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Reviewed, UniProtKB/Swiss-Prot P12526 (MAS_RAT)

Last modified July 13, 2010. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Proto-oncogene Mas
Gene names
Name:Mas1
Synonyms:Mas, Mas-1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
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Protein attributesHide

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.
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General annotation (Comments)Hide

Function

Receptor for angiotensin 1-7 By similarity. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 By similarity.

Subunit structure

Interacts with AGTR1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in platelets. Ref.3

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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OntologiesHide

Keywords
   Cellular componentCell membrane
Membrane
   DiseaseProto-oncogene
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to peptide hormone stimulus

Inferred from expression pattern. Source: RGD

hippocampus development

Inferred from expression pattern. Source: RGD

male gonad development

Inferred from expression pattern. Source: RGD

negative regulation of protein amino acid phosphorylation

Inferred from mutant phenotype. Source: RGD

positive regulation of DNA replication

Inferred from direct assay. Source: RGD

positive regulation of cell proliferation

Inferred from direct assay. Source: RGD

positive regulation of inositol phosphate biosynthetic process

Inferred from direct assay. Source: RGD

response to activity

Inferred from expression pattern. Source: RGD

response to drug

Inferred from expression pattern. Source: RGD

response to gonadotropin stimulus

Inferred from expression pattern. Source: RGD

spermatogenesis

Inferred from mutant phenotype. Source: RGD

   Cellular componentcell surface

Inferred from direct assay. Source: RGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionangiotensin receptor activity

Inferred from mutant phenotype. Source: RGD

peptide hormone binding

Inferred from mutant phenotype. Source: RGD

Complete GO annotation...
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Proto-oncogene Mas
PRO_0000069716

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6025Helical; Name=1; Potential
Topological domain61 – 644Cytoplasmic Potential
Transmembrane65 – 8622Helical; Name=2; Potential
Topological domain87 – 10317Extracellular Potential
Transmembrane104 – 12724Helical; Name=3; Potential
Topological domain128 – 14821Cytoplasmic Potential
Transmembrane149 – 17123Helical; Name=4; Potential
Topological domain172 – 18413Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 22318Cytoplasmic Potential
Transmembrane224 – 24421Helical; Name=6; Potential
Topological domain245 – 26218Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 32441Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
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SequencesHide

Sequence LengthMass (Da)Tools
P12526-1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: AD810229BF1E7D36

FASTA32437,131
        10         20         30         40         50         60 
MDQSNMTSFA EEKAMNTSSR NASLGTSHPP IPIVHWVIMS ISPLGFVENG ILLWFLCFRM 

        70         80         90        100        110        120 
RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH YYTIVTLSVT FLFGYNTGLY 

       130        140        150        160        170        180 
LLTAISVERC LSVLYPIWYR CHRPKHQSAF VCALLWALSC LVTTMEYVMC IDSGEESHSQ 

       190        200        210        220        230        240 
SDCRAVIIFI AILSFLVFTP LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA 

       250        260        270        280        290        300 
MPMRVLYLLY YEYWSTFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR 

       310        320 
AFKDEMQPRR QEGNGNTVSI ETVV

« Hide

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ReferencesHide

« Hide 'large scale' references
[1]"Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain."
Young D., O'Neill K., Jessell T., Wigler M.
Proc. Natl. Acad. Sci. U.S.A. 85:5339-5342(1988) [PubMed: 2455902] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets."
Fraga-Silva R.A., Pinheiro S.V.B., Goncalves A.C., Alenina N., Bader M., Santos R.A.S.
Mol. Med. 14:28-35(2008) [PubMed: 18026570] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ		J03823 Genomic DNA. Translation: AAA41573.1.
BC078884 mRNA. Translation: AAH78884.1.
IPIIPI00198560.
PIRTVRTAS. A31816.
RefSeqNP_036889.1.
UniGeneRn.21943

3D structure databases

SMRP12526. Positions 34-312.
ModBaseSearch...

Protein-protein interaction databases

STRINGP12526.

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSRNOT00000020100; ENSRNOP00000020100; ENSRNOG00000014971; Rattus norvegicus. [Genome view]
GeneID25153.
KEGGrno:25153.
UCSCNM_012757. rat.

Organism-specific databases

CTD25153.
RGD3049. Mas1.

Phylogenomic databases

eggNOGroNOG14620.
HOVERGENHBG098384.
InParanoidP12526.
OMAKKKRFKE.
OrthoDBEOG92C0TX.
PhylomeDBP12526.

Gene expression databases

ArrayExpressP12526.
GenevestigatorP12526.
GermOnlineENSRNOG00000014971. Rattus norvegicus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR000820. Mas_TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio605603.
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Entry informationHide

Entry nameMAS_RAT
AccessionPrimary (citable) accession number: P12526
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 13, 2010
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
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Relevant documentsHide

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents