##gff-version 3 P12473 UniProtKB Chain 1 776 . . . ID=PRO_0000041108;Note=Outer capsid protein VP4;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04132 P12473 UniProtKB Chain 1 231 . . . ID=PRO_0000041109;Note=Outer capsid protein VP8*;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04132 P12473 UniProtKB Chain 248 776 . . . ID=PRO_0000041110;Note=Outer capsid protein VP5*;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_04132 P12473 UniProtKB Region 65 224 . . . Note=Spike head;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:21157433;Dbxref=PMID:21157433 P12473 UniProtKB Region 248 479 . . . Note=Spike body and stalk (antigen domain);Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:21157433;Dbxref=PMID:21157433 P12473 UniProtKB Region 389 409 . . . Note=Hydrophobic%3B possible role in virus entry into host cell;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:20375171;Dbxref=PMID:20375171 P12473 UniProtKB Region 510 776 . . . Note=Spike foot;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:21157433;Dbxref=PMID:21157433 P12473 UniProtKB Coiled coil 484 511 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:21157433;Dbxref=PMID:21157433 P12473 UniProtKB Motif 308 310 . . . Note=DGE motif%3B interaction with ITGA2/ITGB1 heterodimer;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:11112480;Dbxref=PMID:11112480 P12473 UniProtKB Motif 448 450 . . . Note=YGL motif%3B interaction with ITGA4;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:16298987;Dbxref=PMID:16298987 P12473 UniProtKB Motif 644 646 . . . Note=KID motif%3B interaction with HSPA8;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:12805424;Dbxref=PMID:12805424 P12473 UniProtKB Site 101 101 . . . Note=Binding to sialic acid;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:18974199;Dbxref=PMID:18974199 P12473 UniProtKB Site 190 190 . . . Note=Binding to sialic acid;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:18974199;Dbxref=PMID:18974199 P12473 UniProtKB Site 231 232 . . . Note=Cleavage;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:8709201;Dbxref=PMID:8709201 P12473 UniProtKB Site 241 242 . . . Note=Cleavage;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:8709201;Dbxref=PMID:8709201 P12473 UniProtKB Site 247 248 . . . Note=Cleavage%3B associated with enhancement of infectivity;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:8709201,ECO:0000269|PubMed:9573313;Dbxref=PMID:8709201,PMID:9573313 P12473 UniProtKB Disulfide bond 203 216 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:8392619;Dbxref=PMID:8392619 P12473 UniProtKB Disulfide bond 318 380 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04132,ECO:0000269|PubMed:8392619;Dbxref=PMID:8392619 P12473 UniProtKB Natural variant 109 110 . . . Note=In strain: Isolate MMU-18006. EP->VA P12473 UniProtKB Natural variant 146 146 . . . Note=In strain: Isolate MMU-18006. T->S P12473 UniProtKB Natural variant 166 166 . . . Note=In strain: Isolate MMU-18006. A->G P12473 UniProtKB Natural variant 235 240 . . . Note=In strain: Isolate MMU-18006. PLALSA->LALSAS P12473 UniProtKB Natural variant 244 245 . . . Note=In strain: Isolate MMU-18006. IS->TY P12473 UniProtKB Mutagenesis 101 101 . . . Note=Reduced ability to bind sialic acid binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18974199;Dbxref=PMID:18974199 P12473 UniProtKB Mutagenesis 190 190 . . . Note=Reduced ability to bind sialic acid. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18974199;Dbxref=PMID:18974199 P12473 UniProtKB Mutagenesis 231 231 . . . Note=Complete loss of trypsin activation of VP4%2C resulting in a blockage to viral entry. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9573313;Dbxref=PMID:9573313 P12473 UniProtKB Mutagenesis 241 241 . . . Note=Complete loss of trypsin activation of VP4%2C resulting in a blockage to viral entry. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9573313;Dbxref=PMID:9573313 P12473 UniProtKB Mutagenesis 247 247 . . . Note=Complete loss of trypsin activation of VP4%2C resulting in a blockage to viral entry and inhability to induce polykaryon formation. This cleavage is required to promote viral entry. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9573313;Dbxref=PMID:9573313 P12473 UniProtKB Mutagenesis 287 287 . . . Note=About 50%25 loss of association with liposomes. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20375171;Dbxref=PMID:20375171 P12473 UniProtKB Mutagenesis 333 333 . . . Note=Slight loss of infectivity. About 50%25 loss of association with liposomes. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20375171;Dbxref=PMID:20375171 P12473 UniProtKB Mutagenesis 391 391 . . . Note=Drastic loss of infectivity by blocking the host membrane permeabilization after virus internalization. Almost complete loss of association with liposomes. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20375171;Dbxref=PMID:20375171 P12473 UniProtKB Mutagenesis 394 394 . . . Note=Slight loss of infectivity. No effect on the association with liposomes. W->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20375171;Dbxref=PMID:20375171 P12473 UniProtKB Sequence conflict 73 73 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 132 132 . . . Note=N->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 311 311 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 338 338 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 421 421 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 445 446 . . . Note=GG->SR;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 454 454 . . . Note=Y->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 468 468 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 519 519 . . . Note=Y->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Sequence conflict 690 690 . . . Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P12473 UniProtKB Beta strand 66 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 71 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 80 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 88 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 98 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 102 108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 110 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 124 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 135 147 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 153 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 165 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 173 180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 185 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Helix 194 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 198 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 205 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Helix 210 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Helix 213 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1KQR P12473 UniProtKB Beta strand 249 258 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 260 275 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 278 283 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 290 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 299 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 310 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 324 329 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 338 345 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 350 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Helix 360 362 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 367 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 378 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 384 386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SLQ P12473 UniProtKB Beta strand 390 392 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 396 399 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 401 415 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 420 432 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 437 439 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 449 454 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Turn 455 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Beta strand 462 475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B4I P12473 UniProtKB Helix 492 512 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SLQ P12473 UniProtKB Turn 513 519 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SLQ