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P12388

- PAI2_MOUSE

UniProt

P12388 - PAI2_MOUSE

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Protein
Plasminogen activator inhibitor 2, macrophage
Gene
Serpinb2, Pai2, Planh2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei380 – 3812Reactive bond

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of apoptotic process Source: InterPro
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
  4. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2, macrophage
Short name:
PAI-2
Alternative name(s):
Serpin B2
Gene namesi
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:97609. Serpinb2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Plasminogen activator inhibitor 2, macrophage
PRO_0000223297Add
BLAST
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP12388.
PaxDbiP12388.
PRIDEiP12388.

PTM databases

PhosphoSiteiP12388.

Expressioni

Gene expression databases

ArrayExpressiP12388.
BgeeiP12388.
GenevestigatoriP12388.

Interactioni

Subunit structurei

Interacts with PSMB1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP12388.
SMRiP12388. Positions 3-415.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiP12388.
KOiK13963.
OMAiLFLIMHK.
OrthoDBiEOG7327PB.
PhylomeDBiP12388.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12388-1 [UniParc]FASTAAdd to Basket

« Hide

MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT    50
EQQMAKVLQF NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG 100
DKIHSAFSSL SSTINTPQGD YLLESANKLF GEKSARFKEE YIQLSKKYYS 150
TEPEAVDFLE CAEEAREKIN SWVKTQTKGE IPNLLPEGSV DEDTKMVLVN 200
AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK LNIGYIKDLK 250
TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL 300
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF 350
LSEVFHQASV DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD 400
KITHTILFVG RFSSP 415
Length:415
Mass (Da):46,292
Last modified:October 1, 1989 - v1
Checksum:iC4FC78C5C3CA7D8B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391A → E.1 Publication
Natural varianti258 – 2581H → Y.1 Publication
Natural varianti259 – 2591T → I.1 Publication
Natural varianti284 – 2841S → R.1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551A → T1 Publication
Sequence conflicti55 – 551A → T1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16490 mRNA. Translation: CAA34507.1.
AJ000386, AJ000384, AJ000385 Genomic DNA. Translation: CAA04047.1.
AF069683 Genomic DNA. Translation: AAD08915.1.
AF069685, AF069684 Genomic DNA. Translation: AAD08916.1.
AF069687, AF069686 Genomic DNA. Translation: AAD08917.1.
AF069689, AF069688 Genomic DNA. Translation: AAD08918.1.
AF069690 Genomic DNA. Translation: AAD08919.1.
AF069692, AF069691 Genomic DNA. Translation: AAD08920.1.
AF069694, AF069693 Genomic DNA. Translation: AAD08921.1.
CCDSiCCDS15219.1.
PIRiS20047.
RefSeqiNP_001167641.1. NM_001174170.1.
NP_035241.1. NM_011111.4.
UniGeneiMm.271870.

Genome annotation databases

EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
GeneIDi18788.
KEGGimmu:18788.
UCSCiuc007chn.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16490 mRNA. Translation: CAA34507.1 .
AJ000386 , AJ000384 , AJ000385 Genomic DNA. Translation: CAA04047.1 .
AF069683 Genomic DNA. Translation: AAD08915.1 .
AF069685 , AF069684 Genomic DNA. Translation: AAD08916.1 .
AF069687 , AF069686 Genomic DNA. Translation: AAD08917.1 .
AF069689 , AF069688 Genomic DNA. Translation: AAD08918.1 .
AF069690 Genomic DNA. Translation: AAD08919.1 .
AF069692 , AF069691 Genomic DNA. Translation: AAD08920.1 .
AF069694 , AF069693 Genomic DNA. Translation: AAD08921.1 .
CCDSi CCDS15219.1.
PIRi S20047.
RefSeqi NP_001167641.1. NM_001174170.1.
NP_035241.1. NM_011111.4.
UniGenei Mm.271870.

3D structure databases

ProteinModelPortali P12388.
SMRi P12388. Positions 3-415.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.007.

PTM databases

PhosphoSitei P12388.

Proteomic databases

MaxQBi P12388.
PaxDbi P12388.
PRIDEi P12388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009356 ; ENSMUSP00000009356 ; ENSMUSG00000062345 .
ENSMUST00000064916 ; ENSMUSP00000065277 ; ENSMUSG00000062345 .
GeneIDi 18788.
KEGGi mmu:18788.
UCSCi uc007chn.2. mouse.

Organism-specific databases

CTDi 5055.
MGIi MGI:97609. Serpinb2.

Phylogenomic databases

eggNOGi COG4826.
HOVERGENi HBG005957.
InParanoidi P12388.
KOi K13963.
OMAi LFLIMHK.
OrthoDBi EOG7327PB.
PhylomeDBi P12388.
TreeFami TF352619.

Miscellaneous databases

ChiTaRSi SERPINB2. mouse.
NextBioi 295060.
PROi P12388.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12388.
Bgeei P12388.
Genevestigatori P12388.

Family and domain databases

InterProi IPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 2 hits.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2."
    Belin D., Wohlwend A., Schleuning W.-D., Kruithof E.K.O., Vassalli J.-D.
    EMBO J. 8:3287-3294(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-27.
    Strain: AKR.
    Tissue: Myeloid.
  2. Belin D.
    Submitted (SEP-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AKR.
    Tissue: Myeloid.
  3. "Sequence and tissue-specific expression of the murine PAI-2 gene."
    Belin D., Tapparel C., Sappino N., Silva F.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-239; TYR-258; ILE-259 AND ARG-284.
    Strain: 129.
    Tissue: Liver.
  4. "The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival."
    Dougherty K.M., Pearson J.M., Yang A.Y., Westrick R.J., Baker M.S., Ginsburg D.
    Proc. Natl. Acad. Sci. U.S.A. 96:686-691(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34; 54-74; 89-115; 124-156; 163-237 AND 265-302.
    Strain: 129/Sv.

Entry informationi

Entry nameiPAI2_MOUSE
AccessioniPrimary (citable) accession number: P12388
Secondary accession number(s): O35687
, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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