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P12430 (GP_BUNGE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 3 chains:

  1. Glycoprotein G2
    Short name=Gn
  2. Non-structural protein NSm
  3. Glycoprotein G1
    Short name=Gc
Gene names
Name:GP
OrganismBunyavirus germiston
Taxonomic identifier11574 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostCulex [TaxID: 53527]

Protein attributes

Sequence length1437 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Non-structural protein NSm: Host Golgi apparatus membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the orthobunyavirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 14371416Envelope glycoprotein
PRO_0000036786
Chain22 – 306285Glycoprotein G2 By similarity
PRO_0000036787
Chain307 – 481175Non-structural protein NSm By similarity
PRO_0000036788
Chain482 – 1437956Glycoprotein G1 By similarity
PRO_0000036789

Regions

Topological domain22 – 207186Lumenal Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 31284Cytoplasmic Potential
Transmembrane313 – 33321Helical; Potential
Topological domain334 – 37340Lumenal Potential
Transmembrane374 – 39421Helical; Potential
Topological domain395 – 46066Cytoplasmic Potential
Transmembrane461 – 48121Helical; Potential
Topological domain482 – 1391910Lumenal Potential
Transmembrane1392 – 141221Helical; Potential
Topological domain1413 – 143725Cytoplasmic Potential

Sites

Site481 – 4822Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation651N-linked (GlcNAc...); by host Potential
Glycosylation881N-linked (GlcNAc...); by host Potential
Glycosylation6271N-linked (GlcNAc...); by host Potential
Glycosylation11731N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P12430 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: C4FB3001BD09A30D

FASTA1,437162,494
        10         20         30         40         50         60 
MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK DDISILKSEI 

        70         80         90        100        110        120 
TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE VDKNLNLVAK NYMCTRPCVI 

       130        140        150        160        170        180 
TIDKENAQLL FQTEQLNQFE VTGTTISTGW FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC 

       190        200        210        220        230        240 
FKQHMSCVRF LHRSVLPGYM ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF 

       250        260        270        280        290        300 
APIAYLYGWL YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK 

       310        320        330        340        350        360 
SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE VNDIVLGRDM 

       370        380        390        400        410        420 
EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR STIFCKECNL IHDKKSMTYR 

       430        440        450        460        470        480 
GDFTNKCGFC PCGELEDPEG LVIHTTRKSC TYYIKIRNLK LIMLIFSIVI LMQNATMLVV 

       490        500        510        520        530        540 
AGENCWTNTE IKADCVGPLI GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT 

       550        560        570        580        590        600 
IESALDAITS QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN 

       610        620        630        640        650        660 
TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA AFPGSATAFL 

       670        680        690        700        710        720 
FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV GLSHASTYQL KQEWVAKSLS 

       730        740        750        760        770        780 
LTRAQRTGLK MSMANAEPGP ATKECSDAKT IACLTPKFQV EVNNLMSCGA SPNFKIYVKT 

       790        800        810        820        830        840 
GELYKAHDRN SVWCLNDMHC LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ 

       850        860        870        880        890        900 
MKDRGLCNSG ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS 

       910        920        930        940        950        960 
LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN LPHIKPTYKY 

       970        980        990       1000       1010       1020 
ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD LLDIVVYIKA SVVKSIYNHI 

      1030       1040       1050       1060       1070       1080 
YDTGPTININ SKHDELCTGQ CPKKIPADPN WLTFSQERTS RWGCEEFGCL AINTGCVYGS 

      1090       1100       1110       1120       1130       1140 
CQDVIRTETK VYRKANEETV MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL 

      1150       1160       1170       1180       1190       1200 
PNLVAVTNHK LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR 

      1210       1220       1230       1240       1250       1260 
CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY KLYTENMELE 

      1270       1280       1290       1300       1310       1320 
LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD RIQIKTTKKD YAMKISCTRD 

      1330       1340       1350       1360       1370       1380 
PGDKASFRVC GKSYDFNFHT VPKNDKIEVN VGDETSYIKE KDNRCGRWLC RVRDEGLSVI 

      1390       1400       1410       1420       1430 
FEPLNNFFGN YLNMFLYILG GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR 

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References

[1]"Nucleotide sequence of the M segment of Germiston virus: comparison of the M gene product of several bunyaviruses."
Pardigon N., Vialat P., Gerbaud S., Girard M., Bouloy M.
Virus Res. 11:73-85(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21951 Genomic RNA. Translation: AAA42778.1.
PIRS07430.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsTIGR04210. bunya_NSm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_BUNGE
AccessionPrimary (citable) accession number: P12430
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families