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Protein

Thymidylate synthase

Gene

TMP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29dUMPBy similarity1
Active sitei176NucleophileBy similarity1
Binding sitei2165,10-methylenetetrahydrofolateBy similarity1
Binding sitei224dUMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 157dUMP; shared with dimeric partnerBy similarity2
Nucleotide bindingi213 – 216dUMPBy similarity4
Nucleotide bindingi254 – 256dUMPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processNucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:TMP1
Synonyms:CDC21, TSA1
Ordered Locus Names:CAALFM_C205190WA
ORF Names:CaO19.11033, CaO19.3549
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000189182 CDC21

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364680
DrugBankiDB01099 Flucytosine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001409092 – 315Thymidylate synthaseAdd BLAST314

Proteomic databases

PRIDEiP12461

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP12461
SMRiP12461
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

InParanoidiP12461
KOiK00560
OMAiKQYLDLC
OrthoDBiEOG092C3QQ6

Family and domain databases

CDDicd00351 TS_Pyrimidine_HMase, 1 hit
Gene3Di3.30.572.10, 1 hit
HAMAPiMF_00008 Thymidy_synth_bact, 1 hit
InterProiView protein in InterPro
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PRINTSiPR00108 THYMDSNTHASE
SUPFAMiSSF55831 SSF55831, 1 hit
TIGRFAMsiTIGR03284 thym_sym, 1 hit
PROSITEiView protein in PROSITE
PS00091 THYMIDYLATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND
60 70 80 90 100
TFPLLTTKKV FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD
110 120 130 140 150
KLGLTHRREG DLGPVYGFQW RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK
160 170 180 190 200
TNPYDRRIIM SAWNPPDFAK MALPPCHVFC QFYVNFPTSS PDPNNPKQAK
210 220 230 240 250
TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD MDCGEFIHTL
260 270 280 290 300
GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI
310
VGYEPYPPIK MKMSV
Length:315
Mass (Da):35,996
Last modified:January 23, 2007 - v3
Checksum:i343F0E6D41FCD494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04230 Genomic DNA Translation: AAA34374.2
CP017624 Genomic DNA Translation: AOW27536.1
PIRiA32805 YXCKTA
RefSeqiXP_714908.1, XM_709815.1

Genome annotation databases

EnsemblFungiiAOW27536; AOW27536; CAALFM_C205190WA
GeneIDi3643463
KEGGical:CAALFM_C205190WA

Similar proteinsi

Entry informationi

Entry nameiTYSY_CANAL
AccessioniPrimary (citable) accession number: P12461
Secondary accession number(s): A0A1D8PHC1, Q59ZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health