Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P12394

- CP17A_CHICK

UniProt

P12394 - CP17A_CHICK

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi445 – 4451Iron (heme axial ligand)

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB
    2. steroid biosynthetic process Source: UniProtKB-UniPathway
    3. steroid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:CYP17A1
    Synonyms:CYP17
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051943Add
    BLAST

    Proteomic databases

    PaxDbiP12394.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013167.

    Structurei

    3D structure databases

    ProteinModelPortaliP12394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    KOiK00512.
    PhylomeDBiP12394.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12394-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPLAVLLLA LALLCAWRLS YSQGPTGTGT GRPRSLPALP LVGSLLQLAG    50
    HPQLHLRLWR LQGRYGSLYG LWMGSHYVVV VNSYQHAREV LLKKGKAFAG 100
    RPRTVTTDLL SRGGKDIAFA SYGPLWKFQR KLVHAALSMF GEGSVALEKI 150
    ICREAASLCE TLGAAQDMAL DMAPELTRAV TNVVCSLCFN SSYRRGDPEF 200
    EAMLEYSQGI VDTVAKESLV DIFPWLQIFP NRDLALLKRC LKVRDQLLQQ 250
    KFTEHKEAFC GDTVRDLMDA LLQVRLNAEN NSPLEPGLEL TDDHLLMTVG 300
    DIFGAGVETT TTVLKWAVLY LLHYPEVQKK IQEEMDQKIG LARHPHLSDR 350
    PLLPYLEATI SEGLRIRPVS PLLIPHVSLA DTSIGEYSIP KGARVVINLW 400
    SVHHDEKEWD KPEEFNPGRF LDEQGQHIHS PSPSYLPFGA GIRVCLGEVL 450
    AKMELFLFLA WVLQRFTLEC PQDQPLPSLE GKFGVVLQVQ KFRVKARLRE 500
    AWRGEMVR 508
    Length:508
    Mass (Da):56,984
    Last modified:October 1, 1989 - v1
    Checksum:i52BE915B46E237AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21406 mRNA. Translation: AAA48997.1.
    PIRiJT0318. O4CHC7.
    RefSeqiNP_001001901.1. NM_001001901.2.
    UniGeneiGga.834.

    Genome annotation databases

    GeneIDi425056.
    KEGGigga:425056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21406 mRNA. Translation: AAA48997.1 .
    PIRi JT0318. O4CHC7.
    RefSeqi NP_001001901.1. NM_001001901.2.
    UniGenei Gga.834.

    3D structure databases

    ProteinModelPortali P12394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013167.

    Proteomic databases

    PaxDbi P12394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 425056.
    KEGGi gga:425056.

    Organism-specific databases

    CTDi 1586.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    KOi K00512.
    PhylomeDBi P12394.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .

    Miscellaneous databases

    NextBioi 20827300.
    PROi P12394.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and sequence analysis of a chicken gene expressed during the gonadal development and homologous to mammalian cytochrome P-450c17."
      Ono H., Iwasaki M., Sakamoto N., Mizuno S.
      Gene 66:77-85(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP17A_CHICK
    AccessioniPrimary (citable) accession number: P12394
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3