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Protein

UDP-glucose 6-dehydrogenase

Gene

UGDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Enzyme regulationi

UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.By similarity

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (UGDH)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei41NADBy similarity1
Binding sitei165NADBy similarity1
Binding sitei260SubstrateBy similarity1
Active sitei276NucleophileBy similarity1
Binding sitei346NADBy similarity1
Binding sitei442SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADBy similarity6
Nucleotide bindingi89 – 93NADBy similarity5
Nucleotide bindingi130 – 131NADBy similarity2
Nucleotide bindingi276 – 279NADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-BTA-173599 Formation of the active cofactor, UDP-glucuronate
UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:UGDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:36648 UGDH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740591 – 494UDP-glucose 6-dehydrogenaseAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107N6-acetyllysineBy similarity1
Modified residuei476PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP12378
PeptideAtlasiP12378
PRIDEiP12378

Expressioni

Gene expression databases

BgeeiENSBTAG00000014521

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019302

Structurei

3D structure databases

ProteinModelPortaliP12378
SMRiP12378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate bindingBy similarity5
Regioni220 – 224Substrate bindingBy similarity5
Regioni267 – 273Substrate bindingBy similarity7
Regioni338 – 339Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
InParanoidiP12378
KOiK00012
OMAiLCTEWDE
OrthoDBiEOG091G05RK
TreeFamiTF105671

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

P12378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDINES RINAWNSPTL
60 70 80 90 100
PIYEPGLKEV VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKYIE ACARRIVQNS HGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQR AVQALCAVYE
210 220 230 240 250
HWVPREKILT TNTWSSELSK LTANAFLAQR ISSINSISAL CEATGADVEE
260 270 280 290 300
VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
310 320 330 340 350
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSKDDQ VARLVTISKD
410 420 430 440 450
PYEACDGAHA VVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDGLHN
460 470 480 490
ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP KFSLQDMPNK KPRV
Length:494
Mass (Da):55,136
Last modified:December 15, 1998 - v2
Checksum:i8560E27089C4D03E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157Missing AA sequence (PubMed:7920253).Curated1
Sequence conflicti278 – 281QKDV → ZZGK AA sequence (PubMed:6896145).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095792 mRNA Translation: AAC64183.1
BC150068 mRNA Translation: AAI50069.1
PIRiA17150
RefSeqiNP_776636.1, NM_174211.3
XP_005207890.1, XM_005207833.2
UniGeneiBt.5538

Genome annotation databases

EnsembliENSBTAT00000019302; ENSBTAP00000019302; ENSBTAG00000014521
GeneIDi281564
KEGGibta:281564

Similar proteinsi

Entry informationi

Entry nameiUGDH_BOVIN
AccessioniPrimary (citable) accession number: P12378
Secondary accession number(s): A6QR10, O77806
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health