P12345 (AATM_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate aminotransferase, mitochondrial
Short name=mAspAT
EC=2.6.1.1
EC=2.6.1.7

Alternative name(s):
Fatty acid-binding protein
Short name=FABP-1
Glutamate oxaloacetate transaminase 2
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV
Plasma membrane-associated fatty acid-binding protein
Short name=FABPpm
Transaminase A

Gene names

Name:

GOT2

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids By similarity.
Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer.
Subcellular location	Mitochondrion matrix. Cell membrane By similarity.
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cell membrane Membrane Mitochondrion
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	2-oxoglutarate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB aspartate biosynthetic process Inferred from electronic annotation. Source: Compara aspartate catabolic process Inferred from electronic annotation. Source: Compara aspartate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB fatty acid transport Inferred from electronic annotation. Source: Compara glutamate catabolic process to 2-oxoglutarate Inferred from electronic annotation. Source: Compara glutamate catabolic process to aspartate Inferred from electronic annotation. Source: Compara glutamate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxaloacetate metabolic process Inferred from electronic annotation. Source: Compara protein folding Traceable author statement PubMed 9683573. Source: HGNC response to ethanol Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: Compara mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from sequence or structural similarity. Source: UniProtKB L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC kynurenine-oxoglutarate transaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›30	›30	Aspartate aminotransferase, mitochondrial		PRO_0000123886
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P12345 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 410321530B95B673	FASTA	30	3,401
	10 20 30 SSWWAHVEMG PPDPILGVTE AYKRDTNSKK

References

[1]	"Aspartate aminotransferase isozymes from rabbit liver. Purification and properties." Kuramitsu S., Inoue K., Kondo K., Aki K., Kagamiyama H. J. Biochem. 97:1337-1345(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	B27103.
3D structure databases
ProteinModelPortal	P12345.
SMR	P12345. Positions 1-30.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000003357.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG1448.
HOGENOM	HOG000185898.
OrthoDB	EOG4RXZ07.
Family and domain databases
PROSITE	PS00105. AA_TRANSFER_CLASS_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AATM_RABIT

Accession

Primary (citable) accession number: P12345

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program