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Protein

Plasminogen activator inhibitor 2, macrophage

Gene

Serpinb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei380 – 381Reactive bond2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Enzyme and pathway databases

ReactomeiR-MMU-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2, macrophage
Short name:
PAI-2
Alternative name(s):
Serpin B2
Gene namesi
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97609. Serpinb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232971 – 415Plasminogen activator inhibitor 2, macrophageAdd BLAST415
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12388.
PeptideAtlasiP12388.
PRIDEiP12388.

PTM databases

PhosphoSitePlusiP12388.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062345.
ExpressionAtlasiP12388. baseline and differential.
GenevisibleiP12388. MM.

Interactioni

Subunit structurei

Interacts with PSMB1.By similarity

Protein-protein interaction databases

BioGridi202226. 1 interactor.
STRINGi10090.ENSMUSP00000009356.

Structurei

3D structure databases

ProteinModelPortaliP12388.
SMRiP12388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiP12388.
KOiK19821.
OMAiMANTMFA.
OrthoDBiEOG091G0ION.
PhylomeDBiP12388.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PTHR11461:SF61. PTHR11461:SF61. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT
60 70 80 90 100
EQQMAKVLQF NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG
110 120 130 140 150
DKIHSAFSSL SSTINTPQGD YLLESANKLF GEKSARFKEE YIQLSKKYYS
160 170 180 190 200
TEPEAVDFLE CAEEAREKIN SWVKTQTKGE IPNLLPEGSV DEDTKMVLVN
210 220 230 240 250
AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK LNIGYIKDLK
260 270 280 290 300
TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL
310 320 330 340 350
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF
360 370 380 390 400
LSEVFHQASV DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD
410
KITHTILFVG RFSSP
Length:415
Mass (Da):46,292
Last modified:October 1, 1989 - v1
Checksum:iC4FC78C5C3CA7D8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T (Ref. 3) Curated1
Sequence conflicti55A → T (PubMed:9892694).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti239A → E.1 Publication1
Natural varianti258H → Y.1 Publication1
Natural varianti259T → I.1 Publication1
Natural varianti284S → R.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16490 mRNA. Translation: CAA34507.1.
AJ000386, AJ000384, AJ000385 Genomic DNA. Translation: CAA04047.1.
AF069683 Genomic DNA. Translation: AAD08915.1.
AF069685, AF069684 Genomic DNA. Translation: AAD08916.1.
AF069687, AF069686 Genomic DNA. Translation: AAD08917.1.
AF069689, AF069688 Genomic DNA. Translation: AAD08918.1.
AF069690 Genomic DNA. Translation: AAD08919.1.
AF069692, AF069691 Genomic DNA. Translation: AAD08920.1.
AF069694, AF069693 Genomic DNA. Translation: AAD08921.1.
CCDSiCCDS15219.1.
PIRiS20047.
RefSeqiNP_001167641.1. NM_001174170.1.
NP_035241.1. NM_011111.4.
UniGeneiMm.271870.

Genome annotation databases

EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
GeneIDi18788.
KEGGimmu:18788.
UCSCiuc007chn.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16490 mRNA. Translation: CAA34507.1.
AJ000386, AJ000384, AJ000385 Genomic DNA. Translation: CAA04047.1.
AF069683 Genomic DNA. Translation: AAD08915.1.
AF069685, AF069684 Genomic DNA. Translation: AAD08916.1.
AF069687, AF069686 Genomic DNA. Translation: AAD08917.1.
AF069689, AF069688 Genomic DNA. Translation: AAD08918.1.
AF069690 Genomic DNA. Translation: AAD08919.1.
AF069692, AF069691 Genomic DNA. Translation: AAD08920.1.
AF069694, AF069693 Genomic DNA. Translation: AAD08921.1.
CCDSiCCDS15219.1.
PIRiS20047.
RefSeqiNP_001167641.1. NM_001174170.1.
NP_035241.1. NM_011111.4.
UniGeneiMm.271870.

3D structure databases

ProteinModelPortaliP12388.
SMRiP12388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202226. 1 interactor.
STRINGi10090.ENSMUSP00000009356.

Protein family/group databases

MEROPSiI04.007.

PTM databases

PhosphoSitePlusiP12388.

Proteomic databases

PaxDbiP12388.
PeptideAtlasiP12388.
PRIDEiP12388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
GeneIDi18788.
KEGGimmu:18788.
UCSCiuc007chn.2. mouse.

Organism-specific databases

CTDi5055.
MGIiMGI:97609. Serpinb2.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOVERGENiHBG005957.
InParanoidiP12388.
KOiK19821.
OMAiMANTMFA.
OrthoDBiEOG091G0ION.
PhylomeDBiP12388.
TreeFamiTF352619.

Enzyme and pathway databases

ReactomeiR-MMU-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

ChiTaRSiSerpinb2. mouse.
PROiP12388.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062345.
ExpressionAtlasiP12388. baseline and differential.
GenevisibleiP12388. MM.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PTHR11461:SF61. PTHR11461:SF61. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAI2_MOUSE
AccessioniPrimary (citable) accession number: P12388
Secondary accession number(s): O35687
, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.