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P12430

- GP_BUNGE

UniProt

P12430 - GP_BUNGE

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Protein
Envelope glycoprotein
Gene
GP
Organism
Bunyavirus germiston
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei481 – 4822Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus germiston
Taxonomic identifieri11574 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCulex [TaxID: 53527]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 207186Lumenal Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Topological domaini229 – 31284Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei313 – 33321Helical; Reviewed prediction
Add
BLAST
Topological domaini334 – 37340Lumenal Reviewed prediction
Add
BLAST
Transmembranei374 – 39421Helical; Reviewed prediction
Add
BLAST
Topological domaini395 – 46066Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei461 – 48121Helical; Reviewed prediction
Add
BLAST
Topological domaini482 – 1391910Lumenal Reviewed prediction
Add
BLAST
Transmembranei1392 – 141221Helical; Reviewed prediction
Add
BLAST
Topological domaini1413 – 143725Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 14371416Envelope glycoprotein
PRO_0000036786Add
BLAST
Chaini22 – 306285Glycoprotein G2 By similarity
PRO_0000036787Add
BLAST
Chaini307 – 481175Non-structural protein NSm By similarity
PRO_0000036788Add
BLAST
Chaini482 – 1437956Glycoprotein G1 By similarity
PRO_0000036789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi88 – 881N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi627 – 6271N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1173 – 11731N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12430-1 [UniParc]FASTAAdd to Basket

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MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK     50
DDISILKSEI TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE 100
VDKNLNLVAK NYMCTRPCVI TIDKENAQLL FQTEQLNQFE VTGTTISTGW 150
FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC FKQHMSCVRF LHRSVLPGYM 200
ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF APIAYLYGWL 250
YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK 300
SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE 350
VNDIVLGRDM EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR 400
STIFCKECNL IHDKKSMTYR GDFTNKCGFC PCGELEDPEG LVIHTTRKSC 450
TYYIKIRNLK LIMLIFSIVI LMQNATMLVV AGENCWTNTE IKADCVGPLI 500
GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT IESALDAITS 550
QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN 600
TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA 650
AFPGSATAFL FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV 700
GLSHASTYQL KQEWVAKSLS LTRAQRTGLK MSMANAEPGP ATKECSDAKT 750
IACLTPKFQV EVNNLMSCGA SPNFKIYVKT GELYKAHDRN SVWCLNDMHC 800
LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ MKDRGLCNSG 850
ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS 900
LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN 950
LPHIKPTYKY ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD 1000
LLDIVVYIKA SVVKSIYNHI YDTGPTININ SKHDELCTGQ CPKKIPADPN 1050
WLTFSQERTS RWGCEEFGCL AINTGCVYGS CQDVIRTETK VYRKANEETV 1100
MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL PNLVAVTNHK 1150
LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR 1200
CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY 1250
KLYTENMELE LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD 1300
RIQIKTTKKD YAMKISCTRD PGDKASFRVC GKSYDFNFHT VPKNDKIEVN 1350
VGDETSYIKE KDNRCGRWLC RVRDEGLSVI FEPLNNFFGN YLNMFLYILG 1400
GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR 1437
Length:1,437
Mass (Da):162,494
Last modified:October 1, 1989 - v1
Checksum:iC4FB3001BD09A30D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1.
PIRiS07430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1 .
PIRi S07430.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the M segment of Germiston virus: comparison of the M gene product of several bunyaviruses."
    Pardigon N., Vialat P., Gerbaud S., Girard M., Bouloy M.
    Virus Res. 11:73-85(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_BUNGE
AccessioniPrimary (citable) accession number: P12430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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