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P12429

- ANXA3_HUMAN

UniProt

P12429 - ANXA3_HUMAN

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Protein

Annexin A3

Gene
ANXA3, ANX3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB
  2. calcium-dependent protein binding Source: AgBase
  3. calcium ion binding Source: InterPro
  4. phospholipase A2 inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB
  2. neutrophil degranulation Source: UniProtKB
  3. phagocytosis Source: UniProtKB
  4. positive regulation of angiogenesis Source: UniProtKB
  5. positive regulation of endothelial cell migration Source: UniProtKB
  6. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Inositol 1,2-cyclic phosphate 2-phosphohydrolase
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:ANXA3
Synonyms:ANX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:541. ANXA3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. membrane Source: UniProtKB
  4. phagocytic vesicle membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB
  6. specific granule Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 323322Annexin A3PRO_0000067477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP12429.
PaxDbiP12429.
PRIDEiP12429.

2D gel databases

OGPiP12429.
SWISS-2DPAGEP12429.

PTM databases

PhosphoSiteiP12429.

Expressioni

Gene expression databases

ArrayExpressiP12429.
BgeeiP12429.
CleanExiHS_ANXA3.
GenevestigatoriP12429.

Organism-specific databases

HPAiHPA013398.
HPA013431.

Interactioni

Protein-protein interaction databases

BioGridi106803. 12 interactions.
IntActiP12429. 6 interactions.
MINTiMINT-4998835.
STRINGi9606.ENSP00000264908.

Structurei

Secondary structure

1
323
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 3112
Beta strandi32 – 354
Helixi38 – 458
Helixi50 – 6415
Helixi68 – 758
Helixi78 – 8811
Helixi91 – 10313
Beta strandi105 – 1073
Helixi110 – 11910
Helixi122 – 13615
Helixi140 – 1478
Helixi150 – 16011
Helixi172 – 18514
Turni186 – 1883
Beta strandi189 – 1913
Helixi194 – 20310
Helixi206 – 22015
Helixi224 – 2318
Helixi234 – 26229
Beta strandi263 – 2664
Helixi269 – 27911
Turni280 – 2834
Helixi284 – 29512
Helixi299 – 3068
Helixi309 – 31911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AIIX-ray1.95A1-323[»]
1AXNX-ray1.78A2-323[»]
ProteinModelPortaliP12429.
SMRiP12429. Positions 2-323.

Miscellaneous databases

EvolutionaryTraceiP12429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 8761Annexin 1Add
BLAST
Repeati99 – 15961Annexin 2Add
BLAST
Repeati183 – 24361Annexin 3Add
BLAST
Repeati258 – 31861Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP12429.
KOiK17089.
OMAiHRGTVRD.
OrthoDBiEOG74XS72.
PhylomeDBiP12429.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12429-1 [UniParc]FASTAAdd to Basket

« Hide

MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN    50
AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK 100
KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG 150
DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI 200
LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT 250
PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY 300
SAIKSDTSGD YEITLLKICG GDD 323
Length:323
Mass (Da):36,375
Last modified:January 23, 2007 - v3
Checksum:i4128C715491FC132
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191S → N.1 Publication
Corresponds to variant rs5951 [ dbSNP | Ensembl ].
VAR_013914
Natural varianti219 – 2191I → N.1 Publication
Corresponds to variant rs5948 [ dbSNP | Ensembl ].
VAR_013915
Natural varianti251 – 2511P → L.1 Publication
Corresponds to variant rs5949 [ dbSNP | Ensembl ].
VAR_013916
Natural varianti291 – 2911F → S.1 Publication
Corresponds to variant rs5941 [ dbSNP | Ensembl ].
VAR_013917

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351G → R in CAG28576. 1 Publication
Sequence conflicti146 – 1461S → G AA sequence 1 Publication
Sequence conflicti294 – 2941H → R AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20560 mRNA. Translation: AAA59496.1.
M63310 mRNA. Translation: AAA52284.1.
L20591 Genomic DNA. Translation: AAA16713.1.
CR407648 mRNA. Translation: CAG28576.1.
AK313945 mRNA. Translation: BAG36663.1.
CH471057 Genomic DNA. Translation: EAX05822.1.
BC000871 mRNA. Translation: AAH00871.1.
CCDSiCCDS3584.1.
PIRiA47658. LUHU3.
RefSeqiNP_005130.1. NM_005139.2.
XP_005263030.1. XM_005262973.1.
UniGeneiHs.480042.

Genome annotation databases

EnsembliENST00000264908; ENSP00000264908; ENSG00000138772.
GeneIDi306.
KEGGihsa:306.
UCSCiuc003hld.3. human.

Polymorphism databases

DMDMi113954.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20560 mRNA. Translation: AAA59496.1 .
M63310 mRNA. Translation: AAA52284.1 .
L20591 Genomic DNA. Translation: AAA16713.1 .
CR407648 mRNA. Translation: CAG28576.1 .
AK313945 mRNA. Translation: BAG36663.1 .
CH471057 Genomic DNA. Translation: EAX05822.1 .
BC000871 mRNA. Translation: AAH00871.1 .
CCDSi CCDS3584.1.
PIRi A47658. LUHU3.
RefSeqi NP_005130.1. NM_005139.2.
XP_005263030.1. XM_005262973.1.
UniGenei Hs.480042.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AII X-ray 1.95 A 1-323 [» ]
1AXN X-ray 1.78 A 2-323 [» ]
ProteinModelPortali P12429.
SMRi P12429. Positions 2-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106803. 12 interactions.
IntActi P12429. 6 interactions.
MINTi MINT-4998835.
STRINGi 9606.ENSP00000264908.

PTM databases

PhosphoSitei P12429.

Polymorphism databases

DMDMi 113954.

2D gel databases

OGPi P12429.
SWISS-2DPAGE P12429.

Proteomic databases

MaxQBi P12429.
PaxDbi P12429.
PRIDEi P12429.

Protocols and materials databases

DNASUi 306.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264908 ; ENSP00000264908 ; ENSG00000138772 .
GeneIDi 306.
KEGGi hsa:306.
UCSCi uc003hld.3. human.

Organism-specific databases

CTDi 306.
GeneCardsi GC04P079403.
HGNCi HGNC:541. ANXA3.
HPAi HPA013398.
HPA013431.
MIMi 106490. gene.
neXtProti NX_P12429.
PharmGKBi PA24831.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267770.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P12429.
KOi K17089.
OMAi HRGTVRD.
OrthoDBi EOG74XS72.
PhylomeDBi P12429.
TreeFami TF105452.

Miscellaneous databases

EvolutionaryTracei P12429.
GeneWikii Annexin_A3.
GenomeRNAii 306.
NextBioi 1235.
PROi P12429.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12429.
Bgeei P12429.
CleanExi HS_ANXA3.
Genevestigatori P12429.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view ]
PANTHERi PTHR10502:SF25. PTHR10502:SF25. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I."
    Pepinsky R.B., Tizard R., Mattaliano R.J., Sinclair L.K., Miller G.T., Browning J.L., Chow E.P., Burne C., Huang K.-S., Pratt D., Wachter L., Hession C., Frey A.Z., Wallner B.P.
    J. Biol. Chem. 263:10799-10811(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Chromosomal localization of the human annexin III (ANX3) gene."
    Tait J.F., Frankenberry D.A., Miao C.H., Killary A.M., Adler D.A., Disteche C.M.
    Genomics 10:441-448(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and polymorphisms of the human annexin III (ANX3) gene."
    Tait J.F., Smith C., Xu L., Cookson B.T.
    Genomics 18:79-86(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-8.
    Tissue: Platelet.
  9. Bienvenut W.V., Heiserich L., Gottlieb E.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-9; 40-48; 105-120; 155-163; 249-257; 264-274 AND 280-288, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  10. "Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III."
    Ross T.S., Tait J.F., Majerus P.W.
    Science 248:605-607(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-102 AND 126-138.
  11. "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family."
    Tait J.F., Sakata M., McMullen B.A., Miao C.H., Funakoshi T., Hendrickson L.E., Fujikawa K.
    Biochemistry 27:6268-6276(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-79; 85-88; 104-119; 126-150 AND 217-323.
  12. "Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules."
    Ernst J.D., Hoye E., Blackwood R.A., Jaye D.
    J. Clin. Invest. 85:1065-1071(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 42-55; 74-82; 105-126; 155-169; 177-209; 264-274 AND 305-315, CALCIUM-DEPENDENT BINDING TO PHOSPHOLIPIDS.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V."
    Favier-Perron B., Lewit-Bentley A., Russo-Marie F.
    Biochemistry 35:1740-1744(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
  15. Cited for: VARIANTS ASN-19; ASN-219; LEU-251 AND SER-291.

Entry informationi

Entry nameiANXA3_HUMAN
AccessioniPrimary (citable) accession number: P12429
Secondary accession number(s): B2R9W6, Q6LET2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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