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Protein

cAMP-dependent protein kinase catalytic subunit

Gene

Pka-C1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by cAMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75ATPPROSITE-ProRule annotation1
Active sitei169Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 60ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cAMP-dependent protein kinase activity Source: FlyBase
  • protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  • anesthesia-resistant memory Source: FlyBase
  • anterior/posterior pattern specification, imaginal disc Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • cAMP-mediated signaling Source: FlyBase
  • compound eye development Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • learning Source: FlyBase
  • learning or memory Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • memory Source: FlyBase
  • modulation of chemical synaptic transmission Source: FlyBase
  • negative regulation of smoothened signaling pathway Source: FlyBase
  • olfactory learning Source: FlyBase
  • oocyte anterior/posterior axis specification Source: FlyBase
  • oocyte microtubule cytoskeleton polarization Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of hh target transcription factor activity Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of apoptotic process Source: FlyBase
  • regulation of bicoid mRNA localization Source: FlyBase
  • regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  • regulation of pole plasm oskar mRNA localization Source: FlyBase
  • rhythmic behavior Source: FlyBase
  • sprouting of injured axon Source: FlyBase
  • thermosensory behavior Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.11. 1994.
ReactomeiR-DME-163615. PKA activation.
R-DME-164378. PKA activation in glucagon signalling.
R-DME-180024. DARPP-32 events.
R-DME-209159. Assembly of the CI containing complexes.
R-DME-209190. Phosphorylation of CI.
R-DME-209360. Ubiquitination and proteolysis of phosphorylated CI.
R-DME-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-DME-392517. Rap1 signalling.
R-DME-422356. Regulation of insulin secretion.
R-DME-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-442720. CREB phosphorylation through the activation of Adenylate Cyclase.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5610787. Hedgehog 'off' state.
R-DME-5621575. CD209 (DC-SIGN) signaling.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP12370.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase catalytic subunit (EC:2.7.11.11)
Short name:
PKA C
Gene namesi
Name:Pka-C1
Synonyms:CdkA, DC0
ORF Names:CG4379
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000273. Pka-C1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000860692 – 353cAMP-dependent protein kinase catalytic subunitAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP12370.
PRIDEiP12370.

Expressioni

Tissue specificityi

More abundant in adult head than adult body.

Gene expression databases

BgeeiFBgn0000273.
GenevisibleiP12370. DM.

Interactioni

Subunit structurei

Composed of two regulatory chains and two catalytic chains.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi60383. 21 interactors.
DIPiDIP-23727N.
IntActiP12370. 7 interactors.
MINTiMINT-1019424.
STRINGi7227.FBpp0079448.

Structurei

3D structure databases

ProteinModelPortaliP12370.
SMRiP12370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 300Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini301 – 353AGC-kinase C-terminalAdd BLAST53

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0616. Eukaryota.
ENOG410XPQQ. LUCA.
GeneTreeiENSGT00810000125385.
InParanoidiP12370.
KOiK04345.
OMAiGQHFAMK.
OrthoDBiEOG091G10O8.
PhylomeDBiP12370.

Family and domain databases

InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNATTSNK KVDAAETVKE FLEQAKEEFE DKWRRNPTNT AALDDFERIK
60 70 80 90 100
TLGTGSFGRV MIVQHKPTKD YYAMKILDKQ KVVKLKQVEH TLNEKRILQA
110 120 130 140 150
IQFPFLVSLR YHFKDNSNLY MVLEYVPGGE MFSHLRKVGR FSEPHSRFYA
160 170 180 190 200
AQIVLAFEYL HYLDLIYRDL KPENLLIDSQ GYLKVTDFGF AKRVKGRTWT
210 220 230 240 250
LCGTPEYLAP EIILSKGYNK AVDWWALGVL VYEMAAGYPP FFADQPIQIY
260 270 280 290 300
EKIVSGKVRF PSHFGSDLKD LLRNLLQVDL TKRYGNLKAG VNDIKNQKWF
310 320 330 340 350
ASTDWIAIFQ KKIEAPFIPR CKGPGDTSNF DDYEEEALRI SSTEKCAKEF

AEF
Length:353
Mass (Da):40,839
Last modified:January 23, 2007 - v3
Checksum:i9611D1001C791874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18655 Genomic DNA. Translation: AAA28412.1.
X16969 Genomic DNA. Translation: CAA34840.1.
AE014134 Genomic DNA. Translation: AAF52797.1.
AE014134 Genomic DNA. Translation: AAN10703.1.
AE014134 Genomic DNA. Translation: AAS64669.1.
AY069425 mRNA. Translation: AAL39570.1.
PIRiC31751.
RefSeqiNP_476977.1. NM_057629.4.
NP_723479.1. NM_164866.3.
NP_995672.1. NM_205950.3.
UniGeneiDm.2136.

Genome annotation databases

EnsemblMetazoaiFBtr0079851; FBpp0079448; FBgn0000273.
FBtr0079852; FBpp0089382; FBgn0000273.
FBtr0335495; FBpp0307466; FBgn0000273.
GeneIDi34284.
KEGGidme:Dmel_CG4379.
UCSCiCG4379-RB. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiKAPC_DROME
AccessioniPrimary (citable) accession number: P12370
Secondary accession number(s): A4V0I0, Q9VL99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families