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P12462 (TYSY_HSVAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:TS
OrganismHerpesvirus ateles
Taxonomic identifier10380 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostAteles [TaxID: 9506]

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer.

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000141064

Sites

Active site1721 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12462 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 57C8B4C916121B1F

FASTA29032,912
        10         20         30         40         50         60 
MEELHAEHQY LSQVKHILNC GNFKHDRTGV GTLSVFGMQS RYSLEKDFPL LTTKRVFWRG 

        70         80         90        100        110        120 
VVEELLWFIR GSTDSKELAA SGVHIWDANG SRSYLDKLGL FDREEGDLGP VYGFQWRHFG 

       130        140        150        160        170        180 
AEYQGLKHNY GGEGVDQLKQ IINTIHTNPT DRRMLMCAWN VLDVPKMALP PCHVLSQFYV 

       190        200        210        220        230        240 
CDGKLSCQLY QRSADMGLGV PFNIASYSLL TCMIAHVTDL VPGEFIHTLG DAHVYVNHVD 

       250        260        270        280        290 
ALTEQLTRTP RPFPTLKFAR KVASIDDFKA NDIILENYNP YPSIKMPMAV 

« Hide

References

[1]"Thymidylate synthase gene of herpesvirus ateles."
Richter J., Puchtler I., Fleckenstein B.
J. Virol. 62:3530-3535(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 810.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22036 Genomic DNA. Translation: AAA46170.1.
PIRSYBEAT. A28879.

3D structure databases

ProteinModelPortalP12462.
SMRP12462. Positions 5-290.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_HSVAT
AccessionPrimary (citable) accession number: P12462
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways