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P12430

- GP_BUNGE

UniProt

P12430 - GP_BUNGE

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Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyavirus germiston
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei481 – 4822Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus germiston
Taxonomic identifieri11574 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCulex [TaxID: 53527]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs (By similarity).By similarity
Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 207186LumenalSequence AnalysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Topological domaini229 – 31284CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 37340LumenalSequence AnalysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence AnalysisAdd
BLAST
Topological domaini395 – 46066CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Topological domaini482 – 1391910LumenalSequence AnalysisAdd
BLAST
Transmembranei1392 – 141221HelicalSequence AnalysisAdd
BLAST
Topological domaini1413 – 143725CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 14371416Envelope glycoproteinPRO_0000036786Add
BLAST
Chaini22 – 306285Glycoprotein G2By similarityPRO_0000036787Add
BLAST
Chaini307 – 481175Non-structural protein NSmBy similarityPRO_0000036788Add
BLAST
Chaini482 – 1437956Glycoprotein G1By similarityPRO_0000036789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi627 – 6271N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1173 – 11731N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12430-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK
60 70 80 90 100
DDISILKSEI TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE
110 120 130 140 150
VDKNLNLVAK NYMCTRPCVI TIDKENAQLL FQTEQLNQFE VTGTTISTGW
160 170 180 190 200
FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC FKQHMSCVRF LHRSVLPGYM
210 220 230 240 250
ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF APIAYLYGWL
260 270 280 290 300
YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK
310 320 330 340 350
SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE
360 370 380 390 400
VNDIVLGRDM EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR
410 420 430 440 450
STIFCKECNL IHDKKSMTYR GDFTNKCGFC PCGELEDPEG LVIHTTRKSC
460 470 480 490 500
TYYIKIRNLK LIMLIFSIVI LMQNATMLVV AGENCWTNTE IKADCVGPLI
510 520 530 540 550
GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT IESALDAITS
560 570 580 590 600
QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN
610 620 630 640 650
TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA
660 670 680 690 700
AFPGSATAFL FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV
710 720 730 740 750
GLSHASTYQL KQEWVAKSLS LTRAQRTGLK MSMANAEPGP ATKECSDAKT
760 770 780 790 800
IACLTPKFQV EVNNLMSCGA SPNFKIYVKT GELYKAHDRN SVWCLNDMHC
810 820 830 840 850
LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ MKDRGLCNSG
860 870 880 890 900
ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS
910 920 930 940 950
LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN
960 970 980 990 1000
LPHIKPTYKY ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD
1010 1020 1030 1040 1050
LLDIVVYIKA SVVKSIYNHI YDTGPTININ SKHDELCTGQ CPKKIPADPN
1060 1070 1080 1090 1100
WLTFSQERTS RWGCEEFGCL AINTGCVYGS CQDVIRTETK VYRKANEETV
1110 1120 1130 1140 1150
MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL PNLVAVTNHK
1160 1170 1180 1190 1200
LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR
1210 1220 1230 1240 1250
CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY
1260 1270 1280 1290 1300
KLYTENMELE LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD
1310 1320 1330 1340 1350
RIQIKTTKKD YAMKISCTRD PGDKASFRVC GKSYDFNFHT VPKNDKIEVN
1360 1370 1380 1390 1400
VGDETSYIKE KDNRCGRWLC RVRDEGLSVI FEPLNNFFGN YLNMFLYILG
1410 1420 1430
GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR
Length:1,437
Mass (Da):162,494
Last modified:October 1, 1989 - v1
Checksum:iC4FB3001BD09A30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1.
PIRiS07430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21951 Genomic RNA. Translation: AAA42778.1 .
PIRi S07430.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the M segment of Germiston virus: comparison of the M gene product of several bunyaviruses."
    Pardigon N., Vialat P., Gerbaud S., Girard M., Bouloy M.
    Virus Res. 11:73-85(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_BUNGE
AccessioniPrimary (citable) accession number: P12430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3