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P12345

- AATM_RABIT

UniProt

P12345 - AATM_RABIT

Protein

Aspartate aminotransferase, mitochondrial

Gene

GOT2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids By similarity.By similarity

    Catalytic activityi

    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
    L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651Substrate; via amide nitrogenBy similarity
    Binding sitei162 – 1621SubstrateBy similarity
    Binding sitei215 – 2151SubstrateBy similarity
    Binding sitei407 – 4071SubstrateBy similarity

    GO - Molecular functioni

    1. kynurenine-oxoglutarate transaminase activity Source: UniProtKB-EC
    2. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB
    3. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    4. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: UniProtKB
    2. aspartate biosynthetic process Source: Ensembl
    3. aspartate catabolic process Source: Ensembl
    4. aspartate metabolic process Source: UniProtKB
    5. fatty acid transport Source: Ensembl
    6. glutamate catabolic process to 2-oxoglutarate Source: Ensembl
    7. glutamate catabolic process to aspartate Source: Ensembl
    8. glutamate metabolic process Source: UniProtKB
    9. oxaloacetate metabolic process Source: Ensembl
    10. protein folding Source: HGNC
    11. response to ethanol Source: Ensembl
    12. response to lipopolysaccharide Source: AgBase

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate aminotransferase, mitochondrial (EC:2.6.1.1, EC:2.6.1.7)
    Short name:
    mAspAT
    Alternative name(s):
    Fatty acid-binding protein
    Short name:
    FABP-1
    Glutamate oxaloacetate transaminase 2
    Kynurenine aminotransferase 4
    Kynurenine aminotransferase IV
    Kynurenine--oxoglutarate transaminase 4
    Kynurenine--oxoglutarate transaminase IV
    Plasma membrane-associated fatty acid-binding protein
    Short name:
    FABPpm
    Transaminase A
    Gene namesi
    Name:GOT2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 5

    Subcellular locationi

    Mitochondrion matrix By similarity. Cell membrane By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: UniProtKB
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929Mitochondrion1 PublicationAdd
    BLAST
    Chaini30 – 430401Aspartate aminotransferase, mitochondrialPRO_0000123886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591N6-acetyllysineBy similarity
    Modified residuei73 – 731N6-acetyllysine; alternateBy similarity
    Modified residuei73 – 731N6-succinyllysine; alternateBy similarity
    Modified residuei82 – 821N6-acetyllysineBy similarity
    Modified residuei90 – 901N6-acetyllysine; alternateBy similarity
    Modified residuei90 – 901N6-succinyllysine; alternateBy similarity
    Modified residuei96 – 961Nitrated tyrosineBy similarity
    Modified residuei122 – 1221N6-acetyllysine; alternateBy similarity
    Modified residuei122 – 1221N6-succinyllysine; alternateBy similarity
    Modified residuei159 – 1591N6-acetyllysine; alternateBy similarity
    Modified residuei159 – 1591N6-succinyllysine; alternateBy similarity
    Modified residuei185 – 1851N6-acetyllysine; alternateBy similarity
    Modified residuei185 – 1851N6-succinyllysine; alternateBy similarity
    Modified residuei227 – 2271N6-succinyllysineBy similarity
    Modified residuei234 – 2341N6-acetyllysineBy similarity
    Modified residuei279 – 2791N6-(pyridoxal phosphate)lysine; alternateBy similarity
    Modified residuei279 – 2791N6-acetyllysine; alternateBy similarity
    Modified residuei296 – 2961N6-acetyllysine; alternateBy similarity
    Modified residuei296 – 2961N6-succinyllysine; alternateBy similarity
    Modified residuei302 – 3021N6-acetyllysineBy similarity
    Modified residuei309 – 3091N6-acetyllysine; alternateBy similarity
    Modified residuei309 – 3091N6-succinyllysine; alternateBy similarity
    Modified residuei338 – 3381N6-acetyllysine; alternateBy similarity
    Modified residuei338 – 3381N6-succinyllysine; alternateBy similarity
    Modified residuei345 – 3451N6-acetyllysineBy similarity
    Modified residuei363 – 3631N6-acetyllysine; alternateBy similarity
    Modified residuei363 – 3631N6-succinyllysine; alternateBy similarity
    Modified residuei364 – 3641N6-acetyllysineBy similarity
    Modified residuei387 – 3871N6-acetyllysineBy similarity
    Modified residuei396 – 3961N6-acetyllysine; alternateBy similarity
    Modified residuei396 – 3961N6-succinyllysine; alternateBy similarity
    Modified residuei404 – 4041N6-acetyllysine; alternateBy similarity
    Modified residuei404 – 4041N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation, Nitration

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000003357.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1448.
    GeneTreeiENSGT00390000014081.
    HOGENOMiHOG000185898.
    OMAiRVGAFTM.
    OrthoDBiEOG74J980.
    TreeFamiTF300641.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR000796. Asp_trans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11879. PTHR11879. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00799. TRANSAMINASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12345-1 [UniParc]FASTAAdd to Basket

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    MALLHSARVL SGVASAFHPG LAAAASARAS SWWAHVEMGP PDPILGVTEA    50
    YKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK GLDKEYLPIG 100
    GLAEFCRASA ELALGENSEV VKSGRFVTVQ TISGTGALRI GASFLQRFFK 150
    FSRDVFLPKP SWGNHTPIFR DAGMQLQSYR YYDPKTCGFD FTGALEDISK 200
    IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA 250
    SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTVICKDADE 300
    AKRVESQLKI LIRPMYSNPP IHGARIASTI LTSPDLRKQW LQEVKGMADR 350
    IIGMRTQLVS NLKKEGSTHS WQHITDQIGM FCFTGLKPEQ VERLTKEFSI 400
    YMTKDGRISV AGVTSGNVGY LAHAIHQVTK 430
    Length:430
    Mass (Da):47,409
    Last modified:September 18, 2013 - v2
    Checksum:i12F54284974D27A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAGW02052878 Genomic DNA. No translation available.
    PIRiB27103.
    RefSeqiXP_002711597.1. XM_002711551.2.
    UniGeneiOcu.5296.

    Genome annotation databases

    EnsembliENSOCUT00000003872; ENSOCUP00000003357; ENSOCUG00000003871.
    GeneIDi100348732.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAGW02052878 Genomic DNA. No translation available.
    PIRi B27103.
    RefSeqi XP_002711597.1. XM_002711551.2.
    UniGenei Ocu.5296.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000003357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000003872 ; ENSOCUP00000003357 ; ENSOCUG00000003871 .
    GeneIDi 100348732.

    Organism-specific databases

    CTDi 2806.

    Phylogenomic databases

    eggNOGi COG1448.
    GeneTreei ENSGT00390000014081.
    HOGENOMi HOG000185898.
    OMAi RVGAFTM.
    OrthoDBi EOG74J980.
    TreeFami TF300641.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR000796. Asp_trans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11879. PTHR11879. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00799. TRANSAMINASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequence of Oryctolagus cuniculus (European rabbit)."
      The Genome Sequencing Platform
      Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., Lindblad-Toh K.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Thorbecke.
    2. "Aspartate aminotransferase isozymes from rabbit liver. Purification and properties."
      Kuramitsu S., Inoue K., Kondo K., Aki K., Kagamiyama H.
      J. Biochem. 97:1337-1345(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-59.
      Tissue: Liver.

    Entry informationi

    Entry nameiAATM_RABIT
    AccessioniPrimary (citable) accession number: P12345
    Secondary accession number(s): G1SKL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3