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P12346

- TRFE_RAT

UniProt

P12346 - TRFE_RAT

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Protein

Serotransferrin

Gene

Tf

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Iron 1PROSITE-ProRule annotation
Metal bindingi114 – 1141Iron 1PROSITE-ProRule annotation
Binding sitei139 – 1391Carbonate 1PROSITE-ProRule annotation
Binding sitei143 – 1431Carbonate 1PROSITE-ProRule annotation
Binding sitei145 – 1451Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Binding sitei146 – 1461Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi207 – 2071Iron 1PROSITE-ProRule annotation
Metal bindingi268 – 2681Iron 1PROSITE-ProRule annotation
Metal bindingi410 – 4101Iron 2PROSITE-ProRule annotation
Metal bindingi447 – 4471Iron 2PROSITE-ProRule annotation
Binding sitei473 – 4731Carbonate 2PROSITE-ProRule annotation
Binding sitei477 – 4771Carbonate 2PROSITE-ProRule annotation
Binding sitei479 – 4791Carbonate 2; via amide nitrogenPROSITE-ProRule annotation
Binding sitei480 – 4801Carbonate 2; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi536 – 5361Iron 2PROSITE-ProRule annotation
Metal bindingi604 – 6041Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: RGD
  2. ferric iron transmembrane transporter activity Source: RGD

GO - Biological processi

  1. acute-phase response Source: RGD
  2. apoptotic process Source: UniProtKB
  3. cellular iron ion homeostasis Source: RGD
  4. cellular response to cAMP Source: UniProtKB
  5. cellular response to follicle-stimulating hormone stimulus Source: UniProtKB
  6. ferric iron transport Source: RGD
  7. iron ion transport Source: RGD
  8. positive regulation of myelination Source: RGD
  9. positive regulation of oligodendrocyte progenitor proliferation Source: RGD
  10. response to hypoxia Source: RGD
  11. response to lead ion Source: RGD
  12. response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196255. Transferrin endocytosis and recycling.
REACT_248611. Iron uptake and transport.

Protein family/group databases

MEROPSiS60.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Liver regeneration-related protein LRRG03
Siderophilin
Gene namesi
Name:Tf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3845. Tf.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: RGD
  2. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1417. Rat n Transferrin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 698679SerotransferrinPRO_0000035718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
Modified residuei42 – 421Dimethylated arginine1 Publication
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Disulfide bondi420 ↔ 693PROSITE-ProRule annotation
Disulfide bondi435 ↔ 656PROSITE-ProRule annotation
Disulfide bondi471 ↔ 542PROSITE-ProRule annotation
Disulfide bondi495 ↔ 684PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi516 ↔ 525PROSITE-ProRule annotation
Disulfide bondi582 ↔ 596PROSITE-ProRule annotation
Disulfide bondi634 ↔ 639PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PRIDEiP12346.

2D gel databases

World-2DPAGE0004:P12346.

PTM databases

PhosphoSiteiP12346.
UniCarbKBiP12346.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

ExpressionAtlasiP12346. baseline and differential.
GenevestigatoriP12346.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi246945. 1 interaction.
IntActiP12346. 1 interaction.
MINTiMINT-246684.

Structurei

3D structure databases

ProteinModelPortaliP12346.
SMRiP12346. Positions 22-697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 347323Transferrin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 683324Transferrin-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00390000001619.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiP12346.
KOiK14736.
PhylomeDBiP12346.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P12346-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFAVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
ADGPRLACVK KTSYQDCIKA ISGGEADAIT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSLEHP QTHYLAVAVV KKGTDFQLNQ LQGKKSCHTG LGRSAGWIIP
160 170 180 190 200
IGLLFCNLPE PRKPLEKAVA SFFSGSCVPC ADPVAFPQLC QLCPGCGCSP
210 220 230 240 250
TQPFFGYVGA FKCLRDGGGD VAFVKHTTIF EVLPQKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARNGDGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFGSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHSYVT AIRNQREGVC
360 370 380 390 400
PEGSIDSAPV KWCALSHQER AKCDEWSVSS NGQIECESAE STEDCIDKIV
410 420 430 440 450
NGEADAMSLD GGHAYIAGQC GLVPVMAENY DISSCTNPQS DVFPKGYYAV
460 470 480 490 500
AVVKASDSSI NWNNLKGKKS CHTGVDRTAG WNIPMGLLFS RINHCKFDEF
510 520 530 540 550
FSQGCAPGYK KNSTLCDLCI GPAKCAPNNR EGYNGYTGAF QCLVEKGDVA
560 570 580 590 600
FVKHQTVLEN TNGKNTAAWA KDLKQEDFQL LCPDGTKKPV TEFATCHLAQ
610 620 630 640 650
APNHVVVSRK EKAARVSTVL TAQKDLFWKG DKDCTGNFCL FRSSTKDLLF
660 670 680 690
RDDTKCLTKL PEGTTYEEYL GAEYLQAVGN IRKCSTSRLL EACTFHKS
Length:698
Mass (Da):76,395
Last modified:January 9, 2007 - v3
Checksum:iB91ABB41CA447194
GO
Isoform 2 (identifier: P12346-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-266: Missing.

Show »
Length:496
Mass (Da):54,524
Checksum:i7FADB62945314E20
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571A → P in CAA54403. (PubMed:7717992)Curated
Sequence conflicti110 – 1101P → R in CAA54403. (PubMed:7717992)Curated
Sequence conflicti318 – 3181A → R in CAA54403. (PubMed:7717992)Curated
Sequence conflicti321 – 3233LLR → CYG in BAA07458. (PubMed:8829802)Curated
Sequence conflicti324 – 35431VPPRM…CPEGS → APKDGLQAVPRPQLCHCHSK SAGSCPDA in CAA54403. (PubMed:7717992)CuratedAdd
BLAST
Sequence conflicti353 – 3531G → A in BAA07458. (PubMed:8829802)Curated
Sequence conflicti379 – 3791S → T in CAA54403. (PubMed:7717992)Curated
Sequence conflicti379 – 3791S → T in BAA07458. (PubMed:8829802)Curated
Sequence conflicti380 – 3801S → G in CAA54403. (PubMed:7717992)Curated
Sequence conflicti691 – 6911E → D in AAA42267. (PubMed:3023031)Curated
Sequence conflicti696 – 6972HK → TA in AAA42267. (PubMed:3023031)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei65 – 266202Missing in isoform 2. 1 PublicationVSP_011840Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77158 mRNA. Translation: CAA54403.1.
D38380 mRNA. Translation: BAA07458.1.
AY327504 mRNA. Translation: AAP97736.1.
BC087021 mRNA. Translation: AAH87021.1.
M26113 mRNA. Translation: AAA42266.1.
M27966 mRNA. Translation: AAA42267.1.
PIRiS49163.
RefSeqiNP_001013128.1. NM_001013110.1. [P12346-1]
UniGeneiRn.91296.

Genome annotation databases

EnsembliENSRNOT00000012946; ENSRNOP00000012946; ENSRNOG00000030625. [P12346-2]
ENSRNOT00000045628; ENSRNOP00000045637; ENSRNOG00000030625. [P12346-1]
GeneIDi24825.
KEGGirno:24825.
UCSCiRGD:3845. rat. [P12346-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77158 mRNA. Translation: CAA54403.1 .
D38380 mRNA. Translation: BAA07458.1 .
AY327504 mRNA. Translation: AAP97736.1 .
BC087021 mRNA. Translation: AAH87021.1 .
M26113 mRNA. Translation: AAA42266.1 .
M27966 mRNA. Translation: AAA42267.1 .
PIRi S49163.
RefSeqi NP_001013128.1. NM_001013110.1. [P12346-1 ]
UniGenei Rn.91296.

3D structure databases

ProteinModelPortali P12346.
SMRi P12346. Positions 22-697.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246945. 1 interaction.
IntActi P12346. 1 interaction.
MINTi MINT-246684.

Protein family/group databases

Allergomei 1417. Rat n Transferrin.
MEROPSi S60.975.

PTM databases

PhosphoSitei P12346.
UniCarbKBi P12346.

2D gel databases

World-2DPAGE 0004:P12346.

Proteomic databases

PRIDEi P12346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012946 ; ENSRNOP00000012946 ; ENSRNOG00000030625 . [P12346-2 ]
ENSRNOT00000045628 ; ENSRNOP00000045637 ; ENSRNOG00000030625 . [P12346-1 ]
GeneIDi 24825.
KEGGi rno:24825.
UCSCi RGD:3845. rat. [P12346-1 ]

Organism-specific databases

CTDi 7018.
RGDi 3845. Tf.

Phylogenomic databases

GeneTreei ENSGT00390000001619.
HOGENOMi HOG000043759.
HOVERGENi HBG000055.
InParanoidi P12346.
KOi K14736.
PhylomeDBi P12346.

Enzyme and pathway databases

Reactomei REACT_196255. Transferrin endocytosis and recycling.
REACT_248611. Iron uptake and transport.

Miscellaneous databases

NextBioi 604536.
PROi P12346.

Gene expression databases

ExpressionAtlasi P12346. baseline and differential.
Genevestigatori P12346.

Family and domain databases

InterProi IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view ]
Pfami PF00405. Transferrin. 2 hits.
[Graphical view ]
PIRSFi PIRSF002549. Transferrin. 1 hit.
PRINTSi PR00422. TRANSFERRIN.
SMARTi SM00094. TR_FER. 2 hits.
[Graphical view ]
PROSITEi PS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rat mammary-gland transferrin: nucleotide sequence, phylogenetic analysis and glycan structure."
    Escriva H., Pierce A., Coddeville B., Gonzalez F., Benaissa M., Leger D., Wieruszeski J.-M., Spik G., Pamblanco M.
    Biochem. J. 307:47-55(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Wistar.
    Tissue: Mammary gland.
  2. "Complete sequence analysis of rat transferrin and expression of transferrin but not lactoferrin in the digestive glands."
    Hosino A., Hisayasu S., Shimada T.
    Comp. Biochem. Physiol. 113B:491-497(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Wistar.
    Tissue: Liver.
  3. "Liver regeneration after PH."
    Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Synthesis of rat transferrin in Escherichia coli containing a recombinant bacteriophage."
    Aldred A.R., Howlett G.J., Schreiber G.
    Biochem. Biophys. Res. Commun. 122:960-965(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-295 (ISOFORM 2).
  6. "Transferrin messenger ribonucleic acid: molecular cloning and hormonal regulation in rat Sertoli cells."
    Huggenvik J.I., Idzerda R.L., Haywood L., Lee D.C., McKnight G.S., Griswold M.D.
    Endocrinology 120:332-340(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 521-698.
  7. "The synthesis and secretion of rat transferrin."
    Schreiber G., Dryburgh H., Millership A., Matsuda Y., Inglis A., Phillips J., Edwards K., Maggs J.
    J. Biol. Chem. 254:12013-12019(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-47.
  8. "Properties of the transferrin associated with rat intestinal mucosa."
    Purves L.R., Purves M., Linton N., Brandt W., Johnson G., Jacobs P.
    Biochim. Biophys. Acta 966:318-327(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-30 AND 642-653.
  9. "Lung-derived growth factor that stimulates the growth of lung-metastasizing tumor cells: identification as transferrin."
    Cavanaugh P.G., Nicolson G.L.
    J. Cell. Biochem. 47:261-271(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 89-102; 232-243 AND 404-411.
  10. Lubec G., Afjehi-Sadat L., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 144-162; 240-251; 332-343; 588-609; 616-624; 630-642 AND 660-682, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Spinal cord.
  11. Cited for: METHYLATION AT ARG-42, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTRFE_RAT
AccessioniPrimary (citable) accession number: P12346
Secondary accession number(s): Q63602
, Q64628, Q64630, Q7TNX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3