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P12429

- ANXA3_HUMAN

UniProt

P12429 - ANXA3_HUMAN

Protein

Annexin A3

Gene

ANXA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB
    2. calcium-dependent protein binding Source: AgBase
    3. calcium ion binding Source: InterPro
    4. phospholipase A2 inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB
    2. neutrophil degranulation Source: UniProtKB
    3. phagocytosis Source: UniProtKB
    4. positive regulation of angiogenesis Source: UniProtKB
    5. positive regulation of endothelial cell migration Source: UniProtKB
    6. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB

    Keywords - Molecular functioni

    Phospholipase A2 inhibitor

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A3
    Alternative name(s):
    35-alpha calcimedin
    Annexin III
    Annexin-3
    Inositol 1,2-cyclic phosphate 2-phosphohydrolase
    Lipocortin III
    Placental anticoagulant protein III
    Short name:
    PAP-III
    Gene namesi
    Name:ANXA3
    Synonyms:ANX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:541. ANXA3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. phagocytic vesicle membrane Source: UniProtKB
    5. plasma membrane Source: UniProtKB
    6. specific granule Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24831.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 323322Annexin A3PRO_0000067477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP12429.
    PaxDbiP12429.
    PRIDEiP12429.

    2D gel databases

    OGPiP12429.
    SWISS-2DPAGEP12429.

    PTM databases

    PhosphoSiteiP12429.

    Expressioni

    Gene expression databases

    ArrayExpressiP12429.
    BgeeiP12429.
    CleanExiHS_ANXA3.
    GenevestigatoriP12429.

    Organism-specific databases

    HPAiHPA013398.
    HPA013431.

    Interactioni

    Protein-protein interaction databases

    BioGridi106803. 12 interactions.
    IntActiP12429. 6 interactions.
    MINTiMINT-4998835.
    STRINGi9606.ENSP00000264908.

    Structurei

    Secondary structure

    1
    323
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 3112
    Beta strandi32 – 354
    Helixi38 – 458
    Helixi50 – 6415
    Helixi68 – 758
    Helixi78 – 8811
    Helixi91 – 10313
    Beta strandi105 – 1073
    Helixi110 – 11910
    Helixi122 – 13615
    Helixi140 – 1478
    Helixi150 – 16011
    Helixi172 – 18514
    Turni186 – 1883
    Beta strandi189 – 1913
    Helixi194 – 20310
    Helixi206 – 22015
    Helixi224 – 2318
    Helixi234 – 26229
    Beta strandi263 – 2664
    Helixi269 – 27911
    Turni280 – 2834
    Helixi284 – 29512
    Helixi299 – 3068
    Helixi309 – 31911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AIIX-ray1.95A1-323[»]
    1AXNX-ray1.78A2-323[»]
    ProteinModelPortaliP12429.
    SMRiP12429. Positions 2-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12429.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati27 – 8761Annexin 1Add
    BLAST
    Repeati99 – 15961Annexin 2Add
    BLAST
    Repeati183 – 24361Annexin 3Add
    BLAST
    Repeati258 – 31861Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP12429.
    KOiK17089.
    OMAiHRGTVRD.
    OrthoDBiEOG74XS72.
    PhylomeDBiP12429.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002390. AnnexinIII.
    [Graphical view]
    PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00199. ANNEXINIII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12429-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN    50
    AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK 100
    KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG 150
    DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI 200
    LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT 250
    PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY 300
    SAIKSDTSGD YEITLLKICG GDD 323
    Length:323
    Mass (Da):36,375
    Last modified:January 23, 2007 - v3
    Checksum:i4128C715491FC132
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351G → R in CAG28576. 1 PublicationCurated
    Sequence conflicti146 – 1461S → G AA sequence (PubMed:2975506)Curated
    Sequence conflicti294 – 2941H → R AA sequence (PubMed:2975506)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191S → N.1 Publication
    Corresponds to variant rs5951 [ dbSNP | Ensembl ].
    VAR_013914
    Natural varianti219 – 2191I → N.1 Publication
    Corresponds to variant rs5948 [ dbSNP | Ensembl ].
    VAR_013915
    Natural varianti251 – 2511P → L.1 Publication
    Corresponds to variant rs5949 [ dbSNP | Ensembl ].
    VAR_013916
    Natural varianti291 – 2911F → S.1 Publication
    Corresponds to variant rs5941 [ dbSNP | Ensembl ].
    VAR_013917

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20560 mRNA. Translation: AAA59496.1.
    M63310 mRNA. Translation: AAA52284.1.
    L20591 Genomic DNA. Translation: AAA16713.1.
    CR407648 mRNA. Translation: CAG28576.1.
    AK313945 mRNA. Translation: BAG36663.1.
    CH471057 Genomic DNA. Translation: EAX05822.1.
    BC000871 mRNA. Translation: AAH00871.1.
    CCDSiCCDS3584.1.
    PIRiA47658. LUHU3.
    RefSeqiNP_005130.1. NM_005139.2.
    XP_005263030.1. XM_005262973.1.
    UniGeneiHs.480042.

    Genome annotation databases

    EnsembliENST00000264908; ENSP00000264908; ENSG00000138772.
    GeneIDi306.
    KEGGihsa:306.
    UCSCiuc003hld.3. human.

    Polymorphism databases

    DMDMi113954.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20560 mRNA. Translation: AAA59496.1 .
    M63310 mRNA. Translation: AAA52284.1 .
    L20591 Genomic DNA. Translation: AAA16713.1 .
    CR407648 mRNA. Translation: CAG28576.1 .
    AK313945 mRNA. Translation: BAG36663.1 .
    CH471057 Genomic DNA. Translation: EAX05822.1 .
    BC000871 mRNA. Translation: AAH00871.1 .
    CCDSi CCDS3584.1.
    PIRi A47658. LUHU3.
    RefSeqi NP_005130.1. NM_005139.2.
    XP_005263030.1. XM_005262973.1.
    UniGenei Hs.480042.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AII X-ray 1.95 A 1-323 [» ]
    1AXN X-ray 1.78 A 2-323 [» ]
    ProteinModelPortali P12429.
    SMRi P12429. Positions 2-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106803. 12 interactions.
    IntActi P12429. 6 interactions.
    MINTi MINT-4998835.
    STRINGi 9606.ENSP00000264908.

    PTM databases

    PhosphoSitei P12429.

    Polymorphism databases

    DMDMi 113954.

    2D gel databases

    OGPi P12429.
    SWISS-2DPAGE P12429.

    Proteomic databases

    MaxQBi P12429.
    PaxDbi P12429.
    PRIDEi P12429.

    Protocols and materials databases

    DNASUi 306.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264908 ; ENSP00000264908 ; ENSG00000138772 .
    GeneIDi 306.
    KEGGi hsa:306.
    UCSCi uc003hld.3. human.

    Organism-specific databases

    CTDi 306.
    GeneCardsi GC04P079403.
    HGNCi HGNC:541. ANXA3.
    HPAi HPA013398.
    HPA013431.
    MIMi 106490. gene.
    neXtProti NX_P12429.
    PharmGKBi PA24831.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267770.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P12429.
    KOi K17089.
    OMAi HRGTVRD.
    OrthoDBi EOG74XS72.
    PhylomeDBi P12429.
    TreeFami TF105452.

    Miscellaneous databases

    EvolutionaryTracei P12429.
    GeneWikii Annexin_A3.
    GenomeRNAii 306.
    NextBioi 1235.
    PROi P12429.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12429.
    Bgeei P12429.
    CleanExi HS_ANXA3.
    Genevestigatori P12429.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002390. AnnexinIII.
    [Graphical view ]
    PANTHERi PTHR10502:SF25. PTHR10502:SF25. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00199. ANNEXINIII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I."
      Pepinsky R.B., Tizard R., Mattaliano R.J., Sinclair L.K., Miller G.T., Browning J.L., Chow E.P., Burne C., Huang K.-S., Pratt D., Wachter L., Hession C., Frey A.Z., Wallner B.P.
      J. Biol. Chem. 263:10799-10811(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Chromosomal localization of the human annexin III (ANX3) gene."
      Tait J.F., Frankenberry D.A., Miao C.H., Killary A.M., Adler D.A., Disteche C.M.
      Genomics 10:441-448(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure and polymorphisms of the human annexin III (ANX3) gene."
      Tait J.F., Smith C., Xu L., Cookson B.T.
      Genomics 18:79-86(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-8.
      Tissue: Platelet.
    9. Bienvenut W.V., Heiserich L., Gottlieb E.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 40-48; 105-120; 155-163; 249-257; 264-274 AND 280-288, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Colon carcinoma.
    10. "Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III."
      Ross T.S., Tait J.F., Majerus P.W.
      Science 248:605-607(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-102 AND 126-138.
    11. "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family."
      Tait J.F., Sakata M., McMullen B.A., Miao C.H., Funakoshi T., Hendrickson L.E., Fujikawa K.
      Biochemistry 27:6268-6276(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-79; 85-88; 104-119; 126-150 AND 217-323.
    12. "Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules."
      Ernst J.D., Hoye E., Blackwood R.A., Jaye D.
      J. Clin. Invest. 85:1065-1071(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 42-55; 74-82; 105-126; 155-169; 177-209; 264-274 AND 305-315, CALCIUM-DEPENDENT BINDING TO PHOSPHOLIPIDS.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V."
      Favier-Perron B., Lewit-Bentley A., Russo-Marie F.
      Biochemistry 35:1740-1744(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
    15. Cited for: VARIANTS ASN-19; ASN-219; LEU-251 AND SER-291.

    Entry informationi

    Entry nameiANXA3_HUMAN
    AccessioniPrimary (citable) accession number: P12429
    Secondary accession number(s): B2R9W6, Q6LET2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 155 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3