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Protein

Neuronal acetylcholine receptor subunit beta-3

Gene

Chrnb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: RGD
  • acetylcholine binding Source: RGD
  • drug binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-RNO-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit beta-3
Gene namesi
Name:Chrnb3
Synonyms:Acrb3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621544. Chrnb3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 238ExtracellularSequence analysisAdd BLAST208
Transmembranei239 – 263HelicalSequence analysisAdd BLAST25
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Transmembranei305 – 326HelicalSequence analysisAdd BLAST22
Topological domaini327 – 434CytoplasmicSequence analysisAdd BLAST108
Transmembranei435 – 453HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: RGD
  • cell junction Source: UniProtKB-KW
  • membrane Source: RGD
  • neuron projection Source: RGD
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3137275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000038631 – 464Neuronal acetylcholine receptor subunit beta-3Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi159 ↔ 173By similarity
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12391.

PTM databases

PhosphoSitePlusiP12391.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012448.
GenevisibleiP12391. RN.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and beta.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016656.

Chemistry databases

BindingDBiP12391.

Structurei

3D structure databases

ProteinModelPortaliP12391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP12391.
KOiK04814.
OMAiDHKLSWN.
OrthoDBiEOG091G0R20.
PhylomeDBiP12391.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGFLRVFLV LSATLSGSWV TLTATAGLSS VAEHEDALLR HLFQGYQKWV
60 70 80 90 100
RPVLNSSDII KVYFGLKISQ LVDVDEKNQL MTTNVWLKQE WTDQKLRWNP
110 120 130 140 150
EEYGGINSIK VPSESLWLPD IVLFENADGR FEGSLMTKAI VKSSGTVSWT
160 170 180 190 200
PPASYKSSCT MDVTFFPFDR QNCSMKFGSW TYDGTMVDLI LINENVDRKD
210 220 230 240 250
FFDNGEWEIL NAKGMKGNRR EGFYSYPFVT YSFVLRRLPL FYTLFLIIPC
260 270 280 290 300
LGLSFLTVLV FYLPSDEGEK LSLSTSVLVS LTVFLLVIEE IIPSSSKVIP
310 320 330 340 350
LIGEYLLFIM IFVTLSIIVT VFVINVHHRS SSTYHPMAPW VKRLFLQRLP
360 370 380 390 400
RWLCMKDPMD RFSFPDGKES DTAVRGKVSG KRKQTPASDG ERVLVAFLEK
410 420 430 440 450
ASESIRYISR HVKKEHFISQ VVQDWKFVAQ VLDRIFLWLF LIASVLGSIL
460
IFIPALKMWI HRFH
Length:464
Mass (Da):53,261
Last modified:October 1, 1989 - v1
Checksum:i5D3B1F7DB934D1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04636 mRNA. Translation: AAC28887.1.
PIRiA33523.
RefSeqiNP_598281.1. NM_133597.1.
UniGeneiRn.9694.

Genome annotation databases

EnsembliENSRNOT00000016656; ENSRNOP00000016656; ENSRNOG00000012448.
GeneIDi171131.
KEGGirno:171131.
UCSCiRGD:621544. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04636 mRNA. Translation: AAC28887.1.
PIRiA33523.
RefSeqiNP_598281.1. NM_133597.1.
UniGeneiRn.9694.

3D structure databases

ProteinModelPortaliP12391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016656.

Chemistry databases

BindingDBiP12391.
ChEMBLiCHEMBL3137275.

PTM databases

PhosphoSitePlusiP12391.

Proteomic databases

PaxDbiP12391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016656; ENSRNOP00000016656; ENSRNOG00000012448.
GeneIDi171131.
KEGGirno:171131.
UCSCiRGD:621544. rat.

Organism-specific databases

CTDi1142.
RGDi621544. Chrnb3.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP12391.
KOiK04814.
OMAiDHKLSWN.
OrthoDBiEOG091G0R20.
PhylomeDBiP12391.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiR-RNO-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-RNO-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

PROiP12391.

Gene expression databases

BgeeiENSRNOG00000012448.
GenevisibleiP12391. RN.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHB3_RAT
AccessioniPrimary (citable) accession number: P12391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.