P12462 (TYSY_HSVAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

Name:

TS

Organism

Herpesvirus ateles

Taxonomic identifier

10380 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus

Virus host

Ateles [TaxID: 9506]

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Thymidylate synthase		PRO_0000141064
Sites
	Active site	172	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12462 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 57C8B4C916121B1F	FASTA	290	32,912
	10 20 30 40 50 60 MEELHAEHQY LSQVKHILNC GNFKHDRTGV GTLSVFGMQS RYSLEKDFPL LTTKRVFWRG 70 80 90 100 110 120 VVEELLWFIR GSTDSKELAA SGVHIWDANG SRSYLDKLGL FDREEGDLGP VYGFQWRHFG 130 140 150 160 170 180 AEYQGLKHNY GGEGVDQLKQ IINTIHTNPT DRRMLMCAWN VLDVPKMALP PCHVLSQFYV 190 200 210 220 230 240 CDGKLSCQLY QRSADMGLGV PFNIASYSLL TCMIAHVTDL VPGEFIHTLG DAHVYVNHVD 250 260 270 280 290 ALTEQLTRTP RPFPTLKFAR KVASIDDFKA NDIILENYNP YPSIKMPMAV

References

[1]	"Thymidylate synthase gene of herpesvirus ateles." Richter J., Puchtler I., Fleckenstein B. J. Virol. 62:3530-3535(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 810.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22036 Genomic DNA. Translation: AAA46170.1.
PIR	SYBEAT. A28879.
3D structure databases
ProteinModelPortal	P12462.
SMR	P12462. Positions 5-290.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_HSVAT

Accession

Primary (citable) accession number: P12462

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program