526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZP. Eukaryota.
ENOG410YK5N. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP12526.
KOiK04303.
OMAiGYYYTIV.
OrthoDBiEOG091G0BGC.
PhylomeDBiP12526.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNMTSFA EEKAMNTSSR NASLGTSHPP IPIVHWVIMS ISPLGFVENG
60 70 80 90 100
ILLWFLCFRM RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH
110 120 130 140 150
YYTIVTLSVT FLFGYNTGLY LLTAISVERC LSVLYPIWYR CHRPKHQSAF
160 170 180 190 200
VCALLWALSC LVTTMEYVMC IDSGEESHSQ SDCRAVIIFI AILSFLVFTP
210 220 230 240 250
LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA MPMRVLYLLY
260 270 280 290 300
YEYWSTFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR
310 320
AFKDEMQPRR QEGNGNTVSI ETVV
Length:324
Mass (Da):37,131
Last modified:October 1, 1989 - v1
Checksum:iAD810229BF1E7D36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03823 Genomic DNA. Translation: AAA41573.1.
BC078884 mRNA. Translation: AAH78884.1.
PIRiA31816. TVRTAS.
RefSeqiNP_036889.1. NM_012757.2.
XP_006227922.1. XM_006227860.3.
XP_017444296.1. XM_017588807.1.
XP_017444297.1. XM_017588808.1.
UniGeneiRn.21943.

Genome annotation databases

EnsembliENSRNOT00000020100; ENSRNOP00000020100; ENSRNOG00000014971.
GeneIDi25153.
KEGGirno:25153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03823 Genomic DNA. Translation: AAA41573.1.
BC078884 mRNA. Translation: AAH78884.1.
PIRiA31816. TVRTAS.
RefSeqiNP_036889.1. NM_012757.2.
XP_006227922.1. XM_006227860.3.
XP_017444296.1. XM_017588807.1.
XP_017444297.1. XM_017588808.1.
UniGeneiRn.21943.

3D structure databases

ProteinModelPortaliP12526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020100.

Chemistry databases

GuidetoPHARMACOLOGYi150.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP12526.

Proteomic databases

PaxDbiP12526.
PRIDEiP12526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020100; ENSRNOP00000020100; ENSRNOG00000014971.
GeneIDi25153.
KEGGirno:25153.

Organism-specific databases

CTDi4142.
RGDi3049. Mas1.

Phylogenomic databases

eggNOGiENOG410IFZP. Eukaryota.
ENOG410YK5N. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP12526.
KOiK04303.
OMAiGYYYTIV.
OrthoDBiEOG091G0BGC.
PhylomeDBiP12526.
TreeFamiTF336336.

Miscellaneous databases

PROiP12526.

Gene expression databases

BgeeiENSRNOG00000014971.
ExpressionAtlasiP12526. baseline and differential.
GenevisibleiP12526. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAS_RAT
AccessioniPrimary (citable) accession number: P12526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.