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Protein

Adenine phosphoribosyltransferase

Gene

Aprt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (Aprt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiR-DME-74217. Purine salvage.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:Aprt
ORF Names:CG18315
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000109. Aprt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Adenine phosphoribosyltransferasePRO_0000149512Add
BLAST

Proteomic databases

PaxDbiP12426.

Expressioni

Gene expression databases

BgeeiFBgn0000109.
ExpressionAtlasiP12426. differential.
GenevisibleiP12426. DM.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi71230. 7 interactions.
DIPiDIP-22863N.
IntActiP12426. 1 interaction.
MINTiMINT-979410.
STRINGi7227.FBpp0088438.

Structurei

3D structure databases

ProteinModelPortaliP12426.
SMRiP12426. Positions 7-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
InParanoidiP12426.
KOiK00759.
OMAiKKHIGEY.
OrthoDBiEOG091G0XZC.
PhylomeDBiP12426.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSISAEDK LDYVKSKIGE YPNFPKEGIL FRDIFGALTD PKACVYLRDL
60 70 80 90 100
LVDHIRESAP EAEVIVGLDS RGFLFNLLIA TELGLGCAPI RKKGKLAGEV
110 120 130 140 150
VSVEYKLEYG IDTFELQKSA IKPGQKVVVV DDLLATGGSL VAATELIGKV
160 170 180
GGVVVESLVV MELVGLEGRK RLDGKVHSLI KY
Length:182
Mass (Da):19,690
Last modified:May 9, 2003 - v3
Checksum:iE69C129905AE4745
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641V → I in AAA28377 (PubMed:3125085).Curated
Sequence conflicti64 – 641V → I in AAA57204 (PubMed:8492806).Curated
Sequence conflicti111 – 1111I → S in AAA28377 (PubMed:3125085).Curated
Sequence conflicti111 – 1111I → S in AAA57204 (PubMed:8492806).Curated
Sequence conflicti148 – 1481G → R in AAA28377 (PubMed:3125085).Curated
Sequence conflicti148 – 1481G → R in AAA57204 (PubMed:8492806).Curated
Sequence conflicti160 – 1601V → VV in AAA28377 (PubMed:3125085).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18432 mRNA. Translation: AAA28377.1.
L06280 Genomic DNA. Translation: AAA57204.1.
AE014296 Genomic DNA. Translation: AAF47589.1.
AY119066 mRNA. Translation: AAM50926.1.
PIRiA29596.
S34831.
RefSeqiNP_001286908.1. NM_001299979.1.
NP_001286909.1. NM_001299980.1.
NP_476637.1. NM_057289.3.
UniGeneiDm.20322.

Genome annotation databases

EnsemblMetazoaiFBtr0089420; FBpp0088438; FBgn0000109.
FBtr0346440; FBpp0312098; FBgn0000109.
FBtr0346441; FBpp0312099; FBgn0000109.
GeneIDi48224.
KEGGidme:Dmel_CG18315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18432 mRNA. Translation: AAA28377.1.
L06280 Genomic DNA. Translation: AAA57204.1.
AE014296 Genomic DNA. Translation: AAF47589.1.
AY119066 mRNA. Translation: AAM50926.1.
PIRiA29596.
S34831.
RefSeqiNP_001286908.1. NM_001299979.1.
NP_001286909.1. NM_001299980.1.
NP_476637.1. NM_057289.3.
UniGeneiDm.20322.

3D structure databases

ProteinModelPortaliP12426.
SMRiP12426. Positions 7-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71230. 7 interactions.
DIPiDIP-22863N.
IntActiP12426. 1 interaction.
MINTiMINT-979410.
STRINGi7227.FBpp0088438.

Proteomic databases

PaxDbiP12426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089420; FBpp0088438; FBgn0000109.
FBtr0346440; FBpp0312098; FBgn0000109.
FBtr0346441; FBpp0312099; FBgn0000109.
GeneIDi48224.
KEGGidme:Dmel_CG18315.

Organism-specific databases

CTDi353.
FlyBaseiFBgn0000109. Aprt.

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
InParanoidiP12426.
KOiK00759.
OMAiKKHIGEY.
OrthoDBiEOG091G0XZC.
PhylomeDBiP12426.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
ReactomeiR-DME-74217. Purine salvage.

Miscellaneous databases

GenomeRNAii48224.
PROiP12426.

Gene expression databases

BgeeiFBgn0000109.
ExpressionAtlasiP12426. differential.
GenevisibleiP12426. DM.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr. 1 hit.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPT_DROME
AccessioniPrimary (citable) accession number: P12426
Secondary accession number(s): Q9W069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 9, 2003
Last modified: September 7, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.