Reviewed,
UniProtKB/Swiss-Prot P12378 (UGDH_BOVIN)
Last modified
November 25, 2008.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 494 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. |
| Catalytic activity | UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Subunit structure | Homohexamer. |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | gastrulation with mouth forming second Inferred from sequence or structural similarity. Source: AgBase oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 494 | 494 | UDP-glucose 6-dehydrogenase | PRO_0000074059 | |||||
Regions | |||||||||
| Nucleotide binding | 6 – 23 | 18 | NAD By similarity | ||||||
| Region | 162 – 165 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 276 | 1 | Nucleophile By similarity | ||||||
| Binding site | 36 | 1 | NAD By similarity | ||||||
| Binding site | 41 | 1 | NAD By similarity | ||||||
| Binding site | 93 | 1 | NAD By similarity | ||||||
| Binding site | 131 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 165 | 1 | NAD By similarity | ||||||
| Binding site | 220 | 1 | Substrate By similarity | ||||||
| Binding site | 273 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 279 | 1 | NAD By similarity | ||||||
| Binding site | 339 | 1 | Substrate By similarity | ||||||
| Binding site | 346 | 1 | NAD By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 473 | 1 | Phosphotyrosine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 157 | 1 | Missing AA sequence Ref.3 | ||||||
| Sequence conflict | 278 – 281 | 4 | QKDV → ZZGK AA sequence Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning and expression of UDP-glucose dehydrogenase from bovine kidney." Lind T., Falk E., Hjertson E., Kusche-Gullberg M., Lidholt K. Glycobiology 9:595-600(1999) [PubMed: 10336992] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon. |
| [3] | "UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases." Hempel J., Perozich J., Romovacek H., Hinich A., Kuo I., Feingold D.S. Protein Sci. 3:1074-1080(1994) [PubMed: 7920253] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-469. Tissue: Liver. |
| [4] | "Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase." Franzen B., Carrubba C., Feingold D.S., Ashcom J., Franzen J.S. Biochem. J. 199:599-602(1981) [PubMed: 6896145] [Abstract] Cited for: PROTEIN SEQUENCE OF 268-281. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AF095792 mRNA. Translation: AAC64183.1. BC150068 mRNA. Translation: AAI50069.1. | |
| PIR | A17150. |
| RefSeq | NP_776636.1. |
| UniGene | Bt.5538 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000014521. Bos taurus. [Contig view] |
| GeneID | 281564. |
| KEGG | bta:281564. |
Phylogenomic databases | |
| HOVERGEN | P12378. |
Family and domain databases | |
| InterPro | IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DHase_C. IPR014026. UDP-Glc/GDP-Man_DHase_dimer. IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DHase_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UGDH_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P12378 Secondary accession number(s): A6QR10, O77806 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


