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Protein

Prolactin

Gene

PRL

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 229199ProlactinPRO_0000032915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 41By similarity
Modified residuei56 – 561PhosphoserineBy similarity
Glycosylationi61 – 611N-linked (GlcNAc...); partial
Modified residuei64 – 641PhosphoserineBy similarity
Disulfide bondi88 ↔ 204By similarity
Modified residuei120 – 1201PhosphoserineBy similarity
Disulfide bondi221 ↔ 229By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12420.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000120.

Structurei

3D structure databases

ProteinModelPortaliP12420.
SMRiP12420. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP12420.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKRSSLKG SLLLLLLLVS DLLLCKSVAS LPICPSGAVN CQVSLRELFD
60 70 80 90 100
RAVILSHYIH NLSSEMFNEF DKRYAQGRGF VTKAINSCHT SSLSTPEDKE
110 120 130 140 150
QAQQIHHEDL LNLILRVLRS WNDPLYHLVS EVRGMQEAPE AILSKAIEIE
160 170 180 190 200
EQNRRLLEGM EKIVGQVQPR IKENEVYSVW SGLPSLQMAD EDSRLFAFYN
210 220
LLHCLRRDSH KIDNYLKLLK CRIVYDSNC
Length:229
Mass (Da):26,256
Last modified:April 12, 2005 - v2
Checksum:iA7B891BA9ADE737C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191R → K AA sequence (PubMed:3045032).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY373339 mRNA. Translation: AAQ76548.1.
PIRiJK0016. LCHO.
RefSeqiNP_001075365.1. NM_001081896.1.
UniGeneiEca.12783.

Genome annotation databases

GeneIDi100034034.
KEGGiecb:100034034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY373339 mRNA. Translation: AAQ76548.1.
PIRiJK0016. LCHO.
RefSeqiNP_001075365.1. NM_001081896.1.
UniGeneiEca.12783.

3D structure databases

ProteinModelPortaliP12420.
SMRiP12420. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000120.

Proteomic databases

PaxDbiP12420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034034.
KEGGiecb:100034034.

Organism-specific databases

CTDi5617.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP12420.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_HORSE
AccessioniPrimary (citable) accession number: P12420
Secondary accession number(s): Q6UBP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 12, 2005
Last modified: December 9, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.