Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P12388 (PAI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasminogen activator inhibitor 2, macrophage

Short name=PAI-2
Alternative name(s):
Serpin B2
Gene names
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.

Subunit structure

Interacts with PSMB1 By similarity.

Subcellular location

Cytoplasm. Secretedextracellular space.

Post-translational modification

The signal sequence is not cleaved.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Plasminogen activator inhibitor 2, macrophage
PRO_0000223297
Signal peptide1 – ?Not cleaved

Sites

Site380 – 3812Reactive bond

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential

Natural variations

Natural variant2391A → E. Ref.3
Natural variant2581H → Y. Ref.3
Natural variant2591T → I. Ref.3
Natural variant2841S → R. Ref.3

Experimental info

Sequence conflict551A → T Ref.3
Sequence conflict551A → T Ref.4

Sequences

Sequence LengthMass (Da)Tools
P12388 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: C4FC78C5C3CA7D8B

FASTA41546,292
        10         20         30         40         50         60 
MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT EQQMAKVLQF 

        70         80         90        100        110        120 
NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG DKIHSAFSSL SSTINTPQGD 

       130        140        150        160        170        180 
YLLESANKLF GEKSARFKEE YIQLSKKYYS TEPEAVDFLE CAEEAREKIN SWVKTQTKGE 

       190        200        210        220        230        240 
IPNLLPEGSV DEDTKMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK 

       250        260        270        280        290        300 
LNIGYIKDLK TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL 

       310        320        330        340        350        360 
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF LSEVFHQASV 

       370        380        390        400        410 
DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD KITHTILFVG RFSSP 

« Hide

References

[1]"Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2."
Belin D., Wohlwend A., Schleuning W.-D., Kruithof E.K.O., Vassalli J.-D.
EMBO J. 8:3287-3294(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-27.
Strain: AKR.
Tissue: Myeloid.
[2]Belin D.
Submitted (SEP-1989) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AKR.
Tissue: Myeloid.
[3]"Sequence and tissue-specific expression of the murine PAI-2 gene."
Belin D., Tapparel C., Sappino N., Silva F.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-239; TYR-258; ILE-259 AND ARG-284.
Strain: 129.
Tissue: Liver.
[4]"The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival."
Dougherty K.M., Pearson J.M., Yang A.Y., Westrick R.J., Baker M.S., Ginsburg D.
Proc. Natl. Acad. Sci. U.S.A. 96:686-691(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34; 54-74; 89-115; 124-156; 163-237 AND 265-302.
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16490 mRNA. Translation: CAA34507.1.
AJ000386, AJ000384, AJ000385 Genomic DNA. Translation: CAA04047.1.
AF069683 Genomic DNA. Translation: AAD08915.1.
AF069685, AF069684 Genomic DNA. Translation: AAD08916.1.
AF069687, AF069686 Genomic DNA. Translation: AAD08917.1.
AF069689, AF069688 Genomic DNA. Translation: AAD08918.1.
AF069690 Genomic DNA. Translation: AAD08919.1.
AF069692, AF069691 Genomic DNA. Translation: AAD08920.1.
AF069694, AF069693 Genomic DNA. Translation: AAD08921.1.
CCDSCCDS15219.1.
PIRS20047.
RefSeqNP_001167641.1. NM_001174170.1.
NP_035241.1. NM_011111.4.
UniGeneMm.271870.

3D structure databases

ProteinModelPortalP12388.
SMRP12388. Positions 3-415.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.007.

PTM databases

PhosphoSiteP12388.

Proteomic databases

MaxQBP12388.
PaxDbP12388.
PRIDEP12388.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
GeneID18788.
KEGGmmu:18788.
UCSCuc007chn.2. mouse.

Organism-specific databases

CTD5055.
MGIMGI:97609. Serpinb2.

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
InParanoidP12388.
KOK13963.
OMALFLIMHK.
OrthoDBEOG7327PB.
PhylomeDBP12388.
TreeFamTF352619.

Gene expression databases

ArrayExpressP12388.
BgeeP12388.
GenevestigatorP12388.

Family and domain databases

InterProIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 2 hits.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERPINB2. mouse.
NextBio295060.
PROP12388.
SOURCESearch...

Entry information

Entry namePAI2_MOUSE
AccessionPrimary (citable) accession number: P12388
Secondary accession number(s): O35687 expand/collapse secondary AC list , Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot