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P12388

- PAI2_MOUSE

UniProt

P12388 - PAI2_MOUSE

Protein

Plasminogen activator inhibitor 2, macrophage

Gene

Serpinb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei380 – 3812Reactive bond

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of apoptotic process Source: InterPro
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome
    4. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Plasminogen activation

    Protein family/group databases

    MEROPSiI04.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen activator inhibitor 2, macrophage
    Short name:
    PAI-2
    Alternative name(s):
    Serpin B2
    Gene namesi
    Name:Serpinb2
    Synonyms:Pai2, Planh2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:97609. Serpinb2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Plasminogen activator inhibitor 2, macrophagePRO_0000223297Add
    BLAST
    Signal peptidei1 – ?Not cleaved

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The signal sequence is not cleaved.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP12388.
    PaxDbiP12388.
    PRIDEiP12388.

    PTM databases

    PhosphoSiteiP12388.

    Expressioni

    Gene expression databases

    ArrayExpressiP12388.
    BgeeiP12388.
    GenevestigatoriP12388.

    Interactioni

    Subunit structurei

    Interacts with PSMB1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP12388.
    SMRiP12388. Positions 3-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiP12388.
    KOiK13963.
    OMAiLFLIMHK.
    OrthoDBiEOG7327PB.
    PhylomeDBiP12388.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR015556. PAI-2.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF61. PTHR11461:SF61. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 2 hits.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12388-1 [UniParc]FASTAAdd to Basket

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    MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT    50
    EQQMAKVLQF NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG 100
    DKIHSAFSSL SSTINTPQGD YLLESANKLF GEKSARFKEE YIQLSKKYYS 150
    TEPEAVDFLE CAEEAREKIN SWVKTQTKGE IPNLLPEGSV DEDTKMVLVN 200
    AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK LNIGYIKDLK 250
    TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL 300
    DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF 350
    LSEVFHQASV DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD 400
    KITHTILFVG RFSSP 415
    Length:415
    Mass (Da):46,292
    Last modified:October 1, 1989 - v1
    Checksum:iC4FC78C5C3CA7D8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551A → T1 PublicationCurated
    Sequence conflicti55 – 551A → T(PubMed:9892694)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti239 – 2391A → E.1 Publication
    Natural varianti258 – 2581H → Y.1 Publication
    Natural varianti259 – 2591T → I.1 Publication
    Natural varianti284 – 2841S → R.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16490 mRNA. Translation: CAA34507.1.
    AJ000386, AJ000384, AJ000385 Genomic DNA. Translation: CAA04047.1.
    AF069683 Genomic DNA. Translation: AAD08915.1.
    AF069685, AF069684 Genomic DNA. Translation: AAD08916.1.
    AF069687, AF069686 Genomic DNA. Translation: AAD08917.1.
    AF069689, AF069688 Genomic DNA. Translation: AAD08918.1.
    AF069690 Genomic DNA. Translation: AAD08919.1.
    AF069692, AF069691 Genomic DNA. Translation: AAD08920.1.
    AF069694, AF069693 Genomic DNA. Translation: AAD08921.1.
    CCDSiCCDS15219.1.
    PIRiS20047.
    RefSeqiNP_001167641.1. NM_001174170.1.
    NP_035241.1. NM_011111.4.
    UniGeneiMm.271870.

    Genome annotation databases

    EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
    ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
    GeneIDi18788.
    KEGGimmu:18788.
    UCSCiuc007chn.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16490 mRNA. Translation: CAA34507.1 .
    AJ000386 , AJ000384 , AJ000385 Genomic DNA. Translation: CAA04047.1 .
    AF069683 Genomic DNA. Translation: AAD08915.1 .
    AF069685 , AF069684 Genomic DNA. Translation: AAD08916.1 .
    AF069687 , AF069686 Genomic DNA. Translation: AAD08917.1 .
    AF069689 , AF069688 Genomic DNA. Translation: AAD08918.1 .
    AF069690 Genomic DNA. Translation: AAD08919.1 .
    AF069692 , AF069691 Genomic DNA. Translation: AAD08920.1 .
    AF069694 , AF069693 Genomic DNA. Translation: AAD08921.1 .
    CCDSi CCDS15219.1.
    PIRi S20047.
    RefSeqi NP_001167641.1. NM_001174170.1.
    NP_035241.1. NM_011111.4.
    UniGenei Mm.271870.

    3D structure databases

    ProteinModelPortali P12388.
    SMRi P12388. Positions 3-415.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.007.

    PTM databases

    PhosphoSitei P12388.

    Proteomic databases

    MaxQBi P12388.
    PaxDbi P12388.
    PRIDEi P12388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009356 ; ENSMUSP00000009356 ; ENSMUSG00000062345 .
    ENSMUST00000064916 ; ENSMUSP00000065277 ; ENSMUSG00000062345 .
    GeneIDi 18788.
    KEGGi mmu:18788.
    UCSCi uc007chn.2. mouse.

    Organism-specific databases

    CTDi 5055.
    MGIi MGI:97609. Serpinb2.

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi P12388.
    KOi K13963.
    OMAi LFLIMHK.
    OrthoDBi EOG7327PB.
    PhylomeDBi P12388.
    TreeFami TF352619.

    Miscellaneous databases

    ChiTaRSi SERPINB2. mouse.
    NextBioi 295060.
    PROi P12388.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12388.
    Bgeei P12388.
    Genevestigatori P12388.

    Family and domain databases

    InterProi IPR015556. PAI-2.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF61. PTHR11461:SF61. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 2 hits.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2."
      Belin D., Wohlwend A., Schleuning W.-D., Kruithof E.K.O., Vassalli J.-D.
      EMBO J. 8:3287-3294(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-27.
      Strain: AKR.
      Tissue: Myeloid.
    2. Belin D.
      Submitted (SEP-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AKR.
      Tissue: Myeloid.
    3. "Sequence and tissue-specific expression of the murine PAI-2 gene."
      Belin D., Tapparel C., Sappino N., Silva F.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-239; TYR-258; ILE-259 AND ARG-284.
      Strain: 129.
      Tissue: Liver.
    4. "The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival."
      Dougherty K.M., Pearson J.M., Yang A.Y., Westrick R.J., Baker M.S., Ginsburg D.
      Proc. Natl. Acad. Sci. U.S.A. 96:686-691(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34; 54-74; 89-115; 124-156; 163-237 AND 265-302.
      Strain: 129/Sv.

    Entry informationi

    Entry nameiPAI2_MOUSE
    AccessioniPrimary (citable) accession number: P12388
    Secondary accession number(s): O35687
    , Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3