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Protein

Protein brown

Gene

bw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Brown and white dimerize for the transport of guanine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • eye pigment precursor transport Source: FlyBase
  • ommochrome biosynthetic process Source: FlyBase
  • sensory perception of sound Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

TCDBi3.A.1.204.18. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein brown
Gene namesi
Name:bw
ORF Names:CG17632
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000241. bw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei423 – 44119HelicalSequence analysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence analysisAdd
BLAST
Transmembranei504 – 52219HelicalSequence analysisAdd
BLAST
Transmembranei531 – 55222HelicalSequence analysisAdd
BLAST
Transmembranei565 – 58319HelicalSequence analysisAdd
BLAST
Transmembranei645 – 66521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675Protein brownPRO_0000093375Add
BLAST

Proteomic databases

PaxDbiP12428.
PRIDEiP12428.

Expressioni

Gene expression databases

ExpressionAtlasiP12428. differential.
GenevisibleiP12428. DM.

Interactioni

Subunit structurei

Heterodimer of brown with white.

Protein-protein interaction databases

BioGridi63324. 1 interaction.
DIPiDIP-387N.
IntActiP12428. 1 interaction.
STRINGi7227.FBpp0072026.

Structurei

3D structure databases

ProteinModelPortaliP12428.
SMRiP12428. Positions 17-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
InParanoidiP12428.
OrthoDBiEOG091G02Z5.
PhylomeDBiP12428.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQESGGSSGQ GGPSLCLEWK QLNYYVPDQE QSNYSFWNEC RKKRELRILQ
60 70 80 90 100
DASGHMKTGD LIAILGGSGA GKTTLLAAIS QRLRGNLTGD VVLNGMAMER
110 120 130 140 150
HQMTRISSFL PQFEINVKTF TAYEHLYFMS HFKMHRRTTK AEKRQRVADL
160 170 180 190 200
LLAVGLRDAA HTRIQQLSGG ERKRLSLAEE LITDPIFLFC DEPTTGLDSF
210 220 230 240 250
SAYSVIKTLR HLCTRRRIAK HSLNQVYGED SFETPSGESS ASGSGSKSIE
260 270 280 290 300
MEVVAESHES LLQTMRELPA LGVLSNSPNG THKKAAICSI HQPTSDIFEL
310 320 330 340 350
FTHIILMDGG RIVYQGRTEQ AAKFFTDLGY ELPLNCNPAD FYLKTLADKE
360 370 380 390 400
GKENAGAVLR AKYEHETDGL YSGSWLLARS YSGDYLKHVQ NFKKIRWIYQ
410 420 430 440 450
VYLLMVRFMT EDLRNIRSGL IAFGFFMITA VTLSLMYSGI GGLTQRTVQD
460 470 480 490 500
VGGSIFMLSN EMIFTFSYGV TYIFPAALPI IRREVGEGTY SLSAYYVALV
510 520 530 540 550
LSFVPVAFFK GYVFLSVIYA SIYYTRGFLL YLSMGFLMSL SAVAAVGYGV
560 570 580 590 600
FLSSLFESDK MASECAAPFD LIFLIFGGTY MNVDTVPGLK YLSLFFYSNE
610 620 630 640 650
ALMYKFWIDI DNIDCPVNED HPCIKTGVEV LQQGSYRNAD YTYWLDCFSL
660 670
VVVAVIFHIV SFGLVRRYIH RSGYY
Length:675
Mass (Da):75,943
Last modified:October 1, 1989 - v1
Checksum:i81DEBDF856F4F174
GO

Sequence cautioni

The sequence AAM50157 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281D → A in AAC37214 (PubMed:7956072).Curated
Sequence conflicti28 – 281D → A in AAA28398 (PubMed:7753025).Curated
Sequence conflicti28 – 281D → A in AAM50157 (PubMed:12537569).Curated
Sequence conflicti44 – 441R → P in AAA28398 (PubMed:7753025).Curated
Sequence conflicti274 – 2741L → I in AAC37214 (PubMed:7956072).Curated
Sequence conflicti274 – 2741L → I in AAA28398 (PubMed:7753025).Curated
Sequence conflicti331 – 3311E → Q in AAC37214 (PubMed:7956072).Curated
Sequence conflicti407 – 4071R → P in AAC37214 (PubMed:7956072).Curated
Sequence conflicti638 – 6381N → T in AAC37214 (PubMed:7956072).Curated
Sequence conflicti638 – 6381N → T in AAA28398 (PubMed:7753025).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20630 mRNA. Translation: AAA28397.1.
L23543 Genomic DNA. Translation: AAC37214.1.
L05635 Genomic DNA. Translation: AAA28398.1.
AE013599 Genomic DNA. Translation: AAF47020.3.
AY119503 mRNA. Translation: AAM50157.1. Sequence problems.
PIRiA31399. FYFFB.
RefSeqiNP_001286769.1. NM_001299840.1.
NP_523824.1. NM_079100.3.
UniGeneiDm.19990.

Genome annotation databases

GeneIDi37724.
KEGGidme:Dmel_CG17632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20630 mRNA. Translation: AAA28397.1.
L23543 Genomic DNA. Translation: AAC37214.1.
L05635 Genomic DNA. Translation: AAA28398.1.
AE013599 Genomic DNA. Translation: AAF47020.3.
AY119503 mRNA. Translation: AAM50157.1. Sequence problems.
PIRiA31399. FYFFB.
RefSeqiNP_001286769.1. NM_001299840.1.
NP_523824.1. NM_079100.3.
UniGeneiDm.19990.

3D structure databases

ProteinModelPortaliP12428.
SMRiP12428. Positions 17-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63324. 1 interaction.
DIPiDIP-387N.
IntActiP12428. 1 interaction.
STRINGi7227.FBpp0072026.

Protein family/group databases

TCDBi3.A.1.204.18. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP12428.
PRIDEiP12428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi37724.
KEGGidme:Dmel_CG17632.

Organism-specific databases

CTDi37724.
FlyBaseiFBgn0000241. bw.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
InParanoidiP12428.
OrthoDBiEOG091G02Z5.
PhylomeDBiP12428.

Miscellaneous databases

GenomeRNAii37724.
PROiP12428.

Gene expression databases

ExpressionAtlasiP12428. differential.
GenevisibleiP12428. DM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBROWN_DROME
AccessioniPrimary (citable) accession number: P12428
Secondary accession number(s): Q24264
, Q7KVI1, Q7KVI2, Q8MRN9, Q9W1N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.