Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidylate synthase

Gene

TMP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29dUMPBy similarity1
Active sitei176NucleophileBy similarity1
Binding sitei2165,10-methylenetetrahydrofolateBy similarity1
Binding sitei224dUMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 157dUMP; shared with dimeric partnerBy similarity2
Nucleotide bindingi213 – 216dUMPBy similarity4
Nucleotide bindingi254 – 256dUMPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processNucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:TMP1
Synonyms:CDC21, TSA1
Ordered Locus Names:CAALFM_C205190WA
ORF Names:CaO19.11033, CaO19.3549
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000189182. CDC21.

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364680.
DrugBankiDB01099. Flucytosine.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001409092 – 315Thymidylate synthaseAdd BLAST314

Proteomic databases

PRIDEiP12461.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP12461.
SMRiP12461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

InParanoidiP12461.
KOiK00560.
OrthoDBiEOG092C3QQ6.

Family and domain databases

CDDicd00351. TS_Pyrimidine_HMase. 1 hit.
Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact. 1 hit.
InterProiView protein in InterPro
IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
PfamiView protein in Pfam
PF00303. Thymidylat_synt. 1 hit.
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiView protein in PROSITE
PS00091. THYMIDYLATE_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND
60 70 80 90 100
TFPLLTTKKV FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD
110 120 130 140 150
KLGLTHRREG DLGPVYGFQW RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK
160 170 180 190 200
TNPYDRRIIM SAWNPPDFAK MALPPCHVFC QFYVNFPTSS PDPNNPKQAK
210 220 230 240 250
TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD MDCGEFIHTL
260 270 280 290 300
GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI
310
VGYEPYPPIK MKMSV
Length:315
Mass (Da):35,996
Last modified:January 23, 2007 - v3
Checksum:i343F0E6D41FCD494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04230 Genomic DNA. Translation: AAA34374.2.
CP017624 Genomic DNA. Translation: AOW27536.1.
PIRiA32805. YXCKTA.
RefSeqiXP_714908.1. XM_709815.1.

Genome annotation databases

GeneIDi3643463.
KEGGical:CAALFM_C205190WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTYSY_CANAL
AccessioniPrimary (citable) accession number: P12461
Secondary accession number(s): A0A1D8PHC1, Q59ZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families