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P12461

- TYSY_CANAL

UniProt

P12461 - TYSY_CANAL

Protein

Thymidylate synthase

Gene

TMP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761By similarity

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dTMP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase (EC:2.1.1.45)
    Short name:
    TS
    Short name:
    TSase
    Gene namesi
    Name:TMP1
    Synonyms:CDC21, TSA1
    ORF Names:CaO19.11033, CaO19.3549
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005915. CDC21.

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 315314Thymidylate synthasePRO_0000140909Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi5476.CAL0005915.

    Structurei

    3D structure databases

    ProteinModelPortaliP12461.
    SMRiP12461. Positions 6-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0207.
    KOiK00560.
    OrthoDBiEOG7X6M9G.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12461-1 [UniParc]FASTAAdd to Basket

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    MTVSPNTAEQ AYLDLCKRII DEGEHRPDRT GTGTKSLFAP PQLRFDLSND    50
    TFPLLTTKKV FSKGIIHELL WFVAGSTDAK ILSEKGVKIW EGNGSREFLD 100
    KLGLTHRREG DLGPVYGFQW RHFGAEYKDC DSDYTGQGFD QLQDVIKKLK 150
    TNPYDRRIIM SAWNPPDFAK MALPPCHVFC QFYVNFPTSS PDPNNPKQAK 200
    TAKPKLSCLL YQRSCDMGLG VPFNIASYAL LTKMIAHVVD MDCGEFIHTL 250
    GDAHVYLDHI DALKEQFERI PKQFPKLVIK EERKNEIKSI DDFKFEDFEI 300
    VGYEPYPPIK MKMSV 315
    Length:315
    Mass (Da):35,996
    Last modified:January 23, 2007 - v3
    Checksum:i343F0E6D41FCD494
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04230 Genomic DNA. Translation: AAA34374.2.
    AACQ01000094 Genomic DNA. Translation: EAK95868.1.
    AACQ01000093 Genomic DNA. Translation: EAK95932.1.
    PIRiA32805. YXCKTA.
    RefSeqiXP_714908.1. XM_709815.1.
    XP_714971.1. XM_709878.1.

    Genome annotation databases

    GeneIDi3643367.
    3643463.
    KEGGical:CaO19.11033.
    cal:CaO19.3549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04230 Genomic DNA. Translation: AAA34374.2 .
    AACQ01000094 Genomic DNA. Translation: EAK95868.1 .
    AACQ01000093 Genomic DNA. Translation: EAK95932.1 .
    PIRi A32805. YXCKTA.
    RefSeqi XP_714908.1. XM_709815.1.
    XP_714971.1. XM_709878.1.

    3D structure databases

    ProteinModelPortali P12461.
    SMRi P12461. Positions 6-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005915.

    Chemistry

    ChEMBLi CHEMBL2364680.
    DrugBanki DB01099. Flucytosine.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643367.
    3643463.
    KEGGi cal:CaO19.11033.
    cal:CaO19.3549.

    Organism-specific databases

    CGDi CAL0005915. CDC21.

    Phylogenomic databases

    eggNOGi COG0207.
    KOi K00560.
    OrthoDBi EOG7X6M9G.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, purification, and properties of Candida albicans thymidylate synthase."
      Singer S.C., Richards C.A., Ferone R., Benedict D., Ray P.
      J. Bacteriol. 171:1372-1378(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 11651 / B792 / 171D.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTYSY_CANAL
    AccessioniPrimary (citable) accession number: P12461
    Secondary accession number(s): Q59ZH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3