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Protein

Protein brown

Gene

bw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Brown and white dimerize for the transport of guanine.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 73ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • aminergic neurotransmitter loading into synaptic vesicle Source: FlyBase
  • eye pigment precursor transport Source: FlyBase
  • ommochrome biosynthetic process Source: FlyBase
  • sensory perception of sound Source: FlyBase
  • transmembrane transport Source: FlyBase

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.18 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Protein brown
Gene namesi
Name:bw
ORF Names:CG17632
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000241 bw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei423 – 441HelicalSequence analysisAdd BLAST19
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Transmembranei504 – 522HelicalSequence analysisAdd BLAST19
Transmembranei531 – 552HelicalSequence analysisAdd BLAST22
Transmembranei565 – 583HelicalSequence analysisAdd BLAST19
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933751 – 675Protein brownAdd BLAST675

Proteomic databases

PaxDbiP12428
PRIDEiP12428

Expressioni

Gene expression databases

BgeeiFBgn0000241
ExpressionAtlasiP12428 differential
GenevisibleiP12428 DM

Interactioni

Subunit structurei

Heterodimer of brown with white.

Protein-protein interaction databases

BioGridi6332438 interactors.
DIPiDIP-387N
IntActiP12428 2 interactors.
STRINGi7227.FBpp0072026

Structurei

3D structure databases

ProteinModelPortaliP12428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261ABC transporterPROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG1131 LUCA
InParanoidiP12428
OrthoDBiEOG091G02Z5
PhylomeDBiP12428

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005284 Pigment_permease/Abcg
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00955 3a01204, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P12428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQESGGSSGQ GGPSLCLEWK QLNYYVPDQE QSNYSFWNEC RKKRELRILQ
60 70 80 90 100
DASGHMKTGD LIAILGGSGA GKTTLLAAIS QRLRGNLTGD VVLNGMAMER
110 120 130 140 150
HQMTRISSFL PQFEINVKTF TAYEHLYFMS HFKMHRRTTK AEKRQRVADL
160 170 180 190 200
LLAVGLRDAA HTRIQQLSGG ERKRLSLAEE LITDPIFLFC DEPTTGLDSF
210 220 230 240 250
SAYSVIKTLR HLCTRRRIAK HSLNQVYGED SFETPSGESS ASGSGSKSIE
260 270 280 290 300
MEVVAESHES LLQTMRELPA LGVLSNSPNG THKKAAICSI HQPTSDIFEL
310 320 330 340 350
FTHIILMDGG RIVYQGRTEQ AAKFFTDLGY ELPLNCNPAD FYLKTLADKE
360 370 380 390 400
GKENAGAVLR AKYEHETDGL YSGSWLLARS YSGDYLKHVQ NFKKIRWIYQ
410 420 430 440 450
VYLLMVRFMT EDLRNIRSGL IAFGFFMITA VTLSLMYSGI GGLTQRTVQD
460 470 480 490 500
VGGSIFMLSN EMIFTFSYGV TYIFPAALPI IRREVGEGTY SLSAYYVALV
510 520 530 540 550
LSFVPVAFFK GYVFLSVIYA SIYYTRGFLL YLSMGFLMSL SAVAAVGYGV
560 570 580 590 600
FLSSLFESDK MASECAAPFD LIFLIFGGTY MNVDTVPGLK YLSLFFYSNE
610 620 630 640 650
ALMYKFWIDI DNIDCPVNED HPCIKTGVEV LQQGSYRNAD YTYWLDCFSL
660 670
VVVAVIFHIV SFGLVRRYIH RSGYY
Length:675
Mass (Da):75,943
Last modified:October 1, 1989 - v1
Checksum:i81DEBDF856F4F174
GO

Sequence cautioni

The sequence AAM50157 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28D → A in AAC37214 (PubMed:7956072).Curated1
Sequence conflicti28D → A in AAA28398 (PubMed:7753025).Curated1
Sequence conflicti28D → A in AAM50157 (PubMed:12537569).Curated1
Sequence conflicti44R → P in AAA28398 (PubMed:7753025).Curated1
Sequence conflicti274L → I in AAC37214 (PubMed:7956072).Curated1
Sequence conflicti274L → I in AAA28398 (PubMed:7753025).Curated1
Sequence conflicti331E → Q in AAC37214 (PubMed:7956072).Curated1
Sequence conflicti407R → P in AAC37214 (PubMed:7956072).Curated1
Sequence conflicti638N → T in AAC37214 (PubMed:7956072).Curated1
Sequence conflicti638N → T in AAA28398 (PubMed:7753025).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20630 mRNA Translation: AAA28397.1
L23543 Genomic DNA Translation: AAC37214.1
L05635 Genomic DNA Translation: AAA28398.1
AE013599 Genomic DNA Translation: AAF47020.3
AY119503 mRNA Translation: AAM50157.1 Sequence problems.
PIRiA31399 FYFFB
RefSeqiNP_001286769.1, NM_001299840.1
NP_523824.1, NM_079100.3
UniGeneiDm.19990

Genome annotation databases

EnsemblMetazoaiFBtr0072117; FBpp0072026; FBgn0000241
FBtr0346612; FBpp0312192; FBgn0000241
GeneIDi37724
KEGGidme:Dmel_CG17632

Similar proteinsi

Entry informationi

Entry nameiBROWN_DROME
AccessioniPrimary (citable) accession number: P12428
Secondary accession number(s): Q24264
, Q7KVI1, Q7KVI2, Q8MRN9, Q9W1N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome