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P12461

- TYSY_CANAL

UniProt

P12461 - TYSY_CANAL

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Protein
Thymidylate synthase
Gene
TMP1, CDC21, TSA1, CaO19.11033, CaO19.3549
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:TMP1
Synonyms:CDC21, TSA1
ORF Names:CaO19.11033, CaO19.3549
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005915. CDC21.

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 315314Thymidylate synthaseUniRule annotation
PRO_0000140909Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi5476.CAL0005915.

Structurei

3D structure databases

ProteinModelPortaliP12461.
SMRiP12461. Positions 6-315.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
KOiK00560.
OrthoDBiEOG7X6M9G.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12461-1 [UniParc]FASTAAdd to Basket

« Hide

MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND    50
TFPLLTTKKV FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD 100
KLGLTHRREG DLGPVYGFQW RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK 150
TNPYDRRIIM SAWNPPDFAK MALPPCHVFC QFYVNFPTSS PDPNNPKQAK 200
TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD MDCGEFIHTL 250
GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI 300
VGYEPYPPIK MKMSV 315
Length:315
Mass (Da):35,996
Last modified:January 23, 2007 - v3
Checksum:i343F0E6D41FCD494
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04230 Genomic DNA. Translation: AAA34374.2.
AACQ01000094 Genomic DNA. Translation: EAK95868.1.
AACQ01000093 Genomic DNA. Translation: EAK95932.1.
PIRiA32805. YXCKTA.
RefSeqiXP_714908.1. XM_709815.1.
XP_714971.1. XM_709878.1.

Genome annotation databases

GeneIDi3643367.
3643463.
KEGGical:CaO19.11033.
cal:CaO19.3549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04230 Genomic DNA. Translation: AAA34374.2 .
AACQ01000094 Genomic DNA. Translation: EAK95868.1 .
AACQ01000093 Genomic DNA. Translation: EAK95932.1 .
PIRi A32805. YXCKTA.
RefSeqi XP_714908.1. XM_709815.1.
XP_714971.1. XM_709878.1.

3D structure databases

ProteinModelPortali P12461.
SMRi P12461. Positions 6-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005915.

Chemistry

ChEMBLi CHEMBL2364680.
DrugBanki DB01099. Flucytosine.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643367.
3643463.
KEGGi cal:CaO19.11033.
cal:CaO19.3549.

Organism-specific databases

CGDi CAL0005915. CDC21.

Phylogenomic databases

eggNOGi COG0207.
KOi K00560.
OrthoDBi EOG7X6M9G.

Enzyme and pathway databases

UniPathwayi UPA00575 .

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, purification, and properties of Candida albicans thymidylate synthase."
    Singer S.C., Richards C.A., Ferone R., Benedict D., Ray P.
    J. Bacteriol. 171:1372-1378(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11651 / B792 / 171D.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTYSY_CANAL
AccessioniPrimary (citable) accession number: P12461
Secondary accession number(s): Q59ZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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