P12384 (STE2_LACKL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pheromone alpha factor receptor

Gene names

Name:

STE2

Organism

Lachancea kluyveri (Yeast) (Saccharomyces kluyveri)

Taxonomic identifier

4934 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Lachancea

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 4 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	mating-type factor pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Pheromone alpha factor receptor		PRO_0000195069
Regions
	Transmembrane	50 – 72	23	Helical; Potential
	Transmembrane	79 – 101	23	Helical; Potential
	Transmembrane	131 – 153	23	Helical; Potential
	Transmembrane	160 – 182	23	Helical; Potential
	Transmembrane	202 – 224	23	Helical; Potential
	Transmembrane	245 – 267	23	Helical; Potential
	Transmembrane	277 – 299	23	Helical; Potential
Experimental info
	Sequence conflict	13	1	Y → N Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P12384 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 72E4635966ECAC02	FASTA	426	47,078
	10 20 30 40 50 60 MSGKQDLSPL GLYSSYDPTK GLISYTSLYG SGTTVTFEEL QIFVNKKITQ GILFGTRIGA 70 80 90 100 110 120 AGLAIIVLWM VSKNRKTPIF IINQISLFLI LLHSSLFLRY LLGDYASVVF NFTLFSQSIS 130 140 150 160 170 180 RNDVHVYGAT NMIQVLLVAA VEISLIFQVR VIFKGDSYKG VGRILTSISA VLGFTTVVMY 190 200 210 220 230 240 FITAVKSMTS VYSDLTKTSD RYFFNIASIL LSSSVNFMTL LLTVKLILAV RSRRFLGLKQ 250 260 270 280 290 300 FDSFHVLLIM SFQTLIFPSI LFILAYALNP NQGTDTLTSI ATLLVTLSLP LSSMWATSAN 310 320 330 340 350 360 NSSHPSSINT QFRQRNYDDV SFKTGITSFY SESSKPSSKY RHTNNLYDLY PVSRTSNSRC 370 380 390 400 410 420 NGYPNDGSKL APNPNCVGHN GSTMSVNDKN GAHATCVQNN VTLNTDSTLN YSNVDTQDTS KILMTT

References

[1]	"STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor." Marsh L., Herskowitz I. Proc. Natl. Acad. Sci. U.S.A. 85:3855-3859(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: XM8-2.
[2]	Marsh L. Submitted (AUG-1988) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03265 Genomic DNA. Translation: AAA34961.1.
PIR	A30212. A94801.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000366. GPCR_STE2. [Graphical view]
Pfam	PF02116. STE2. 1 hit. [Graphical view]
PRINTS	PR00250. GPCRSTE2.
ProtoNet	Search...

Entry information

Entry name

STE2_LACKL

Accession

Primary (citable) accession number: P12384

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program