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P12428

- BROWN_DROME

UniProt

P12428 - BROWN_DROME

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Protein

Protein brown

Gene
bw, CG17632
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Brown and white dimerize for the transport of guanine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. pigment binding Source: UniProtKB-KW

GO - Biological processi

  1. eye pigment precursor transport Source: FlyBase
  2. ommochrome biosynthetic process Source: FlyBase
  3. sensory perception of sound Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.18. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein brown
Gene namesi
Name:bw
ORF Names:CG17632
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000241. bw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei423 – 44119Helical; Reviewed predictionAdd
BLAST
Transmembranei454 – 47421Helical; Reviewed predictionAdd
BLAST
Transmembranei504 – 52219Helical; Reviewed predictionAdd
BLAST
Transmembranei531 – 55222Helical; Reviewed predictionAdd
BLAST
Transmembranei565 – 58319Helical; Reviewed predictionAdd
BLAST
Transmembranei645 – 66521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675Protein brownPRO_0000093375Add
BLAST

Proteomic databases

PRIDEiP12428.

Expressioni

Gene expression databases

BgeeiP12428.

Interactioni

Subunit structurei

Heterodimer of brown with white.

Protein-protein interaction databases

BioGridi63324. 1 interaction.
DIPiDIP-387N.

Structurei

3D structure databases

ProteinModelPortaliP12428.
SMRiP12428. Positions 17-266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228ABC transporterAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000114855.
InParanoidiP12428.
OMAiPTSDIFE.
OrthoDBiEOG7TQV0H.
PhylomeDBiP12428.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P12428-4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQESGGSSGQ GGPSLCLEWK QLNYYVPDQE QSNYSFWNEC RKKRELRILQ    50
DASGHMKTGD LIAILGGSGA GKTTLLAAIS QRLRGNLTGD VVLNGMAMER 100
HQMTRISSFL PQFEINVKTF TAYEHLYFMS HFKMHRRTTK AEKRQRVADL 150
LLAVGLRDAA HTRIQQLSGG ERKRLSLAEE LITDPIFLFC DEPTTGLDSF 200
SAYSVIKTLR HLCTRRRIAK HSLNQVYGED SFETPSGESS ASGSGSKSIE 250
MEVVAESHES LLQTMRELPA LGVLSNSPNG THKKAAICSI HQPTSDIFEL 300
FTHIILMDGG RIVYQGRTEQ AAKFFTDLGY ELPLNCNPAD FYLKTLADKE 350
GKENAGAVLR AKYEHETDGL YSGSWLLARS YSGDYLKHVQ NFKKIRWIYQ 400
VYLLMVRFMT EDLRNIRSGL IAFGFFMITA VTLSLMYSGI GGLTQRTVQD 450
VGGSIFMLSN EMIFTFSYGV TYIFPAALPI IRREVGEGTY SLSAYYVALV 500
LSFVPVAFFK GYVFLSVIYA SIYYTRGFLL YLSMGFLMSL SAVAAVGYGV 550
FLSSLFESDK MASECAAPFD LIFLIFGGTY MNVDTVPGLK YLSLFFYSNE 600
ALMYKFWIDI DNIDCPVNED HPCIKTGVEV LQQGSYRNAD YTYWLDCFSL 650
VVVAVIFHIV SFGLVRRYIH RSGYY 675
Length:675
Mass (Da):75,943
Last modified:October 1, 1989 - v1
Checksum:i81DEBDF856F4F174
GO
Isoform B (identifier: P12428-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-328: RTEQAAKFFTDL → VVCAYAILRTIK
     329-675: Missing.

Note: No experimental confirmation available.

Show »
Length:328
Mass (Da):36,487
Checksum:iA89859424382476C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei317 – 32812RTEQA…FFTDL → VVCAYAILRTIK in isoform B. VSP_040308Add
BLAST
Alternative sequencei329 – 675347Missing in isoform B. VSP_040309Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281D → A in AAC37214. 1 Publication
Sequence conflicti28 – 281D → A in AAA28398. 1 Publication
Sequence conflicti28 – 281D → A in AAM50157. 1 Publication
Sequence conflicti44 – 441R → P in AAA28398. 1 Publication
Sequence conflicti274 – 2741L → I in AAC37214. 1 Publication
Sequence conflicti274 – 2741L → I in AAA28398. 1 Publication
Sequence conflicti331 – 3311E → Q in AAC37214. 1 Publication
Sequence conflicti407 – 4071R → P in AAC37214. 1 Publication
Sequence conflicti638 – 6381N → T in AAC37214. 1 Publication
Sequence conflicti638 – 6381N → T in AAA28398. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20630 mRNA. Translation: AAA28397.1.
L23543 Genomic DNA. Translation: AAC37214.1.
L05635 Genomic DNA. Translation: AAA28398.1.
AE013599 Genomic DNA. Translation: AAF47020.3.
AE013599 Genomic DNA. Translation: AAS64761.1.
AY119503 mRNA. Translation: AAM50157.1.
PIRiA31399. FYFFB.
RefSeqiNP_523824.1. NM_079100.2. [P12428-4]
UniGeneiDm.19990.

Genome annotation databases

EnsemblMetazoaiFBtr0072117; FBpp0072026; FBgn0000241. [P12428-4]
GeneIDi37724.
KEGGidme:Dmel_CG17632.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20630 mRNA. Translation: AAA28397.1 .
L23543 Genomic DNA. Translation: AAC37214.1 .
L05635 Genomic DNA. Translation: AAA28398.1 .
AE013599 Genomic DNA. Translation: AAF47020.3 .
AE013599 Genomic DNA. Translation: AAS64761.1 .
AY119503 mRNA. Translation: AAM50157.1 .
PIRi A31399. FYFFB.
RefSeqi NP_523824.1. NM_079100.2. [P12428-4 ]
UniGenei Dm.19990.

3D structure databases

ProteinModelPortali P12428.
SMRi P12428. Positions 17-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 63324. 1 interaction.
DIPi DIP-387N.

Protein family/group databases

TCDBi 3.A.1.204.18. the atp-binding cassette (abc) superfamily.

Proteomic databases

PRIDEi P12428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0072117 ; FBpp0072026 ; FBgn0000241 . [P12428-4 ]
GeneIDi 37724.
KEGGi dme:Dmel_CG17632.

Organism-specific databases

CTDi 37724.
FlyBasei FBgn0000241. bw.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000114855.
InParanoidi P12428.
OMAi PTSDIFE.
OrthoDBi EOG7TQV0H.
PhylomeDBi P12428.

Miscellaneous databases

GenomeRNAii 37724.
NextBioi 805087.
PROi P12428.

Gene expression databases

Bgeei P12428.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view ]
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00955. 3a01204. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes."
    Dreesen T.D., Johnson D.H., Henikoff S.
    Mol. Cell. Biol. 8:5206-5215(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Characterization of sequences responsible for trans-inactivation of the Drosophila brown gene."
    Martin-Morris L.E., Loughney K., Kershisnik E.O., Poortinga G., Henikoff S.
    Cold Spring Harb. Symp. Quant. Biol. 58:577-584(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster."
    Nitasaka E., Yamazaki T., Green M.M.
    Mol. Gen. Genet. 247:164-168(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IG281.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiBROWN_DROME
AccessioniPrimary (citable) accession number: P12428
Secondary accession number(s): Q24264
, Q7KVI1, Q7KVI2, Q8MRN9, Q9W1N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi