Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A3

Gene

ANXA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • phospholipase A2 inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • defense response to bacterium Source: UniProtKB
  • hippocampus development Source: Ensembl
  • neutrophil degranulation Source: UniProtKB
  • phagocytosis Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of DNA metabolic process Source: Ensembl
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • response to glucocorticoid Source: Ensembl
  • response to growth factor Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Inositol 1,2-cyclic phosphate 2-phosphohydrolase
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:ANXA3
Synonyms:ANX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:541. ANXA3.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytoplasm Source: UniProtKB
  • dendrite Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • phagocytic vesicle membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • specific granule Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi306.
OpenTargetsiENSG00000138772.
PharmGKBiPA24831.

Polymorphism and mutation databases

BioMutaiANXA3.
DMDMi113954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000674772 – 323Annexin A3Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei267PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12429.
MaxQBiP12429.
PaxDbiP12429.
PeptideAtlasiP12429.
PRIDEiP12429.

2D gel databases

OGPiP12429.
SWISS-2DPAGEP12429.

PTM databases

iPTMnetiP12429.
PhosphoSitePlusiP12429.
SwissPalmiP12429.

Expressioni

Gene expression databases

BgeeiENSG00000138772.
CleanExiHS_ANXA3.
ExpressionAtlasiP12429. baseline and differential.
GenevisibleiP12429. HS.

Organism-specific databases

HPAiHPA013398.
HPA013431.

Interactioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase

Protein-protein interaction databases

BioGridi106803. 13 interactors.
IntActiP12429. 6 interactors.
MINTiMINT-4998835.
STRINGi9606.ENSP00000264908.

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 31Combined sources12
Beta strandi32 – 35Combined sources4
Helixi38 – 45Combined sources8
Helixi50 – 64Combined sources15
Helixi68 – 75Combined sources8
Helixi78 – 88Combined sources11
Helixi91 – 103Combined sources13
Beta strandi105 – 107Combined sources3
Helixi110 – 119Combined sources10
Helixi122 – 136Combined sources15
Helixi140 – 147Combined sources8
Helixi150 – 160Combined sources11
Helixi172 – 185Combined sources14
Turni186 – 188Combined sources3
Beta strandi189 – 191Combined sources3
Helixi194 – 203Combined sources10
Helixi206 – 220Combined sources15
Helixi224 – 231Combined sources8
Helixi234 – 262Combined sources29
Beta strandi263 – 266Combined sources4
Helixi269 – 279Combined sources11
Turni280 – 283Combined sources4
Helixi284 – 295Combined sources12
Helixi299 – 306Combined sources8
Helixi309 – 319Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIIX-ray1.95A1-323[»]
1AXNX-ray1.78A2-323[»]
ProteinModelPortaliP12429.
SMRiP12429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 87Annexin 1Add BLAST61
Repeati99 – 159Annexin 2Add BLAST61
Repeati183 – 243Annexin 3Add BLAST61
Repeati258 – 318Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP12429.
KOiK17089.
OMAiVNCVRNT.
OrthoDBiEOG091G0H6H.
PhylomeDBiP12429.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN
60 70 80 90 100
AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK
110 120 130 140 150
KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG
160 170 180 190 200
DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI
210 220 230 240 250
LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT
260 270 280 290 300
PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY
310 320
SAIKSDTSGD YEITLLKICG GDD
Length:323
Mass (Da):36,375
Last modified:January 23, 2007 - v3
Checksum:i4128C715491FC132
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → R in CAG28576 (Ref. 4) Curated1
Sequence conflicti146S → G AA sequence (PubMed:2975506).Curated1
Sequence conflicti294H → R AA sequence (PubMed:2975506).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01391419S → N.1 PublicationCorresponds to variant rs5951dbSNPEnsembl.1
Natural variantiVAR_013915219I → N.1 PublicationCorresponds to variant rs5948dbSNPEnsembl.1
Natural variantiVAR_013916251P → L.1 PublicationCorresponds to variant rs5949dbSNPEnsembl.1
Natural variantiVAR_013917291F → S.1 PublicationCorresponds to variant rs5941dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20560 mRNA. Translation: AAA59496.1.
M63310 mRNA. Translation: AAA52284.1.
L20591 Genomic DNA. Translation: AAA16713.1.
CR407648 mRNA. Translation: CAG28576.1.
AK313945 mRNA. Translation: BAG36663.1.
CH471057 Genomic DNA. Translation: EAX05822.1.
BC000871 mRNA. Translation: AAH00871.1.
CCDSiCCDS3584.1.
PIRiA47658. LUHU3.
RefSeqiNP_005130.1. NM_005139.2.
UniGeneiHs.480042.

Genome annotation databases

EnsembliENST00000264908; ENSP00000264908; ENSG00000138772.
GeneIDi306.
KEGGihsa:306.
UCSCiuc003hld.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20560 mRNA. Translation: AAA59496.1.
M63310 mRNA. Translation: AAA52284.1.
L20591 Genomic DNA. Translation: AAA16713.1.
CR407648 mRNA. Translation: CAG28576.1.
AK313945 mRNA. Translation: BAG36663.1.
CH471057 Genomic DNA. Translation: EAX05822.1.
BC000871 mRNA. Translation: AAH00871.1.
CCDSiCCDS3584.1.
PIRiA47658. LUHU3.
RefSeqiNP_005130.1. NM_005139.2.
UniGeneiHs.480042.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIIX-ray1.95A1-323[»]
1AXNX-ray1.78A2-323[»]
ProteinModelPortaliP12429.
SMRiP12429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106803. 13 interactors.
IntActiP12429. 6 interactors.
MINTiMINT-4998835.
STRINGi9606.ENSP00000264908.

PTM databases

iPTMnetiP12429.
PhosphoSitePlusiP12429.
SwissPalmiP12429.

Polymorphism and mutation databases

BioMutaiANXA3.
DMDMi113954.

2D gel databases

OGPiP12429.
SWISS-2DPAGEP12429.

Proteomic databases

EPDiP12429.
MaxQBiP12429.
PaxDbiP12429.
PeptideAtlasiP12429.
PRIDEiP12429.

Protocols and materials databases

DNASUi306.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264908; ENSP00000264908; ENSG00000138772.
GeneIDi306.
KEGGihsa:306.
UCSCiuc003hld.4. human.

Organism-specific databases

CTDi306.
DisGeNETi306.
GeneCardsiANXA3.
HGNCiHGNC:541. ANXA3.
HPAiHPA013398.
HPA013431.
MIMi106490. gene.
neXtProtiNX_P12429.
OpenTargetsiENSG00000138772.
PharmGKBiPA24831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP12429.
KOiK17089.
OMAiVNCVRNT.
OrthoDBiEOG091G0H6H.
PhylomeDBiP12429.
TreeFamiTF105452.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138772-MONOMER.

Miscellaneous databases

ChiTaRSiANXA3. human.
EvolutionaryTraceiP12429.
GeneWikiiAnnexin_A3.
GenomeRNAii306.
PROiP12429.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138772.
CleanExiHS_ANXA3.
ExpressionAtlasiP12429. baseline and differential.
GenevisibleiP12429. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA3_HUMAN
AccessioniPrimary (citable) accession number: P12429
Secondary accession number(s): B2R9W6, Q6LET2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 174 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.