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P12462

- TYSY_HSVAT

UniProt

P12462 - TYSY_HSVAT

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Protein

Thymidylate synthase

Gene

TS

Organism
Herpesvirus ateles
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:TS
OrganismiHerpesvirus ateles
Taxonomic identifieri10380 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiAteles [TaxID: 9506]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Thymidylate synthasePRO_0000141064Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP12462.
SMRiP12462. Positions 5-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12462-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELHAEHQY LSQVKHILNC GNFKHDRTGV GTLSVFGMQS RYSLEKDFPL
60 70 80 90 100
LTTKRVFWRG VVEELLWFIR GSTDSKELAA SGVHIWDANG SRSYLDKLGL
110 120 130 140 150
FDREEGDLGP VYGFQWRHFG AEYQGLKHNY GGEGVDQLKQ IINTIHTNPT
160 170 180 190 200
DRRMLMCAWN VLDVPKMALP PCHVLSQFYV CDGKLSCQLY QRSADMGLGV
210 220 230 240 250
PFNIASYSLL TCMIAHVTDL VPGEFIHTLG DAHVYVNHVD ALTEQLTRTP
260 270 280 290
RPFPTLKFAR KVASIDDFKA NDIILENYNP YPSIKMPMAV
Length:290
Mass (Da):32,912
Last modified:October 1, 1989 - v1
Checksum:i57C8B4C916121B1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22036 Genomic DNA. Translation: AAA46170.1.
PIRiA28879. SYBEAT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22036 Genomic DNA. Translation: AAA46170.1 .
PIRi A28879. SYBEAT.

3D structure databases

ProteinModelPortali P12462.
SMRi P12462. Positions 5-290.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00575 .

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Thymidylate synthase gene of herpesvirus ateles."
    Richter J., Puchtler I., Fleckenstein B.
    J. Virol. 62:3530-3535(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 810.

Entry informationi

Entry nameiTYSY_HSVAT
AccessioniPrimary (citable) accession number: P12462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3