P12524 (MYCL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein L-Myc-1

Alternative name(s):
Class E basic helix-loop-helix protein 38
Short name=bHLHe38

Gene names

Name:	MYCL1
Synonyms:	BHLHE38, LMYC, MYCL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
Subcellular location	Nucleus Ref.5.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.
Sequence caution	The sequence CAA30248.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI19408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement Ref.1. Source: UniProtKB sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P12524-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P12524-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     166-206: ENEEIDVVTV...DPCMKHFHIS → GKDLPEPSKR...ALGPSPPLFG
     207-364: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Protein L-Myc-1		PRO_0000127333
Regions
	Domain	281 – 333	53	bHLH
	Region	333 – 361	29	Leucine-zipper
Amino acid modifications
	Modified residue	310	1	Phosphothreonine By similarity
	Modified residue	313	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	166 – 206	41	ENEEI…HFHIS → GKDLPEPSKRGPPHGWPKLC PCLRSGIGSSQALGPSPPLF G in isoform 2.		VSP_015539
	Alternative sequence	207 – 364	158	Missing in isoform 2.		VSP_015540
	Natural variant	362	1	T → S. Ref.1 Ref.2 Corresponds to variant rs3134614 [ dbSNP | Ensembl ].		VAR_027802

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 58F8A30A1C2ED6D4	FASTA	364	40,327
	10 20 30 40 50 60 MDYDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGLGPG AGDPAPGIGP 70 80 90 100 110 120 PEPWPGGCTG DEAESRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAPGAPRG 130 140 150 160 170 180 NPPKASAAPD CTPSLEAGNP APAAPCPLGE PKTQACSGSE SPSDSENEEI DVVTVEKRQS 190 200 210 220 230 240 LGIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEEASE RGPQEEVLER 250 260 270 280 290 300 DAAGEKEDEE DEEIVSPPPV ESEAAQSCHP KPVSSDTEDV TKRKNHNFLE RKRRNDLRSR 310 320 330 340 350 360 FLALRDQVPT LASCSKAPKV VILSKALEYL QALVGAEKRM ATEKRQLRCR QQQLQKRIAY LTGY
	Isoform 2 (Short) [UniParc]. Checksum: 585C9CD6C9A8EC71	FASTA	206	21,766
	10 20 30 40 50 60 MDYDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGLGPG AGDPAPGIGP 70 80 90 100 110 120 PEPWPGGCTG DEAESRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAPGAPRG 130 140 150 160 170 180 NPPKASAAPD CTPSLEAGNP APAAPCPLGE PKTQACSGSE SPSDSGKDLP EPSKRGPPHG 190 200 WPKLCPCLRS GIGSSQALGP SPPLFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human myc gene family: structure and activity of L-myc and an L-myc pseudogene." DePinho R.A., Hatton K.S., Tesfaye A., Yancopoulos G.D., Alt F.W. Genes Dev. 1:1311-1326(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-362. Tissue: Placenta.
[2]	"Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing." Kaye F., Battey J., Nau M., Brooks B., Seifter E., de Greve J., Birrer M., Sausville E., Minna J. Mol. Cell. Biol. 8:186-195(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT SER-362. Tissue: Placenta.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[5]	"The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences." Ikegaki N., Minna J., Kennett R.H. EMBO J. 8:1793-1799(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 165-179 (ISOFORM 1), SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07262 Genomic DNA. Translation: CAA30248.1. Sequence problems. X07263 Genomic DNA. Translation: CAA30249.1. M19720 Genomic DNA. Translation: AAA59879.1. M19720 Genomic DNA. Translation: AAA59878.1. AL033527 Genomic DNA. Translation: CAB75682.1. AL033527 Genomic DNA. Translation: CAI19407.1. Different initiation. AL033527 Genomic DNA. Translation: CAI19408.1. Different initiation. BC011864 mRNA. Translation: AAH11864.1.
IPI	IPI00643210. IPI00796676.
PIR	TVHUML. A27675.
RefSeq	NP_001028253.1. NM_001033081.2. NP_001028254.2. NM_001033082.2. NP_005367.2. NM_005376.4.
UniGene	Hs.437922.
3D structure databases
ProteinModelPortal	P12524.
SMR	P12524. Positions 282-333.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335376.
PTM databases
PhosphoSite	P12524.
Polymorphism databases
DMDM	311033401.
Proteomic databases
PaxDb	P12524.
PRIDE	P12524.
Protocols and materials databases
DNASU	4610.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372815; ENSP00000361902; ENSG00000116990. ENST00000372816; ENSP00000361903; ENSG00000116990. ENST00000397332; ENSP00000380494; ENSG00000116990. ENST00000429311; ENSP00000389358; ENSG00000116990.
GeneID	4610.
KEGG	hsa:4610.
UCSC	uc001ces.2. human. uc001cet.2. human.
Organism-specific databases
CTD	4610.
GeneCards	GC01M040361.
HGNC	HGNC:7555. MYCL1.
MIM	164850. gene.
neXtProt	NX_P12524.
PharmGKB	PA31355.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43031.
HOGENOM	HOG000043075.
HOVERGEN	HBG000472.
InParanoid	P12524.
KO	K09110.
OrthoDB	EOG4H4642.
PhylomeDB	P12524.
Gene expression databases
ArrayExpress	P12524.
Bgee	P12524.
CleanEx	HS_MYCL1.
Genevestigator	P12524.
GermOnline	ENSG00000116990. Homo sapiens.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF01056. Myc_N. 2 hits. [Graphical view]
PIRSF	PIRSF001705. Myc_protein. 1 hit.
PRINTS	PR00044. LEUZIPPRMYC.
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYCL1. human.
GenomeRNAi	4610.
NextBio	17746.
SOURCE	Search...

Entry information

Entry name

MYCL1_HUMAN

Accession

Primary (citable) accession number: P12524
Secondary accession number(s): A2A2C9 , Q14897, Q5QPL0, Q5QPL1, Q9NUE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 125 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.