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P12345

- AATM_RABIT

UniProt

P12345 - AATM_RABIT

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Protein

Aspartate aminotransferase, mitochondrial

Gene
GOT2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids By similarity.

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

Cofactori

Pyridoxal phosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Substrate; via amide nitrogen By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei215 – 2151Substrate By similarity
Binding sitei407 – 4071Substrate By similarity

GO - Molecular functioni

  1. kynurenine-oxoglutarate transaminase activity Source: UniProtKB-EC
  2. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB
  3. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  4. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: UniProtKB
  2. aspartate biosynthetic process Source: Ensembl
  3. aspartate catabolic process Source: Ensembl
  4. aspartate metabolic process Source: UniProtKB
  5. fatty acid transport Source: Ensembl
  6. glutamate catabolic process to 2-oxoglutarate Source: Ensembl
  7. glutamate catabolic process to aspartate Source: Ensembl
  8. glutamate metabolic process Source: UniProtKB
  9. oxaloacetate metabolic process Source: Ensembl
  10. protein folding Source: HGNC
  11. response to ethanol Source: Ensembl
  12. response to lipopolysaccharide Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase, mitochondrial (EC:2.6.1.1, EC:2.6.1.7)
Short name:
mAspAT
Alternative name(s):
Fatty acid-binding protein
Short name:
FABP-1
Glutamate oxaloacetate transaminase 2
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV
Plasma membrane-associated fatty acid-binding protein
Short name:
FABPpm
Transaminase A
Gene namesi
Name:GOT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 5

Subcellular locationi

Mitochondrion matrix By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. mitochondrion Source: UniProtKB
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion1 PublicationAdd
BLAST
Chaini30 – 430401Aspartate aminotransferase, mitochondrialPRO_0000123886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591N6-acetyllysine By similarity
Modified residuei73 – 731N6-acetyllysine; alternate By similarity
Modified residuei73 – 731N6-succinyllysine; alternate By similarity
Modified residuei82 – 821N6-acetyllysine By similarity
Modified residuei90 – 901N6-acetyllysine; alternate By similarity
Modified residuei90 – 901N6-succinyllysine; alternate By similarity
Modified residuei96 – 961Nitrated tyrosine By similarity
Modified residuei122 – 1221N6-acetyllysine; alternate By similarity
Modified residuei122 – 1221N6-succinyllysine; alternate By similarity
Modified residuei159 – 1591N6-acetyllysine; alternate By similarity
Modified residuei159 – 1591N6-succinyllysine; alternate By similarity
Modified residuei185 – 1851N6-acetyllysine; alternate By similarity
Modified residuei185 – 1851N6-succinyllysine; alternate By similarity
Modified residuei227 – 2271N6-succinyllysine By similarity
Modified residuei234 – 2341N6-acetyllysine By similarity
Modified residuei279 – 2791N6-(pyridoxal phosphate)lysine; alternate By similarity
Modified residuei279 – 2791N6-acetyllysine; alternate By similarity
Modified residuei296 – 2961N6-acetyllysine; alternate By similarity
Modified residuei296 – 2961N6-succinyllysine; alternate By similarity
Modified residuei302 – 3021N6-acetyllysine By similarity
Modified residuei309 – 3091N6-acetyllysine; alternate By similarity
Modified residuei309 – 3091N6-succinyllysine; alternate By similarity
Modified residuei338 – 3381N6-acetyllysine; alternate By similarity
Modified residuei338 – 3381N6-succinyllysine; alternate By similarity
Modified residuei345 – 3451N6-acetyllysine By similarity
Modified residuei363 – 3631N6-acetyllysine; alternate By similarity
Modified residuei363 – 3631N6-succinyllysine; alternate By similarity
Modified residuei364 – 3641N6-acetyllysine By similarity
Modified residuei387 – 3871N6-acetyllysine By similarity
Modified residuei396 – 3961N6-acetyllysine; alternate By similarity
Modified residuei396 – 3961N6-succinyllysine; alternate By similarity
Modified residuei404 – 4041N6-acetyllysine; alternate By similarity
Modified residuei404 – 4041N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation, Nitration

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003357.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1448.
GeneTreeiENSGT00390000014081.
HOGENOMiHOG000185898.
OMAiRVGAFTM.
OrthoDBiEOG74J980.
TreeFamiTF300641.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12345-1 [UniParc]FASTAAdd to Basket

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MALLHSARVL SGVASAFHPG LAAAASARAS SWWAHVEMGP PDPILGVTEA    50
YKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK GLDKEYLPIG 100
GLAEFCRASA ELALGENSEV VKSGRFVTVQ TISGTGALRI GASFLQRFFK 150
FSRDVFLPKP SWGNHTPIFR DAGMQLQSYR YYDPKTCGFD FTGALEDISK 200
IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA 250
SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTVICKDADE 300
AKRVESQLKI LIRPMYSNPP IHGARIASTI LTSPDLRKQW LQEVKGMADR 350
IIGMRTQLVS NLKKEGSTHS WQHITDQIGM FCFTGLKPEQ VERLTKEFSI 400
YMTKDGRISV AGVTSGNVGY LAHAIHQVTK 430
Length:430
Mass (Da):47,409
Last modified:September 18, 2013 - v2
Checksum:i12F54284974D27A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAGW02052878 Genomic DNA. No translation available.
PIRiB27103.
RefSeqiXP_002711597.1. XM_002711551.2.
UniGeneiOcu.5296.

Genome annotation databases

EnsembliENSOCUT00000003872; ENSOCUP00000003357; ENSOCUG00000003871.
GeneIDi100348732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAGW02052878 Genomic DNA. No translation available.
PIRi B27103.
RefSeqi XP_002711597.1. XM_002711551.2.
UniGenei Ocu.5296.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000003357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000003872 ; ENSOCUP00000003357 ; ENSOCUG00000003871 .
GeneIDi 100348732.

Phylogenomic databases

eggNOGi COG1448.
GeneTreei ENSGT00390000014081.
HOGENOMi HOG000185898.
OMAi RVGAFTM.
OrthoDBi EOG74J980.
TreeFami TF300641.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11879. PTHR11879. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00799. TRANSAMINASE.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome Sequence of Oryctolagus cuniculus (European rabbit)."
    The Genome Sequencing Platform
    Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S., Lindblad-Toh K.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Thorbecke.
  2. "Aspartate aminotransferase isozymes from rabbit liver. Purification and properties."
    Kuramitsu S., Inoue K., Kondo K., Aki K., Kagamiyama H.
    J. Biochem. 97:1337-1345(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-59.
    Tissue: Liver.

Entry informationi

Entry nameiAATM_RABIT
AccessioniPrimary (citable) accession number: P12345
Secondary accession number(s): G1SKL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 18, 2013
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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