##gff-version 3 P12504 UniProtKB Chain 1 192 . . . ID=PRO_0000042762;Note=Virion infectivity factor;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Chain 1 150 . . . ID=PRO_0000441079;Note=P17;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Chain 151 192 . . . ID=PRO_0000441080;Note=P7;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 14 17 . . . Note=Interaction with host APOBEC3F%3B F1-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 40 44 . . . Note=Interaction with host APOBEC3G%3B G-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 54 72 . . . Note=Interaction with host APOBEC3F and APOBEC3G%3B FG-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 74 79 . . . Note=Interaction with host APOBEC3F%3B F2-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 75 114 . . . Note=RNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 151 164 . . . Note=Multimerization;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Region 165 192 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P12504 UniProtKB Region 171 172 . . . Note=Membrane association;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Motif 108 139 . . . Note=HCCH motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Motif 144 153 . . . Note=BC-box-like motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Site 150 151 . . . Note=Cleavage in virion (by viral protease);Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Modified residue 96 96 . . . Note=Phosphothreonine%3B by host MAP4K1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Modified residue 144 144 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Modified residue 165 165 . . . Note=Phosphoserine%3B by host MAP4K1;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Modified residue 188 188 . . . Note=Phosphothreonine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04081 P12504 UniProtKB Natural variant 90 93 . . . Note=In strain: Clinical isolate%3B from an asymptomatic patient%3B Vif is mislocalized to the nucleus and non functional. RKKR->KKRK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15989462;Dbxref=PMID:15989462 P12504 UniProtKB Mutagenesis 5 6 . . . Note=44%25 loss of viral infectivity. WQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 12 13 . . . Note=No effect on viral infectivity. QV->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 16 18 . . . Note=29%25 loss of viral infectivity. MRI->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 23 24 . . . Note=14%25 loss of viral infectivity. RL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 29 31 . . . Note=59%25 loss of viral infectivity. MYI->AAV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 33 34 . . . Note=35%25 loss of viral infectivity. RK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 38 40 . . . Note=94%25 loss of viral infectivity. WFY->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 43 44 . . . Note=95%25 loss of viral infectivity. HY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 53 54 . . . Note=39%25 loss of viral infectivity. SE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 58 59 . . . Note=45%25 loss of viral infectivity. PL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 69 70 . . . Note=97%25 loss of viral infectivity. YW->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 73 74 . . . Note=No effect onviral infectivity. HT->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 80 81 . . . Note=19%25 loss of viral infectivity. HL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 86 87 . . . Note=42%25 loss of viral infectivity. SI->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 90 92 . . . Note=No effect on viral infectivity. RKK->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 97 98 . . . Note=27%25 loss of viral infectivity. QV->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 105 107 . . . Note=98%25 loss of viral infectivity. QLI->AAV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 108 108 . . . Note=Complete loss of interaction with CUL5. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16076960;Dbxref=PMID:16076960 P12504 UniProtKB Mutagenesis 111 112 . . . Note=93%25 loss of viral infectivity. YF->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 114 114 . . . Note=98%25 loss of viral infectivity. Complete loss of interaction with CUL5. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10074113,ECO:0000269|PubMed:14672928,ECO:0000269|PubMed:16076960;Dbxref=PMID:10074113,PMID:14672928,PMID:16076960 P12504 UniProtKB Mutagenesis 121 123 . . . Note=35%25 increase of viral infectivity. RNT->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 127 128 . . . Note=10%25 loss of viral infectivity. RI->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 133 133 . . . Note=95%25 loss of viral infectivity. Complete loss of interaction with CUL5. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10074113,ECO:0000269|PubMed:14672928,ECO:0000269|PubMed:16076960;Dbxref=PMID:10074113,PMID:14672928,PMID:16076960 P12504 UniProtKB Mutagenesis 135 136 . . . Note=73%25 loss of viral infectivity. YQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 139 139 . . . Note=Complete loss of interaction with CUL5. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16076960;Dbxref=PMID:16076960 P12504 UniProtKB Mutagenesis 140 141 . . . Note=68%25 loss of viral infectivity. NK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 144 146 . . . Note=93%25 loss of viral infectivity. SLQ->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 144 144 . . . Note=25%25 loss of interaction with CUL5y. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 145 145 . . . Note=Complete loss of interaction with CUL5. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 146 146 . . . Note=90%25 loss of interaction with CUL5. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 147 148 . . . Note=40%25 loss of viral infectivity. YL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 147 147 . . . Note=40%25 loss of interaction with CUL5. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 148 148 . . . Note=35%25 loss of interaction with CUL5. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 149 151 . . . Note=Complete loss of processing between p17 and p7. Complete loss of replication. ALA->RKS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12186895;Dbxref=PMID:12186895 P12504 UniProtKB Mutagenesis 149 149 . . . Note=75%25 loss of CUL5 binding activity. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 150 150 . . . Note=90%25 loss of CUL5 binding activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574592;Dbxref=PMID:15574592 P12504 UniProtKB Mutagenesis 151 151 . . . Note=No effect on processing between p17 and p7. A->E P12504 UniProtKB Mutagenesis 151 151 . . . Note=Slightly increased processing between p17 and p7. A->N P12504 UniProtKB Mutagenesis 151 151 . . . Note=Increased processing between p17 and p7. A->P P12504 UniProtKB Mutagenesis 151 151 . . . Note=Partial loss of processing between p17 and p7. A->Y P12504 UniProtKB Mutagenesis 156 158 . . . Note=No effect on viral infectivity. PKQ->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 157 157 . . . Note=No effect viral infectivity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 158 160 . . . Note=9%25 loss of viral infectivity. QIK->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 160 160 . . . Note=33%25 loss of viral infectivity. K->A P12504 UniProtKB Mutagenesis 161 164 . . . Note=88%25 loss of viral infectivity. PPLP->APLA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 161 163 . . . Note=97%25 loss of viral infectivity. PPL->AAA P12504 UniProtKB Mutagenesis 161 161 . . . Note=27%25 loss of viral infectivity. P->A P12504 UniProtKB Mutagenesis 162 162 . . . Note=No effect viral infectivity. P->A P12504 UniProtKB Mutagenesis 163 163 . . . Note=26%25 loss of viral infectivity. L->A P12504 UniProtKB Mutagenesis 164 164 . . . Note=63%25 loss of viral infectivity. P->A P12504 UniProtKB Mutagenesis 165 165 . . . Note=67%25 loss of viral infectivity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 166 166 . . . Note=20%25 loss of viral infectivity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 169 170 . . . Note=42%25 loss of viral infectivity. LT->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 180 181 . . . Note=5%25 loss of viral infectivity. TK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Mutagenesis 189 190 . . . Note=4%25 loss of viral infectivity. MN->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074113;Dbxref=PMID:10074113 P12504 UniProtKB Beta strand 5 13 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Helix 15 30 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Turn 34 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 39 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Turn 43 45 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 51 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 62 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 73 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 83 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Beta strand 94 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Helix 100 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Helix 119 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Helix 136 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F P12504 UniProtKB Helix 145 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3DCG P12504 UniProtKB Helix 166 169 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4N9F