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Protein

Serotransferrin

Gene

Tf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Iron 1PROSITE-ProRule annotation1
Metal bindingi114Iron 1PROSITE-ProRule annotation1
Binding sitei139Carbonate 1PROSITE-ProRule annotation1
Binding sitei143Carbonate 1PROSITE-ProRule annotation1
Binding sitei145Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei146Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi207Iron 1PROSITE-ProRule annotation1
Metal bindingi268Iron 1PROSITE-ProRule annotation1
Metal bindingi410Iron 2PROSITE-ProRule annotation1
Metal bindingi447Iron 2PROSITE-ProRule annotation1
Binding sitei473Carbonate 2PROSITE-ProRule annotation1
Binding sitei477Carbonate 2PROSITE-ProRule annotation1
Binding sitei479Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei480Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi536Iron 2PROSITE-ProRule annotation1
Metal bindingi604Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-917937 Iron uptake and transport
R-RNO-917977 Transferrin endocytosis and recycling

Protein family/group databases

MEROPSiS60.970

Names & Taxonomyi

Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Liver regeneration-related protein LRRG03
Siderophilin
Gene namesi
Name:Tf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3845 Tf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1417 Rat n Transferrin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000003571820 – 698SerotransferrinAdd BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
Modified residuei42Dimethylated arginine1 Publication1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Modified residuei388PhosphoserineBy similarity1
Disulfide bondi420 ↔ 693PROSITE-ProRule annotation
Disulfide bondi435 ↔ 656PROSITE-ProRule annotation
Disulfide bondi471 ↔ 542PROSITE-ProRule annotation
Disulfide bondi495 ↔ 684PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi516 ↔ 525PROSITE-ProRule annotation
Disulfide bondi582 ↔ 596PROSITE-ProRule annotation
Disulfide bondi634 ↔ 639PROSITE-ProRule annotation
Modified residuei685PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP12346
PRIDEiP12346

2D gel databases

World-2DPAGEi0004:P12346

PTM databases

GlyConnecti557
iPTMnetiP12346
PhosphoSitePlusiP12346
UniCarbKBiP12346

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSRNOG00000030625
ExpressionAtlasiP12346 baseline and differential
GenevisibleiP12346 RN

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246945, 1 interactor
IntActiP12346, 1 interactor
STRINGi10116.ENSRNOP00000012725

Structurei

3D structure databases

ProteinModelPortaliP12346
SMRiP12346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini360 – 683Transferrin-like 2PROSITE-ProRule annotationAdd BLAST324

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
GeneTreeiENSGT00390000001619
HOGENOMiHOG000043759
HOVERGENiHBG000055
InParanoidiP12346
KOiK14736
PhylomeDBiP12346

Family and domain databases

InterProiView protein in InterPro
IPR030685 Serotransferrin_mammal
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405 Transferrin, 2 hits
PIRSFiPIRSF500682 Serotransferrin, 1 hit
PIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 1 hit
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12346-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFAVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
ADGPRLACVK KTSYQDCIKA ISGGEADAIT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSLEHP QTHYLAVAVV KKGTDFQLNQ LQGKKSCHTG LGRSAGWIIP
160 170 180 190 200
IGLLFCNLPE PRKPLEKAVA SFFSGSCVPC ADPVAFPQLC QLCPGCGCSP
210 220 230 240 250
TQPFFGYVGA FKCLRDGGGD VAFVKHTTIF EVLPQKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARNGDGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFGSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHSYVT AIRNQREGVC
360 370 380 390 400
PEGSIDSAPV KWCALSHQER AKCDEWSVSS NGQIECESAE STEDCIDKIV
410 420 430 440 450
NGEADAMSLD GGHAYIAGQC GLVPVMAENY DISSCTNPQS DVFPKGYYAV
460 470 480 490 500
AVVKASDSSI NWNNLKGKKS CHTGVDRTAG WNIPMGLLFS RINHCKFDEF
510 520 530 540 550
FSQGCAPGYK KNSTLCDLCI GPAKCAPNNR EGYNGYTGAF QCLVEKGDVA
560 570 580 590 600
FVKHQTVLEN TNGKNTAAWA KDLKQEDFQL LCPDGTKKPV TEFATCHLAQ
610 620 630 640 650
APNHVVVSRK EKAARVSTVL TAQKDLFWKG DKDCTGNFCL FRSSTKDLLF
660 670 680 690
RDDTKCLTKL PEGTTYEEYL GAEYLQAVGN IRKCSTSRLL EACTFHKS
Length:698
Mass (Da):76,395
Last modified:January 9, 2007 - v3
Checksum:iB91ABB41CA447194
GO
Isoform 2 (identifier: P12346-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-266: Missing.

Show »
Length:496
Mass (Da):54,524
Checksum:i7FADB62945314E20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → P in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti110P → R in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti318A → R in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti321 – 323LLR → CYG in BAA07458 (PubMed:8829802).Curated3
Sequence conflicti324 – 354VPPRM…CPEGS → APKDGLQAVPRPQLCHCHSK SAGSCPDA in CAA54403 (PubMed:7717992).CuratedAdd BLAST31
Sequence conflicti353G → A in BAA07458 (PubMed:8829802).Curated1
Sequence conflicti379S → T in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti379S → T in BAA07458 (PubMed:8829802).Curated1
Sequence conflicti380S → G in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti691E → D in AAA42267 (PubMed:3023031).Curated1
Sequence conflicti696 – 697HK → TA in AAA42267 (PubMed:3023031).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01184065 – 266Missing in isoform 2. 1 PublicationAdd BLAST202

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77158 mRNA Translation: CAA54403.1
D38380 mRNA Translation: BAA07458.1
AY327504 mRNA Translation: AAP97736.1
BC087021 mRNA Translation: AAH87021.1
M26113 mRNA Translation: AAA42266.1
M27966 mRNA Translation: AAA42267.1
PIRiS49163
RefSeqiNP_001013128.1, NM_001013110.1 [P12346-1]
UniGeneiRn.91296

Genome annotation databases

EnsembliENSRNOT00000045628; ENSRNOP00000045637; ENSRNOG00000030625 [P12346-1]
GeneIDi24825
KEGGirno:24825
UCSCiRGD:3845 rat [P12346-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRFE_RAT
AccessioniPrimary (citable) accession number: P12346
Secondary accession number(s): Q63602
, Q64628, Q64630, Q7TNX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 9, 2007
Last modified: April 25, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health