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P12461 (TYSY_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:TMP1
Synonyms:CDC21, TSA1
ORF Names:CaO19.11033, CaO19.3549
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathway

Pyrimidine metabolism; dTTP biosynthesis.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 315314Thymidylate synthase
PRO_0000140909

Sites

Active site1761 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12461 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 343F0E6D41FCD494

FASTA31535,996
        10         20         30         40         50         60 
MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND TFPLLTTKKV 

        70         80         90        100        110        120 
FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD KLGLTHRREG DLGPVYGFQW 

       130        140        150        160        170        180 
RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK TNPYDRRIIM SAWNPPDFAK MALPPCHVFC 

       190        200        210        220        230        240 
QFYVNFPTSS PDPNNPKQAK TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD 

       250        260        270        280        290        300 
MDCGEFIHTL GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI 

       310 
VGYEPYPPIK MKMSV

« Hide

References

« Hide 'large scale' references
[1]"Cloning, purification, and properties of Candida albicans thymidylate synthase."
Singer S.C., Richards C.A., Ferone R., Benedict D., Ray P.
J. Bacteriol. 171:1372-1378(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 11651 / B792 / 171D.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J04230 Genomic DNA. Translation: AAA34374.2.
AACQ01000094 Genomic DNA. Translation: EAK95868.1.
AACQ01000093 Genomic DNA. Translation: EAK95932.1.
PIRYXCKTA. A32805.
RefSeqXP_714908.1. XM_709815.1.
XP_714971.1. XM_709878.1.

3D structure databases

ProteinModelPortalP12461.
SMRP12461. Positions 6-315.
ModBaseSearch...

Protein-protein interaction databases

STRING5476.CAL0005915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643367.
3643463.
KEGGcal:CaO19.11033.
cal:CaO19.3549.

Organism-specific databases

CGDCAL0005915. CDC21.

Phylogenomic databases

eggNOGCOG0207.
KOK00560.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB01099. Flucytosine.

Entry information

Entry nameTYSY_CANAL
AccessionPrimary (citable) accession number: P12461
Secondary accession number(s): Q59ZH0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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