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Protein

Envelopment polyprotein

Gene

GP

Organism
Bunyavirus germiston
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Glycoprotein C and Glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G2
Non-structural protein MBy similarity
Short name:
NSm
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G1
Gene namesi
Name:GP
OrganismiBunyavirus germiston
Taxonomic identifieri11574 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCulex [TaxID: 53527]

Subcellular locationi

Glycoprotein C :
Glycoprotein N :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 207LumenalSequence analysisAdd BLAST186
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 312CytoplasmicSequence analysisAdd BLAST84
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 373LumenalSequence analysisAdd BLAST40
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 460CytoplasmicSequence analysisAdd BLAST66
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 1391LumenalSequence analysisAdd BLAST910
Transmembranei1392 – 1412HelicalSequence analysisAdd BLAST21
Topological domaini1413 – 1437CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003678622 – 1437Envelopment polyproteinAdd BLAST1416
ChainiPRO_000003678722 – 306Glycoprotein NBy similarityAdd BLAST285
ChainiPRO_0000036788307 – 481Non-structural protein MBy similarityAdd BLAST175
ChainiPRO_0000036789482 – 1437Glycoprotein CBy similarityAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi88N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi627N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1173N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, Glycoprotein C, and Glycoprotein N.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei481 – 482Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Glycoprotein C and Glycoprotein N interact with each other.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK
60 70 80 90 100
DDISILKSEI TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE
110 120 130 140 150
VDKNLNLVAK NYMCTRPCVI TIDKENAQLL FQTEQLNQFE VTGTTISTGW
160 170 180 190 200
FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC FKQHMSCVRF LHRSVLPGYM
210 220 230 240 250
ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF APIAYLYGWL
260 270 280 290 300
YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK
310 320 330 340 350
SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE
360 370 380 390 400
VNDIVLGRDM EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR
410 420 430 440 450
STIFCKECNL IHDKKSMTYR GDFTNKCGFC PCGELEDPEG LVIHTTRKSC
460 470 480 490 500
TYYIKIRNLK LIMLIFSIVI LMQNATMLVV AGENCWTNTE IKADCVGPLI
510 520 530 540 550
GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT IESALDAITS
560 570 580 590 600
QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN
610 620 630 640 650
TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA
660 670 680 690 700
AFPGSATAFL FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV
710 720 730 740 750
GLSHASTYQL KQEWVAKSLS LTRAQRTGLK MSMANAEPGP ATKECSDAKT
760 770 780 790 800
IACLTPKFQV EVNNLMSCGA SPNFKIYVKT GELYKAHDRN SVWCLNDMHC
810 820 830 840 850
LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ MKDRGLCNSG
860 870 880 890 900
ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS
910 920 930 940 950
LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN
960 970 980 990 1000
LPHIKPTYKY ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD
1010 1020 1030 1040 1050
LLDIVVYIKA SVVKSIYNHI YDTGPTININ SKHDELCTGQ CPKKIPADPN
1060 1070 1080 1090 1100
WLTFSQERTS RWGCEEFGCL AINTGCVYGS CQDVIRTETK VYRKANEETV
1110 1120 1130 1140 1150
MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL PNLVAVTNHK
1160 1170 1180 1190 1200
LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR
1210 1220 1230 1240 1250
CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY
1260 1270 1280 1290 1300
KLYTENMELE LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD
1310 1320 1330 1340 1350
RIQIKTTKKD YAMKISCTRD PGDKASFRVC GKSYDFNFHT VPKNDKIEVN
1360 1370 1380 1390 1400
VGDETSYIKE KDNRCGRWLC RVRDEGLSVI FEPLNNFFGN YLNMFLYILG
1410 1420 1430
GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR
Length:1,437
Mass (Da):162,494
Last modified:October 1, 1989 - v1
Checksum:iC4FB3001BD09A30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1.
PIRiS07430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1.
PIRiS07430.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGP_BUNGE
AccessioniPrimary (citable) accession number: P12430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 20, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.