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P12394 (CP17A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase

EC=1.14.99.9
EC=4.1.2.30
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name=Cytochrome P450c17
Gene names
Name:CYP17A1
Synonyms:CYP17
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activity

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

Membrane Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051943

Sites

Metal binding4451Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P12394 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 52BE915B46E237AF

FASTA50856,984
        10         20         30         40         50         60 
MPPLAVLLLA LALLCAWRLS YSQGPTGTGT GRPRSLPALP LVGSLLQLAG HPQLHLRLWR 

        70         80         90        100        110        120 
LQGRYGSLYG LWMGSHYVVV VNSYQHAREV LLKKGKAFAG RPRTVTTDLL SRGGKDIAFA 

       130        140        150        160        170        180 
SYGPLWKFQR KLVHAALSMF GEGSVALEKI ICREAASLCE TLGAAQDMAL DMAPELTRAV 

       190        200        210        220        230        240 
TNVVCSLCFN SSYRRGDPEF EAMLEYSQGI VDTVAKESLV DIFPWLQIFP NRDLALLKRC 

       250        260        270        280        290        300 
LKVRDQLLQQ KFTEHKEAFC GDTVRDLMDA LLQVRLNAEN NSPLEPGLEL TDDHLLMTVG 

       310        320        330        340        350        360 
DIFGAGVETT TTVLKWAVLY LLHYPEVQKK IQEEMDQKIG LARHPHLSDR PLLPYLEATI 

       370        380        390        400        410        420 
SEGLRIRPVS PLLIPHVSLA DTSIGEYSIP KGARVVINLW SVHHDEKEWD KPEEFNPGRF 

       430        440        450        460        470        480 
LDEQGQHIHS PSPSYLPFGA GIRVCLGEVL AKMELFLFLA WVLQRFTLEC PQDQPLPSLE 

       490        500 
GKFGVVLQVQ KFRVKARLRE AWRGEMVR 

« Hide

References

[1]"cDNA cloning and sequence analysis of a chicken gene expressed during the gonadal development and homologous to mammalian cytochrome P-450c17."
Ono H., Iwasaki M., Sakamoto N., Mizuno S.
Gene 66:77-85(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21406 mRNA. Translation: AAA48997.1.
PIRO4CHC7. JT0318.
RefSeqNP_001001901.1. NM_001001901.2.
UniGeneGga.834.

3D structure databases

ProteinModelPortalP12394.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000013167.

Proteomic databases

PaxDbP12394.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID425056.
KEGGgga:425056.

Organism-specific databases

CTD1586.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG106944.
KOK00512.
PhylomeDBP12394.

Enzyme and pathway databases

UniPathwayUPA00062.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20827300.
PROP12394.

Entry information

Entry nameCP17A_CHICK
AccessionPrimary (citable) accession number: P12394
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways