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Protein

Annexin A3

Gene

ANXA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • phospholipase A2 inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • defense response to bacterium Source: UniProtKB
  • hippocampus development Source: Ensembl
  • neutrophil degranulation Source: UniProtKB
  • phagocytosis Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of DNA metabolic process Source: Ensembl
  • positive regulation of endothelial cell migration Source: UniProtKB
  • response to glucocorticoid Source: Ensembl
  • response to growth factor Source: Ensembl

Keywordsi

Molecular functionPhospholipase A2 inhibitor
LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Inositol 1,2-cyclic phosphate 2-phosphohydrolase
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:ANXA3
Synonyms:ANX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138772.12
HGNCiHGNC:541 ANXA3
MIMi106490 gene
neXtProtiNX_P12429

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi306
OpenTargetsiENSG00000138772
PharmGKBiPA24831

Chemistry databases

DrugBankiDB03994 Ethanolamine

Polymorphism and mutation databases

BioMutaiANXA3
DMDMi113954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000674772 – 323Annexin A3Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei267PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12429
MaxQBiP12429
PaxDbiP12429
PeptideAtlasiP12429
PRIDEiP12429

2D gel databases

OGPiP12429
SWISS-2DPAGEiP12429

PTM databases

iPTMnetiP12429
PhosphoSitePlusiP12429
SwissPalmiP12429

Expressioni

Gene expression databases

BgeeiENSG00000138772
CleanExiHS_ANXA3
ExpressionAtlasiP12429 baseline and differential
GenevisibleiP12429 HS

Organism-specific databases

HPAiHPA013398
HPA013431

Interactioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase

Protein-protein interaction databases

BioGridi106803, 17 interactors
IntActiP12429, 6 interactors
STRINGi9606.ENSP00000264908

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 31Combined sources12
Beta strandi32 – 35Combined sources4
Helixi38 – 45Combined sources8
Helixi50 – 64Combined sources15
Helixi68 – 75Combined sources8
Helixi78 – 88Combined sources11
Helixi91 – 103Combined sources13
Beta strandi105 – 107Combined sources3
Helixi110 – 119Combined sources10
Helixi122 – 136Combined sources15
Helixi140 – 147Combined sources8
Helixi150 – 160Combined sources11
Helixi172 – 185Combined sources14
Turni186 – 188Combined sources3
Beta strandi189 – 191Combined sources3
Helixi194 – 203Combined sources10
Helixi206 – 220Combined sources15
Helixi224 – 231Combined sources8
Helixi234 – 262Combined sources29
Beta strandi263 – 266Combined sources4
Helixi269 – 279Combined sources11
Turni280 – 283Combined sources4
Helixi284 – 295Combined sources12
Helixi299 – 306Combined sources8
Helixi309 – 319Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIIX-ray1.95A1-323[»]
1AXNX-ray1.78A2-323[»]
ProteinModelPortaliP12429
SMRiP12429
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12429

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 87Annexin 1Add BLAST61
Repeati99 – 159Annexin 2Add BLAST61
Repeati183 – 243Annexin 3Add BLAST61
Repeati258 – 318Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP12429
KOiK17089
OMAiCLRSFPQ
OrthoDBiEOG091G0H6H
PhylomeDBiP12429
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002390 ANX3
PANTHERiPTHR10502:SF25 PTHR10502:SF25, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00199 ANNEXINIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN
60 70 80 90 100
AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK
110 120 130 140 150
KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG
160 170 180 190 200
DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI
210 220 230 240 250
LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT
260 270 280 290 300
PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY
310 320
SAIKSDTSGD YEITLLKICG GDD
Length:323
Mass (Da):36,375
Last modified:January 23, 2007 - v3
Checksum:i4128C715491FC132
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → R in CAG28576 (Ref. 4) Curated1
Sequence conflicti146S → G AA sequence (PubMed:2975506).Curated1
Sequence conflicti294H → R AA sequence (PubMed:2975506).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01391419S → N1 PublicationCorresponds to variant dbSNP:rs5951Ensembl.1
Natural variantiVAR_013915219I → N1 PublicationCorresponds to variant dbSNP:rs5948Ensembl.1
Natural variantiVAR_013916251P → L1 PublicationCorresponds to variant dbSNP:rs5949Ensembl.1
Natural variantiVAR_013917291F → S1 PublicationCorresponds to variant dbSNP:rs5941Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20560 mRNA Translation: AAA59496.1
M63310 mRNA Translation: AAA52284.1
L20591 Genomic DNA Translation: AAA16713.1
CR407648 mRNA Translation: CAG28576.1
AK313945 mRNA Translation: BAG36663.1
CH471057 Genomic DNA Translation: EAX05822.1
BC000871 mRNA Translation: AAH00871.1
CCDSiCCDS3584.1
PIRiA47658 LUHU3
RefSeqiNP_005130.1, NM_005139.2
UniGeneiHs.480042

Genome annotation databases

EnsembliENST00000264908; ENSP00000264908; ENSG00000138772
GeneIDi306
KEGGihsa:306
UCSCiuc003hld.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANXA3_HUMAN
AccessioniPrimary (citable) accession number: P12429
Secondary accession number(s): B2R9W6, Q6LET2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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