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P12430

- GP_BUNGE

UniProt

P12430 - GP_BUNGE

Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyavirus germiston
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei481 – 4822Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. modulation by virus of host morphology or physiology Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiBunyavirus germiston
    Taxonomic identifieri11574 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCulex [TaxID: 53527]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.By similarity
    Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
    Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 14371416Envelope glycoproteinPRO_0000036786Add
    BLAST
    Chaini22 – 306285Glycoprotein G2By similarityPRO_0000036787Add
    BLAST
    Chaini307 – 481175Non-structural protein NSmBy similarityPRO_0000036788Add
    BLAST
    Chaini482 – 1437956Glycoprotein G1By similarityPRO_0000036789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1173 – 11731N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 207186LumenalSequence AnalysisAdd
    BLAST
    Topological domaini229 – 31284CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 37340LumenalSequence AnalysisAdd
    BLAST
    Topological domaini395 – 46066CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini482 – 1391910LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1413 – 143725CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1392 – 141221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view]
    PfamiPF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12430-1 [UniParc]FASTAAdd to Basket

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    MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK     50
    DDISILKSEI TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE 100
    VDKNLNLVAK NYMCTRPCVI TIDKENAQLL FQTEQLNQFE VTGTTISTGW 150
    FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC FKQHMSCVRF LHRSVLPGYM 200
    ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF APIAYLYGWL 250
    YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK 300
    SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE 350
    VNDIVLGRDM EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR 400
    STIFCKECNL IHDKKSMTYR GDFTNKCGFC PCGELEDPEG LVIHTTRKSC 450
    TYYIKIRNLK LIMLIFSIVI LMQNATMLVV AGENCWTNTE IKADCVGPLI 500
    GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT IESALDAITS 550
    QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN 600
    TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA 650
    AFPGSATAFL FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV 700
    GLSHASTYQL KQEWVAKSLS LTRAQRTGLK MSMANAEPGP ATKECSDAKT 750
    IACLTPKFQV EVNNLMSCGA SPNFKIYVKT GELYKAHDRN SVWCLNDMHC 800
    LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ MKDRGLCNSG 850
    ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS 900
    LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN 950
    LPHIKPTYKY ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD 1000
    LLDIVVYIKA SVVKSIYNHI YDTGPTININ SKHDELCTGQ CPKKIPADPN 1050
    WLTFSQERTS RWGCEEFGCL AINTGCVYGS CQDVIRTETK VYRKANEETV 1100
    MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL PNLVAVTNHK 1150
    LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR 1200
    CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY 1250
    KLYTENMELE LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD 1300
    RIQIKTTKKD YAMKISCTRD PGDKASFRVC GKSYDFNFHT VPKNDKIEVN 1350
    VGDETSYIKE KDNRCGRWLC RVRDEGLSVI FEPLNNFFGN YLNMFLYILG 1400
    GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR 1437
    Length:1,437
    Mass (Da):162,494
    Last modified:October 1, 1989 - v1
    Checksum:iC4FB3001BD09A30D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21951 Genomic RNA. Translation: AAA42778.1.
    PIRiS07430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21951 Genomic RNA. Translation: AAA42778.1 .
    PIRi S07430.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view ]
    Pfami PF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the M segment of Germiston virus: comparison of the M gene product of several bunyaviruses."
      Pardigon N., Vialat P., Gerbaud S., Girard M., Bouloy M.
      Virus Res. 11:73-85(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_BUNGE
    AccessioniPrimary (citable) accession number: P12430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3