ID MYCL_HUMAN Reviewed; 364 AA. AC P12524; A2A2C9; B4DJH2; Q14897; Q5QPL0; Q5QPL1; Q9NUE9; DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot. DT 02-NOV-2010, sequence version 2. DT 24-JAN-2024, entry version 204. DE RecName: Full=Protein L-Myc; DE AltName: Full=Class E basic helix-loop-helix protein 38; DE Short=bHLHe38; DE AltName: Full=Protein L-Myc-1; DE AltName: Full=V-myc myelocytomatosis viral oncogene homolog; GN Name=MYCL; Synonyms=BHLHE38, LMYC, MYCL1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-362. RC TISSUE=Placenta; RX PubMed=3322939; DOI=10.1101/gad.1.10.1311; RA DePinho R.A., Hatton K.S., Tesfaye A., Yancopoulos G.D., Alt F.W.; RT "The human myc gene family: structure and activity of L-myc and an L-myc RT pseudogene."; RL Genes Dev. 1:1311-1326(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANT RP SER-362. RC TISSUE=Placenta; RX PubMed=2827002; DOI=10.1128/mcb.8.1.186-195.1988; RA Kaye F., Battey J., Nau M., Brooks B., Seifter E., de Greve J., Birrer M., RA Sausville E., Minna J.; RT "Structure and expression of the human L-myc gene reveal a complex pattern RT of alternative mRNA processing."; RL Mol. Cell. Biol. 8:186-195(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT SER-362. RC TISSUE=Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-362. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 165-179 (ISOFORM 1), AND SUBCELLULAR LOCATION. RX PubMed=2548855; DOI=10.1002/j.1460-2075.1989.tb03573.x; RA Ikegaki N., Minna J., Kennett R.H.; RT "The human L-myc gene is expressed as two forms of protein in small cell RT lung carcinoma cell lines: detection by monoclonal antibodies specific to RT two myc homology box sequences."; RL EMBO J. 8:1793-1799(1989). CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH CC protein. Binds DNA as a heterodimer with MAX. CC -!- INTERACTION: CC P12524-2; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-18936665, EBI-744545; CC P12524-2; O75909-2: CCNK; NbExp=3; IntAct=EBI-18936665, EBI-12010594; CC P12524-2; Q7L8S5: OTUD6A; NbExp=3; IntAct=EBI-18936665, EBI-11960139; CC P12524-2; P54646: PRKAA2; NbExp=3; IntAct=EBI-18936665, EBI-1383852; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, CC ECO:0000269|PubMed:2548855}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P12524-1; Sequence=Displayed; CC Name=2; Synonyms=Short; CC IsoId=P12524-2; Sequence=VSP_053766, VSP_015539, VSP_015540; CC Name=3; CC IsoId=P12524-3; Sequence=VSP_053766; CC -!- SEQUENCE CAUTION: CC Sequence=AAH11864.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAA30248.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07262; CAA30248.1; ALT_SEQ; Genomic_DNA. DR EMBL; X07263; CAA30249.1; -; Genomic_DNA. DR EMBL; M19720; AAA59879.1; -; Genomic_DNA. DR EMBL; M19720; AAA59878.1; -; Genomic_DNA. DR EMBL; AK296078; BAG58834.1; -; mRNA. DR EMBL; AL033527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471059; EAX07251.1; -; Genomic_DNA. DR EMBL; BC011864; AAH11864.1; ALT_INIT; mRNA. DR CCDS; CCDS30682.1; -. [P12524-1] DR CCDS; CCDS44117.2; -. [P12524-2] DR CCDS; CCDS53300.1; -. [P12524-3] DR PIR; A27675; TVHUML. DR RefSeq; NP_001028253.1; NM_001033081.2. [P12524-1] DR RefSeq; NP_001028254.2; NM_001033082.2. [P12524-3] DR RefSeq; NP_005367.2; NM_005376.4. [P12524-2] DR AlphaFoldDB; P12524; -. DR SMR; P12524; -. DR BioGRID; 110695; 47. DR ComplexPortal; CPX-2548; MYCL-MAX transcriptional activator complex. DR IntAct; P12524; 44. DR STRING; 9606.ENSP00000380494; -. DR iPTMnet; P12524; -. DR PhosphoSitePlus; P12524; -. DR BioMuta; MYCL; -. DR DMDM; 311033401; -. DR MassIVE; P12524; -. DR PaxDb; 9606-ENSP00000380494; -. DR PeptideAtlas; P12524; -. DR ProteomicsDB; 52853; -. [P12524-1] DR Antibodypedia; 17920; 184 antibodies from 27 providers. DR DNASU; 4610; -. DR Ensembl; ENST00000372815.1; ENSP00000361902.1; ENSG00000116990.12. [P12524-2] DR Ensembl; ENST00000372816.3; ENSP00000361903.2; ENSG00000116990.12. [P12524-1] DR Ensembl; ENST00000397332.3; ENSP00000380494.2; ENSG00000116990.12. [P12524-3] DR GeneID; 4610; -. DR KEGG; hsa:4610; -. DR MANE-Select; ENST00000372816.3; ENSP00000361903.2; NM_001033081.3; NP_001028253.1. DR UCSC; uc001cer.3; human. [P12524-1] DR AGR; HGNC:7555; -. DR CTD; 4610; -. DR DisGeNET; 4610; -. DR GeneCards; MYCL; -. DR HGNC; HGNC:7555; MYCL. DR HPA; ENSG00000116990; Tissue enhanced (pancreas, skin). DR MIM; 164850; gene. DR neXtProt; NX_P12524; -. DR OpenTargets; ENSG00000116990; -. DR PharmGKB; PA31355; -. DR VEuPathDB; HostDB:ENSG00000116990; -. DR eggNOG; ENOG502QWSU; Eukaryota. DR GeneTree; ENSGT00940000158613; -. DR HOGENOM; CLU_052560_0_0_1; -. DR InParanoid; P12524; -. DR OMA; ATQSCHP; -. DR OrthoDB; 3039999at2759; -. DR PhylomeDB; P12524; -. DR TreeFam; TF106001; -. DR PathwayCommons; P12524; -. DR SignaLink; P12524; -. DR SIGNOR; P12524; -. DR BioGRID-ORCS; 4610; 16 hits in 1176 CRISPR screens. DR ChiTaRS; MYCL; human. DR GeneWiki; MYCL1; -. DR GenomeRNAi; 4610; -. DR Pharos; P12524; Tbio. DR PRO; PR:P12524; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; P12524; Protein. DR Bgee; ENSG00000116990; Expressed in monocyte and 141 other cell types or tissues. DR ExpressionAtlas; P12524; baseline and differential. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005694; C:chromosome; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0003677; F:DNA binding; TAS:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0045607; P:regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd11457; bHLHzip_L-Myc; 1. DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR InterPro; IPR002418; Tscrpt_reg_Myc. DR InterPro; IPR012682; Tscrpt_reg_Myc_N. DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1. DR PANTHER; PTHR45851:SF5; PROTEIN L-MYC-RELATED; 1. DR Pfam; PF00010; HLH; 1. DR Pfam; PF01056; Myc_N; 3. DR PIRSF; PIRSF001705; Myc_protein; 1. DR PRINTS; PR00044; LEUZIPPRMYC. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1. DR PROSITE; PS50888; BHLH; 1. DR Genevisible; P12524; HS. PE 1: Evidence at protein level; KW Alternative splicing; Direct protein sequencing; DNA-binding; Nucleus; KW Reference proteome. FT CHAIN 1..364 FT /note="Protein L-Myc" FT /id="PRO_0000127333" FT DOMAIN 281..333 FT /note="bHLH" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981" FT REGION 41..81 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 111..172 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 219..285 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 333..361 FT /note="Leucine-zipper" FT COMPBIAS 41..63 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 242..257 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1 FT /note="M -> MCVCAGCRAAPSRRGAGPLQVAGGWSEGADM (in isoform 2 FT and isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_053766" FT VAR_SEQ 166..206 FT /note="ENEEIDVVTVEKRQSLGIRKPVTITVRADPLDPCMKHFHIS -> GKDLPEP FT SKRGPPHGWPKLCPCLRSGIGSSQALGPSPPLFG (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_015539" FT VAR_SEQ 207..364 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_015540" FT VARIANT 362 FT /note="T -> S (in dbSNP:rs3134614)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:2827002, ECO:0000269|PubMed:3322939, FT ECO:0000269|Ref.5" FT /id="VAR_027802" SQ SEQUENCE 364 AA; 40327 MW; 58F8A30A1C2ED6D4 CRC64; MDYDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGLGPG AGDPAPGIGP PEPWPGGCTG DEAESRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAPGAPRG NPPKASAAPD CTPSLEAGNP APAAPCPLGE PKTQACSGSE SPSDSENEEI DVVTVEKRQS LGIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEEASE RGPQEEVLER DAAGEKEDEE DEEIVSPPPV ESEAAQSCHP KPVSSDTEDV TKRKNHNFLE RKRRNDLRSR FLALRDQVPT LASCSKAPKV VILSKALEYL QALVGAEKRM ATEKRQLRCR QQQLQKRIAY LTGY //