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Protein

Adenine phosphoribosyltransferase

Gene

Aprt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (Aprt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-74217 Purine salvage
UniPathwayiUPA00588; UER00646

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:Aprt
ORF Names:CG18315
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000109 Aprt

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495121 – 182Adenine phosphoribosyltransferaseAdd BLAST182

Proteomic databases

PaxDbiP12426
PRIDEiP12426

Expressioni

Gene expression databases

BgeeiFBgn0000109
ExpressionAtlasiP12426 baseline and differential
GenevisibleiP12426 DM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi71230, 7 interactors
DIPiDIP-22863N
IntActiP12426, 1 interactor
STRINGi7227.FBpp0088438

Structurei

3D structure databases

ProteinModelPortaliP12426
SMRiP12426
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712 Eukaryota
COG0503 LUCA
InParanoidiP12426
KOiK00759
OMAiCAPIRKK
OrthoDBiEOG091G0XZC
PhylomeDBiP12426

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00004 Aden_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR005764 Ade_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

P12426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSISAEDK LDYVKSKIGE YPNFPKEGIL FRDIFGALTD PKACVYLRDL
60 70 80 90 100
LVDHIRESAP EAEVIVGLDS RGFLFNLLIA TELGLGCAPI RKKGKLAGEV
110 120 130 140 150
VSVEYKLEYG IDTFELQKSA IKPGQKVVVV DDLLATGGSL VAATELIGKV
160 170 180
GGVVVESLVV MELVGLEGRK RLDGKVHSLI KY
Length:182
Mass (Da):19,690
Last modified:May 9, 2003 - v3
Checksum:iE69C129905AE4745
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64V → I in AAA28377 (PubMed:3125085).Curated1
Sequence conflicti64V → I in AAA57204 (PubMed:8492806).Curated1
Sequence conflicti111I → S in AAA28377 (PubMed:3125085).Curated1
Sequence conflicti111I → S in AAA57204 (PubMed:8492806).Curated1
Sequence conflicti148G → R in AAA28377 (PubMed:3125085).Curated1
Sequence conflicti148G → R in AAA57204 (PubMed:8492806).Curated1
Sequence conflicti160V → VV in AAA28377 (PubMed:3125085).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18432 mRNA Translation: AAA28377.1
L06280 Genomic DNA Translation: AAA57204.1
AE014296 Genomic DNA Translation: AAF47589.1
AY119066 mRNA Translation: AAM50926.1
PIRiA29596
S34831
RefSeqiNP_001286908.1, NM_001299979.1
NP_001286909.1, NM_001299980.1
NP_476637.1, NM_057289.3
UniGeneiDm.20322

Genome annotation databases

EnsemblMetazoaiFBtr0089420; FBpp0088438; FBgn0000109
FBtr0346440; FBpp0312098; FBgn0000109
FBtr0346441; FBpp0312099; FBgn0000109
GeneIDi48224
KEGGidme:Dmel_CG18315

Similar proteinsi

Entry informationi

Entry nameiAPT_DROME
AccessioniPrimary (citable) accession number: P12426
Secondary accession number(s): Q9W069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 9, 2003
Last modified: May 23, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health