Reviewed, UniProtKB/Swiss-Prot P12345 (AATM_RABIT)

Names and origin

Protein names

Recommended name:
    Aspartate aminotransferase, mitochondrial
    EC=2.6.1.1
Alternative name(s):
    mAspAT
    Transaminase A
    Glutamate oxaloacetate transaminase 2
    Fatty acid-binding protein
    FABP-1
    FABPpm

Gene names

Name:

GOT2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Facilitates cellular uptake of long-chain free fatty acids By similarity.
Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer.
Subcellular location	Mitochondrion matrix. Cell membrane By similarity.
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cell membrane Membrane Mitochondrion
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of vascular permeability Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB protein folding Traceable author statement. Source: HGNC
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›30	›30	Aspartate aminotransferase, mitochondrial		PRO_0000123886
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P12345-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 410321530B95B673	FASTA	30	3,401
	10 20 30 SSWWAHVEMG PPDPILGVTE AYKRDTNSKK

References

[1]	"Aspartate aminotransferase isozymes from rabbit liver. Purification and properties." Kuramitsu S., Inoue K., Kondo K., Aki K., Kagamiyama H. J. Biochem. 97:1337-1345(1985) [PubMed: 4030726] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	B27103.
3D structure databases
HSSP	HSSP built from PDB template 7AAT based on UniProtKB P00508.
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000003871. Oryctolagus cuniculus. [Contig view]
Phylogenomic databases
HOVERGEN	P12345.
Enzyme and pathway databases
BRENDA	2.6.1.1. 255.
Family and domain databases
InterPro	IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. [Graphical view]
PANTHER	PTHR11879. Asp_trans. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AATM_RABIT

Accession

Primary (citable) accession number: P12345

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)